Publikationen
2026
The effect of SSRI/SNRI antidepressant treatment on the gut microbiota of patients with major depressive disorder
Natasha EE, Mulder D, Fehse L, Winter NR, Fisch L, Welzel M, Bang C, Meinert S, Flinkenflügel K, Borgers T, Goltermann J, Leehr EJ, Culmsee C, Stein F, Thomas-Odenthal F, Usemann P, Teutenberg L, Nenadic I, Straube B, Alexander N, Jamalabadi H, Jansen A, Nitsch R, Lügering A, Franke A, Dannlowski U, Kircher T, Heider D, Hahn T, Vrijsen JN, van Eijndhoven P, Tendolkar I, Reif A, Edwin Thanarajah S, Matura S, Arias Vasquez A, Bloemendaal M
Communications Medicine, Juli 16, 2026Experimental evaluation of large language models for proofreading PET reports
Roll W, Kober L, Ventura D, Masthoff M, Backhaus C, Gerwing M, Schäfers M, Rahbar K, Plagwitz L, Schindler P
European Journal of Radiology Artificial Intelligence, Volume 7, Article 100113, September 2026Radiotherapy for indolent primary cutaneous B-cell lymphoma: an international multicenter ILROG analysis
Oertel M, Dabaja B, Görlich D, Thomas BR, Sim V, Johnstone P, Hashmi A, Levis M, Ackerson B, Hague C, Weil CR, Plastaras J, Roos D, Kirova Y, Fietkau R, Fang PQ, Ng A, Bock F, Tseng YD, Linde P, Dunst J, Terezakis S, Easwaran T, Peeken JC, Wittig A, Yoon HI, Tao R, Illidge T, Kelsey CR, Ricardi U, Binkley MS, Campbell BA, Morris S, Elsayad K, Storck M, Hoppe RT, Eich HT
Blood, Jun 18, 2026
Big Five personality dimensions and their association with depressive symptom severity over the treatment course
Berg MC, Richter M, Gruber M, Goltermann J, Golaß LV, Herpertz J, Leenings R, Gutfleisch L, Fasshauer JM, Storck M, Blitz R, Dannlowski U, Back M, Opel N
J Affect Disord 413; 122173, November 15, 2026
Depth of neutrophil mobilization stratifies survival in ST-elevation myocardial infarction
Richter M, von Göwels J, Fähndrich M, Lipgens Fernandez Ch, Grohn K, Welzel M, Schwarz D, Lang A, Polzin A, Reinartz Groba S, Farinola L, Ghosh S, Heming JN, Aleth H, Akhalkatsi A, Marjani K, Rübsamen N, Radecke T, Rosenbauer F, Sickmann A, Karch A, Zarbock A, Minnerup J, Sindermann J, Bender A, Rossaint J, Ormanns S, Gunzer M, Malamud M, Kaiser R, Pekayvaz K, Heider D, Reinecke H, Makowski L, Jung C, Silvestre-Roig C, Kelm M, Gerdes N, Chevre R, Lange SA, Soehnlein O
Nat Cardiovasc Res, July 3, 2026
Expert-aided causal discovery of ancestral graphs
da Silva T, Bazaluk B, de Souza da Silva E, Góis A, Lahlou S, Heider D, Kaski S, Mesquita D, Ribeiro AH
Information Sciences, Volume 756, June 29, 2026Clinical, Dietary, Lifestyle and Genetic Factors Associated With Age at Onset of Esophageal Adenocarcinoma
Koch V, Gockel I, Reingruber J, Kreuser N, Bigge J, Venerito M, Alakus H, May A, Gerges C, Thieme R, Heider D, Hillmer AM, Egibo A, Bruns CJ, Lang H, Messmann H, Rösch T, Wissniowski TT, Müller M, Denzer UW, Nöthen MM, Vieth M, Thrift AP, Maj C, Schumacher J
United European Gastroenterology Journal; e70236, June 11, 2026
Health status of living kidney donors and attitude toward donation–Results from the German Living Donor Registry (SOLKID-GNR)
Suwelack B, Kröncke S, Wegner J, Bormann E, Gerß J, Riepenhausen S, Neuhaus P, Storck M, Koch M, Sommerer C
