Clinical Trials in Ophthalmology (CTO)

Clinical trials help develop new medical treatments and improve existing ones. Drugs and new treatments are tested for their efficacy and safety. The Department of Ophthalmology participates in numerous national and international multicenter studies. This is the only way we can guarantee you state-of-the-art patient care. 

By participating in a clinical trial, we can offer you innovative treatment options that are not yet available in routine care. 

If you are interested in participating in a study, please contact our study team! 

Our current studies

Clarity Study

Clinical trial for patients with active, non-infectious, intermediate, posterior or pan-uveitis. Oral administration of brepocitinib

 

REVISION Study

Clinical trial on early lysis in central retinal artery occlusion (inclusion in the treatment arm possible up to 4.5 hours after symptom onset)

 

SAMSARA trial

Implantation of a mini-telescope in patients with geographic atrophy who have not yet undergone cataract surgery

 

SIENNA trial

Clinical trial for patients with geographic atrophy without foveal involvement; subcutaneous injections of pozelimab + cemdisiran versus cemdisiran monotherapy versus placebo

 

UplighTED trial

Clinical trial for patients with endocrine orbitopathy; subcutaneous injection of efgartigimod; initial diagnosis <12 months

Our current registers

CCS Register

Prospective data collection on patients with central serous chorioretinopathy

 

LHON Register

Non-interventional study / LHON Register for LHON patients with and without treatment

 

ROP Register

Database for recording patients with retinopathy of prematurity

 

Fungal Keratitis Register

German Fungal Keratitis Register. Prospective collection of clinical and diagnostic data

 

Acanthamoeba Register

German Acanthamoeba Keratitis Register. Retrospective and prospective collection of clinical and diagnostic data

 

TOFU Register

Register of treatment discharge options for non-infectious uveitis

Ongoing studies for which recruitment has closed

AIM trial (recruitment closed)

Clinical trial to slow the progression of myopia in children aged 8–12. Study drug: low-dose atropine

 

ASCENT trial (recruitment closed)

Clinical trial for patients with nAMD. Subretinal injection of RGX-314. Initial diagnosis < 4 years

 

HONU trial (recruitment closed)

Observational study on the progression of intermediate age-related macular degeneration

 

HORIZON trial (recruitment closed)

Clinical trial for endocrine orbitopathy. Infusion of teprotumumab
 

 

 

The Department of Ophthalmology at the University Hospital Münster is an EVICR.net certified center.