CV & Publications
Prof. Dr. Klaus Ebnet
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Publications
A:
Original Articles and Reviews Otani T., T.P. Nguyen, S. Tokuda, K. Sugihara, T. Sugawara, K. Furuse, T. Miura, K. Ebnet and M. Furuse (2019). Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity. J. Cell Biol. 218(10):3372-3396. G. Merlen, N. Kahale, J. Ursic-Bedoya, V. Bidault-Jourdainne, H. Simerabet, T. Doignon, Z. Tanfin, I. Garcin, N. Péan, J. Gautherot, A. Davit-Spraul, C. Guettier, L. Humbert, D. Rainteau, K. Ebnet, C. Ullmer, D. Cassio and T. Tordjmann (2019). TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function. Gut. doi: 10.1136/gutjnl-2018-316975. Riddell M., A. Nakayama, T. Hikita, F. Mirzapourshafiyi, T. Kawamura, A. Pasha, M. Li, M. Masuzawa, M. Looso, T. Steinbacher, K. Ebnet, M. Potente, T. Hirose, S. Ohno, I. Fleming, S. Gattenlöhner, P.P. Aung, T. Phung, O. Yamasaki, T. Yanagi, H. Umemura and M. Nakayama (2018). aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA binding ability. Nat Commun. 2018 Dec 17;9(1):5357. doi: 10.1038/s41467-018-07739-0. Steinbacher T. and K. Ebnet (2018). The regulation of junctional actin dynamics by cell adhesion receptors. Histochem. Cell Biol. 150(4):341-350. Kummer D. and K. Ebnet (2018). Junctional Adhesion Molecules (JAMs): The JAM - Integrin connection. Cells. Mar 26;7(4). pii: E25. doi: 10.3390/cells7040025. Steinbacher
T., D. Kummer and K. Ebnet (2018). Junctional adhesion molecule-A:
functional diversity through molecular promiscuity. Cell Mol Life Sci. 75:1393–1409. Ebnet
K. (2017). Junctional adhesion molecules (JAMs): Cell adhesion
receptors with pleiotropic functions in cell physiology and
development. Physiol. Rev. 97: 1529-1554. Ebnet
K., D. Kummer, T. Steinbacher, A. Singh, M. Nakayama and M. Matis
(2017). Regulation of cell polarity by cell adhesion receptors. Sem. Cell Dev. Biol. 81: 2-12. Fededa
J.P., C. Esk, B. Mierzwa, R. Stanyte, S. Yuan, H. Zheng, K. Ebnet, W.
Yan, J.A. Knoblich and D.W. Gerlich (2016). MicroRNA-34/449 controls
mitotic spindle orientation during mammalian cortex development. EMBO J. 35: 2386–2398. Brinkmann B.F., T. Steinbacher, C. Hartmann, D. Kummer, D. Pajonczyk, F. Mirzapourshafiyi, M. Nakayama, T. Weide, V. Gerke and K. Ebnet (2016). VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Mol. Biol. Cell 27: 2811-2821. Squarr A.J., K. Brinkmann, B. Chen, T. Steinbacher, K. Ebnet, M.K. Rosen and S. Bogdan (2016). Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation. J. Cell Biol. 212: 591-603. Franz J., B.F. Brinkmann, M. König, J. Hüve, C. Stock, K. Ebnet, C. Riethmüller (2016). Nanoscale Imaging Reveals a Tetraspanin-CD9 Coordinated Elevation of Endothelial ICAM-1 Clusters. PLoS One 11(1):e0146598. doi: 10.1371/journal.pone.0146598. Tuncay H. and K. Ebnet (2016). Cell adhesion molecule control of planar spindle orientation. Cell Mol Life Sci. 73: 1195-207. Tuncay H., B.F. Brinkmann and K. Ebnet (2015). Mitotic spindle orientation: JAM-A can fix it. Cell Cycle 14(24):3773-4. doi: 10.1080/15384101.2015.1105696. Schwickert A., E. Weghake, K. Brüggemann, A. Engbers, B.F. Brinkmann, B. Kemper, J. Seggewiß, C. Stock, K. Ebnet, L. Kiesel, C. Riethmüller and M. Götte (2015). microRNA miR-142-3p inhibits breast cancer cell invasiveness by synchronous targeting of WASL, integrin alpha V, and Additional Cytoskeletal Elements. PLoS One 10(12):e0143993. doi: 10.1371/journal.pone.0143993. Tuncay H., B.F. Brinkmann, T. Steinbacher, A. Schürmann, V. Gerke, S. Iden and K. Ebnet (2015). JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128. Peddibhotla