Front. Med. Sec. Nephrology, 13:1781270, June 10, 2026Harnessing generative AI for predicting and optimizing antimicrobial peptides against drug-resistant infections
Clemens S, Löchel HF, Häußer N, Wannemacher F, Bertrams W, Schmeck B, Heider D
npj Antimicrob Resist 4; 42 (2026), June 2, 2026dcFCI: Robust Causal Discovery Under Latent Confounding, Unfaithfulness, and Mixed Data
Ribeiro AH, Heider D
IEEE Transactions on Pattern Analysis and Machine Intelligence; PrePrints pp. 1-12, 2026The Rlign algorithm for enhanced electrocardiogram analysis through heart rate–corrected ECG alignment for explainable classification and clustering
Plagwitz L, Bickmann L, Fujarski M, Brenner A, Gobalakrishnan W, Eckardt L, Büscher A, Varghese J
European Heart Journal – Digital Health, Jun 2026
Deep learning electrocardiogram model for risk stratification of coronary revascularization need in the emergency department
Büscher A, Plagwitz L, Yildirim K, Brix TJ, Neuhaus P, Bickmann L, Menke AF, van Almsick VF, Pavenstädt H, Kümpers P, Heider D, Varghese J, Eckardt L
Eur Heart J. 2026;47(18): 2155-2167The State of Peptide Detectability in Computational Proteomics and Guidelines for AI Applications
Schilling V, Anžel A, Doellinger J, Lasch P, Heider D, Hattab G
Comput. Struct.Biotechnol. J.; 5(1):Article0037, April 7, 2026
Elevated lymphoma risk in patients with chronic pruritus and chronic prurigo
, , , et al. Elevated lymphoma risk in patients with chronic pruritus and chronic prurigo
JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2026; 1-9MedChat: A Fully Offline Multimodal AI System for Privacy-Preserving Clinical Anamnesis
Ruhland JB, Bahcivan D, Sowa J-P, Canbay A, Heider D
Front. Artif. Intell.; March 31, 2026
Response to ‘promising advances and remaining challenges in AI-driven QTc estimation’ by Zekai Yu
Plagwitz L, Doldi F, Magerfleisch J, Zotov M, Bickmann L, Heider D, Varghese J, Eckardt L, Büscher A
EP Europace, Volume 28, Issue 3, euag043, March 2026
Artificial intelligence in risk stratification of acute coronary syndrome : Future vision or already reality?
Büscher A, Plagwitz L, Blaschke J, Heider D, Eckardt L
Herz. 2026;51(2): 92-99Editorial: Advancements in AI for the analysis and interpretation of large-scale data by omics techniques
Facchiano A, Giordano D, Heider D
Front. Genet.; Volume 17, February 13, 2026
A corona-like distribution and patchy pattern of cerebellar infarcts identify patients with giant cell arteritis
Beuker C, Strecker JK, Jungmann V, Werring N, Brix T, Thomas C, Wankner MC, Schmidt-Pogoda A, Stracke P, Eckert B, Meinel TR, Arnold M, Schaumberg J, Krüger S, Deb-Chatterji M, Krüger C, Magnus T, Röther J, Minnerup J
Therapeutic Advances in Neurological Disorders, Volume 19, Article 17562864251405203, February 2026
Symptom trajectories and their predictive factors in psychiatric inpatients with depression
Herpertz J, Leenings R, Claa LV, Fasshauer JM, Ratzsch J, Emden D, Blitz R, Rau M, Gutfleisch L, Steinmann A, Berg C, Storck M, Dannlowski U, Dugas M, Ri Chae W, Gold SM, Wingenfeld K, Otte C, Richter M, Opel N
Journal of Affective Disorders,Volume 394, Part B, February 1st, 2026
T1w/T2w Ratio Identifies the Basolateral Amygdala as a Preferential Target in Autoimmune Limbic Encephalitis
