Clinical Trials in Ophthalmology (CTO)
Clinical trials help develop new medical treatments and improve existing ones. Drugs and new treatments are tested for their efficacy and safety. The Department of Ophthalmology participates in numerous national and international multicenter studies. This is the only way we can guarantee you state-of-the-art patient care.
By participating in a clinical trial, we can offer you innovative treatment options that are not yet available in routine care.
If you are interested in participating in a study, please contact our study team!
Our current studies
Clinical trial for patients with geographic atrophy with or without foveal involvement; subcutaneous injections of pozelimab + cemdisiran versus cemdisiran monotherapy versus placebo
OptimUM-10 trial
Clinical trial for patients with non-metastatic choroidal melanoma; neoadjuvant darovasertib + brachytherapy
ACHIEVE trial
Subretinal administration of surabgene lomparvovec in patients with neovascular AMD, previously treated, with a duration of diagnosis < 4 years; the study eye must be pseudophakic
ADX-038 GA trial
ADX-038 vs. placebo, subcutaneous injections in patients with GA with or without a residual foveal island
Study start: approx. November 2026
NAION study
Intranasal cenegermin in NAION patients with diagnosis/onset of first symptoms < 14 days
Study start: approx. winter 2026
NORTHSTAR
Clinical trial for patients with Stargardt’s disease (1 pathogenic mutation in the ABCA4 gene), gildeuretinol acetate (ALK-001) versus placebo.
Study start: approx. winter 2026
Our current registers
CAVES Register
International Register for Chitosan-Associated Oculo-Auditory Inflammatory Syndrome
Contact: nataliia.mala@ukmuenster.de
CCS Register
Prospective data collection on patients with central serous chorioretinopathy
LHON Register
Non-interventional study / LHON Register for LHON patients with and without treatment
ROP Register
Database for recording patients with retinopathy of prematurity
Fungal Keratitis Register
German Fungal Keratitis Register. Prospective collection of clinical and diagnostic data
Acanthamoeba Register
German Acanthamoeba Keratitis Register. Retrospective and prospective collection of clinical and diagnostic data
TOFU Register
Register of treatment discharge options for non-infectious uveitis
Ongoing studies for which recruitment has closed
Clarity Study (recruitment closed)
Clinical trial for patients with active, non-infectious, intermediate, posterior or pan-uveitis. Oral administration of brepocitinib
AIM Study (recruitment closed)
Clinical trial to reduce the progression of myopia in children aged 8–12 years. Study medication: low-dose atropine
ASCENT Long-term Follow-up Study (recruitment closed)
Clinical trial for patients with nAMD who have received a subretinal injection of RGX-314; participants are being monitored for 5 years in this study
HONU Study (recruitment closed)
Observational study on the progression of intermediate age-related macular degeneration
VELODROME Study (recruitment closed)
Clinical trial for patients with wet AMD, initially diagnosed no more than 9 months ago. Implantation of a port delivery system containing ranibizumab
PORTAL Study (Recruitment via the Velodrome study)
Clinical trial for patients with wet AMD who received a port delivery system (PDS) as part of the Velodrome study; these patients will continue to be treated in this study.
The Department of Ophthalmology at the University Hospital Münster is an EVICR.net certified center.