Dynamic IL6R-STAT3 signaling leads to heterogeneity of metabolic phenotype in
pancreatic ductal adenocarcinoma cells.

Blaszczak W, White B, Monterisi S, Swietach P

Cell Reports, in press.

Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells.

Duranti C, Iorio J, Bagni G, Chioccioli Altadonna G, Fillion T, Lulli M, D'Alessandro FN, Montalbano A, Lastraioli E, Fanelli D, Coppola S, Schmidt T, Piazza F, Becchetti A, Arcangeli A

Life Sci Alliance. 2023 Nov 3;7(1):e202302135. doi: 10.26508/lsa.202302135. Print 2024 Jan.

The context-dependent role of the Na+/Ca2+-exchanger (NCX) in pancreatic stellate cell migration

Loeck T, Rugi M, Todesca LM, Soret B, Neumann I, Schimmelpfennig S, Najder K, Pethő Z, Farfariello V, Prevarskaya N, Schwab A

Pflügers Archiv-Eur J Physiol 2023; doi: 10.1007/s00424-023-02847-3

Acidic growth conditions promote epithelial-to-mesenchymal transition to select more aggressive PDAC cell phenotypes in vitro

Audero MM, Carvalho TMA, Ruffinatti FA, Loeck T, Yassine M, Chinigò G, Folcher A, Farfariello V, Amadori S, Vaghi C, Schwab A, Reshkin SJ, Cardone R.,Prevarskaya N, Fiorio Pla A.A

Cancers 2023; doi: 10.3390/cancers15092572

Transcriptomic data of bevacizumab-adapted colorectal adenocarcinoma cells HCT-116

Sala C, Lottini T, Lastraioli E, Ruffinatti FA, Visentin L, Arcangeli A

Data Brief 2023; doi: 10.1016/j.dib.2023.109069

Increased demand for FAD synthesis in differentiated and stem pancreatic cancer cells is accomplished by modulating FLAD1 gene expression: the inhibitory effect of Chicago Sky Blue

Nisco A, Carvalho TMA, Tolomeo nM, Di Molfetta D, Leone P, Galluccio M, Medina M, Indiveri C, Reshkin SJ, Cardone RA, Barile M

FEBS J 2023; doi: 10.1111/febs16881

ECM composition differentially regulates intracellular and extracellular pH in normal and cancer pancreatic duct epithelial cells.

Di Molfetta D, Cannone S, Greco MR, Caroppo R, Piccapane F, Carvalho TMA, Altamura C, Saltarella I, Tavares Valente D, Desaphy JF, Reshkin SJ, Cardone RA.

Int J Mol Sci 2023; doi: 10.3390/ijms241310632

Synergistic effects of agonists and two-pore-domain potassium channels on secretory responses of human pancreatic duct cells Capan-1.

Sørensen CE, Trauzold A, Christensen N, Tawfik D., Szczepanowski M, Novak, I

Pflügers Archiv-Eur J Physiol 2023; doi: 10.1007/s00124-022-02782-9

Combination Therapy with a Bispecific Antibody Targeting the hERG1/β1 Integrin Complex and Gemcitabine in Pancreatic Ductal Adenocarcinoma

Lottini T , Duranti C, Iorio J, Martinelli M, Colasurdo R, D’Alessandro FN, Buonamici M, Coppola S, Devescovi V, La Vaccara V, Coppola A, Coppola R, Lastraioli E, Arcangeli A

Cancers 2023; doi: 10.3390/cancers15072013

The role of potassium channels in tumours of the gastrointestinal tract: a focus on the human ethe- à-go-go related gene 1 channels

Arcangeli A, Duranti C, Iorio J, Lastraioli E

J Physiol 2023; doi: 10.1113/jp282310

Whole body bioluminescence imaging of T-cell response in PDAC models.

McMorrow R, Zambito G, Nigg A, Lila K, van den Bosch T, Lowik C, Mezzanotte L

Front Immunol 2023; doi: 10.3389/fimmu.2023.1207533

Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness.

