2024

Groh, AC., Moeller-Kerutt, A., Gilhaus, K., Hoeffken, V., Nedvestky, P., Kleimann, S., Behrens, M., Ghosh, S., Hansen, U., Krahn, MP., Ebnet, K., Pavenstaedt, H., Ludwig, A. and Weide, T. (2023) PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells. J Cell Sci Mar 1;137(5):jcs261303

   Alavizargar, A., Gass, M., Krahn, MP. and Heuer, A. Elucidating the Membrane Binding Process of a Disordered Protein: Dynamic Interplay of Anionic Lipids and the Polybasic Region. https://doi.org/10.1101/2023.08.02.551595. ACS Physical Chemistry Au. Jan 18;4(2):167-179

2023

 Fiedler, F., Moennig, T., Hinrichs, JH., Weber, A., Wgner, T., Hemmer, T., Schröter, R., Weide, T., Epting, D., Bergmann, C., Nedvetsky, P. and Krahn, MP. (2023) PATJ inhibits histone deacetylase 7 to control tight junction formation and cell polarity. Cell Mol Life Sciences, Oct 25;80(11):333  

 Borkowsky, S., Gass, M., Alavizargar, A., Hanewinkel, J., Hallstein, I., Nedvetsky, P., Heuer, A. and Krahn, MP. (2023) Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK. Cells.12(5):812.

  Gilhaus, K., Cepok, C., Kamm, D., Saatkamp, K., Janßen, M., Emich, J., Surmann, B., Nedvetsky, P., Krahn, MP., Nüsse, H., Klingauf, J., Wennmann, DO., Pavenstädt, H. and Vollenbröker, B. (2023) Ajuba proteins as regulators of Hippo pathway activity maintain slit diaphragm functionality in podocytes. J Am Soc Nephrol. Jun 1;34(6):1039-1055.

  Krausel, V., Pund, L., Nüsse, H., Bachir, H., Ricker, R., Klingauf, J., Weide, T., Pavenstädt, H., Krahn, MP. and Braun, AA. ATF4 related signaling mediates podocyte injury and slit diaphragm defects in nephrocytes. Kidney international.103(5):872-885

Schlevogt, B., Schlieper, V., Krader, J., Schröter, R., Wagner, T., Weiand, M., Zibert, A., Schmidt, HH., Bergmann, C., Nedvetsky, PI.*, and Krahn, MP.*. A SEC61A1 variant causes autosomal dominant polycystic liver disease. Liver International. Feb;43(2):401-412

Harms, H.,  Lüttgenau, SM., Emming, C., Guske, J., Weber, K., Wagner, T., Schowe, L., Nedvetsky P., and Krahn, MP. Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion. Cancer Gene Therapy. 30(3):497-506

2022

Gass, M., Borkowsky, S., Schröter, R., Nedvetsky, P., Luschnig, S., Rohlmann, A., Missler, M. and Krahn, M.P. (2021) Phosphoinositides are essential regulators of slit diaphragm integrity and nephrocyte function. Cell Mol Life Sciences, 79(5):248.

Maywald, M-L., Picciotto, C., Lepa, C., Bertgen, L., Yousaf, F.S., Ricker, A., Klingauf, J., Krahn M.P., Pavenstädt, H. and George, B., Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity. Front Cell Dev Biol. 10:790365.

2021

Marzano, M., Herzmann, S., Elsbroek, L., Sanal, N., Tarbashevich, K., Raz, E., Krahn, M.P.and Rumpf, S. AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila. Cell reports. 37(7):110024.

Schwertner, B., Lindner, G., Stauner, C.T.,Klapproth E., Magnus, C., Rohrhofer, A., Gross, S.,Schuler-Thurner, B., Öttl, V., Feichtgruber, N., Drexler, K., Evert, K., Krahn, M.P., Berneburg, M., Schmidt, B., Schuster, P. and Haferkamp, S. (2021) Nectin-1 expression correlates with the susceptibility of malignant melanoma to oncolytic herpes simplex virus in vitro and in vivo. Cancers. Jun 19;13(12):3058

Lüttgenau, S.M., Emming, C., Wagner, T., Harms, J., Guske, J., Weber, K., Neugebauer, U., Schröter, R., Panichkina, O., Pethö, Z., Weber, F., Schwab, A., Wege, A.K., Nedvetsky, P. and Krahn, M.P. Pals1 prevents Rac1-dependent colorectal cancer cell metastasis by inhibiting Arf6. Molecular Cancer. 20(1):74.

Heiden, S., Siwek, R., Lotz,M-L., Borkowsky, S., Schröter, R., Nedvetsky, P., Rohlmann, A., Missler, M., Krahn, M.P. (2021). Apical-basal polarity regulators are essential for slit diaphragm assembly and endocytosis in Drosophila nephrocytes. Cell Mol Life Sciences, 78(7), 3657-3672.

