Mission
The Institute of Molecular Tumor Biology (IMTB) is an experimental medical research institute. We combine state-of-the-art molecular biology research with modern “omics” technologies to investigate central mechanisms of differentiation, tumorigenesis and effector functions of mammalian cells, in particular immune cells.
The IMTB currently hosts a research department and an independent emeritus group:
Innate immune cell function and leukemia
Head of institut: Prof. Dr. Frank Rosenbauer
Molecular and Cellular Biology
Head: Emeritus Prof. Dr. Michael Meisterernst
The health and disease state of human cells is closely linked to their inherent gene expression programs. Biological or pathological processes usually have a direct effect on these programs. In the IMTB, we study the mechanistic basis of cellular programs at the level of gene control, epigenetics and signal transduction of mammalian cells, in particular cells of the innate immune system such as macrophages and neutrophils. In general, we are interested in understanding basic and cell-type-specific mechanisms of malignant transformation, cellular differentiation and cell effector function control. Based on this understanding, new therapies for cancer and infectious diseases can be derived. The disease models we work on range from leukemia and other tumor types to infectious diseases.
Innate immune cell function and leukemia (Frank Rosenbauer)
Molecular and Cellular Biology (Michael Meisterernst)