Czaplinska D, Ialchina R, Andersen HB, Yao J, Stigliani A, Dannesboe J, Flinck M, Chen X, Mitrega J, Gnosa SP, Dmytriyeva O, Alves F, Napp J, Sandelin A, Pedersen SF

Int J Cancer 2023; doi: 10.1002/ijc.34367

Immunosuppressive effects of new thiophene-based KV1.3 inhibitors

Gubič Š, Montalbano A, Sala C, Becchetti A, Hendrickx LA, Van Theemsche KM, Pinheiro-Junior EL, Altadonna GC, Peigneur S, Ilaš J, Labro AJ, Pardo LA, Tytgat J, Tomašič T, Arcangeli A, Peterlin Mašič L

Euro J Med Chem 2023; doi: 10.1016/j.ejmech.2023.115561

Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters?

Blaszczak W, Swietach P

Oncotarget 2023; doi: 10.18632/oncotarget.28351

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2.

Michl J, Monterisi S, White B, Blaszczak W, Hulikova A, Abdullayeva G, Bridges E, Yin Z, Bodmer WF, Swietach P.

Cell Reports 2023; doi: 10.1016/j.celrep.2023.112601

The Voltage-Gated Hv1 H+ Channel Is Expressed in Tumor-Infiltrating Myeloid-Derived Suppressor Cells

Cozzolino M, Gyöngyösi A, Korpos E, Gogolak P, Umair Naseem M, Kállai J, Lanyi A, Panyi G

Int J Mol Sci 2023; doi: 10.3390/ijms24076216

- 2022 -

Resistance to gemcitabine in pancreatic ductal adenocarcinoma: A physiopathologic and pharmacologic review

Koltai T, Reshkin SJ, Carvalho TMA, Di Molfetta D, Greco MR, Alfarouk KO, Cardone RA.

Cancers 2022; doi: 10.3390/cancers14102486

Role of pH in Regulating Cancer Pyrimidine Synthesis

Alqahtani SS, Koltai T, Ibrahim ME, Bashir AHH, Alhoufie STS, Ahmed SBM, Molfetta DD, Carvalho TMA, Cardone RA, Reshkin SJ, Hifny A, Ahmed ME, Alfarouk KO

J Xenobiot 2022; doi: 10.3390/jox12030014

Cancer Associated Fibroblast (CAF) Regulation of PDAC Parenchymal (CPC) and CSC Phenotypes Is Modulated by ECM Composition

Cannone S, Greco MR, Carvalho TMA, Guizouarn H, Soriani O, Di Molfetta D, Tomasini R, Zeeberg K, Reshkin SJ, Cardone RA

Cancers 2022; doi: 10.3390/cancers14153737

The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models

Chioccioli Altadonna G, Montalbano A, Iorio J, Becchetti A, Arcangeli A, Duranti C

Membranes 2022; doi: 10.3390/membranes12111162

Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumours of the Ileum and Pancreas

Iorio J, Antonuzzo L, Scarpi E, D’Amico M, Duranti C, Messerini L, Sparano C, Caputo D, Lavacchi D, Borzomati D, Antonelli A, Nibid L, Perrone G, Coppola A, Coppola R, di Costanzo F, Lastraioli E, Arcangeli A

Int J Mol Sci 2022; doi: 10.3390/ijms231810623

hERG1 Potassium Channel Expression in Colorectal Adenomas: Comparison with Other Preneoplastic Lesions of the Gastrointestinal Tract

Lastraioli E, Iorio J, Petrelli F, Tomezzoli A, Battista S, Ambrosio MR, Chiudinelli M, De Salvatore F, Messerini L, Villanacci V, Saragoni L, Arcangeli A

Applied Sciences 2022; doi: 10.3390/app12020666

Biophysical and Biomechanical Effect of Low Intensity US Treatments on Pancreatic Adenocarcinoma 3D Cultures

Dimitri M, Duranti C, Aquino S, Mazzantini L, Iorio J, Lulli M, Ricci M, Capineri L, Arcangeli A, Corvi A

Curr Issues Mol Biol 2022; doi: 10.3390/cim44030089

Impact of Extracellular pH on Apoptotic and Non-Apoptotic TRAIL-Induced Signaling in Pancreatic Ductal Adenocarcinoma Cells

Hagelund S, Trauzold A

Front Cell Dev Biol 2022; doi: 10.3389/fcell.2022.768579

Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells

Rambow AC, Aschenbach I, Hagelund S, Tawfik D, Gundlach JP, Weiße S, Maass N, Trauzold A

Front Cell Dev Biol 2022; doi: 10.3389/fcell.2022.942718

New Diarylamine KV10.1 Inhibitors and Their Anticancer Potential

Gubič S, Toplak Z, Shi X, Dernovšek J, Hendrickx LA, Lopes Pinheiro-Junior E, Peigneur S, Tytgat J Pardo LA, Peterlin Mašič L, Tomašič T

Pharmaceutics 2022; doi: 10.3390/pharmaceutics14091963

Overcoming challenges of HERG potassium channel liability throughrational design: Eag1 inhibitors for cancer treatment.