Dadarwal R, Dik A, Bierhansl L, Gmahl N, Landmeyer NC, Brix TJ, Jaeger VK, Bauer J, Küker W, Wiendl H, Elger CE, Kovac S, Bischof A
J Neuroimaging. 2026;36(1):
End-to-End Platform for Electrocardiogram Analysis and Model Fine-Tuning: Development and Validation Study
Bickmann L, Plagwitz L, Büscher A, Eckardt L, Varghese J
J Med Internet Res. 2026;28():Polygenic risk scores of COPD predict lung function decline and early COPD: Results from COSYCONET
Pott H, Martin R, Köbbe L, Ma C, Abdo M, Hinz L, Bertrams W, Mattutat J, Kutzinski M, Weckler BC, Alter P, Biertz F, Speicher T, Jung AL, Laakmann K, Lehmann M, Vogelmeier CF, Heider D, Schumacher J, Schmeck B
American Journal of Respiratory and Critical Care Medicine; aamaf054, January 23, 2026LOXL2 labels inflammation-associated myofibroblasts predicting kidney allograft dysfunction and fibrosis
Schütz P, Hüchtmann B, Van Marck V, Heitplatz B, Walter C, Rixen R, Pavenstädt H, Reuter S, Buscher K
Front. Immunol.; 16, January 13, 2026
Blood eosinopenia (≤30/µL) as an early predictor of respiratory failure in community-acquired pneumonia: A prospective multicentre study
Weckler BC, Martin R, Kutzinski M, Bertrams W, Jung AL, Pott H, Laakmann K, Schulte L, Ahnert P, Heider D, Ringshandl S, Seidemann C, Suttorp N, Witzenrath M, Wildberg C, Lehmann M, Rohde G, Greulich T, Vogelmeier CF, Schmeck B
Pulmonology; 32(1), January 9, 2026
2025
In vivo intratumoral heterogeneity in a dish: scalable forebrain organoid models of embryonal brain tumors for high-throughput personalized drug discovery
Riedel NC, Walter C, de Faria FW, Altendorf L, Aust P, Göbel C, Verma A, Ballast A, Bedzhov I, Roy R, Münter D, Schüftan E, Albert TK, Rössig C, Johann P, von Zezschwitz B, Sandmann S, Varghese J, Thomas C, Schüller U, Bruder JM, Kerl K
Cancer Commun (Lond); 45(12):1670-1675, November 2, 2025QTcNet: A Deep Learning Model for Direct Heart Rate Corrected QT Interval Estimation
Plagwitz L, Doldi F, Magerfleisch J, Zotov M, Bickmann L, Heider D, Varghese J, Eckardt L, Büscher A
EP Europace; euaf274, October 27, 2025Associations of maternal and paternal characteristics with cardiac malformations using real-world data and machine learning
Brown JP, Huybrechts KF, Straub L, Heider D, Bateman BT, Hernández-Díaz S
Commun Med 5; 423, October 15, 2025MetaMP: Seamless Metadata Enrichment and AI Application Framework for Enhanced Membrane Protein Visualization and Analysis
Awotoro E, Ezekannagha C, Schwarz F, Tauscher J, Heider D, Ladewig K, Le Bon C, Moncoq K, Miroux B, Hattab G
arXiv; 2510.04776, October 6, 2025Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations
Thanarajah SE, Ribeiro AH, Lee J, Winter NR, Stein F, Lippert RN, Hanssen R, Schiweck C, Fehse L, Bloemendaal M, Aichholzer M, Bouzouina A, Uckermark C, Welzel M, Repple J, Matura S, Meinert S, Bang C, Franke A, Leenings R, Konowski M, Ernsting J, Fisch L, Barkhau C, Thomas-Odenthal F, Usemann P, Teutenberg L, Straube B, Alexander N, Jamalabadi Nenadić I, Lügering A, Nitsch R, Kittel-Schneider S, Cryan JF, Reif A, Kircher T, Heider D, Dannlowski U, Hahn T
JAMA Psychiatry, September 24, 2025PSTPIP1 and pyrin, two key regulators of macrophage differentiation
