* co-corresponding author
** equal contributions
2025
Quas A, Rickhoff C, Wedlich-Söldner R, Heuer A. bioRxiv 2025 Apr., doi: 10.1101/2025.04.08.647797.
Zhao XT, Diep DTV, Percifull L, Fausten RM, Hugenroth M, Höhne P, Leite B, Esch BM, Collado J, Keller J, Wilmes S, Turhan MA, Wälte M, Becker T, Kümmel D, Schuberth C, Fernández-Busnadiego R, Fröhlich F, Wedlich-Söldner R, Bohnert M. The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility. Cell Rep. 2025 Nov. doi: 10.1016/j.celrep.2025.116475.
Wiesner E, Binz-Lotter J, Tröder SE, Unnersjö-Jess D, Rutkowski N, Zevnik B, Schermer B, Benzing T, Wedlich-Söldner R, Hackl MJ. A red fluorescent lifeact marker to study actin morphology in podocytes. Sci Rep. 2025 Apr. doi: 10.1038/s41598-025-96822-w.
Dzikonski D, Zamboni R, Bandyopadhyay A, Paul D, Wedlich-Söldner R, Denz C, Imbrock J. Lab-on-a-chip device for microfluidic trapping and TIRF imaging of single cells. Biomed Microdevices. 2025 Mar. doi: 10.1007/s10544-025-00739-0.
Shatskiy D, Sivan A, Wedlich-Söldner R*, Belyy A*. Structure of the F-tractin-F-actin complex. J Cell Biol. 2025 Apr. doi: 10.1083/jcb.202409192.
2023
Haase D, Rasch C, Keller U, Tsytsyura Y, Glyvuk N, Elting A, Wittmar J, Janning A, Kahms M Wedlich N, Schuberth C, Heuer A, Klingauf J, Wedlich-Soldner R. Tetraspanner-based nanodomains modulate BAR domain-induced membrane curvature. EMBO Rep. 2023 Dec. doi: 10.15252/embr.202357232.
Keller F, Alavizargar A, Wedlich-Söldner R, Heuer A. The impact of bilayer composition on the dimerization properties of the Slg1 stress sensor TMD from a multiscale analysis. Phys Chem Chem Phys. 2023 Jan 4;25(2):1299-1309. doi: 10.1039/d2cp03497b. PMID: 36533706.
2022
Alavizargar A, Elting A, Wedlich-Söldner R, Heuer A. Lipid-Mediated Association of the Slg1 Transmembrane Domains in Yeast Plasma Membranes. J Phys Chem B. 2022 May 5;126(17):3240-3256. doi: 10.1021/acs.jpcb.2c00192. Epub 2022 Apr 21. PMID: 35446028.
Doeser MC, Krygin J, Röpke A, Han D, Wedlich-Söldner R, Schöler HR, Pavenstädt H, Kim KP. Generation of a human iPSC line (MPIi008-A) from a patient with Denys-Drash syndrome. Stem Cell Res. 2022 Jul;62:102826. doi: 10.1016/j.scr.2022.102826. Epub 2022 May 30. PMID: 35667217.
2021
Alavizargar A, Keller F, Wedlich-Söldner R, Heuer A Effect of Cholesterol Versus Ergosterol on DPPC Bilayer Properties: Insights from Atomistic Simulations. J Phys Chem B Condens Matter Mater Surf Interfaces Biophys 2021; 125(28): 7679-7690
2020
Struk T, Nair V, Eichinger F, Kretzler M, Wedlich-Söldner R, Bayraktar S, Pavenstädt H. Transcriptome analysis of primary podocytes reveals novel calcium regulatory networks. FASEB J. 2020 Nov;34(11):14490-14506.
