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Anhlan, D., Hrincius, E., Scholtissek, C., and Ludwig S. Introduction of silent mutations into the NP gene of influenza A viruses as a possible strategy for the creation of a live attenuated vaccine. (2012). Vaccine 30, 4480-4489.

Bauer K, Dürrwald R, Schlegel M, Pfarr K, Topf D, Wiesener N, Dahse HM, Wutzler P, Schmidtke M. Neuraminidase inhibitor susceptibility of swine influenza A viruses isolated in Germany between 1981 and 2008. (2012). Med Microbiol Immunol. 201(1):61-72.

Buchäckert Y, Rummel S, Vohwinkel CU, Gabrielli NM, Grzesik BA, Mayer K, Herold S, Morty RE, Seeger W, Vadász I. Megalin mediates transepithelial albumin clearance from the alveolar space of intact rabbit lungs. (2012). J Physiol. 590(Pt 20):5167-81.

Chase GP, Schwemmle M. Affinity purification of influenza virus ribonucleoprotein complexes from the chromatin of infected cells. (2012). J Vis Exp. Jun 3;(64):e4028.

Corman VM, Müller MA, Costabel U, Timm J, Binger T, Meyer B, Kreher P, Lattwein E, Eschbach-Bludau M, Nitsche A, Bleicker T, Landt O, Schweiger B, Drexler JF, Osterhaus AD, Haagmans BL, Dittmer U, Bonin F, Wolff T, Drosten C. Assays for laboratory confirmation of novel human coronavirus (HCOV-EMC) infections. (2012). Eurosurveillance 17(49).

Demirov, D., Gabriel, G., Schneider, C., Hohenberg, H., and Ludwig, S. Interaction of influenza A virus matrix protein with RACK1 is required for virus release. (2012). Cell. Microbiol. 14, 774-789.

Dengler L, May M, Wilk E, Bahgat MM, Schughart K. Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection. (2012). Virology Journal. 9:212.

Friesenhagen J, Boergeling Y, Hrincius E, Ludwig S, Roth J, Viemann D. Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages. (2012). J. Leukoc. Biol. 92: 11-20.

Gambaryan AS, Matrosovich TY, Philipp J, Munster VJ, Fouchier RA, Cattoli G, Capua I, Krauss SL, Webster RG, Banks J, Bovin NV, Klenk HD, Matrosovich MN. Receptor-binding profiles of H7 subtype influenza viruses in different host species. (2012). J Virol. Apr;86(8):4370-9.

Gerlach T, Kühling L, Uhlendorff J, Laukemper V, Matrosovich T, Czudai-Matwich V, Schwalm F, Klenk HD, Matrosovich M. Characterization of the neuraminidase of the H1N1/09 pandemic influenza virus. (2012). Vaccine. 30(51):7348-52.

Grienke U, Schmidtke M, von Grafenstein S, Kirchmair J, Liedl KR, Rollinger JM. Influenza neuraminidase: a druggable target for natural products. (2012). Nat Prod Rep. Jan;29(1):11-36.

Hackstein H, Hagel N, Knoche A, Kranz S, Lohmeyer J, von Wulffen W, Kershaw O, Gruber AD, Bein G, Baal N. Skin TLR7 Triggering Promotes Accumulation of Respiratory Dendritic Cells and Natural Killer Cells. (2012). PLoS One. 2012;7(8):e43320.

Herold S, Ludwig S, Pleschka S, Wolff T. Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury. (2012). J Leukoc Biol. Jul;92(1):75-82.

Hocke AC, Berg J, Becher A, Knepper J, Klauschen F, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Hippenstiel S, Wolff T. Type II pneumocyte infection by influenza A virus in human pulmonary fibrosis. (2012). J Infect Dis. doi: 10.1093/infdis/jis740.

Hrincius, E. R., Hennecke, A.-K., Gensler, L., Nordhoff, C., Anhlan, D., Vogel, P., McCullers, J. A., Ludwig S., and Ehrhardt C. A single point mutation (Y89F) within the non-structural protein 1 of influenza A viruses limits epithelial cell tropism and virulence in mice. (2012). Am J. Pathol. 180(6):2361-2374.

Kaminski MM, Ohnemus A, Cornitescu M, Staeheli P. Plasmacytoid dendritic cells and Tolllike receptor 7-dependent signalling promote efficient protection of mice against highly virulent influenza A virus. (2012). J Gen Virol. 93(Pt 3):555-9.

Koerner I, Matrosovich M, Haller O, Staeheli P, Kochs G. Altered receptor specificity and fusion activity of the hemagglutinin contribute to high virulence of a mouse-adapted influenza A virus. (2012). J. Gen. Virol. 93:970–979.

Mänz B, Brunotte L, Reuther P, Schwemmle M. Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells. (2012). Nat Commun. 1;3:802.

Meisen, I., Dzudzek, T., Ehrhardt, C., Ludwig, S., Mormann, M., Rosenbrück, R., Lümen, R., Kniep, B., Karch, H., and Müthing, J. The human H3N2 influenza viruses A/Victoria/3/75 and A/Hiroshima/52/2005 preferentially bind to α2-3-sialylated monosialogangliosides with fucosylated poly-N-acetyllactosaminyl chains. (2012). Glycobiology. 22(8):1055-1076.

Müller-Redetzky HC, Kummer W, Pfeil U, Hellwig K, Will D, Paddenberg R, Tabeling C, Hippenstiel S, Suttorp N, Witzenrath M. Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice. (2012). PLoS One. 7(5):e35832.

Nacken, W., Ehrhardt, C., and Ludwig, S. Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A viruses. (2012). Biol. Chem. 393(6):525-534.

