Johannes Brockhaus
Dr. rer. nat.

Wissenschaftlicher Mitarbeiter
Institut für Anatomie & Molekulare Neurobiologie

Vesaliusweg 2-4
48149 Münster

Telefon: +49 (0) 251 83-50203
Telefax: +49 (0) 251 83-50248
Email: Johannes Brockhaus

  • Lebenslauf

    Titel:Dr. rer. nat.

    Beruflicher Werdegang

    1985 - 1991Studium der Biologie, Georg-August Universität Göttingen
    1994Promotion (Dr. rer. nat.), Institut für Neurobiologie, Universität Heidelberg
    1995 - 1998Wissenschaftlicher Mitarbeiter, Institut für Physiologie II, Georg-August Universität Göttingen
    1998 - 2005Hochschulassistent, Fachgebiet Allgemeine Zoologie, Technische Universität Kaiserslautern
    2005 - 2006Wissenschaftlicher Mitarbeiter, Institut für Physiologie, Julius-Maximilians-Universität Würzburg
    2006 - 2007Wissenschaftlicher Mitarbeiter, Institut für Pharmakologie & Toxikologie, Universität Zürich (CH)
    2007 - 2010Wissenschaftlicher Mitarbeiter, Institut für Physiologie I, Universitätsklinikum der Universität Münster
    seit 2010Wissenschaftlicher Mitarbeiter, Institut für Anatomie & Molekulare Neurobiologie, Universitätsklinikum der Universität Münster
  • Publikationen

    Originalarbeiten (nur „peer-reviewed“):