S.S.D., B.F. Brinkmann, D. Kummer, H. Tuncay, M. Nakayama, R. Adams, V. Gerke, and K. Ebnet (2013). Tetraspanin CD9 links junctional adhesion molecule-A to avb3 integrin to mediate bFGF-specific angiogenic signaling. Mol. Biol. Cell 24: 933-944. Ebnet, K. (2012). JAM-A and aPKC: A close pair during cell-cell contact maturation and tight junction formation in epithelial cells. Tissue Barriers 1(1):e22993. doi: 10.4161/tisb.22993 Iden* S., S. Misselwitz*, S.S.D. Peddibhotla, H. Tuncay, D. Rehder, V. Gerke, H. Robenek, A. Suzuki and K. Ebnet (2012). aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation. J. Cell Biol. 196: 623-639(* equal contribution). Stelzer S., M.M. Worlitzer, L. Bahnassawy, K. Hemmer, K. Rugani, I. Werthschulte, A.L. Schön, B.F. Brinkmann, E.C. Bunk, T. Palm, K. Ebnet and J.C. Schwamborn (2012). JAM-C is an apical surface marker for neural stem cells. Stem Cells Dev. 21: 757-766. Fabritz L, M.G. Hoogendijk, B.P. Scicluna, S.C. van Amersfoorth, L. Fortmueller, S. Wolf, S. Laakmann, N. Kreienkamp, I. Piccini, G. Breithardt, P.R. Noppinger, H. Witt, K. Ebnet, T. Wichter, B. Levkau, W.W. Franke, S. Pieperhoff, J.M. de Bakker, R. Coronel and P. Kirchhof (2011). Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice. J. Am. Coll. Cardiol. 57: 740-750. Götte M., C.
Mohr, C.-Y. Koo, C. Stock, A.-K. Vaske, M. Viola, S.A. Ibrahim, S. Peddibhotla,
Y.H.-F. Teng, J.-Y. Low, K. Ebnet, L. Kiesel and G.W. Yip (2010).
miR-145-dependent targeting of Junctional Adhesion Molecule A and modulation of
fascin expression are associated with reduced breast cancer cell motility and
invasiveness. Oncogene 29: 6569-6580. Stelzer S., K. Ebnet and J.C.
Schwamborn (2010). JAM-A is a novel surface marker for NG2-Glia in the
adult mouse brain. BMC Neurosci. 11: 27, 1-9. Ebnet K.
(2008). Organization of multiprotein complexes at cell-cell junctions. Histochem.
Cell Biol. 130:1-20. Ebnet K., S. Iden, V. Gerke and A.
Suzuki (2008). Regulation of epithelial and endothelial junctions
by PAR proteins. Front. Biosci. 13: 6520-6536. Pardo J., R. Wallich, K. Ebnet, S.
Iden, H. Zentgraf, P. Martin, A. Ekiciler, A. Prins, A. Müllbacher, M. Huber
and M.M. Simon (2007). Granzyme B is expressed in mouse
mast cells in vivo and in vitro and causes delayed cell death independent of
perforin. Cell Death Differ. 14: 1768-1779. Mandicourt
G., S. Iden, K. Ebnet, M. Aurrand-Lions and B.A. Imhof (2007). JAM-C regulates
tight junctions and integrin-mediated cell adhesion and migration. J. Biol Chem. 282: 1830-1837. Iden S., D. Rehder, B. August, A.
Suzuki, K. Wolburg-Buchholz, H. Wolburg, S. Ohno, J. Behrens, D. Vestweber and K.
Ebnet (2006). A distinct PAR complex associates physically with
VE-cadherin in vertebrate endothelial cells. EMBO Rep. 7: 1239-1246. Rehder D., S. Iden, I. Nasdala, J.
Wegener, M.K. Meyer Zu Brickwedde, D. Vestweber and K. Ebnet (2006). Junctional
adhesion molecule-A participates in the formation of apico-basal polarity
through different domains. Exp. Cell Res.312: 3389-3403. Kondrashov
A.V., M. Kiefmann, K. Ebnet, T. Khanam, R.S. Muddashetty and J. Brosius (2005).
Inhibitory effect of naked neural BC1 RNA or BC200 RNA on eukaryotic in vitro
translation systems is reversed by poly(A)-binding protein (PABP). J. Mol. Biol.353: 88-103. Baumeister U., R. Funke, K. Ebnet, H.
Vorschmitt, S. Koch and D. Vestweber (2005). Association
of Csk to VE-cadherin and inhibition of cell proliferation. EMBO J.24: 1686-1695. Wegmann F., K. Ebnet, L. Du Pasquier,
D. Vestweber and S. Butz (2004). Endothelial adhesion molecule ESAM
binds directly to the multidomain adaptor MAGI-1 and recruits it to cell
contacts. Exp. Cell Res.300: 121-133. Gliki G., K.
Ebnet, M. Aurrand-Lions, B.A. Imhof and R.H. Adams (2004) Spermatid
differentiation requires the assembly of a cell polarity complex downstream of
junctional adhesion molecule-C. Nature431: 320-324. Ebnet K., A.
Suzuki, S. Ohno and D. Vestweber (2004). Junctional adhesion molecules (JAMs):
More molecules with dual functions? J. Cell Sci.117: 19-29. Ebnet K., M. Aurrand-Lions, A. Kuhn,
F. Kiefer, S. Butz, K. Zander, M.K. Meyer Zu Brickwedde, A. Suzuki, B.A. Imhof
and D. Vestweber (2003). The junctional adhesion molecule
(JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3:
A possible role for JAMs in endothelial cell polarity. J. Cell Sci.116:
3879-3891. Suzuki A., C.
Ishiyama, K. Hashiba, M. Shimizu, K. Ebnet and S. Ohno (2002). aPKC kinase
activity is required for the asymmetric differentiation of the premature junctional
complex during epithelial cell polarization. J. Cell Sci.115:
3565-3573. Nasdala I., K. Wolburg-Buchholz, H.
Wolburg, A. Kuhn, K. Ebnet, G. Brachtendorf, U. Samulowitz, B. Kuster, B. Engelhardt,
D. Vestweber and S. Butz (2002). A transmembrane tight junction
protein selectively expressed on endothelial cells and platelets. J.
Biol. Chem.277: 16294-16303. Ebnet K., A.
Suzuki, Y. Horikoshi, T. Hirose, M.K. Meyer Zu Brickwedde, S. Ohno and D.
Vestweber (2001). The cell polarity protein ASIP/PAR-3 directly associates with
junctional adhesion molecule (JAM). EMBO J.20: 3738-3748. Ebnet K., C.U.
Schulz, M.K. Meyer Zu Brickwedde, G.G. Pendl and D. Vestweber (2000). Junctional
adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and
ZO-1. J. Biol. Chem.275: 27979-27988. Ebnet K. and
D. Vestweber (1999). Molecular mechanisms that control leukocyte extravasation:
the selectins and the chemokines. Histochem. Cell Biol.112:
1-23. Simon M.M., M.
Hausmann, T. Tran, K. Ebnet, J. Tschopp, R.T. Hla and A. Mullbacher (1997). In
vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double
knockout mice are defective in granule-mediated apoptosis but not lysis of
target cells. J. Exp. Med.186: 1781-1786. Ebnet K., K.D.
Brown, U.K. Siebenlist, M.M. Simon and S. Shaw S. (1997). Borrelia burgdorferi
activates nuclear factor-kappa B and is a potent inducer of chemokine and
adhesion molecule gene expression in endothelial cells and fibroblasts. J.
Immunol.158: 3285-3292. Ebnet K., M.M.
Simon and S. Shaw (1996). Regulation of chemokine gene expression in human
endothelial cells by proinflammatory cytokines and Borrelia burgdorferi. Ann. N. Y. Acad. Sci.797: 107-117. Mullbacher A., K. Ebnet, R.V.
Blanden, R.T. Hla, T. Stehle, C. Museteanu and M.M. Simon (1996). Granzyme
A is critical for recovery of mice from infection with the natural cytopathic
viral pathogen, ectromelia. Proc. Natl Acad. Sci. USA93:
5783-5787. Ebnet K., E.P.
Kaldjian, A.O. Anderson and S. Shaw (1996). Orchestrated information transfer
underlying leukocyte endothelial interactions. Annu. Rev. Immunol.14: 155-177. Ebnet K., M. Hausmann, F.
Lehmann-Grube, A. Mullbacher, M. Kopf, M. Lamers and M.M. Simon (1995). Granzyme
A-deficient mice retain potent cell-mediated cytotoxicity. EMBO J.14:
4230-4239. Ebnet K., C.N.
Levelt, T.T. Tran, K. Eichmann and M.M. Simon (1995). Transcription of granzyme
A and B genes is differentially regulated during lymphoid ontogeny. J. Exp. Med.181: 755-763. Dick T., G. Reichmann, K. Ebnet, M.M.
Simon, H.P. Dienes, B. Echternacher, P.H. Krammer and A.B. Reske-Kunz (1993). An
ovalbumin peptide-specific cytotoxic T cell clone with antigen
self-presentation capacity uses two distinct mechanisms to kill target cells. Cell.
Immunol.152: 333-347. Ebnet K., M.D.
Kramer and M.M. Simon (1992). Organization of the gene encoding the mouse
T-cell-specific serine proteinase "granzyme A". Genomics13:
502-508. Ebnet K., J.
Chluba-de Tapia, U. Hurtenbach, M.D. Kramer and M.M. Simon (1991). In vivo
primed mouse T cells selectively express T cell-specific serine proteinase-1
and the proteinase-like molecules granzyme B and C. Int. Immunol.3:
9-19. Kramer M.D.,
S.E. Moter, M.M. Simon, K. Ebnet and R. Wallich (1990). Polymerase chain
reaction in the demonstration of Borrelia burgdorferi DNA. Hautarzt41: 587-590. Wallich R., S.E. Moter, M.M. Simon, K.
Ebnet, A. Heiberger and M.D. Kramer (1990). The Borrelia
burgdorferi flagellum-associated 41-kilodalton antigen (flagellin): molecular
cloning, expression, and amplification of the gene. Infect. Immun.58:
1711-1719.
Brinkmann, B.F., H. Tuncay, and K. Ebnet (2015). Homotypic cell-cell interactions and apico-basal polarity in epithelial cells and endothelial cells. In “Cell Polarity 1: Biological role and basic mechanisms”. Ed. K. Ebnet, Springer International Publishing AG Switzerland, pp. 277-302 Ebnet K., B.F. Brinkmann, D. Kummer, S. Misselwitz, S.S.D. Peddibhotla, and H. Tuncay (2013). Tight junctions, Junctional Adhesion Molecules (JAMs), and the Blood Brain Barrier. In "Tight Junctions in Cancer Metastasis", Cancer Metastasis - Biology and Treatment 19. Ed. T.A. Martin and W.G. Jiang , Springer, Dordrecht-Heidelberg-New York-London, pp. 119-129. Ebnet K., V. Gerke and S. Iden
(2010). Cadherins and the regulation of tight junctions and
cell polarity. In "Molecular and Functional Diversities of Cadherin and
Protocadherin". Ed. K. Yoshida, Research Signpost, Kerala, India, pp.
57-68. Ebnet K., V.
Gerke and M. Aurrand-Lions (2010). Junctional Adhesion Molecules (JAMs). In
"Modern Insights Into Disease From Molecules to Man. Adhesion
Molecules". Ed. Victor R Preedy, Science Publishers, Enfield, USA, pp.
37-51. Wolburg H., A.
Lippoldt and K. Ebnet (2007). Tight junctions in the blood-brain barrier. In
"Handbook of Neurochemistry and Molecular Neurobiology". Ed. A.
Lajtha, Vol. 11: "Neural Membranes and Transport". Ed. M.E.A. Reith, Springer
Berlin-Heidelberg, pp. 4-27. Wolburg H., A. Lippoldt and K. Ebnet
(2006). Tight junctions and the blood-brain barrier. In
"Selected topics on tight junctions". Eds. L. Mariscal, RG Landes
Bioscience, Georgetown, TX, USA, pp. 175-195. Simon M.M., K. Ebnet, O. Gires, C.
Museteanu, A. Siebers, T. Stehle, T.T. Tran, W. Zhong, L. Gern, M.D. Kramer and
R. Wallich (1997). Lyme Borreliosis: progress in the development of
a vaccine and new insights into the pathogenesis of the disease. In
"Emerging and Re-Emerging Diseases Transmitted by Arthropod Vectors and
Rodents; Proceedings of the 2nd Int. Symposium on Lyme Disease" in
Japan". Eds. Y. Yanagihara and T. Masuzawa, pp. 245-259. Sarin A., K.
Ebnet, C.M. Zacharchuk and P.A. Henkart (1997). Caspase inhibitors as molecular
probes of cell death. In "Programmed Cell Death: Proceedings of the 1996
International Symposium on Programmed Cell Death" in Shanghai. Eds. Y.B.
Shi, Y. Shi, D.W. Scott, and Y. Xu, Plenum Press, New York, pp. 51-62. Kramer M.D.,
U. Vettel, K. Ebnet and M.M. Simon (1993). The murine T cell-specific serine
proteinase-1: cleavage activity on synthetic and natural substrates. In
"Cytotoxic Cells: Recognition, Effector Function, Generation, and
Methods", chapter 59, p. 516-520. Eds. M. Sitkovsky and P. Henkart,
Birkhäuser, Boston. Simon M.M., K.
Ebnet and M.D. Kramer (1993). Molecular analysis and possible pleiotropic
function(s) of the T cell-specific serine proteinase-1 (TSP-1). In
"Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods",
chapter. 26, p. 278-294. Eds. M. Sitkovsky and P. Henkart, Birkhäuser, Boston.
Vestweber D. and K. Ebnet (2001).
Leukozyteneinwanderung in entzündete Gewebe – wie kommen die Abwehrzellen zum
Wirkungsort? Biologen heute 25: 1-5. Ebnet K. (1999). Immunüberwachung und Entzündung – ein komplexes Wechselspiel zwischen Leukozyten und Endothelzellen. Biologie in unserer Zeit 29: 26-35. |
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