Schreiber A, Boff L, Anhlan D, Krischuns T, Brunotte L, Schuberth C, Wedlich-Söldner R, Drexler H, Ludwig S. Dissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16557-16566
Bayraktar S**, Nehrig J**, Menis E, Karli K, Janning A, Struk T, Halbritter J, Michgehl U, Krahn MP, Schuberth CE*, Pavenstädt H*, Wedlich-Söldner R* (2020). A Deregulated Stress Response Underlies Distinct INF2-Associated Disease Profiles. J Am Soc Nephrol 2020 Jun;31(6):1296-1313.
Skryabin BV, Kummerfeld DM, Gubar L, Seeger B, Kaiser H, Stegemann A, Roth J, Meuth SG, Pavenstädt H, Sherwood J, Pap T, Wedlich-Söldner R, Sunderkötter C, Schwartz YB, Brosius J, Rozhdestvensky TS (2020) Pervasive head-to-tail insertions of DNA templates mask desired CRISPR-Cas9-mediated genome editing events. Sci Adv. 6(7).
2019
Mewes M, Lenders M, Stappers F, Scharnetzki D, Nedele J, Fels J, Wedlich-Söldner R, Brand SM, Schmitz B, Brand E. (2019) Soluble adenylyl cyclase (sAC) regulates calcium signaling in the vascular endothelium. FASEB J. 33: 13762-13774.
Mietkowska M, Schuberth C, Wedlich-Söldner R, Gerke V. (2019). Actin dynamics during Ca2+-dependent exocytosis of endothelial Weibel-Palade bodies. Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1218-1229.
Dlugos CP, Picciotto C, Lepa C, Krakow M, Stöber A, Eddy ML, Weide T, Jeibmann A, P Krahn M, Van Marck V, Klingauf J, Ricker A, Wedlich-Söldner R, Pavenstädt H, Klämbt C, George B. (2019). Nephrin Signaling Results in Integrin β1 Activation. J Am Soc Nephrol. 2019 Jun;30(6):1006-1019.
Busto JV, Wedlich-Söldner R. (2019). Integration Through Separation - The Role of Lateral Membrane Segregation in Nutrient Uptake. Front Cell Dev Biol. 2019 Jun 25;7:97.
2018
Wedlich-Soldner, R. and Betz, T. (2018). Self-organization: the fundamenof cell biology. Philos Trans R Soc Lond B. 2018 May 26; 373(1747). pii: 20170103. doi: 10.1098/rstb.2017.0103.
Prystopiuk, V., Fels, B., Simon, C. S., Liashkovich, I., Pasrednik, D., Kronlage, C., Wedlich-Soldner, R., Oberleithner, H. and Fels, J. (2018). A two-phase response of endothelial cells to hydrostatic pressure. J Cell Sci. pii: jcs.206920.
Busto, J.V., Elting, A., Haase, D., Spira, F., Kuhlman, J., Schäfer-Herte, M. and Wedlich-Soldner, R. (2018). Lateral plasma membrane compartmentalization links protein function and turnover. EMBO J. 37: pii: e99473
2017
Aufschnaiter, R., Wedlich-Soldner, R., Zhang, X. and Hobmayer, B. (2017). Apical and basal epitheliomuscular F-actin dynamics during Hydra bud evagination. Biology Open 6: 1137-1148.
Granado, D., Müller, D., Krausel, V., Kruzel-Davilla, E., Schuberth, C., Eschborn, M., Wedlich-Soldner, R., Skorecki, K., Pavenstädt, H., Michgehl, U. and Weide, T. (2017). Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletation. J AM Soc Nephrol. 28: 3227-3238.
Horsthemke, M., Bachg, A.C., Groll, K., Moyzio, S., Müther, B., Hemkemeyer, S.A., Wedlich-Soldner, R., Sixt, M., Tacke, S., Bähler, M. and Hanley, P.J. (2017). Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion. J Biol Chem. 292: 7258-7273.