    1. Brockhaus J., Ballanyi K., Smith J.C., Richter D.W. (1993) Microenvironment of respiratory neurons in the in vitro brainstem-spinal cord of neonatal rats. J PHYSIOL. 462:421-445
    2. Brockhaus J., Ilschner S., Banati R.B., Kettenmann H. (1993) Membrane properties of ameboid microglial cells in the corpus callosum slice from early postnatal mice. J NEUROSCI. 13(10):4412-4421
    3. Brockhaus J., Moller T. and Kettenmann H. (1996) Phagocytozing ameboid microglial cells studied in a mouse corpus callosum slice preparation. GLIA. 16(1):81-90; doi: 10.1002/(SICI)1098-1136(199601)16:1<81::AID-GLIA9>3.0.CO;2-E
    4. Ballanyi K., Doutheil J. and Brockhaus, J. (1996) Membrane potentials and microenvironment of rat dorsal vagal cells in vitro during energy depletion. J PHYSIOL. 495(3):769-784
    5. Haas S., Brockhaus J., Verkhratsky A. and Kettenmann H. (1996) ATP-induced membrane currents in ameboid microglia acutely isolated from mouse brain slices. NEUROSCIENCE; 75(1):257-261; doi: 10.1016/0306-4522(96)00270-9
    6. Karschin, A., Brockhaus J. and Ballanyi K. (1998) K-ATP channel formation by the sulphonylurea receptors SUR1 with Kir6.2 subunits in rat dorsal vagal neurons in situ. J PHYSIOL. 509(2):339-346; doi: 10.1111/j.1469-7793.1998.339bn.x
    7. Töpert C., Doring F., Wischmeyer E., Karschin C., Brockhaus J., Ballanyi K., Derst C. and Karschin A. (1998) Kir2.4: A novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei. J NEUROSCI. 18(11):4096-4105
    8. Brockhaus, J. and Ballanyi K. (1998) Synaptic inhibition in the isolated respiratory network of neonatal rats. EUR J NEUROSCI. 10(12):3823-3839; doi: 10.1046/j.1460-9568.1998.00396.x
    9. Brockhaus J. and Ballanyi, K. (2000) Anticonvulsant A(1) receptor-mediated adenosine action on neuronal networks in the brainstem-spinal cord of newborn rats. NEUROSCIENCE. 96(2):359-371; doi: 10.1016/S0306-4522(99)00544-8
    10. Brockhaus J. and Deitmer J.W. (2000) Developmental downregulation of ATP-sensitive potassium conductance in astrocytes in situ. GLIA. 32(3):205-213; doi: 10.1002/1098-1136(200012)32:3<205::AID-GLIA10>3.0.CO;2-6
    11. Müller M., Brockhaus J. and Ballanyi K. (2002) ATP-independent anoxic activation of ATP-sensitive K+ channels in dorsal vagal neurons of juvenile mice in situ. NEUROSCIENCE. 109(2):313-328; doi: 10.1016/S0306-4522(01)00498-5
    12. Kulik A., Brockhaus J., Pedarzani P. and Ballanyi K. (2002) Chemical anoxia activates ATP-sensitive and blocks Ca2+-dependent K+ channels in rat dorsal vagal neurons in situ. NEUROSCIENCE. 110(3):541-554; doi: 10.1016/S0306-4522(01)00468-7
    13. Brockhaus J. and Deitmer J.W. (2002) Long-lasting modulation of synaptic input to Purkinje neurons by Bergmann glia stimulation in rat brain slices. J PHYSIOL. 545(2):581-593; doi: 10.1113/jphysiol.2002.028423
    14. Brockhaus J., Dressel, D., Herold, S. and Deitmer J.W. (2004) Purinergic modulation of synaptic input to Purkinje neurons in rat cerebellar brain slices. EUR J NEUROSCI. 19(8):2221-2230; doi: 10.1111/j.1460-9568.2004.03325.x
    15. Casel D., Brockhaus J. and Deitmer J.W. (2005) Enhancement of spontaneous synaptic activity in rat Purkinje neurones by ATP during development. J PHYSIOL. 568(1):111-122; doi: 10.1113/jphysiol.2005.091371
    16. Herold S., Hecker C., Deitmer J.W. and Brockhaus J. (2005) alpha 1-adrenergic modulation of synaptic input to Purkinje neurons in rat cerebellar brain slices. J NEUROSCI RES. 82(4):571-579; doi: 10.1002/jnr.20660
    17. Deitmer J.W., Brockhaus J. and Casel D. (2006) Modulation of synaptic activity in Purkinje neurons by ATP. CEREBELLUM. 5(1):49-54; doi: 10.1080/14734220500497456
    18. Knabl J., Witschi R., Hoesl K., Reinold, H., Zeilhofer U.B., Ahmadi S., Brockhaus J., Sergejeva M., Hess A., Brune K., Fritschy J.M., Rudolph U., Moehler H. and Zeilhofer H.U. (2008) Reversal of pathological pain through specific spinal GABA(A) receptor subtypes. NATURE. 451(7176):330-334; doi: 10.1038/nature06493
    19. Andratsch M., Mair N., Constantin C.E., Scherbakov N., Benetti C., Quarta S., Vogl C., Sailer C., Ueceyler N., Brockhaus J., Martini R., Sommer C., Zeilhofer H.U., Mueller W., Kuner R., Davis J.B., Rose-John S. and Kress M. (2009) A Key Role for gp130 Expressed on Peripheral Sensory Nerves in Pathological Pain. J NEUROSCI. 29(43):13473-13483; doi: 10.1523/JNEUROSCI.1822-09.2009
    20. Brockhaus J. and Pape H.C. (2011) Abnormalities in GABAergic synaptic transmission of intralaminar thalamic neurons in a genetic rat model of absence epilepsy. MOL CELL NEUROSCI. 46(2):444-451; doi: 10.1016/j.mcn.2010.11.009
    21. Niesmann K., Breuer D., Brockhaus J., Born G., Wolff I., Reissner C., Kilimann M.W., Rohlmann A. and Missler M. (2011) Dendritic spine formation and synaptic function require neurobeachin; Nat. Commun. 2:557; doi: 10.1038/ncomms1565
    22. Blanque A., Repetto D., Rohlmann A., Brockhaus J., Duning K., Pavenstädt H., Wolff I. and Missler M. (2015) Deletion of KIBRA, protein expressed in kidney and brain, increases filopodial-like long dendritic spines in neocortical and hippocampal neurons in vivo and in vitro. Front Neuroanat 9:13; doi: 10.3389/fnana.2015.00013
    23. Palm T., Bolognin S., Meiser J., Nickels S., Träger C., Meilenbrock R.L., Brockhaus J., Schreitmüller M., Missler M., Schwamborn J.C. (2015) Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia; Sci Rep. 5:16321.; doi: 10.1038/srep16321
    24. Hallmann A.L., Araúzo-Bravo M.J., Mavrommatis L., Ehrlich M., Röpke A., Brockhaus J., Missler M., Sterneckert J., Schöler H.R., Kuhlmann T., Zaehres H., Hargus G. (2017) Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein; Sci Rep. 7:42991; doi: 10.1038/srep42991
    25. Repetto D., Brockhaus J., Rhee H.J., Lee C.K., Kilimann M.W., Rhee J. S., Northoff L.M., Guo W., Reissner C., Missler M. (2018) Molecular Dissection of Neurobeachin Function at Excitatory Synapses; Front Synaptic Neurosci 10:28; doi: 10.3389/fnsyn.2018.00028
    26. Brockhaus J., Schreitmüller M., Repetto D., Klatt O., Reissner C., Elmslie K., Heine M., Missler M. (2018) α-Neurexins together with α2δ-1 auxiliary subunits regulate Ca2+ influx through CaV2.1 channels; J Neurosci 38(38):8277-8294; doi: 10.1523/JNEUROSCI.0511-18.2018
    27. Brockhaus J., Brüggen B., Missler M. (2019) Imaging and analysis of presynaptic calcium influx in cultured neurons using synGCaMP6f; Front Synaptic Neurosci 11:12; doi: 10.3389/fnsyn.2019.00012
    28. Darici D., Reissner C., Brockhaus J., Missler M. (2021) Implementation of a fully digital histology course in the anatomical teaching curriculum during COVID-19 pandemic; Ann Anat 236:151718; doi: 10.1016/j.aanat.2021.151718
    29. Schöpf C.L., Ablinger C., Geisler S.M., Stanika R.I., Campiglio M., Kaufmann W.A., Nimmervoll B., Schlick B., Brockhaus J., Missler M., Shigemoto R. and Obermair G.J. (2021) Presynaptic α2δ subunits are key organizers of glutamatergic synapses; PNAS 118(14):e1920827118; doi: 10.1073/pnas.1920827118
    30. Klatt O., Repetto D., Brockhaus J., Reissner C., El Khallouqi A., Rohlmann A., Heine M., Missler M. (2021) Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior; Cell Rep. 35(11):109266; doi: 10.1016/j.celrep.2021.109266
    31. Ferdos S., Brockhaus J., Missler M., Rohlmann A. (2022) Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons; Front. Neuroanat. 15:757017; doi: 10.3389/fnana.2021.757017
    32. Brockhaus J., Kahl I., Ahmad M., Repetto D., Reissner C., Missler M. (2024) Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx; Cells 13(11), 981; doi: 10.3390/cells13110981  -  [ epub ahead of print ]


  • Stipendien & Auszeichnungen

    1993 -1994Promotionsstipendium, Studienstiftung des Deutschen Volkes