Astrid Rohlmann
Dr. rer. nat.

Wissenschaftliche Mitarbeiterin
Institut für Anatomie & Molekulare Neurobiologie

Vesaliusweg 2-4
48149 Münster

Telefon: +49 (0) 251 83-50207
Telefax: +49 (0) 251 83-50248
Email: Astrid Rohlmann

  • Lebenslauf


    Beruflicher Werdegang

    1985 - 1988Studium der Biologie, Universität Münster
    1988 - 1990Fortsetzung des Studiums der Biologie an der Eberhard-Karl-Universität Tübingen
    1991Wissenschaftliche Mitarbeiterin, Institut für Pathologie, Eberhard-Karl-Universität Tübingen
    1991 - 1994Promotion (Dr. rer. nat.), Georg-August-Universität Göttingen
    "Dynamics and organization of gap junctions of the astrocytic network in the cerebral cortex of adult rats"
    1994 - 1999Postdoctoral Fellow, Department of Molecular Genetics, University of Texas, Southwestern Medical Center, Dallas, USA
    1999 - 2001Wissenschaftliche Mitarbeiterin (Postdoc), Zentrum für Physiologie, Georg-August-Universität Göttingen
    2003 - 2004Wissenschaftliche Mitarbeiterin (Postdoc), Zentrum für Physiologie, Georg-August-Universität Göttingen
    2006Wissenschaftliche Mitarbeiterin (Postdoc), Zentrum für Physiologie, Georg-August-Universität Göttingen
    seit 2007Wissenschaftliche Mitarbeiterin, Institut für Anatomie & Molekulare Neurobiologie, Universitätsklinikum der Universität Münster

  • Publikationen


    Originalarbeiten (nur „peer-reviewed“):

