Our current research is focussed on the following aspects of cell biology:
● how do epithelial and endothelial cells establish cell-cell contacts and in particular tight junctions?
● how do epithelial and endothelial cells develop apico-basal polarity?
● what is the role of cell adhesion molecules in these processes?
In our projects, we apply primarily methods of protein biochemistry, molecular biology and fluorescence microscopy
(including confocal and 4Pi microscopy).
For further information on our research activities, lab members, and publications from the group, click on the respective links.
Institute-Associated Research Group: Cell Adhesion and Cell Polarity
Prof. Dr. Klaus Ebnet
Institute of Medical Biochemistry, ZMBE
phone +49 251 83-52127 / Fax - 56748
e-mail: ebnetk at uni-muenster.de
Open PhD position in Molecular Cell Biology - The molecular function of the cell adhesion molecule JAM-M
We study the role of cell adhesion molecules of the JAM family in epithelial cells, endothelial cells and tumor cells. We have recently identified a novel JAM family member called JAM-M. JAM-M is localized at the brush border of cultured epithelial cells and is expressed by a specific subset of intestinal epithelial cells, in which it might play a role in brush border dynamics after helminth infection. In this project, we will study the role of JAM-M in the small intestine and in small intestine-derived organoids derived from mice. In our projects, we apply primarily methods of molecular biology, protein biochemistry and fluorescence microscopy. This project will largely make use of immunohistochemistry and high resolution microscopy. You should be interested in molecular cell biology, open to new technologies, and highly motivated. A willingness to work with laboratory animals will be essential. We offer an exciting new project, intensive supervision, and a strong scientific environment. For additional information, feel free to contact us by telephone or e-mail.