Toplak Z, Hendrickx LA, Abdelaziz R, Shi X, Peigneur S, Tomašič T, Tytgat J, Peterlin-Mašič L, Pardo LA

Med Res Rev 2022; doi: 10.1002/med.21808.

Acid Adaptation Promotes TRPC1 Plasma Membrane Localization Leading to Pancreatic Ductal Adenocarcinoma Cell Proliferation and Migration through Ca2+ Entry and Interaction with PI3K/CaM

Schnipper J, Kouba S, Hague F, Girault A, Telliez MS, Guénin S, Ahidouch A, Pedersen SF, Ouadid-Ahidouch H

Cancers 2022; doi: 10.3390/cancers14194946.

The TRPC1 Channel Forma a PI3K/CaM Complex and Regulates Ductal Adenocarcinoma Cell Proliferation in a Ca2+-Independent Manner.

Schnipper J, Kouba S, Hague F, Girault A, Rybarczyk P, Telliez MS, Guénin S, Tebbakha R, Sevestre H, Ahidouch A, Pedersen SF, Ouadid-Ahidouch H

Int J Mol Sci 2022; doi: 10.3390/ijms23147923.

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.

Michl J, Wang Y, Monterisi S, Blaszczak W, Beveridge R, Bridges EM, Koth J, Bodmer WF, Swietach P

Cell Reports 2022; doi: 10.1016/j.celrep.2022.110493.

Design of New Potent and Selective Thiophene-Based KV1.3 and Their Potential for Anticancer Activity

Gubič S; Hendrickx LA; Shi X; Toplak Z; Možina S; Van Theemsche KM; Lopes Pinheiro-Junior E; Peigneur S; Labro AJ; Pardo LA; Tytgat J; Tomašič T; Peterlin Mašič L

Cancers 2022; doi: 10.3390/cancers14112595.

The Transcriptional Landscape of BRAF Wild Type Metastatic Melanoma: A Pilot Study

Lastraioli E, Ruffinatti FA, Bagni G, Visentin L, di Costanzo F, Munaron L, Arcangeli A

Int J Mol Sci 2022; doi: 10.3390/ijms23136898.

Activation mechsnism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles.

Somodi L, Beke Debreceni I, Kis G, Cozzolino M, Kappelmayer J, Antal M, Panyi G, Bárdos H, Mutch NJ, Muszbek L

J Thrombosis Haemostasis 2022; doi: 10.1111/jth.15668.

Extracellular pH Controls Chemotaxis of Neutrophil Granulocytes by Regulating Leukotriene B4 Production and Cdc42 Signaling.

Oster L, Schröder J, Rugi M, Schimmelpfennig S, Sargin S, Schwab A, Najder K

J Immunol 2022; doi: 10.4049/jimmunol.2100475.

Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production.

Blaszczak W, Williams H, Swietach P

Br J Cancer 2022; doi: 10.1038/s41416-022-01910-7.

Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression.

Audero MM, Prevarskaya N, Fiorio Pla A

Int J Mol Sci 2022; doi: 10.3390/ijms23137377.

Monitoring Immune Cell Function Through Optical Imaging: a Review Highlighting Transgenic Mouse Models.

Chawda C, McMorrow R, Gaspar N, Zambito G, Mezzanotte L

Mol Imaging Biol 2022; doi: 10.1007/s11307-021-01662-5.

Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment.

Toplak Z, Hendrickx LA, Abdelaziz R, Shi X, Peigneur S, Tomašič T, Tytgat J, Peterlin‐Mašič L, Pardo LA

J Vis Exp 2022; doi: 10.3791/63123.

- 2021 -

Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression.

Ouadid-Ahidouch H, Morjani H, Schnipper J, Girault A, Ahidouch A

Med Res Rev 2021; doi: 10.1002/med.21808.

Generation of an orthotopic xenograft of pancreatic cancer cells by ultrasound-guided injection.

