Selected Original Publications

Silvestre-Roig, C*., González-Granado, J.M., Osei-Sarpong, C., Gricar, E., Gonzalo, P., Farjia, M., Malamud, M., Vöcking, L.-M., Alonso-Gonzalez, N., Chevre, R., Esteban, V., and Andrés, V. (2026). 
The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease.
J. Leukoc. Biol. Published online August 14, 2026. doi: 10.1093/jleuko/qiag113. *Corresponding author.

Richter, M., von Göwels, J., Fähndrich, M., Lipgens Fernandez, C., Grohn, K., Welzel, M., Schwarz, D., Lang, A., Polzin, A., Reinartz Groba, S., Farinola, L., Ghosh, S., Heming, J.N., Aleth, H., Akhalkatsi, A., Marjani, K., Rübsamen, N., Radecke, T., Rosenbauer, F., Sickmann, A., Karch, A., Zarbock, A., Minnerup, J., Sindermann, J., Bender, A., Rossaint, J., Ormanns, S., Gunzer, M., Malamud, M., Kaiser, R., Pekayvaz, K., Heider, D., Reinecke, H., Makowski, L., Jung, C., Silvestre-Roig, C., Kelm, M., Gerdes, N., Chevre, R., Lange, S.A., and Soehnlein, O. (2026). 
Depth of neutrophil mobilization stratifies survival in ST-elevation myocardial infarction. 
Nat. Cardiovasc. Res. Published online July 3, 2026. doi: 10.1038/s44161-026-00836-0.

Farjia M, Pan C, Braster Q, Lemnitzer P, Sachs N, Vöcking LM, Chevre R, Malamud M, Schulz C, Maegdefesel L, Soehnlein O, Silvestre-Roig C. 
CCR2+ neutrophils exhibit a proinflammatory phenotype and contribute to plaque vulnerability. 
Arterioscler Thromb Vasc Biol. 2026 Jul;46(7):e324654. doi: 10.1161/ATVBAHA.126.324654.

Silvestre-Roig C*, Chevre R, Farjia M, Bender A, Vöcking LM, Richter M, Hageb A, Suerdieck V, Arenas Cerro FJ, Braster Q, Guzman M, Sintes J, Sharma S, Lemnitzer P, Tulotta C, Börgeling Y, Herrero-Cervera A, Flueter H, Reinartz Groba SN, Ahern D, Osei-Sarpong C, Zimmer R, Alonso-Gonzalez N, Ortega E, Lienenklaus S, Kalinke U, Ludwig S, Engel DR, Rosenbauer F, Monaco C, Dersch P, Kibler A, Cerutti A, Chavakis T, Benedito R, Hidalgo A, Jablonska J, Palomino-Segura M, Soehnlein O*. 
Divergent granulopoiesis at extramedullary sites safeguards antibacterial host defense. 
Sci Immunol. 2026 Apr 17;11(118):eadw7077. doi: 10.1126/sciimmunol.adw7077. *Corresponding author.

Zhang Y, Silvestre-Roig C, Fu H, Alimohamadi H, Mandal T, Chen JW, Luo EW, Anda J, Linard Matos AL, Richter M, Mennella A, Lee H, Chan LC, Wang Y, Wang N, Wang H, Wang X, Lee CK, Ghosh S, Matsui T, Weiss TM, Guo T, Zhang M, Li D, Wolfgang MC, Hagan RS, Li MMH, Gunzer M, Sickmann A, Frasca L, Yeaman MR, Lande R, Cui Q, Soehnlein O, Wong GCL. 
SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting. 
Proc Natl Acad Sci U S A. 2026 Jan 13;123(2):e2521841122. doi: 10.1073/pnas.2521841122.

Ozel I, Sha G, Będzińska A, Pylaeva E, Naumova Y, Thiel I, Antczak J, Squire A, Gunzer M, Zelinskyy G, Kürten C, Lang S, Silvestre-Roig C, Kortylewski M, Granot Z, Jablonska J. 
Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8+ T cells. 
Signal Transduct Target Ther. 2025 Aug 30;10(1):279. doi: 10.1038/s41392-025-02363-z.

