Publications
Hidalgo A, Libby P, Soehnlein O, Aramburu IV, Papayannopoulos V, Silvestre-Roig C. Cardiovasc Res. 2021, Oct 14;cvab329. doi: 10.1093/cvr/cvab329. PMID: 34648022
Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, Liu W, Thomas DG, Hajebrahimi MA, Pricher J, Silvestre-Roig C, Kotini A, Luchsinger LL, Wei Y, Westerterp M, Snoeck HW, Papapetrou E, Schulz C, Massberg S, Soehnlein O, Ebert B, Levine RL, Reilly MP, Libby P, Wang N, Alan R. Tall. The Aim2 inflammasome and Gasdermin D promote atherosclerotic plaque necrosis in Jak2V617F clonal hematopoiesis. Nature. 2021 Apr;592(7853):296-301.
Wichapong K., Silvestre-Roig C., Braster Q., Schumski A., Soehnlein O., Nicolaes G.A.F. Structure-based peptide design targeting intrinsically disordered proteins: Novel histone H4 and H2A peptidic inhibitors. Comput Struct Biotechnol J. 2021 Jan 21;19:934-948. doi: 10.1016/j.csbj.2021.01.026. eCollection 2021.
Silvestre-Roig C., Lemnitzer P., Gall J., Schwager S., Toska A., Yvan-Charvet L., Detmar M., Soehnlein O. Arterial Delivery of VEGF-C Stabilizes Atherosclerotic Lesions. Circ Res. 2020.
Asare Y., Campbell-James T.A., Bokov Y., Yu L.L., Prestel M., El Bounkari O., Roth S., Megens R.T.A., Straub T., Thomas K., Yan G., Schneider M., Ziesch N., Tiedt S., Silvestre-Roig C., Braster Q., Huang Y., Schneider M., Malik R., Haffner C., Liesz A., Soehnlein O., Bernhagen J., Dichgans M. Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability. Circ Res. 2020 Aug 28;127(6):811-823. doi: 10.1161/CIRCRESAHA.120.316743.
Silvestre-Roig C., Braster Q., Ortega-Gomez A., Soehnlein O. Neutrophils as regulators of cardiovascular inflammation. Nat Rev Cardiol. 2020 Jan 29. doi: 10.1038/s41569-019-0326-7.
Silvestre-Roig C*, Fridlender Z.G*., Glogauer M, and Scapini P. Neutrophil diversity in health and disease. Trends Immunology. 2019 Jul;40(7):565-583. doi: 10.1016/j.it.2019.04.012. * equal contribution
Vila-Caballer M, González-Granado JM, Zorita V, Abu Nabah YN, Silvestre-Roig C, Del Monte-Monge A, Molina-Sánchez P, Ait-Oufella H, Andrés-Manzano MJ, Sanz MJ, Weber C, Kremer L, Gutiérrez J, Mallat Z, Andrés V. Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice. J Mol Cell Cardiol. 2019 May 20. pii: S0022-2828(19)30096-3. doi: 10.1016/j.yjmcc.2019.05.009.
Silvestre-Roig C*, Braster Q*, Wichapong K, Lee EY, Teulon JM, Berrebeh J, Winter J, Froese A, Adrover JM, Santiago Santos G, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre C, Marschner J, Schumski A, Winter C, Perez-olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes G, Wong GCL, Soehnlein O. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature. 2019. May;569(7755):236-240. doi: 10.1038/s41586-019-1167-6.* equal contribution
Adrover JM, Del Fresno C, Crainiciuc G, Cuartero MI, Casanova-Acebes M, Weiss LA, Huerga-Encabo H, Silvestre-Roig C, Rossaint J, Cossío I, Lechuga-Vieco AV, García-Prieto J, Gómez-Parrizas M, Quintana JA, Ballesteros I, Martin-Salamanca S, Aroca-Crevillen A, Chong SZ, Evrard M, Balabanian K, López J, Bidzhekov K, Bachelerie F, Abad-Santos F, Muñoz-Calleja C, Zarbock A, Soehnlein O, Weber C, Ng LG, Lopez-Rodriguez C, Sancho D, Moro MA, Ibáñez B, Hidalgo A. A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. Immunity. 2019 Feb 19;50(2):390-402.e10.
Wang W, Liu W, Fidler T, Wang Y, Tang Y, Woods B, Welch C, Cai B, Silvestre-Roig C, Ai D, Yang YG, Hidalgo A, Soehnlein O, Tabas I, Levine RL, Tall AR, Wang N. Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice. Circ Res. 2018 Nov 9;123(11):e35-e47.
