The Immune-Microbiota Interactions Laboratory investigates the cellular and molecular mechanisms of host-microbiota interactions in immune-mediated diseases. The group explores in particular basic mechanisms of immunologic tolerance in the context of the gut, skin, and oral microbiota. The lab has previously investigated this field at Yale University (https://medicine.yale.edu/lab/kriegel/) before relocating to the University of Münster, Germany. The lab has identified several pathobionts in autoimmunity (Vieira et al, Science 2018; Greiling et al, Sci Transl Med 2018; Ruff et al, Cell Host Microbe 2019; Zegarra-Ruiz et al, Cell Host Microbe 2019) that are being studied in more depth in Münster. The lab is highly interdisciplinary and uses gnotobiotic approaches in order to study human microbiota in in-vivo models and to identify commensal triggers in autoimmunity and cancer. Techniques span a broad range from immunology, microbiology, cell and molecular biology to metagenomics.
The Immune-Microbiota Interactions Laboratory is affiliated with the Department of Translational Rheumatology and Immunology at the Institute of Muscoloskeletal Medicine an the Section of Rheumatology and Clinical Immunology at the University Hospital of Münster. It is located in the Röntgen and von-Esmarch-Streets adjacent to the Max-Planck Institute for Molecular Biomedicine and partly housed in the Center for Molecular Biology of Inflammation with nearby labs from virology, infection biology, immunology, and proteomics among other disciplines.
Prof. Dr. Martin Kriegel
Immune-Microbiota Interactions Laboratory
Department of Translational Rheumatology and Immunology
Institute of Musculoskeletal Medicine
University of Münster
D-48149 Münster, Germany
Email contact: Martin Kriegel