Transcription factor PU.1 safeguards against an uncontrolled immune activation of neutrophils: Congratulations to Josi Fischer from the Laboratory of Molecular Stem Cell Biology on her paper in Nature Immunology

Neutrophils eradicate invading pathogens, but they can also cause substantial collateral damage to host tissues when inappropriately activated. However, whether or not the immune response of neutrophils is adjusted by a cell-intrinsic mechanism was not known. In her paper (, Josi and colleagues could now show that the myeloid transcription factor PU.1 provides the transcriptional prerequisite for eradicating pathogens, but does also install a cell-intrinsic inhibitor program to safeguard the epigenome of neutrophils from undergoing uncontrolled activation.