Berger P, Wilming L, Jürgens R, Minchuk Y, Leußink S, Gandhi S, Walter C, Wind S-M, Heider D, Lamparter L, Galic M, Stoll M, Jorch SK, Roth J, Austermann J, Fehler O
European Journal of Cell Biology;104 (4):151518, September 24, 2025Single-cell analysis of Barrett's esophagus and carcinoma reveals cell types conferring risk via genetic predisposition
Wenzel MC, Dasmeh P, Plum PS, Giel A-S, Hoppe S, Franitza M, Jonas C, Thieme R, Zhao Y, Heider D
Cell Genomics.;5(10), September 8, 2025Towards fairness in synthetic healthcare data: a framework for the evaluation of synthetization algorithms
Warnecke Y, Kuhn M, Diederichs F, Brix TJ, Clever L, Bergmann R, Heider D, Storck M
Stud Health Technol Inform.; 25-34, September 3, 2025Inkjet printing of adamantane-type organotin sulfide clusters featuring extreme nonlinear optical properties
Nier S, Lohse YR, Rinn N, Cadilha Marques G, Rosemann NW, Welzel M, Heider D, Aghassi-Hagmann J, Dehnen S
Communications Materials; 6(1):197, August 26, 2025The virtual doctor prescribing the future: Diagnostics with interactive clinical decision support
Ruhland JB, Wichmann J, Degtyar E, Martin R, Fehse L, Klau JH, Papenbrock T, Sowa J-P, Canbay A, Freisleben B
Computers in Biology and Medicine; 196:110968, August 20, 2025Self-organising map clustering identifies high-risk clusters of post-acute mortality in a prospective multicentre study of community-acquired pneumonia
Pott H, Gaffron S, Martin R, Maier D, Kutzinski M, Weckler B, Bertrams W, Jung AL, Laakmann K, Heider D
ERJ Open Res; 7(2):123-135, August 7, 2025Cross-Platform Availability of Smartphone Sensors for Depression Indication Systems: Mixed-Methods Umbrella Review
Leimhofer J, Petrovic M, Dominik A, Heider D, Hegerl U
Interact J Med Res.;14(1):e69686, August 7, 2025gLinDA: A privacy-preserving, swarm learning toolbox for differential abundance analysis of microbiomes
Fehse L, Tajabadi M, Martin R, Holzmann H, Heider D
Comput Struct Biotechnol J, August 5, 2025LegionProfiler: A computational tool for the identification of virulence factors and classification of Legionella pneumophila serogroup 1 isolates
Sarumi OA, Bertrams W, Schwengers O, Herrmann J-P, Hain T, Kieper L, Petzold M, Goesmann A, Schmeck BT, Heider D
Bioinformatics;41(7): btaf3982025, July 28, 2025Enhancing deep neural network training through learnable adaptive normalization
Ruhland JB, Masoudian I, Heider D
Knowl Based Syst; 113968, July 7, 2025dcFCI: Robust Causal Discovery Under Latent Confounding, Unfaithfulness, and Mixed Data
Ribeiro AH, Heider D
arXiv; 2505.06542, May 10, 2025From bites to bytes: understanding how and why individual malaria risk varies using artificial intelligence and causal inference
Ribeiro AH, Soler JMP, Corder RM, Ferreira MU, Heider D
Front Genet; 16:1599826, May 16, 2025Deep learning electrocardiogram model for risk stratification of coronary revascularization need in the emergency department
Büscher A, Plagwitz L, Yildirim K, Brix TJ, Neuhaus P, Bickmann L, Menke AF, van Almsick VF, Pavenstädt H, Kümpers P
Eur Heart J.;ehaf254, March 29, 2025Eosinophil count as biomarker for risk stratification of community-acquired pneumonia: a prospective cohort study
Weckler B, Martin R, Kutzinski M, Bertrams W, Jung A, Pott H, Laakmann K, Schulte L, Ahnert P, Heider D