Lottini T, Buonamici M, Duranti C, Arcangeli A

Rev Physiol Biochem Phyrmacol 2021; doi: 10.1007/112_2020_19

A Transcriptomic Approach Reveals Selective Ribosomal Remodelling in the Tumour Versus the Stromal Compartment of Metastatic Colorectal Cancer

Lastraioli E, Ruffinatti FA, Di Costanzo F, Sala C, Munaron L, Arcangeli A

Cancers 2021; doi: 10.3390/cancers13164188

Harnessing the hERG1/ß1 integrin complex via a novel bispecific single-chain antibody: An effective strategy against solid cancers.

Duranti C.; Iorio J.; Lottini T.; Lastraioli E.; Crescioli S.; Bagni G.; Lulli M.; Capitani C.; Bouazzi R.; Stefanini M.; Carraresi L.; Iamele L.; De Jonge H.; Arcangeli A.

Mol Cancer Ther 2021; doi: 10.1158/1535-7163.mct-20-1111

Expression and purification of a novel single-chain diabody (scDb-hERG1/ß1) from Pichia pastoris transformants.

Duranti C, Lastraioli E, Iorio J, Capitani C, Carraresi L, Gonnelli L, Arcangeli A

Protein Expr Purif. 2021; doi: 10.1016/j.pep.2021.105879

Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets.

Andersen HB, Ialchina R, Pedersen SF, Czaplinska D

Cancer Metastasis Rev. 2021; doi: 10.1007/s10555-021-10004-4

Discovery of KV1.3 ion channel inhibitors.

Gubič Š, Hendrickx LA, Toplak Ž, Sterle M, Peigneur S, Tomašič T, Pardo LA, Tytgat J, Zega A, Peterlin-Mašič L

Med Res Rev. 2021; doi: 10.1002/med.21800

The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer.

Pedersen SF, Flinck M, Pardo LA

Int J Mol Sci. 2021; doi: 10.3390/ijms22105209.

Tumor microenvironment features and chemoresistance in pancreatic ductal adenocarcinoma: Insights into targeting physicochemical barriers and metabolism as therapeutic approaches.

Carvalho TMA, Di Molfetta D, Greco MR, Koltai T, Alfarouk KO, Reshkin SJ, Cardone RA.

Cancer (Basel).2021 Dec 6;13(23):6135; doi: 10.3390/cancers13236135.

What do cellular responses to acidity tell us about cancer?

Blaszczak W, Swietach P.

Cancer and Metastasis Reviews 2021 Nov 30; doi.org/10.1007/s10555-021-10005-3.

Monitoring Immune Cell Function Through Optical Imaging: a Review Highlighting Transgenic Mouse Models.

Chawda C, McMorrow R, Gaspar N, Zambito G, Mezzanotte L.

Mol Imaging Biol 2021 Nov 4; doi.org/10.1007/s11307-021-01662-5.

Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment.

Toplak Ž, Hendrickx LA, Abdelaziz R, Shi X, Peigneur S, Tomašič T, Tytgat J, Peterlin‐Mašič L, Pardo LA.

Med Res Rev 2021 May 4; doi: 10.1002/med.21808.

Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays.

Błaszczak W, Tan Z, Swietach P.

Chemosensors 2021, 9(6), 139; doi: 0.3390/chemosensors9060139.

Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer.

Koltai T, Reshkin SJ, Carvalho TMA, Cardone RA.

Int J. Mol. Sci 2021, 22(8), 3953; doi: 10.3390/ijms22083953.

3D Pharmacophore-Based Discovery of Novel KV10.1 Inhibitors with Antiproliferative Activity.

Toplak Ž, Hendrickx LA, Gubič Š, Možina Š, Žegura B, Štern A, Novak M, Shi X, Peigneur S, Tytgat J, Tomašič T, Pardo LA, Mašič LP.

Cancers. 2021 Jan 13(6), 1244. doi: 10.3390/cancers13061244.

Houvast RD, Vankemmelbeke M, Durrant LG, Wuhrer M, Baart VM, Kuppen PJK, de Geus-Oei LF, Vahrmeijer AL, Sier CFM.

Cancers (Basel). 2020 Dec 21;12(12):3870. doi: 10.3390/cancers12123870.

Purinergic Signaling in Pancreas - From Physiology to Therapeutic Strategies in Pancreatic Cancer.