Lee MW*, Luo EW*, Silvestre-Roig C*, Srinivasan Y, Akabori K, Lemnitzer P, Schmidt NW, Lai GH, Santangelo CD, Soehnlein O, Wong GCL. 
Apolipoprotein Mimetic Peptide Inhibits Neutrophil-Driven Inflammatory Damage via Membrane Remodeling and Suppression of Cell Lysis. 
ACS Nano. 2021 Oct 26;15(10):15930-15939. doi: 10.1021/acsnano.1c03978. * equal contribution

Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, Liu W, Thomas DG, Hajebrahimi MA, Pricher J, Silvestre-Roig C, Kotini A, Luchsinger LL, Wei Y, Westerterp M, Snoeck HW, Papapetrou E, Schulz C, Massberg S, Soehnlein O, Ebert B, Levine RL, Reilly MP, Libby P, Wang N, Alan R. Tall. 
The Aim2 inflammasome and Gasdermin D promote atherosclerotic plaque necrosis in Jak2V617F clonal hematopoiesis. 
Nature. 2021 Apr;592(7853):296-301.

Silvestre-Roig C., Lemnitzer P., Gall J., Schwager S., Toska A., Yvan-Charvet L., Detmar M., Soehnlein O. 
Arterial Delivery of VEGF-C Stabilizes Atherosclerotic Lesions. 
Circ Res. 2020. doi: 10.1161/CIRCRESAHA.120.317186.

Silvestre-Roig C*, Braster Q*, Wichapong K, Lee EY, Teulon JM, Berrebeh J, Winter J, Froese A, Adrover JM, Santiago Santos G, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre C, Marschner J, Schumski A, Winter C, Perez-olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes G, Wong GCL, Soehnlein O. 
Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. 
Nature. 2019. May;569(7755):236-240. doi: 10.1038/s41586-019-1167-6.* equal contribution

Adrover JM, Del Fresno C, Crainiciuc G, Cuartero MI, Casanova-Acebes M, Weiss LA, Huerga-Encabo H, Silvestre-Roig C, Rossaint J, Cossío I, Lechuga-Vieco AV, García-Prieto J, Gómez-Parrizas M, Quintana JA, Ballesteros I, Martin-Salamanca S, Aroca-Crevillen A, Chong SZ, Evrard M, Balabanian K, López J, Bidzhekov K, Bachelerie F, Abad-Santos F, Muñoz-Calleja C, Zarbock A, Soehnlein O, Weber C, Ng LG, Lopez-Rodriguez C, Sancho D, Moro MA, Ibáñez B, Hidalgo A. 
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. 
Immunity. 2019 Feb 19;50(2):390-402.e10.

Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Poelmann H, Schumski A, Winter J, Drechsler M, de Jong R, Immler R, Sperandio M, Hristov M, Zeller T, Nicolaes GAF, Weber C, Viola J, Hidalgo A, Scheiermann C, Soehnlein O. 
Chrono-pharmacological targeting of the CCL2-CCR2 axis ameliorates atherosclerosis. 
Cell Metab. 2018 Jul 3;28(1):175-182.e5.

Selected reviews

Richter M, Maier-Begandt D, Jablonska J, Silvestre-Roig C. 
Sex differences in neutrophil biology. 
J Leukoc Biol. 2025 Dec 1;117(12):qiaf161. doi: 10.1093/jleuko/qiaf161.

Hageb A, Farjia M, Osei-Sarpong C, Silvestre-Roig C. 
Ontogenetic drivers of neutrophil heterogeneity. 
Exp Hematol. 2025 Nov;151:104863. doi: 10.1016/j.exphem.2025.104863.

Hidalgo A, Libby P, Soehnlein O, Aramburu IV, Papayannopoulos V, Silvestre-Roig C. 
Neutrophil extracellular traps: from physiology to pathology. 
Cardiovasc Res. 2021, Oct 14;cvab329. doi: 10.1093/cvr/cvab329. 

Silvestre-Roig C., Braster Q., Ortega-Gomez A., Soehnlein O. 
Neutrophils as regulators of cardiovascular inflammation. 
Nat Rev Cardiol. 2020 Jan 29. doi: 10.1038/s41569-019-0326-7.

Silvestre-Roig C*, Fridlender Z.G*., Glogauer M, and Scapini P. 
Neutrophil diversity in health and disease. 
Trends Immunology. 2019 Jul;40(7):565-583. doi: 10.1016/j.it.2019.04.012. * equal contribution 

Silvestre-Roig C, Hidalgo A, Soehnlein O. 
Neutrophil heterogeneity: implications for homeostasis and pathogenesis. 
Blood. 2016 May 5;127(18):2173-81.

For complete list of publications on Pubmed:
https://pubmed.ncbi.nlm.nih.gov/?term=silvestre-roig&sort=date