2016
Wales, P.**, Schuberth, C.E.**, Aufschnaiter, R.**, Fels, J., García-Aguilar, I., Janning, A., Dlugos, C.P., Schäfer-Herte, M., Klingner, C., Wälte, M., Kuhlmann, J., Menis, K., Hockaday Kang, L., Maier, K.C., Hou, W., Russo, A., Higgs, H.N., Pavenstädt, H., Vogl, T., Roth, J., Qualmann, B., Kessels, M.M., Martin, D.E., Mulder, B. and Wedlich-Soldner, R. (2016). Calcium-mediated actin reset (CaAR) mediates acute cell adaptions. Elife 5: e19850.
Zhu, J., Baily, A., Zwiewka, M., Sovero, V., Di Donato, M., Ge, P., Oehri, J., Aryal, B., Hao, P., Linnert, M., Burgardt, N.I., Lücke, C., Weiwad, M., Michel, M., Weiergräber, O.H., Pollmann, S., Azzarello, E., Mancuso, S., Ferro, N., Fukao, Y., Hoffmann, C., Wedlich-Soldner, R., Friml, J., Thomas, C., Geisler, M. (2016). Twisted Dwarf1 Mediates the actioAuxin Transport Inhibitors on Actin Cytoskeleton Dynamics. Plant Cell. 28: 930-48.
2015
Crevenna, A.H., Arciniega, M., Dupont, A., Mizuno, N., Kowalska, K., Lange, O.F., Wedlich-Soldner, R. and Lamb, D.C. (2015). Side-binding proteins modulate actin filament dynamics. Elife 4: e04599.
Schuberth, C. and Wedlich-Soldner, R. (2015). Building a patchwork - The yeast plasma membrane as model to study lateral domain formation. Biochim Biophys Acta 1853: 767-774.
2014
Klingner, C. **, Cherian, A.V. **, Fels, J., Diesinger, P.M., Aufschnaiter, R., Maghelli, N., Keil, T., Beck, G., Tolić-Nørrelykke, I.M., Bathe, M. and Wedlich-Soldner, R. (2014). Isotropic acto-myosin dynamics promote organization of the apical cell cortex in epithelial cells. J Cell Biol. 207: 107-21.
Wedlich-Soldner, R. (2014). A longer life for yeast with good memory. Dev Cell. 31: 391-2.
Marel, A.K., Zorn, M., Klingner, C., Wedlich-Soldner, R., Frey, E. and Rädler, J.O. (2014). Flow and diffusion in channel-guided cell migration. Biophys J. 107: 1054-64.
Domínguez-Escobar, J.**, Wolf, D.**, Fritz, G., Höfler, C., Wedlich-Soldner, R. and Mascher, T. (2014). Subcellular localization, interactions and dynamics of the phage-shock protein-like Lia response in Bacillus subtilis. Mol Microbiol. 92: 716-32.
Rueff, A.S., Chastanet, A., Dominguez-Escobar, J., Yao, Z., Yates, J., Prejean, M.V., Delumeau, O., Noirot, P., Wedlich-Soldner, R., Filipe, S.R. and Carballido-López, R. (2014). An early cytoplasmic step of peptidoglycan synthesis is associated to MreB in Bacillus subtilis. Mol Microbiol. 91: 348-62.
2013
Klünder, B.**, Freisinger, T.**, Wedlich-Soldner, R.* and Frey, E.* (2013). GDI-Mediated Cell Polarization in Yeast Provides Precise Spatial and Temporal Control of Cdc42 Signaling, PLoS Comp Biology. 9: e1003396.
Abdelhady, S., Kitambi, S.S., Lundin, V., Aufschnaiter, R., Sekyrova, P., Sinha, I., Lundgren, K.T., Castelo-Branco, G., Linnarsson, S., Wedlich-Soldner, R., Teixeira, A. and Andäng, M. (2013). Erg channel is critical in controlling cell volume during cell cycle in embryonic stem cells. PLoS One 8: e72409.
Freisinger, T. ** Klünder, B. **, Johnson, J., Müller, N., Pichler, G., Beck, G., Costanzo, M., Boone, C., Cerione, R. A., Frey, E.* and Wedlich-Soldner, R.* (2013). Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops. Nat Commun. 4: 1807.