Nedelko T, Kollmus H, Klawonn F, Spijker S, Lu L, Heßman M, Alberts R, Williams RW, Schughart K. Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. (2012). BMC Genomics. 13:411.

Niemann, S., Ehrhardt, C., Medina, E., Warnking, K., Tuchscherr, L., Heitmann, V., Ludwig, S., Peters, G., and Löffler, B. Combined Action of Influenza Virus and Staphylococcus aureus Panton-Valentine Leukocidin Provokes Severe Lung Epithelium Damage. (2012). J. Infect. Dis. 206(7):1138-1148.

Nordhoff C, Hillesheim A, Walter BM, Haasbach E, Planz O, Ehrhardt C, Ludwig S, Wixler V. The adaptor protein FHL2 enhances the cellular innate immune response to influenza A virus infection. (2012). Cell Microbiol. 14(7):1135-47.

Nordmann, A., Wixler, L., Boergeling, Y., Wixler, V., and Ludwig, S. A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication. (2012). FASEB J. 26(3), 1290-1300.

Ott U, Sauerbrei A, Lange J, Schäfler A, Walther M, Wolf G, Wutzler P, Zell R, Krumbholz A. Serological response to influenza A H1N1 vaccine (Pandemrix®) and seasonal influenza vaccine 2009/2010 in renal transplant recipients and in hemodialysis patients. (2012). Med Microbiol Immunol. 201(3):297-302.

Petersen H, Matrosovich M, Pleschka S, Rautenschlein S. Replication and adaptive mutations of low pathogenic avian influenza viruses in tracheal organ cultures of different avian species. (2012). PLoS One. 2012;7(8):e42260.

Pommerenke C, Wilk E, Srivastava B, Schulze A, Novoselova N, Geffers R, Schughart K. Global transcriptome analysis in influenza-infected mouse lungs reveals the kinetics of innate and adaptive host immune responses. (2012). PLOS ONE. 7(7):e41169.

Rückle A, Haasbach E, Julkunen I, Planz O, Ehrhardt C, Ludwig S. The NS1 protein of influenza A virus blocks RIG-I-mediated activation of the noncanonical NF-κB pathway and p52/RelB-dependent gene expression in lung epithelial cells. (2012). J Virol. 86(18):10211-7.

Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP,Lohmeyer J, Preissner KT. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. (2012). PLoS One. 7(2):e32366.

Sauer A-K, Liang C-H, Stech J, Peeters B, Quéré P, Schwegmann-Wessels C, Wu C-Y, Chi- Huey Wong C-H, Herrler G. Characterization of the sialic acid binding activity of the hemagglutinins of the H7 and H9 subtypes by using soluble proteins as lectins. Submitted.

Schughart K, Libert C, Kas MJ. Human disease: Strength to strength for mouse models. (2012). Nature. 492(7427):41.

Seliger C, Schaerer B, Kohn M, Pendl H, Weigend S, Kaspers B, Härtle S. A rapid high-precision flow cytometry based technique for total white blood cell counting in chickens. (2012). Vet Immunol Immunopathol. 145(1-2):86-99.

Seyer R, Hrincius ER, Ritzel D, Abt M, Mellmann A, Marjuki H, Kühn J, Wolff T, Ludwig S, Ehrhardt C. Synergistic adaptive mutations in the hemagglutinin and polymerase acidic protein lead to increased virulence of pandemic 2009 H1N1 influenza A virus in mice. (2012). J Infect Dis. 205(2):262-71.

Thaa B, Tielesch C, Möller L, Schmitt AO, Wolff T, Bannert N, Herrmann A, Veit M. Growth of influenza A virus is not impeded by simultaneous removal of the cholesterol-binding and acylation sites in the M2 protein. (2012). J Gen Virol. 93(Pt 2):282-92.

Terrier O, Moules V, Carron C, Cartet G, Frobert E, Yver M, Traversier A, Wolff T, Riteau B, Naffakh N, Lina B, Diaz JJ, Rosa-Calatrava M. The influenza fingerprints: NS1 and M1 proteins contribute to specific host cell ultrastructure signatures upon infection by different influenza A viruses. (2012). Virology. 432(1):204-18.

Unkel B, Hoegner K, Clausen BE, Lewe-Schlosser P, Bodner J, Gattenloehner S, Janßen H, Seeger W, Lohmeyer J, Herold S. Alveolar epithelial cells orchestrate DC function in murine viral pneumonia. (2012). J Clin Invest. 122(10):3652-64.  

Weinheimer VK, Becher A, Tönnies M, Holland G, Knepper J, Bauer TT, Schneider P, Neudecker J, Rückert JC, Szymanski K, Temmesfeld-Wollbrueck B, Gruber AD, Bannert N, Suttorp N, Hippenstiel S, Wolff T*, Hocke AC. Influenza A viruses target type II pneumocytes in the human lung. *corresponding author. (2012). J Infect Dis. 206(11):1685-94.

Wilk E, Schughart K. The mouse as model system to study host-pathogen-interactions in influenza A infections. (2012). Curr. Protoc. Mouse Biol. 2:177-205.

Winkler M, Bertram S, Gnirß K, Nehlmeier I, Gawanbacht A, Kirchhoff F, Ehrhardt C, Ludwig S, Kiene M, Moldenhauer AS, Goedecke U, Karsten CB, Kühl A, Pöhlmann S. Influenza A Virus Does Not Encode a Tetherin Antagonist with Vpu-Like Activity and Induces IFN-Dependent Tetherin Expression in Infected Cells. (2012). PLoS One. 7(8):e43337.