Our research group investigates the molecular mechanisms underlying the development of malignant lymphomas and their treatment with specific therapeutics. We are further addressing the question of how we can more accurately classify and diagnose malignant lymphomas based on molecular alterations (Figure 1). Finally, we seek to identify predictive markers or gene expression signatures for response to specific therapies, such as signal transduction inhibitors, to predict whether or not patients will respond to an intended treatment regimen.
A special emphasis in our work is put on the translation of our research results into the clinic. To this end, we conduct numerous clinical trials in which innovative therapeutic concepts are investigated. Our scientific focus is on diffuse large B-cell lymphomas, mantle cell lymphomas, Burkitt lymphomas and aggressive T-cell lymphomas.
Contact and Adress
Location: Laboratory
Source: Google Maps
Catarina Pereira Rodrigues
Outer office of clinic director University hospital Münster Department of Medicine A
Albert Schweitzer Campus 1
Building A1 (former Albert-Schweitzer-Str. 33)
48149 Münster
Tel.: 0251 83 47587
Fax: 0251 83 47588
Laboratory
University Hospital Münster Department of Medicine A Albert-Schweitzer-Campus 1 Building D3 (Domagkstraße 3) 48149 Münster
Head of Research Group
Univ.-Prof. Dr. med. Georg Lenz Director Department of Medicine A
E-Mail: lenzsekr@ukmuenster.de
Telephone: +49 (0)251 83 47587
Postdoctoral Researcher
Dr. rer. nat. Corinna Kosnopfel
E-Mail: corinnaveronica.kosnopfel@ukmuenster.de
Telephone: +49 (0)251 83 52671
Dr. Michael Grau
E-Mail: michael.grau@ukmuenster.de
Telephone: +49 (0)251 83 57591
Technical Assistant
Daniela Schwammbach
E-Mail: daniela.schwammbach@ukmuenster.de
Telephone: +49 (0)251 83 57591
Doctoral Candidates
Ling Jin
E-Mail: ling.jin@ukmuenster.de
Telephone: +49 (0)251 83 57591
Zhen Kou
E-Mail: zhen.kou@ukmuenster.de
Telephone: +49 (0)251 83 57591
Yang Li
E-Mail: yang.li@ukmuenster.de
Telephone: +49 (0)251 83 57591
Yi Liu
E-Mail: yi.liu@ukmuenster.de
Telephone: +49 (0)251 83 52671
Duo Xu
E-Mail: duo.xu@ukmuenster.de
Telephone: +49 (0)251 83 52671
Danning Yu
E-Mail: danning.yu@ukmuenster.de
Telephone: +49 (0)251 83 57591
Clinician Scientists
Dr. med. Imke Karsten
E-Mail: imkeelisabeth.karsten@ukmuenster.de
Telephone: +49 (0)251 83 51119
Dr. med Lina Kolloch
E-Mail: linajenny.kolloch@ukmuenster.de
Telephone: +49 (0)251 83 57591
Donations for our research
If you would like to support our research financially, we would be very pleased:
University Hospital Münster
Deutsche Bank AG
IBAN: DE42 4007 0080 0013 8842 00
BIC Code: DEUTDE3B400
Reference: ZUW80207 (Lymphoma Research)
Or contact us via: spenden.lymphom@ukmuenster.de
Publications
Li Y., Kosnopfel C., Schwammbach D., Jin L., Grau M., Lenz G., Hailfinger S. LNS-8801 as a therapeutic agent for aggressive lymphomas: ROS-induced cytotoxicity and synergy with existing therapies. Blood Adv. 2025 Jul 8;9(13):3310-3314.
Frontzek F., Staiger AM., Wullenkord R., Grau M., Zapukhlyak M., Kurz KS., Horn H., Erdmann T., Fend F., Richter J., Klapper W., Lenz P., Hailfinger S., Tasidou A., Trautmann M., Hartmann W., Rosenwald A., Quintanilla-Martinez L., Ott G., Anagnostopoulos I., Lenz G. Molecular profiling of EBV associated diffuse large B-cell lymphoma. Leukemia 2023 Mar;37(3):670-679.
Xu W., Berning P., Erdmann T., Grau M., Bettazová N., Zapukhlyak M., Frontzek F., Kosnopfel C., Lenz P., Grondine M., Willis B., Lynch JT., Klener P., Hailfinger S., Barry ST., Lenz G. mTOR inhibition amplifies the anti-lymphoma effect of PI3Kβ/δ blockage in diffuse large B-cell lymphoma. Leukemia 2023 Jan;37(1):178-189.
