The Immune-Microbiota Interactions Laboratory investigates the cellular and molecular mechanisms of host-microbiota interactions in immune-mediated diseases. The group explores in particular basic mechanisms of immunologic tolerance in the context of the gut, skin, and other mucosal microbiota. The lab has previously investigated this field at Yale University (https://medicine.yale.edu/lab/kriegel/) before relocating to the University of Münster, Germany. The lab has recently identified several pathobionts in autoimmunity (Vieira et al, Science 2018; Greiling et al, Sci Transl Med 2018; Ruff et al, Cell Host Microbe 2019; Zegarra-Ruiz et al, Cell Host Microbe 2019) that are being studied in more depth. The lab is highly interdisciplinary and uses human tissue, organoid, and murine gnotobiotic approaches coupled with next-generation human microbiome sequencing to identify commensal triggers in autoimmunity and cancer. Techniques span a broad range from immunology, cell and molecular biology to microbiology including gnotobiotics and metagenomics.

The Immune-Microbiota Interactions Laboratory is affiliated with the Section of Rheumatology and Clinical Immunology at the University Hospital of Münster and the Institute of Experimental Musculoskeletal Medicine. It is located adjacent to the Max-Planck Institute for Molecular Biomedicine and partly housed in the Center for Molecular Biology of Inflammation with nearby labs from virology, infection biology, immunology, and proteomics among other disciplines.

The lab is currently looking to fill several positions and is always interested in highly motivated trainees and staff. A Group Leader position is being formally announced shortly.



Prof. Dr. Martin Kriegel
Chair of Rheumatology and Clinical Immunology
University of Münster
Immune-Microbiota Interactions Laboratory
Röntgenstr. 21 & von-Esmarch-Str. 54
D-48149 Münster
Email contact: martin.kriegel@ukmuenster.de

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