Novak I, Haoran Y, Magni L, Deshar G.

Int J Mol Sci. 2020 Nov 20;21(22):8781. doi: 10.3390/ijms21228781.

Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma.

Schnipper J, Dhennin-Duthille I, Ahidouch A, Ouadid-Ahidouch H.

Front Pharmacol. 2020 Oct 16;11:568993. doi: 10.3389/fphar.2020.568993.

pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology.

Pethő Z, Najder K, Carvalho T, McMorrow R, Todesca LM, Rugi M, Bulk E, Chan A, Löwik CWGM, Reshkin SJ, Schwab A.

Cancers (Basel). 2020 Sep 2;12(9):2484. doi: 10.3390/cancers12092484.

Role of the Intracellular Sodium Homeostasis in Chemotaxis of Activated Murine Neutrophils.

Najder K, Rugi M, Lebel M, Schröder J, Oster L, Schimmelpfennig S, Sargin S, Pethő Z, Bulk E, Schwab A.

Front Immunol. 2020 Sep 8;11:2124. doi: 10.3389/fimmu.2020.02124. eCollection 2020.

Cancer Cell Acid Adaptation Gene Expression Response is Correlated to Tumor-Specific Tissue Expression Profiles and Patient Survival.

Yao J, Czaplinska D, Ialchina R, Schnipper J, Liu B, Sandelin A, Pedersen SF.

Cancers (Basel). 2020 Aug 5;12(8):2183. doi: 10.3390/cancers12082183.

Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study.

Houvast RD, Baart VM, Bhairosingh SS, Crodfunke RA, Chua JX, Vankemmelbeke M, Parsons R, Kuppen PJK, Durrant LG, Vahrmeijer AL, Sier CFM.

Mol Imaging Biol 2020 Dec;22(6):1511-1522. doi: 10.1007/s11307-020-01522-8. Epub 2020 Aug 11. 

K_V11.1 Potassium Channel and the Na⁺/H⁺ Antiporter NHE1 modulate adhesion-dependent intracellular pH in Colorectal Cancer Cells.

Iorio J, Duranti C, Lottini T, Lastraioli E, Bagni G, Becchetti A, Arcangeli A.

Front Pharmacol 2020 Jun 10;11:848. doi: 10.3389/fphar.2020.00848. eCollection 2020.

A novel anti-Kv10.1 nanobody fused to single-chain TRAIL enhances apoptosis induction in cancer cells.

Hartung F, Krüwel T, Shi X, Pfizenmaier K, Kontermann R, Chames P, Alves F, Pardo L.

Front Pharmacol. 11. doi: 10.3389/fphar.2020.00686.

The A818-6 System as an In-Vitro Model for Studying the Role of the Transportome in Pancreatic Cancer.

Tawfik D, Zaccagnino A, Bernt A, Szczepanowski M, Klapper W, Schwab A, Kalthoff H, Trauzold A.

BMC Cancer. 2020 Mar 30;20(1):264. doi: 10.1186/s12885-020-06773-w.

Protonation of Piezo1 impairs cell-matrix interactions of pancreatic stellate cells.

Kuntze A, Goetsch O, Fels B, Najder K, Unger A, Wilhelmi M, Sargin S, Schimmelpfennig S, Neumann I, Schwab A, Pethő Z.

Front. Physiol. 11:89. doi: 10.3389/fphys.2020.00089.

Flinck M, Hagelund S, Gorbatenko A, Severin M, Pedraz-Cuesta E, Novak I, Stock C, Pedersen SF.

Cells. 2020 Feb 18;9(2):465. doi: 10.3390/cells9020465.

The acidic tumor microenvironment as a driver of cancer.

Boedtkjer E, Pedersen SF.

Annu Rev Physiol. 2020 Feb 10;82:103-126. doi: 10.1146/annurev-physiol-021119-034627.

Determinants of enhancer and promoter activities of regulatory elements.

Andersson R, Sandelin A.

Nat Rev Genet. 2020 Feb;21(2):71-87. doi: 10.1038/s41576-019-0173-8.

3D multicellular models to study the regulation and roles of acid-base transporters in breast cancer.

Czaplinska A, Elingaard-Larsen LO, Rolver MG, Severin M, Pedersen SF.

Biochem Soc Trans. 2019 Dec 20;47(6):1689-1700. doi: 10.1042/BST20190131.