5.1 TRP channels in PDAC cell migration and invasion
Natalia Prevarskaya leads WP2.
Previous results of ULi have shown that TRP channels play a key role in cancer cell migration. The ESR project "TRP channels in PDAC cell migration and invasion" is aimed at identifying mechanisms by which TRP channels in PDAC cells control cancer cell adhesion, migration and invasion.
Previous results of ULi have shown that TRP channels play a key role in cancer cell migration. The ESR project "TRP channels in PDAC cell migration and invasion" is aimed at identifying mechanisms by which TRP channels in PDAC cells control cancer cell adhesion, migration and invasion.
5.2 Role of calcium permeable channels in PDAC resistance to chemotherapy
The ER project "Role of calcium permeable channels in PDAC resistance to chemotherapy"
addresses the question of enhanced resistance to apoptosis of cancer cells. ULi has shown that calcium and the altered expression and function of calcium permeable channels (ORAI1) in cancer cells are involved in resistance to apoptosis induced by chemotherapeutical drugs. Therefore, the role of ORAI and other Ca2+ permeable channels in apoptosis and autophagy will be studied.
addresses the question of enhanced resistance to apoptosis of cancer cells. ULi has shown that calcium and the altered expression and function of calcium permeable channels (ORAI1) in cancer cells are involved in resistance to apoptosis induced by chemotherapeutical drugs. Therefore, the role of ORAI and other Ca2+ permeable channels in apoptosis and autophagy will be studied.