Kremerskothen, J., Hermann, A., Wu, G., Nedvetsky, P., Brücher, V., Egbring, C., Bonse, J., Wennmann, D., Marks, M., Krahn, M.P., Schöler, H., Heiduschka, P. and Pavenstädt, H. The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice. Cell Death Dis. Jan 22;12(1):117

2020

Bayraktar, S., Nehrig, J., Menis, E., Karli, K., Janning, A., Struk, T., Halbritter, J., Michgehl, U., Krahn, M.P., Schuberth, C.E., Pavenstädt, H.P. and Wedlich-Söldner, R. (2020). A deregulated stress response underlies distinct INF2 associated disease profiles. J Am Soc Nephrol. 31, 1296-1313.

Krahn, M.P. (2020) Phospholipids of the plasma membrane – regulators or consequence of cell polarity? Front Cell Dev Biol. 8:p. 277.

Blazquez R., Rietkötter E., Wenske B., Wlochowitz D., Sparrer D., Vollmer E., Müller G., Seegerer J., Sun X., Dettmer K., Barrantes-Freer A., Stange L., Utpatel K., Bleckmann A., Treiber H., Bohnenberger H., Lenz C., Schulz M., Reimelt C., Hackl C., Grade M., Büyüktas D., Siam L., Balkenhol M., Stadelmann C., Kube D., Krahn M.P., Proescholdt M.A., Riemenschneider M.J., Evert M., Oefner P.J., Klein C.A., Hanisch U.K., Binder C., Pukrop T. (2020) LEF1 Supports Metastatic Brain Colonization by Regulating Glutathione Metabolism and Increasing ROS Resistance in Breast Cancer. Int J Cancer. Jun 1;146(11):3170-3183.

Blazquez R., Sparrer D., Wendl C., Evert M., Riemenschneider M.J., Krahn M.P., Erez N., Proescholdt M., Pukrop T. (2020). The macro-metastasis/organ Parenchyma Interface (MMPI) - A Hitherto Unnoticed Area. Semin Cancer Biol. Feb;60:324-333.

2019

Dlugos, C.P., Picciotto, C., Lepa, C., Krakow, M., Stöber, A.,, Eddy, M., Weide,, T., Jeibmann, J., Krahn, M.P. Van Marck, V., Klingauf, J., Ricker, A.,  Wedlich-Söldner, R., Pavenstädt, H., Klämbt, C. and George, B. (2019) Nephrin signaling results in C3G-dependent ​Integrin β1 activation. J Am Soc Nephrol. Jun;30(6):1006-1019.

Schütte-Nütgen, K., Edeling, M. Michgehl, U., Mendl, G. Krahn, M.P., Edemir, B., Weide, T., Kremerskothen, J. and Pavenstädt, H. (2019) Getting a Notch closer to renal dysfunction: Activated Notch suppresses expression of the adaptor protein Disabled-2 in tubular epithelial cells. FASEB J. Jan;33(1):821-832.

Moschall R., Rass M., Rossbach O., Lehmann G., Kullmann L., Eichner N., Strauss D., Meister G., Schneuwly S., Krahn M.P. and Medenbach J. (2019) Drosophila Sister-of-Sex-lethal reinforces a male-specific gene expression pattern by controlling Sex-lethal alternative splicing. Nucleic Acids Res. Mar 18;47(5):2276-2288.

2018

Pürkhauer, K., Weymouth, A.J., Pfeffer, K., Kullmann, L., Mulvihill, E., Krahn, M.P., Müller, D.J. and Giessibl, F. Imaging in Biologically-Relevant Environments with AFM Using Stiff qPlus Sensors. Sci Rep. 2018 Jun 19;8(1):9330.

Kullmann, L. and Krahn, M.P. Oligomerization and lipid binding of Par3 function redundantly to promote protein stability and epithelial polarization. Cell Mol Life Sciences, [Epub ahead of print] Mar 10.

Kullmann, L. and Krahn, M.P. Controlling the master: Upstream regulation of the tumour suppressor LKB1. Oncogene, Jun;37(23):3045-3057.

Renschler, F., Bruekner, S., Salomon, P., Mukherjee, A., Kullmann, L., Schütz-Stoffregen, M., Henzler, C., Pawson, T., Krahn, M.P. and Wiesner, S. (2018) Structural basis for the interaction between the cell polarity proteins Par3 and Par6. Science signalling, 11(517)

Hochapfel, F., Denk, L., Maaßen, C., Zaytseva, Y., Rachel, R., Witzgall, R. and Krahn, MP. (2018) Electron microscopy of Drosophila garland cell nephrocytes: optimal preparation, immunostaining and STEM tomography. J Cell Biochem. doi: 10.1002/jcb.26702.

2017

Weide, T., Vollenbroker, B., Djuric, I., Edeling, M., Bonse, J., Hochapfel, F., Panichkina, O., Schulze, U., Wennmann, D-O., George, B., Kim, S., Daniel, C., Seggewiss, J., Walsh, C.A., Amann, K., Kritz, W., Krahn, M.P. and Pavenstaedt, H. (2017) Pals1 haploinsufficiency in nephrons results in proteinuria and cyst formation. J Am Soc Nephrol. Feb 2. pii: ASN.2016040474.

Dogliotti, G., Panichkina, Thiele, C., Dhumale, P., Kullmann, L., Mendl, G., Houben, R., Haferkamp, S., Püschel, A.W., and Krahn, M.P. (2017) Membrane binding of LKB1 and its activation by phosphatidic acid is essential for its function in development and tumour suppression. Nature Commun. 8, 15747.

Hochapfel, F., Mendl, G., Schulze, U., Denk, L., Meese, C., Zaytseva, Y., Pavenstädt, H., Weide, T., Rachel, R., Witzgall, R. and Krahn, M.P. (2017) Distinct function of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes. Cell Mol Life Sciences.74(24): p. 4573-4586.

2016

Cidlinsky, N., Weber, F. and Krahn, M.P. (2016) LKB1 does not contribute to salivary gland tumorigenesis. Cell Oncol, 39(4):389-96.

Koch, L., Sun, R., Feicht, S., Sen, A. and Krahn, M.P.: Domain-specific functions of Stardust in Drosophila embryonic development Royal Society Open Science. 3(11):160776. 

2015

Shahab, J., Tiwari, M.D., Honemann-Capito, M., Krahn, M.P. and Wodarz, A. (2015) Bazooka/PAR3 is dispensable for polarity in Drosophila follicular epithelial cells. Biology Open, 4(4):528-41.

Sen, A. Sun, R. and Krahn, M.P. (2015) Localization and Function of Pals1 Associated Tight Junction Protein in Drosophila is Regulated by Two Distinct Apical Complexes. J Biol Chem.,290(21):13224-33

Burghardt, T., Hochapfel, F., Salecker, B., Meese, C., Gröne, H.-J., Rachel, R., Wanner, G., Krahn, M. P. and Witzgall, R. (2015) Advanced electron microscopical techniques reveal novel features of podocytes. Am J Physiol Renal Physiol, 309(12):F1082-9.

Inga Loedige, I., Jakob, L., Stotz, M., Ray, D., Treiber, T., Treiber, N., Hennig, J., Hughes, T., Engelmann, J., Krahn, M.P. and Meister, G. (2015) The crystal structure of the NHL domain in complex with RNA reveals the molecular basis of Drosophila Brain tumor-mediated gene regulation. Cell reports, 13(6):1206-20.

2014

Wennmann, D. O., Schmitz, J., Wehr, M.C., Krahn, M. P., …..Kremerskothen, J. (2014) Evolutionary and molecular facts link the WWC protein family to Hippo signalling, Molecular Biology of Evolution, 31(7):1710-23.

2013

Sotillos, S., Krahn, M.P., Espinosa J.M.,and Castelli-Gair Hombrian, J. (2013) Src kinases mediate apical determinant Bazooka/PAR3 interaction with STAT92E and increase signalling efficiency in Drosophila ectodermal cells. Development, 140(7):1507-16.

2012

Behrendt, M., Krahn, M.P., Al-Bayati, H., Amiri, M., Rizk, S. and Naim, H.Y. (2012).Cadherin-related protein 24 induces morphological changes and partial cell polarization by Trans-interactions. Biol Chem, 393(6):495-503.

Sen, A., Nagy-Zsvér-Vadas, Z. and Krahn, M.P. (2012) Drosophila PATJ supports adherens junction stability by modulating Myosin Light Chain activity. J Cell Biol, 199(4):685-98.

Krahn, M.P. and Wodarz, A. (2012) Phosphoinositide lipids and cell polarity: Linking the plasma membrane to the cytocortex. Essays Biochem, 53:15-27

2011

Krahn, M.P., Kim, S., Gailite, I., Halbsgut, N. and Wodarz, A. (2011) Die Funktion des PAR/aPKC-Komplexes in Drosophila. Biospektrum 01/2011.

2010

Krahn, M.P., Klopfenstein, D., Fischer, N. and Wodarz, A. (2010). Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids. Curr Biol, 20:636-42.

Krahn, M.P., Rizk, S., Alfalah, M., Behrendt, M. and Naim, H.Y. (2010). Protocadherin of the liver, kidney and colon associates with detergent-resistant membranes during cellular differentiation. J Biol Chem, 285:13193-200.

Krahn, M.P., Bückers, J., Kastrup, L. and Wodarz, A. (2010). Formation of a Bazooka/Stardust complex is essential for plasma membrane polarity in epithelia. J Cell Biol, 190(5):751-60.

2009

Krahn, M.P., Egger-Adam, D. and Wodarz, A. (2009). PP2A antagonizes phospho-rylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts. Dev Cell, 16: 901-908. 

Krahn, M.P., Wodarz, A. (2009). Notch Signalling: Linking Delta Endocytosis and Cell Polarity. Dev Cell,17, 153 – 154

2006

Alfalah, M., Krahn, M.P. Wetzel, G. von Horsten, S. Wolke, C. Hooper, N. Kalinski, T., Krueger, S., Naim, H.Y. and Lendeckel, U. (2006). A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum. J Biol Chem, 281:11894-900.