Crevenna, A.H., Naredi-Rainer, N., Schonichen, A., Dzubiella, J., Barber, D.L., Lamb, D.C., Wedlich-Soldner, R. (2013). Electrostatics control actin filament nucleation and elongation kinetics. J Biol Chem. 288: 12102-13.
2012
Flynn, K.C., Hellal, F., Neukirchen, D., Jacob, S., Tahirovic, S., Dupraz, S., Stern, S., Garvalov, B.K., Gurniak, C., Shaw, A.E., Meyn, L., Wedlich-Soldner, R., Bamburg, J.R., Small, J.V., Witke, W., Bradke, F. (2012). ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain. Neuron 76: 1091-107.
Huang, J., Huang, Y., Yu, H., Subramanian, D., Padmanabhan, A., Thadani, R., Tao, Y., Tang, X., Wedlich-Soldner, R., Balasubramanian, M.K. (2012). Nonmedially assembled F-actin cables incorporate into the actomyosin ring in fission yeast. J Cell Biol. 199: 831-47.
Fraccaroli, A., Franco, C.A., Rognoni, E., Neto, F., Rehberg, M., Aszodi, A., Wedlich-Soldner, R., Pohl, U., Gerhardt, H., Montanez, E. (2012). Visualization of endothelial actin cytoskeleton in the mouse retina. PLoS One 7: e47488.
Mueller, N.S., Wedlich-Soldner, R. and Spira, F. (2012). From mosaic to patchwork: matching lipids and proteins in membrane organization. Mol Membr Biol. 29: 186-96.
Schachtner, H., Li, A., Stevenson, D., Calaminus, S.D., Thomas, S.G., Watson, S.P., Sixt, M., Wedlich-Soldner, R., Strathdee, D., Machesky, L.M. (2012). Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo. Eur J Cell Biol. 91: 923-9.
Spira, F.**, Dominguez-Escobar, J.**, Mueller, N.S., Wedlich-Soldner, R. (2012). Visualization of cortex organization and dynamics in microorganisms, using Total Internal Reflection Fluorescence microscopy. J Vis Exp. 63: e3982.
Spira, F.**, Mueller, N.S.**, Beck, G., von Olshausen, P., Beig, J., Wedlich-Soldner, R. (2012). Patchwork organization of the yeast plasma membrane into numerous coexisting domains. Nat Cell Biol. 14: 640-8.
Crevenna, A. H., Naredi-Rainer, N., Lamb, D.C., Wedlich-Soldner, R., Dzubiella, J. (2012). Effects of Hofmeister Ions on the a -Helical Structure of Proteins. Biophys J. 102: 907-15.
2011
Tønnesen, J., Nadringy, F., Willig, K.I., Wedlich-Soldner, R., Nägerl, U.V. (2011). Two-Color STED Microscopy of Living Synapses Using A Single Laser-Beam Pair. Biophys J. 101: 2545-52.
Freisinger, T. and Wedlich-Soldner, R. (2011). Phosphatidylserine promotes polar Cdc42 localization. Nat Cell Biol. 13: 1387-8.
Wen, P.J., Osborne, S.L., Zanin, M., Low, P.C., Wang, H.T., Schoenwaelder, S.M., Jackson, S.P., Wedlich-Soldner, R., Vanhaesebroeck, B., Keating, D.J., Meunier, F.A. (2011). Phosphatidyl-inositol(4,5)bisphosphate coordinates an actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. Nature Communications 2: 491.
Chesarone-Cataldo, M., Guérin, C., Yu, J.H., Wedlich-Soldner, R., Blanchoin, L., Goode, B.L. (2011). The Myosin passenger protein smy1 controls actin cable structure and dynamics by acting as a formin damper. Dev Cell. 21: 217-30.