    1. Rohlmann A., Gocht A. and Wolburg H. (1992) Reactive astrocytes in myelin-deficient rat optic nerve reveal an altered distribution of orthogonal arrays of particles (OAP). Glia 5: 259-268
    2. Rohlmann A., Laskawi R., Hofer A., Dobo E., Dermietzel R. and Wolff J.R. (1993) Facial nerve lesions lead to increased immunostaining of the astrocytic gap junction protein (connexin 43) in the corresponding facial nucleus of rats. Neurosci. Lett., 154: 206-208
    3. Rohlmann A., Laskawi R., Hofer A., Dermietzel R. and Wolff J.R. (1994) Astrocytes as rapid sensors of peripheral axotomy in the facial nucleus of rats. NeuroReport, 5: 409-412
    4. Wolburg H. und Rohlmann A. (1995) Structure-function relations in gap junctions. Int. Rev. Cytol., 157: 315-373.
    5. Willnow T.E., Rohlmann A., Horton J., Otani H., Braun J.R., Hammer R.E. and Herz J. (1996) RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. EMBO J., 15(11): 2632-2639.
    6. Willnow T.E., Hilpert J. Armstrong S.A., Rohlmann A., Hammer R.E., Burns D.K. and Herz J. (1996) Defective forebrain development in mice lacking gp330/megalin. PNAS, 93: 8460-8464.
    7. Rohlmann A., Gotthardt M., Willnow T.E., Hammer R.E. and Herz J. (1996) Sustained somatic gene inactivation by viral transfer of cre recombinase. Nature Biotechnology, .14(11): 1562-1565.
    8. Laskawi R., Rohlmann A., Landgrebe M., and Wolff J.R. (1997) Rapid astroglial reactions in the motor cortex of adult rats following peripheral facial nerve lesions. Eur. Arch. Otorhinolaryngol., 254: 81-85.
    9. Rohlmann A., Gotthardt M., Hammer R.E., and Herz J. (1998) Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J. Clin. Invest., 101: 689-695.
    10. Wolff J.R., Stuke K., Missler M., Tytko H., Schwarz P., Rohlmann A., and Chao T.I. (1998) Autocellular coupling by gap junctions in cultured astrocytes: A new view on cellular autoregulation during process formation. Glia, 24: 121-140.
    11. Hiesberger T., Wittier S., Rohlmann A., Schneider W., Sandhoff K., and Herz J. (1998) Cellular uptake of Saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP). EMBO J., 17: 4617-4625.
    12. Van Vlijmen B.J., Rohlmann A., Page S.T., Bensadoun A., Bos I. S., van Berke' T.J., Havekes L. M., Herz J. (1999) An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins. JBiol Chem., 274(49): 35219-26.
    13. May P., Rohlmann A., Bock H.H., Zurhove K., Marth J.D., Schomburg E.D., Noebels J.L., Beffert U., Sweatt J.D., Weeber E.J., Herz J. (2004) Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol., 24(20): 8872-83.
    14. Zhang W., Rohlmann A., Sargsyan V., Aramuni G., Hammer R.E., Südhof T.C., Missler M. (2005) Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels. JNeurosci., 25(17): 4330-42.
    15. Beglopoulos V., Montag-Sallaz M., Rohlmann A., Piechotta K., Ahmad M., Montag D., Missler M. (2005) Neurexophilin 3 is higly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination. Mol Cell Biol., 25(16): 7278-88.
    16. Dudanova I., Tabuchi K., Rohlmann A., Südhof T. C., Missler M. (2007) Deletion of α-Neurexins does not cause a major impairment of axonal pathfinding of synapse formation. J Comp Neurol, 502:261-274.
    17. Fairless R., Ahmad M., Masius H., Rohlmann A., Heupel K., Reissner C., Dresbach T. and Missler M. (2008) Polarized targeting of neurexins to synapses is regulated by their c-terminal sequences. J Neuroscience, 28(48): 12969-81.
    18. Medrihan L., Rohlmann A., Fairless R., Andrae J., Döring M., Missler M., Zhang W. and Kilimann M.W. (2009) Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses. J Physiol., 587(21): 5095-5106; doi: 10.1113/jphysiol.2009.178236
    19. Niesmann K., Breuer D., Brockhaus J., Born G., Wolff I., Reissner C., Kilimann M.W., Rohlmann A. and Missler M. (2011) Dendritic spine formation and synaptic function require neurobeachin; Nat. Commun. 2:557; doi: 10.1038/ncomms1565
    20. Runkel F., Rohlmann A., Reissner C., Brand S. M. and Missler M. (2013) Promoter-like sequences regulating transcriptional activity in neurexin and neuroligin genes. J Neurochem. 127(1):36-47 doi:10.1111/jnc.12372
    21. Born G., Breuer D., Wang S., Rohlmann A., Coulon P., Vakili P., Reissner C., Kiefer F., Heine M., Pape H.C., Missler M. (2014) Modulation of synaptic function through the α-neurexin-specific ligand neurexophilin-1. PNAS 111(13):E1274–E1283; doi: 10.1073/pnas.1312112111
    22. Blanque A., Repetto D., Rohlmann A., Brockhaus J., Duning K., Pavenstädt H., Wolff I. and Missler M. (2015) Deletion of KIBRA, protein expressed in kidney and brain, increases filopodial-like long dendritic spines in neocortical and hippocampal neurons in vivo and in vitro. Front Neuroanat 9:13; doi: 10.3389/fnana.2015.00013
    23. Born G., Grayton H.M., Langhorst H., Dudanova I., Rohlmann A., Woodward B., Collier D., Fernandes C. and Missler M. (2015). Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors. Front Synaptic Neurosci 7:3; doi: 10.3389/fnsyn.2015.00003
    24. Shen Y., Ge W.P., Li Y., Hirano A., Lee H.Y., Rohlmann A., Missler M., Tsien R., Jan L.Y., Fu Y.H., Ptáček L.J. (2015) Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis. PNAS 112(10):2935-2941; doi: 10.1073/pnas.1501364112
    25. Lenders M., Hofschröer V., Schmitz B., Kasprzak B., Rohlmann A., Missler M., Pavenstädt H., Oberleithner H., Brand S.M., Kusche-Vihrog K., Brand E. (2015) Differential response to endothelial epithelial sodium channel inhibition ex vivo correlates with arterial stiffness in humans. J Hypertens 33(12):2455-62; doi:10.1097/HJH.0000000000000736
    26. Martinelli D.C., Chew K.S., Rohlmann A., Lum M.Y., Ressl S., Hattar S., Brunger A.T., Missler M., Südhof T.C. (2016) Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors; Neuron 91:1-18.; doi: 10.1016/j.neuron.2016.07.002
    27. Herich S., Schneider-Hohendorf T., Rohlmann A., Khaleghi Ghadiri M., Schulte-Mecklenbeck A., Zondler L., Janoschka C., Ostkamp P., Richter J., Breuer J., Dimitrov S., Rammensee H.G., Grauer O.M., Klotz L., Gross C.C., Stummer W., Missler M., Zarbock A., Vestweber D., Wiendl H., Schwab N. (2019) Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis; Brain 142(11):3411-3427; doi: 10.1093/brain/awz301
    28. Bikbaev A., Ciuraszkiewicz-Wojciech A., Heck J., Klatt O., Freund R., Mitlöhner J., Lacalle S.E., Sun M., Repetto D., Frischknecht R., Ablinger C., Rohlmann A., Missler M., Obermair G.J., Di Biase V., Heine M. (2020) Auxiliary a2d1 and a2d3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development; J Neurosci 40(25):4824-4841; doi: 10.1523/JNEUROSCI.1707-19.2020
    29. Muellerleile J., Blistein A., Rohlmann A., Scheiwe F., Missler M., Schwarzacher S.W., Jedlicka P. (2020) Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin; Sci Rep. 10:16058; doi: 10.1038/s41598-020-72925-4
    30. Heiden S., Siwek R., Lotz M.L., Borkowsky S., Schröter R., Nedvetsky P., Rohlmann A., Missler M., Krahn M.P. (2021) Apical‑basal polarity regulators are essential for slit diaphragm assembly and endocytosis in Drosophila nephrocytes; Cell Mol Life Sci 78(7):3657-3672; doi: 10.1007/s00018-021-03769-y
    31. Albert T.K., Interlandi M., Sill M., Graf M., Moreno N., Menck K., Rohlmann A., Melcher V., Korbanka S., Meyer Zu Hörste G., Lautwein T., Frühwald M.C., Krebs C.F., Holdhof D., Schoof M., Bleckmann A., Missler M., Dugas M., Schüller U., Jäger N., Pfister S.M., Kerl K. (2021) An extracellular vesicle-related gene expression signature identifies high-risk patients in medulloblastoma; Neuro Oncol 23(4):586-598; doi: 10.1093/neuonc/noaa254
    32. Klatt O., Repetto D., Brockhaus J., Reissner C., El Khallouqi A., Rohlmann A., Heine M., Missler M. (2021) Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior; Cell Rep. 35(11):109266; doi: 10.1016/j.celrep.2021.109266
    33. Ferdos S., Brockhaus J., Missler M., Rohlmann A. (2022) Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons; Front. Neuroanat. 15:757017; doi: 10.3389/fnana.2021.757017
    34. Gass M.M., Borkowsky S., Lotz ML., Siwek R., Schröter R., Nedvetsky P., Luschnig S., Rohlmann A., Missler M., Krahn M.P. (2022) PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes; Cellular and Molecular Life Sciences 79:248; doi: 10.1007/s00018-022-04273-7
    35. de Arce K.P., Ribic A., Chowdhury D., Watters K., Thompson G.J., Sanganahalli B.G., Lippard E.T.C., Rohlmann A., Strittmatter S.M., Missler M., Hyder F., Biederer T. (2023) Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions; Nat Commun 28;14(1):459; doi: 10.1038/s41467-023-36042-w
    36. Mohrmann L., Seebach J., Missler M., Rohlmann A. (2024) Distinct Alterations in Dendritic Spine Morphology in the Absence of  β-Neurexins; Int. J. Mol. Sci. 25(2), 1285; doi: 10.3390/ijms25021285  -  [ epub ahead of print ]

    Buchbeiträge:

    1. Rohlmann A. und Wolff J.R. (1996) Subcellular topography and plasticity of gap junction distribution on astrocytes. Neuroscience Intelligence Unit, eds.: Spray D.C. and Dermietzel R., Landes R.G. Company Austin, Springer, 175-189.
    2. Rohlmann A., Gotthardt M., Hammer R.E. and Herz J. (1998) Analysis of chylomicron remnant metabolism by tissue-specific gene inactivation. Atherosclerosis XI, eds.: Jacotot B., Mathe D. and Fruchart J.-C., Elsevier Science, 1019-1021.

     

  • Stipendien & Auszeichnungen

    1991 - 1994Stipendium, Graduiertenkolleg ’’Dynamic and organization of neuronal networks’’, Deutsche Forschungsgemeinschaft (DFG)
    1994 - 1996Stipendium für Postdoktoranden, Deutsche Forschungsgemeinschaft (DFG)