Chevre R, Silvestre-Roig C, Soehnlein O. Nutritional Modulation of Innate Immunity: The Fat-Bile-Gut Connection. Trends Endocrinol Metab. 2018 Oct;29(10):686-698.
Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Poelmann H, Schumski A, Winter J, Drechsler M, de Jong R, Immler R, Sperandio M, Hristov M, Zeller T, Nicolaes GAF, Weber C, Viola J, Hidalgo A, Scheiermann C, Soehnlein O . Chrono-pharmacological targeting of the CCL2-CCR2 axis ameliorates atherosclerosis. Cell Metab. 2018 Jul 3;28(1):175-182.e5.
Soehnlein O, Silvestre-Roig C. Basic research: Standardizing animal atherosclerosis studies to improve reproducibility. Nat Rev Cardiol. 2017 Oct;14(10):574-575.
Braster Q, Silvestre-Roig C et al. Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice. PLoS One. 2016 Oct 4;11(10):e0163922.
Viola, JR, Lemnitzer, P, Jansen, Y, Csaba, G, Winter, C, Neideck, C, Silvestre-Roig, C, Dittmar, G, Döring, Y, Drechsler, M, Weber, C, Zimmer, R, Cenac, N, Soehnlein, O. Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. Circulation Research. 2016 Oct 14;119(9):1030-1038.
Silvestre-Roig C, Hidalgo A, Soehnlein O. Neutrophil heterogeneity: implications for homeostasis and pathogenesis. Blood. 2016 May 5;127(18):2173-81.
Braster Q, Silvestre-Roig C, Hartwig H, Kusters P, Aarts S, den Toom M, Gallo RL, Weber C, Lutgens E, Soehnlein O. Cathelicidin regulates myeloid cell accumulation in adipose tissue and promotes insulin resistance during obesity. Thromb Haemost. 2016 Jun 2;115(6):1237-9
Hartwig H*, Silvestre-Roig C*, Hendrikse J, Beckers L, Paulin N, Van der Heiden K, Braster Q, Drechsler M, Daemen MJ, Lutgens E, Soehnlein O. Atherosclerotic Plaque Destabilization in Mice: A Comparative Study. PLoS One. 2015 Oct 22;10(10). * equal contribution
González-Granado JM, Silvestre-Roig C, Rocha-Perugini V, Trigueros-Motos L, Cibrian D, Morlino G, Blanco-Berrocal M, Osorio FG, Freije JMP, López-Otín C, Sánchez-Madrid P, Andrés V. Nuclear envelope lamin-a couples actin dynamics with immunological synapse architecture and T cell activation. Science Signaling. 2014 Apr 22;7(322):ra37.
Silvestre-Roig C*; Fernández P*; Mansego ML; van Tiel CM; Viana R; Viviani Anselmi C; Condorelli G; de Winter RJ; Martín-Fuentes P; Solanas-Barca M; Civeira F; Focaccio A; de Vries CJ; Chaves FJ; Andrés V. Genetic variants in CCNB1 associated with differential gene transcription and risk of coronary in-stent restenosis. Circulation Cardiovascular Genetics. 2014.Feb;7(1):59-70. * equal contribution
Silvestre-Roig C, de Winther MP, Weber C, Daemen MJ, Lutgens E, Soehnlein O. Atherosclerotic Plaque Destabilization: Mechanisms, Models, and Therapeutic Strategies. Circulation Research. 2014 Jan 3;114(1):214-26.
Chèvre R, González-Granado JM, Megens RT, Sreeramkumar V, Silvestre-Roig C, Molina-Sanchez P, Weber C, Soehnlein O, Hidalgo A, Andrés V. High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice. Circulation Research. 2014 Feb 28;114(5):770-9.
Silvestre-Roig C*, Fernández P*, Esteban V, Pello OM; Indolfi C; Rodríguez C, Rodríguez-Calvo R, López-Maderuelo MD, Bauriedel G, Hutter R, Fuster V, Ibáñez B, Redondo JM, Martínez-González J, Andrés V. Inactivation of Nuclear Factor-Y Inhibits Vascular Smooth Muscle Cell Proliferation and Neointima Formation. Arterioscler Thromb Vasc Biol. 2013 May;33(5):1036-45. * equal contribution
Please click here for a complete list of publications: