+ contributed equally
* shared corresponding authors

 
2019
 
Twittenhoff C., Heroven AK., MühlenS., Dersch P., and Narberhaus F.
An RNA thermometer dictates production of a secreted bacterial toxin.
PLoS Pathogens (accepted)

Kusmierek M., Hoßmann J., Witte R., Opitz W., Vollmer I., Volk M., Heroven AK., Wolf-Watz H., and Dersch P. (2019)
A bacterial secreted translocator hijacks riboregulators to control type III secretion in response to host cell contact.
PLoS Pathogens 15(6):e1007813. doi: 10.1371/journal.ppat.1007813. 

Schmühl C., Beckstette M., Heroven AK., Bunk B., Spröer C., McNally A., Overmann J., and Dersch P. (2019)
Comparative transcriptomic profiling of Yersinia entercolitica O:3 and O:8 reveals major expression differences of fitness- and virulence relevant genes indicating ecological separation.
mSystems23;4(2). pii: e00239-18. doi: 10.1128/mSystems.00239-18.

Kusmierek M., Heroven AK., Beckstette M., Nuss A.M., and Dersch P. (2019) Discovering Yersinia-host interactions by tissue dual RNA-seq.
Book chapterin: Pathogenic Yersinia spp: Methods and Protocols. Editors: Vadyvaloo V., Lawrenz M., Springer
Methods Mol. Biol. 2010: 99-116. Doi: 10-1007/978-1-4939-9541-7_8.

Berndt V., Beckstette M., Volk M., Dersch P*., and Brönstrup M*. (2019)
Metabolome and transcriptome-wide effects of the carbon storage regulator A in entero­pathogenic Escherichia coli.
Scientific Reports9(1):138. doi: 10.1038/s41598-018-36932-w.

Thanikkal E.J., Gahlot D.K., Liu J., Fredriksson Sundbom M., Gurung J.M., Ruuth K., Francis M.K., Obi I.R., Thompson K.M., Chen S., Dersch P., and Francis M.S. (2019).
The Yersinia pseudotuberculosis Cpx envelope stress system contributes to trans­criptional activation of rovM.
Virulence 10(1):37-57. doi: 10.1080/21505594.2018.1556151.

Subramaniam S., Müller V.S, Hering N.A., Mollenkopf H., Becker D., Heroven A.K., Dersch P., Pohlmann A., Tedin K., Porwollik S., McClelland M., Meyer T.F., and Hunke S. (2019)
Contribution of the Cpx envelope stress system to metabolism and virulence regulation in Salmonella enterica serovar Typhimurium.
PLoS One 14(2): 0211584. doi: 10.1371/journal.pone.0211584. 

Schröter L., and Dersch P. (2019)
Phenotypic diversification of microbial pathogens – cooperating and preparing for the future.
J. Mol. Biol. Jun 28. doi: 10.1016/j.jmb.2019.06.024. [Epub ahead of print].

Volk M., Vollmer I., Heroven AK., and Dersch P. (2019)
Transcriptional and posttranscriptional regulatory mechanisms controlling type III secretion.
Curr. Topics of Microbiol. Immunol. June 20. Doi: 10.1007/82_2019_168.

 
2018

Heine W., Beckstette M., Heroven A.K., Thiemann S., Heise U., Nuss A.M., Pisano F., Strowig T., Dersch P. (2018)
Loss of CNFY
 toxin-induced inflammation drives Yersinia pseudotuber­culosis into persistency
PLoS Pathogens14(2):e1006858. doi: 10.1371/journal.ppat.1006858.

Sadana P., Geyer R., Pezoldt J., Helmsing S., Huehn J., Hust M., Dersch P., Scrima A. (2018)
The adhesin protein InvD from Yersinia pseudotuberculosis promotes binding to the Fab-region of antibodies.

J. Biol. Chem.293(22):8672-8690. doi: 10.1074/jbc.RA117.001068.

Neumann-SchaalM., Metzendorf N.G., Nuss A.M., Hofmann J.D., Beckstette M., Dersch P., Otto A., Sievers S. (2018).Tracking gene expression and oxidative damage of O2-stressed Clostridioides difficile by a multi-omics approach.
Anaerobespii: S1075-9964(18)30103-3. doi: 10.1016/j.anaerobe.2018.05.018. 

Pezoldt J., Pasztoi M., Zou M., Wiechrs C., Beckstette M., Thierry G., Vafadarnejad E., Floess S., Arampatzi P., Buettner M., Schweer J., Fleissner D., Vital M., Pieper D., Basic M., Dersch P., Strowig T., Hornef M., Bleich A., Bode U., Pabst O., Bajenoff M., Saliba E.A., and Huehn J. (2018)
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes.

Nature Communications9(1):3903. doi: 10.1038/s41467-018-06423-7.

Lang A., Fruth A., Holland G., Laue M., Mühlen S., Dersch P., Flieger A. (2018)
Novel type of pilus associated with a Shiga-toxigenic E. coli hybrid pathovar conveys aggregative adherence and bacterial virulence.

Emerging Microbes and Infection5;7(1):203. doi: 10.1038/s41426-018-0209-8.

Castoldi A., Empting M., De Rossi C., Mayr K., Dersch P., Hartmann R., Müller R., Gordon S., Lehr CM. (2018)
Aspherical and spherical InvA497-func­tionalized nanocarriers for intracellular delivery of anti-infective agents.

Pharmaceutical Research36(1):22. doi: 10.1007/s11095-018-2521-3.

Berges M., Michel AM., Lassek C., Nuss A.M., Beckstette M., Dersch P., Riedel K., Sievers S., Becher D., Otto A., Maaß S., Rohde M., Eckweiler D., Borrero-de Acuna J.M., Jahn M.J., Neumann-Schaal M., Jahn D. (2018)
Iron regulation in Clostridioides difficile.
Frontiers in Microbiology, section Infectious Diseases Vol. 9 | Article 3183. doi: 10.3389/fmicb.2018.03183. 

ElfikyA., Bonifacius A., Pezoldt J.,Pasztoi M., Chaoprasid P., Sadana P., El-Sherbeeny N., Hagras M, Scrima A., Dersch P., Huehn J. (2018)
Yersi­nia pseudotuberculosis modulates regu­latory T cell stability via injection of Yersinia outer proteins in a type III secretion system-de­pendent manner.
Eur. J. of Microbio. and Immunol. 8(4), 101-106. doi: 10.1556/1886.2018.00015.

Kusmierek M., Dersch, P. (2018)
Regulation of host-pathogen interactions via the post-transcriptional Csr/Rsm system.

Current Opinions of Microbiology 41:58-67. DOI: 10.1016/j.mib.2017.11.022.

Knittel V., Vollmer I., Volk M., Dersch P. (2018)
Discovering RNA-based regulatory systems for Yersinia virulence.

Frontiers in Cellular and Infection Microbiology Vol. 8, Article 378, doi: 10.3389/fcimb.2018.00378

Weigel W.A., Dersch P. (2018)
Phenotypic heterogeneity: a bacterial virulence strategy.
Microbes and Infection20(9-10):570-577.  doi: 10.1016/j.micinf.2018.01.008.

Baumann D., Salia H., Greune L., Norkowski S., Körner B., Uckeley Z.M., Frankel G., Guenot M., Rüter C., Schmidt M.A. (2018)
Multitalented EspB of enteropathogenic E.coli (EPEC) enters cells autonomously and induces programmed cell death in human monocytic THP-1 cells.

Int. J. Med. Microbiol. 308:387–404.doi: 10.1016/j.ijmm.2018.03.005.

Norkowski S., Körner B., Greune L., Stolle A-S., Lubos M.L., Hardwidge P.R., Schmidt M.A., and Rüter C. (2018)
Bacterial LPX motif-harboring virulence factors constitute a species-spanning family of cell-penetrating effectors.

Cell. Mol. Life Sci. 75(12):2273-2289.doi: 10.1007/s00018-017-2733-4.

Kuehnast T., Cakar F., Weinhäupl T., Pilz A., Selak S., Schmidt M.A., Rüter C., and Schild S (2018)
Comparative analyses of biofilm formation among different Cutibacterium acnes isolates.

Int. J. Med. Microbiol.308(8):1027-1035. doi: 10.1016/j.ijmm.2018.09.005.

Rüter C., Lubos M-L., Norkowski S., Schmidt M.A. (2018)
All in-Multiple parallel strategies for intracellular delivery by bacterial pathogens

Int. J. Med. Microbiol.308(7):872-881. doi: 10.1016/j.ijmm.2018.06.007.

Norkowski S., Schmidt M.A., Rüter C. (2018)
The species-spanning family of LPX-motif harboring effector proteins.

Cell. Microbiol.20(11):e12945. doi: 10.1111/cmi.12945

2017

NussA.M.+, Beckstette M.+, Pimenova M., Schmühl C., Opitz W., PisanoF., HerovenAK. and DerschP.(2017)
Tissue dual RNA-seq allows fast discovery of infection-specific functions and riboregulators shaping host-pathogen transcriptomes.
Proc. Natl. Acad. Sci. USA114(5): E791-E800. doi: 10.1073/pnas.1613405114.
mentioned as Research Highlight in Nature Review Genetics by D. Burgess Feb 2017
Paper of the month awarded by the DGHM

Pezoldt J.+, Pisano F.+, HeineW., Pasztoi M., Rosenheinrich M., Nuss A.M., Pils M.C., Prinz I., Förster R., Huehn J. * and, Dersch P.* (2017)
Impact of CCR7 on T-cell response and susceptibility to Yersinia pseudotuberculosis infection.
J. Infect. Dis.216: 752-760. doi: 10.1093/infdis/jix037.

Pasztoi M., Bonifacius A., Pezoldt J., Kulkarni D., Niemz J., Yang J., Teich R., Hajek J., Pisano F., Rohde M., Dersch P. and Huehn J. (2017)
Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling.
Cell. Mol. Life Sci.74: 2839-2850. doi: 10.1007/s00018-017-2516-y.

Dersch P., Khan M.A., Mühlen S., Görke B. (2017)
Roles of regulatory RNAs for antibiotic resistance in bacteria and their potential value as novel drug targets.
Front Microbiol.8:803. doi: 10.3389/fmicb.2017.00803.

Solbach P., Dersch P., Bachmann O. (2017)
Individualized treatment strategies for Clostridium difficile infections.
Internist 58(7): 675-681. doi: 10.1007/s00108-017-0268-2.

Nuss A.M., Heroven A.K. and Dersch P. (2017)
RNA regulators: formidable modulators of Yersinia virulence.
Trends Microbiol.25: 19-34. doi: 10.1016/j.tim.2016.08.006.

Dersch P. and, Laub M. (2017)
Editorial overview: Cell regulation - New insights into the versatile regulatory processes governing bacterial life.
Curr. Opin. Microbiol. 36:v-viii., doi: 10.1016/j.mib.2017.07.002.

Mühlen S., Rohde M, and Dersch P. (2017)
Enterohemorrhagic Escherichia coli (EHEC): How a beneficial bacterium turned evil.
Book chapter in section VI: Infectious Diseases and Epidemics, in Mighty Microbes.

GomarascaM., MartinsT.F.C., Greune L., Hardwidge P.R., Schmidt M.A., and RüterC. (2017)
Bacterium-derived cell-penetrating peptides deliver gentamicin to kill intracellular pathogens.

Antimicrob. Agents Chemother. 61(4):e02545-16.


Bielaszewska M.+, Rüter C.+, Bauwens A.+, GreuneL., Jarosch K-A., SteilD., ZhangW., HeX., LloubesR., FruthA., Kim K.S., Schmidt M.A., DobrindtU., Mellmann A., and Karch H. (2017)
Host Cell Interactions of Outer Membrane Vesicle-Associated Virulence Factors of Enterohemorrhagic Escherichia coli O157: Intracellular Delivery, Trafficking and Mechanisms of Cell Injury.

Plos Pathogens. 13(2):e1006159. doi: 10.1371/journal.ppat.1006159.
Paper of the month awarded by the DGHM

Stolle A-S.,  Norkowski S., Körner B., Schmitz J., Lüken L., Frankenberg M., Rüter C.,* and Schmidt M.A.* (2017)
T3SS-independent uptake of the short-trip toxin-related recombinant NleC effector of enteropathogenic Escherichia coli leads to NF-κB p65 cleavage.

Frontier in Cellular and Infection Microbiology. 7:119. doi:0.3389/fcimb.2017.00119

Wang G., Geisbrecht B.V., Rüter C., and Hardwidge P.R. (2017)
Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells.

Pathogens6(2), 18; doi:10.3390/pathogens6020018

El Qaidi S., Chen K., Halim A., Siukstaite L., Rüter C., Hurtado-Guerrero R., Clausen H., and Hardwidge P.R. (2017)
NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity.

Journal of Biological Chemistry. 292(27):11423-11430.doi: 10.1074/jbc.M117.790675.

Rüter C., and Schmidt M.A. (2017)
Cell-Penetrating Bacterial Effector Proteins: Better Tools than Targets.

Trends in Biotechnology.35(2):109-120. doi: 10.1016/j.tibtech.2016.08.002.

Grabowski B., Schmidt M.A. and Rüter C. (2017)
Immunomodulatory Yersinia outer proteins (Yops) -useful tools for bacteria and humans alike.
Virulence 8(7):1124-1147. doi: 10.1080/21505594.2017.1303588.


2016

NussA.M., SchusterF., RoseliusL., KleinJ., BückerR., HerbstK., HerovenA.K., PisanoF., Witt­mannC., MünchR., Müller J., Jahn D. and DerschP. (2016)
A precise temperature-responsive bistable switch controlling Yersinia virulence.
PLoS Pathog.12(12): e1006091. doi: 10.1371/journal.ppat.1006091. 

Avican U., Beckstette M., Heroven AK., Lavander M., Dersch P., and Forsberg A. (2016)
Transcriptomic and phenotypic analysis reveals new functions for the Tat pathway in Yersinia pseudotuberculosis.
J. Bacteriol. 198(20): 2876-86. doi: 10.1128/JB.00352-16.

Wang H., Avican K., Fahlgren A., Erttmann S.F., Nuss A.M., Dersch P., Fällman M., Edgren T. and Wolf-Watz H. (2016).
Increased plasmid copy number is essential for Yersinia T3SS function and virulence.
Science 353(6298): 492-495. doi: 10.1126/science.aaf7501.

RighettiF., NussA.M., TwittenhoffC., BeeleS., UrbanK., Will S., Bernhart S.H., StadlerP.F., DerschP. and NarberhausF. (2016)
Temperature-responsive in vitro RNA structurome of Yersinia pseudotuberculosis.
Proc. Natl. Acad. Sci. USA 113: 7237-7242. doi: 10.1073/pnas.1523004113. 

Maurer C.K., Fruth, M., Empting M., Avrutina O., Hoßmann J., Nadmid S., Gorges J., Herrmann J., Kazmaier U., Dersch P., Müller R., Hartmann R.W. (2016)
Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies.
Future Med. Chem. 8(9): 931-947. doi: 10.4155/fmc-2016-0033. 

Drechsler-HakeD., AlamirH., Hahn J., GünterM.,WagnerS., SchützM., BohnE., Schenke-Layland K., PisanF., DerschP., Autenrieth IB., and Autenrieth SE. (2016)
Mononuclear phagocytes contribute to intestinal invasion and dissemination of Yersinia entero­colitica.
Int. J. of Med. Microbiol. pii: S1438-4221(16)30040-6. doi: 10.1016/j.ijmm.2016.04.002.

Zeitouni NE, Dersch P, Naim HY, von Köckritz-Blickwede M. (2016)
Hypoxia decreases invasin-mediated Yersinia enterocolitica internalization into Caco-2 Cells.
PLoS One 5;11(1): e0146103. doi: 10.1371/journal.pone.0146103. eCollection 2016.

MeninaS., Labouta H.I., Geyer R., Gordon S., Krause T., Dersch P., Lehr CM. (2016)
Invasin-functionalized liposomes: an effective strategy for intracellular anti-infective delivery.
RCS Advances6, 41622.

