Characterization of inflammatory processes with Next-Generation Sequencing methods

Neurological diseases like Multiple Sclerosis are typically associated with inflammatory processes. A better understanding of these underlying immune-related processes is likely to facilitate an improved understanding of the diseases' mechanisms in general, and to offer opportunities for new therapy approaches. Hence, we cooperate with the Department of Neurology and Institute of Translational Neurology (AG Klotz) to analyze different cell types with Next-Generation Sequencing methods like spatial transcriptomics, scRNA analyses, and RNA sequencing to understand spatial effects of immune cell activity in Multiple Sclerosis, to characterize therapy effects, or to describe processes of immune senescence with bioinformatical techniques. Inflammatory processes are also relevant in the context of strokes, and thus are also a promising target for NGS-based research.

Contact: Dr. Carolin Walter