Pneumologie;79(Suppl 1):FV 227, March 18, 2025Validation of ML-algorithms for the prediction of positive urine cultures from flow cytometry routine data in patients with suspected bacteriuria
Brenner A, Esser J, Schuler F, Varghese J, Schaumburg F
Int J Med Microbiol.;318, March 4, 2025Publication Counts in Context: Normalization Using Query and Reference Terms in PubMed
Varghese J, Bickmann L, Strünker T, Neuhaus N, Tüttelmann F, Sandmann S
J Med Internet Res.;27, February 3, 2025Somatic mutations and DNA methylation identify a subgroup of poor prognosis within lower-risk myelodysplastic syndromes
Rombaut D, Sandmann S, Tekath T, Crouch S, de Graaf AO, Smith A, Painter D, Kosmider O, Tobiasson M, Lennartsson A, van der Reijden BA, Park S, D'Aveni M, Slama B, Clappier E, Fenaux P, Adès L, van de Loosdrecht A, Langemeijer S, Symeonidis A, Čermák J, Preudhomme C, Savic A, Germing U, Stauder R, Bowen D, van Marrewijk C, Bernard E, de Witte T, Varghese J, Hellström-Lindberg E, Dugas M, Martens J, Malcovati L, Jansen JH, Fontenay M
Hemasphere;9(1), January 22, 20252024
Bloemendaal M, Mulder D, Natasha EE, Heider D, Fehse L, Ralf WN, Stein F, Dannlowski U, Kircher T, Franke A
Neurosci Appl;3:104674, December 20, 2024Atlas of Cerebrospinal Fluid Immune Cells Across Neurological Diseases
Heming M, Börsch AL, Melnik S, Gmahl N, Müller-Miny L, Dambietz C, Fisch L, Kühnel T, Brix TJ, Janssen A, Schumann E, Gross CC, Varghese J, Hahn T, Wiendl H, Meyer Zu Hörste G
Ann Neurol.;97(4):779-790, December 12, 2024Ribeiro AH, Crnkovic M, Pereira JL, Fisberg R, Sarti FM, Rogero M, Heider D, Cerqueira A
Front Genet.;15:1436947, December 9, 2024Fehse L, Ribeiro AH, Winter NR, Thanarajah SE, Fisch L, Welzel M, Bang C, Meinert S, Flinkenflügel K, Borgers T
medRxiv, December 6, 2024EyeMatics-Multicenter data evaluation of real-world data with interoperable medical informatics
Holtrup L, Varghese J, Schuster AK, Poschkamp B, Hampf C, Waltemath D, Wahle L, Lipprandt M, Merle DA, Berens P, Kohlbacher O, Kakkassery V, Bartos M, Ziemssen F, Wendt T, Hoffmann K, EyeMatics Study Group, Eter N.
Ophthalmologie;122(4):270-277, November 14, 2024Weckler BC, Ringshandl S, Ahnert P, Pott H, Bertrams W, Kutzinski M, Jung AL, Laakmann K, Seidemann Ch, Suttorp N, Witzenrath M, Wildberg C, Heider D, Martin R, Vogelmeier CF, Schmeck B
Eur Respir J;64: Suppl. 68; PA1493, October 30, 2024Pott H, Weckler B, Gaffron S, Martin R, Maier D, Alter P, Biertz F, Speichert T, Bertrams W, Jung AL
European Respiratory Society;64(suppl 68): PA3971, October 30, 2024Pott H, Weckler B, Gaffron S, Martin R, Maier D, Alter P, Biertz F, Speicher T, Bertrams W, Jung AL, Laakmann K, Heider D, Wouters M, Vogelmeier CF, Schmeck B, COSYCONET Study Group, Andreas S, Bals R, Behr J, Kahnert K, Bahmer T, Bewig B, Ewert R, Stubbe B, Ficker JH, Grohé C, Held M, Henke M, Herth F, Kirsten AM, Watz H, Koczulla R, Kronsbein J, Kropf-Sanchen C, Herzmann C, Pfeifer M, Randerath WJ, Seeger W, Studnicka M, Taube C, Timmermann H, Alter P, Schmeck B, Vogelmeier C, Welte T, Wirtz H
Respirology;30(2):134-146, October 24, 2024Large language models and their applications in bioinformatics
Sarumi OA, Heider D