Heroven A.K., Nuss A.M. and Dersch P. (2016).
RNA-based mechanisms of virulence control in Enterobacteriaceae.
RNA Biol.14:471-487. doi: 10.1080/15476286.2016.1201617.

Mühlen S, and Dersch P. (2016)
Anti-virulence strategies to target bacterial infections.
Curr Top Microbiol Immunol. 398:147-183.  doi: 10.1007/82_2015_490.

Schwiesow L., Lam H., Dersch P.*, and Auerbuch V.* (2016)
The Yersinia type III secretion system master regulator LcrF.
J. Bacteriol. 198(4):604-14. doi: 10.1128/JB.00686-15. 

Dersch P., D. Heinz and Stadler M. (2016)
Editorial preface for the book: How to overcome the antibiotic crisis: Facts, challenges, techno­logies and future perspectives. Ed. M. Stadler, P. Dersch, Springer.

Heroven AK., and Dersch P. (2016)
Metabolic adaptation of human pathogenic yersiniae. Review article in 'Host - Pathogen Interaction: Microbial Metabolism, Patho­genicity and Antiinfectives' edited by G. Unden, E. Thines, and A. Schüffler, Wiley-Blackwell, p. 3-18

Gao X., Pham T.H., Feuerbacher L.A., Chen K., Hays M.P., Singh G., Rüter C., Guerrero R.H., and Hardwidge P.R. (2016)
Citrobacter rodentium NleB inhibits tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) ubiquitination to reduce host type I interferon production.

J. Biol. Chem.26;291(35):18232-8.doi: 10.1074/jbc.M116.738278.

Kossow A., Zhang W., Bielaszewska M., Rhode S., Hansen K., Fruth A., Rüter C.,Karch H., and Mellmann A. (2016)
Molecular Characterization of Human Atypical Sorbitol-Fermenting Enteropathogenic Escherichia coli O157 Reveals High Diversity.

J. Clin. Microbiol.54(5):1357-63.doi: 10.1128/JCM.02897-15.

Starost L., Karassek S., Sano Y., Kanda T.,  Kim K., Dobrindt U., Rüter C., and Schmidt M.A. (2016) 
Pertussis toxin exploits host cell signaling pathways induced by  meningitis-causing E. coli K1-RS218 and enhances adherence of monocytic THP-1  cells to human cerebral endothelial cells.

Toxins 13;8(10).pii: E291.

Cordes, F., Brückner, M., Lenz, P., Veltman, K., Glauben, R., Siegmund, B., Hengst, K., Schmidt, M. A., Cichon, C., Bettenworth, D. (2016)
MicroRNA-320a strengthens intestinal barrier function and follows the course of experimental colitis.

Inflamm. Bowel. Dis. 22:2341–2355. DOI 10.1097/MIB.0000000000000917.

Sabharwal, H., Cichon, C., Ölschläger, T. A., Sonnenborn, U., Schmidt, M. A. (2016)
Interleukin-8, CXCL1, and microRNA miR-146a responses to probiotic Escherichia coli Nissle 1917 and enteropathogenic E. coli in human intestinal epithelial T84 and monocytic THP-1 cells after apical or basolateral infection.

Infect. Immun. 84, 2482-2492


2015

Labouta H.I., Menina S., Kochut A., Gordon S., Geyer R., Dersch P., and Lehr CM. (2015)
Bacteriomimetic invasin-functionalized nanocarriers for intracellular delivery.
J Control Release 28; 220(Pt A):414-24, doi: 10.1016/j.jconrel.2015.10.052.

Möllerherm H.+, Neumann A.+, Schilcher K., Blodkamp S., Zeitouni N.E.; Dersch, P. Lüthje P., Naim H., Zinkernagel A., von Köckritz-Blickwede, M. (2015)
Yersinia enterocolitica-mediated degradation of neutrophil extracellular traps (NETs).
FEMS Microbiol Lett. 362(23). pii: fnv192. doi: 10.1093/femsle/fnv192.