Burkhardt B., Michgehl U., Rohde J., Erdmann T., Berning P., Reutter K., Rohde M., Borkhardt A., Burmeister T., Dave S., Tzankov A., Dugas M., Sandmann S., Fend F., Finger J., Mueller S., Gökbuget N., Haferlach T., Kern W., Hartmann W., Klapper W., Oschlies I., Richter J., Kontny U., Lutz M., Maecker-Kolhoff B., Ott G., Rosenwald A., Siebert R., von Stackelberg A., Strahm B., Woessmann W., Zimmermann M., Zapukhlyak M., Grau M., Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Communications 2022 Jul 6;13(1):3881.
Frontzek F., Staiger AM., Zapukhlyak M., Xu W., Bonzheim I., Borgmann V., Sander P., Baptista MJ., Heming JN., Berning P., Wullenkord R., Erdmann T., Lutz M., Veratti P., Ehrenfeld S., Wienand K., Horn H., Goodlad JR., Wilson MR., Anagnostopoulos I., Lamping M., Gonzalez-Barca E., Climent F., Salar A., Castellvi J., Abrisqueta P., Menarguez J., Aldamiz T., Richter J., Klapper W., Tzankov A., Dirnhofer S., Rosenwald A., Mate JL., Tapia G., Lenz P., Miething C., Hartmann W., Chapuy B., Fend F., Ott G., Navarro JT., Grau M., Lenz G. Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma. Nat Communications 2021 Aug 31;12(1):5183.
Erdmann T, Klener P, Lynch JT, Grau M, Vočková P, Molinsky J, Tuskova D, Hudson K, Polanska UM, Grondine M, Mayo M, Dai B, Pfeifer M, Erdmann K, Schwammbach D, Zapukhlyak M, Staiger AM, Ott G, Berdel WE, Davies BR, Cruzalegui F, Trneny M, Lenz P, Barry ST, Lenz G. Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL.Blood. 2017 Jul 20;130(3):310-322. doi: 10.1182/blood-2016-12-758599. Epub 2017 Feb 15.
Dai B, Grau M, Juilland M, Klener P, Höring E, Molinsky J, Schimmack G, Aukema SM, Hoster E, Vogt N, Staiger AM, Erdmann T, Xu W, Erdmann K, Dzyuba N, Madle H, Berdel WE, Trneny M, Dreyling M, Jöhrens K, Lenz P, Rosenwald A, Siebert R, Tzankov A, Klapper W, Anagnostopoulos I, Krappmann D, Ott G, Thome M, Lenz G. B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma.Blood. 2017 Jan 19;129(3):333-346. doi: 10.1182/blood-2016-05-718775. Epub 2016 Nov 18.
Rahal R., Frick M., Romero R., Korn JM., Kridel R., Chunchan F., Meissner B., Bhang H., Ruddy D., Kauffmann A., Farsidjani A., Derti A., Rakiec D., Naylor T., Pfister E., Kovats S., Kim S., Dietze K., Dörken B., Steidl C., Tzankov A., Hummel M., Monahan J., Morrissey M., Fritsch C., Sellers WR., Cooke VG., Gascoyne RD., Lenz G.*, Stegmeier F*. Pharmacological and genomic profiling identifies NFκB-targeted treatment strategies for mantle cell lymphoma. Nature Medicine 2014 Jan; 20 (1): 87-92. *Equally contributing last and corresponding author
Davis RE.*, Ngo VN.*, Lenz G.*, Tolar P., Young RM., Romesser PB., Kohlhammer H., Lamy L., Zhao H., Yang Y., Xu W., Shaffer AL., Wright G., Xiao W., Powell J., Jiang JK., Thomas CJ., Rosenwald A., Ott G., Muller-Hermelink HK., Gascoyne RD., Connors JM., Johnson NA., Rimsza LM., Campo E., Jaffe ES., Wilson WH., Delabie J., Smeland EB., Fisher RI., Braziel RM., Tubbs RR., Cook JR., Weisenburger DD., Chan WC., Pierce SK., Staudt LM. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 2010 Jan 7; 463 (7277): 88-92. *Authors contributed equally
Lenz G, Wright G, Dave SS, Xiao W, Powell J, Zhao H, Xu W, Tan B, Goldschmidt N, Iqbal J, Vose J, Bast M, Fu K, Weisenburger DD, Greiner TC, Armitage JO, Kyle A, May L, Gascoyne RD, Connors JM, Troen G, Holte H, Kvaloy S, Dierickx D, Verhoef G, Delabie J, Smeland EB, Jares P, Martinez A, Lopez-Guillermo A, Montserrat E, Campo E, Braziel RM, Miller TP, Rimsza LM, Cook JR, Pohlman B, Sweetenham J, Tubbs RR, Fisher RI, Hartmann E, Rosenwald A, Ott G, Muller-Hermelink HK, Wrench D, Lister TA, Jaffe ES, Wilson WH, Chan WC, Staudt LM. Stromal gene signatures in large-B-cell lymphomas.N Engl J Med 2008 Nov 27; 359 (22): 2313-23.
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