Comput Struct Biotechnol J.;23:3498-3505, October 5, 2024Medical researchers' perception of sharing of metadata from case report forms
Meidt A, Walter C, Lehmann CU, Dugas M
Learn Health Syst.;(9)1, September 15, 2024Fair swarm learning: improving incentives for collaboration by a fair reward mechanism
Tajabadi M, Heider D
Knowl Based Syst.;304:112451, September 2, 2024Privacy-preserving decentralized learning methods for biomedical applications
Tajabadi M, Martin R, Heider D
Comput Struct Biotechnol J.;23:3281-3287, August 30, 2024Leite JMRS, Ribeiro A, Pereira JL, de Souza CA, Heider D, Soler JMP, Mingroni-Netto RC, Fisberg RM, Rogero MM, Sarti FM
Clin Nutr ESPEN.;63:311-321, July 2, 2024Genome-wide DNA methylation changes in human spermatogenesis
Siebert-Kuss LM, Dietrich V, Di Persio S, Bhaskaran J, Stehling M, Cremers JF, Sandmann S, Varghese J, Kliesch S, Schlatt S, Vaquerizas JM, Neuhaus N, Laurentino S
Am J Hum Genet.;111(6):1125-1139, June 6, 2024ChatGPT: The transformative influence of generative AI on science and healthcare
Varghese J, Chapiro J
J Hepatol.;80(6):977-980; May 15, 2024Bernhardt F, Bückmann A, Krüger J, Bauer B, Hofmeister U, Juhra C, Eveslage M, Fischhuber K, Storck M, Brix TJ, Lenz P
Telemed J E Health;30(5):1459-1469, May 2, 2024Turbo autoencoders for the DNA data storage channel with Autoturbo-DNA
Welzel M, Dreßler H, Heider D
iScience.;27(5), March 27, 2024Systematic analysis of ChatGPT, Google search and Llama 2 for clinical decision support tasks
Sandmann S, Riepenhausen S, Plagwitz L, Varghese J
Nat Commun.;15(1), March 6, 2024Ren Y, Li C, Sapugahawatte DN, Zhu C, Spänig S, Jamrozy D, Rothen J, Daubenberger CA, Bentley StD, Ip M
Comput Biol Med.;171:108185, February 20, 2024Weihermann GA, Bernhardt F, Brix TJ, Baumeister SE, Lenz P
Support Care Cancer;32(3), February 15, 2024Inkjet-printed quantum dots on paper as concept towards high-density long-term data storage
Mengel N, Welzel M, Niedenthal W, Stein M, Heider D, Chatterjee S
J Phys Commun.:8(2):025005, February 12, 2024POLAR: prediction of prolonged mechanical ventilation in patients with myasthenic crisis
Heider D, Stetefeld H, Meisel A, Bösel J, Artho M, Linker R, Angstwurm K, Neumann B
J Neurol.;271(5):2875-2879, February 8, 2024Artificial Intelligence and Bioinformatics Applications for Omics and Multi-Omics Studies
Facchiano A, Heider D, Mutarelli M
Front Genet.;15:1371473, January 30, 2024Hyperdiploid acute lymphoblastic leukemia in children with LZTR1 germline variants
Zipper L, Wagener R, Fischer U, Hoffmann A, Yasin L, Brandes D, Soura S, Anwar A, Walter C, Varghese J, Hauer J, Auer F, Bhatia S, Dugas M, Junk SV, Stanulla M, Haas OA, Borkhardt A, Reiff T, Brozou T
Hemasphere;8(1), January 26, 2024NeuralBeds: neural embeddings for efficient DNA data compression and optimized similarity search
Sarumi OA, Hahn M, Heider D
Comput Struct Biotechnol J.;23:732-741, January 15, 2024Machine Learning in the Parkinson's disease smartwatch (PADS) dataset
Varghese J, Brenner A, Fujarski M, van Alen CM, Plagwitz L, Warnecke T
NPJ Parkinsons Dis.;10(1), January 5, 2024Reply to: “Can LLMs improve existing scenario of healthcare?”
Varghese J
J Hepatol.;80(1):e29-e30; January 4, 2024
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