Domínguez-Escobar, J., Chastanet, A., Crevenna, A. H., Fromion, V., Wedlich-Soldner, R.* and Carballido-López, R.* (2011). Processive Movement of MreB-Associated Cell Wall Biosynthetic Complexes in Bacteria. Science 333: 225-8.
Yu, H. and Wedlich-Soldner, R. Cortical actin dynamics: Generating randomness by formin(g) and moving (2011). BioArchitecture 1: 165-168.
Yu, J. H., Crevenna, A. H., Bettenbühl, M., Freisinger, T., Wedlich-Soldner, R. (2011). Cortical actin dynamics driven by formins and myosin V. J Cell Sci. 124: 1533-41.
2009-2010
Riedl, J., Flynn, K.C., Raducanu, A., Gärtner, F., Beck, G., Bösl, M., Bradke, F., Massberg, S., Aszodi, A., Sixt, M. and Wedlich-Soldner, R. (2010). Lifeact-mice for studying F-actin dynamics. Nature Methods 7: 168-9.
Li, R., Wedlich-Soldner, R. (2009). Bem1 complexes and the complexity of yeast cell polarization. Curr Biol. 19: R194-5.
2007-2008
Riedl, J., Crevenna, A.H., Kessenbrock, K., Yu, J.H., Neukirchen, D., Bista, M., Bradke, F., Jenne, D., Holak, T.A., Werb, Z., Sixt, M. and Wedlich-Soldner, R. (2008). Lifeact - a versatile marker for the visualization of F-actin. Nature Methods 5: 605-7.
Lämmermann, T., Bader, B.L., Monkley, S.J., Worbs, T., Wedlich-Soldner, R., Hirsch, K., Keller, M., Förster, R., Critchley, D.R., Fässler, R. and Sixt, M. (2008). Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature 453: 51-5.
Wedlich-Soldner, R. and Li, R. (2008). Yeast and fungal morphogenesis from an evolutionary perspective. Semin Cell Dev Biol. 19: 224-33.
Marco, E.**, Wedlich-Soldner, R.**, Li, R., Altschuler, S. and Wu, L. (2007). Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell 129: 411-22.
2003-2004
Wedlich-Soldner, R. and Li, R. (2004). Closing the loops: New insights into the role and regulation of actin during cell polarization. Exp Cell Res. 301: 8-15.
Wedlich-Soldner, R., Wai, S.C., Schmidt, T. and Li, R. (2004). Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling. J Cell Biol. 166: 889-900.
Wedlich-Soldner, R. and Li, R. (2003). Spontaneous cell polarization: undermining determinism. Nat Cell Biol. 5: 267-70.
Wedlich-Soldner, R., Altschuler, S., Wu, L. and Li, R. (2003). Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science 299: 1231-5.
2000-2002
Wedlich-Soldner, R., Straube, A., Friedrich, M.W., Steinberg, G. (2002). A balance of KIF1A-like kinesin and dynein organizes early endosomes in the fungus Ustilago maydis. EMBO J. 21: 2946-57.
Wedlich-Soldner, R., Schulz, I., Straube, A., Steinberg, G. (2002). Dynein supports motility of endoplasmic reticulum in the fungus Ustilago maydis. Mol Biol Cell. 13: 965-77.
Straube, A., Enard, W., Berner, A., Wedlich-Soldner, R., Kahmann, R. and Steinberg, G. (2001). A split motor domain in a fungal cytoplasmic dynein. EMBO J. 20: 5091-100.
Steinberg, G., Wedlich-Soldner, R., Brill, M. and Schulz, I. (2001). Microtubules in the fungal pathogen Ustilago maydis are highly dynamic and determine cell polarity. J Cell Sci 114: 609-22.
Wedlich-Soldner, R., Bölker, M., Kahmann, R. and Steinberg, G. (2000). A putative endosomal t-SNARE links exo- and endocytosis in the phytopathogenic fungus Ustilago maydis. EMBO J. 19: 1974-86.