Rosenheinrich M., Heine W., Schmühl C.M., Pisano F. and Dersch P. (2015)
Natural killer cells mediate protection against Yersinia pseudotuberculosis in the mesenteric lymph nodes.
PLoS One, 10(8): e0136290. doi: 10.1371/journal.pone.0136290

Nuss A.M., Heroven A.K., Waldmann B., Reinkensmeier J., Jarek M., Beckstette M. and Dersch P. (2015).
Transcriptomic profiling of Yersinia pseudotuberculosis reveals reprogramming of the Crp regulon by temperature and uncovers Crp as a master regulator of small RNAs.
PLoS Genet. 11(3): e1005087.

Avican K., Fahlgren A., Heroven A.K., Huss M., Beckstette M., Dersch P. and Fällman M. (2015)
Reprogramming of Yersinia from virulent to persistent mode revealed by complex in vivo RNA-seq analysis.
PLoS Pathog. 11: e1004600.  doi: 10.1371/journal.ppat.1004600. 

Erhardt M., and Dersch P. (2015)
Regulatory principles governing Salmonella and Yersinia virulence.
Front Microbiol. 6:949. eClollection 2015.  doi: 10.3389/fmicb.2015.00949.

Kunsmann L., Rüter C., Bauwens A., Greune L., Glüder M., Kemper B., Fruth A., Wai S.N., He X., Lloubes R., Schmidt M.A., Dobrindt U., Mellmann A., Karch H., and BielaszewskaM. (2015)
Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain.

Sci Rep. 5:13252. doi: 10.1038/srep13252.

Höfling S., Grabowski B., Norkowski S., Schmidt M.A., and Rüter C. (2015)
Current activities of the Yersinia effector protein YopM.

Int J Med Microbiol.305(3):424-32.doi: 10.1016/j.ijmm.2015.03.009


2014

Bücker R., Heroven A.K., Becker J., Dersch P., Wittmann C. (2014)
The pyruvate - tricarboxylic acid cycle node: a focal point of virulence control in the enteric pathogen Yersinia pseudotuberculosis.
J. Biol. Chem. 289(43): 30114-32. doi: 10.1074/jbc.M114.581348

Pisano F.+, Heine W.+, Rosenheinrich M., Schweer J., Nuss A.M., & Dersch P. (2014)
Influence of PhoP and intra-species variations on virulence of Yersinia pseudotuberculosis during the natural oral infection route.
PLoS One9(7): e103541. doi: 10.1371/journal.pone.0103541. 

Nuss A.M.+, Schuster F.+, Heroven A.K., Heine W., Pisano F. and Dersch P. (2014)
A direct link between the global regulator PhoP and the Csr regulon in Y. pseudotuberculosis through the small regulatory RNA CsrC.
RNA Biol. 11: 580-593.

Schaake J.+, Drees A.+, Grüning P.+,Uliczka F., Pisano F., Thiermann T., von Altrock A., Seehusen F., Valentin-Weigand P.*, & Dersch P.* (2014)
Essential role of invasin for colonization and persistence of Yersinia enterocolitica in its natural reservoir host, the pig.
Infect. Immun. 82(3): 960-699. doi: 10.1128/IAI.01001-13.

Heroven A.K., and Dersch P. (2014)
Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae.
Front Cell Infect Microbiol. 20(4):146. eCollection 2014.  doi: 10.3389/fcimb.2014.00146. 

Valentin-Weigand P., Heesemann J., Dersch P. (2014)
Unique virulence properties of Yersinia enterocolitica O:3 - an emerging zoonotic pathogen using pigs as preferred reservoir host.
Int. J. Med. Microbiol. 304: 824-834.  doi: 10.1016/j.ijmm.2014.07.008.

Heroven AK., & Dersch P. (2014)
Molekulare Thermometer zur Steuerung der Virulenz von Yersinia.

Biospektrum 20(4): 376-379.

Cichon C.,Sabharwal, H., Rüter, C., and Schmidt M.A. (2014)
MicroRNAs regulate tight junction proteins and modulate epithelial/endothelial barrier functions.

Tissue Barriers 2:4, e944446. doi: 10.4161/21688362.2014.944446 

Rüter, C.+, Ruiz-Silva, M.+, Grabowski, B.+, Lubos M-L., Scharnert J., Poceva M., von Tils D., Flieger A., Heesemann J., Bliska J.B. and Schmidt M.A. (2014)
Rabbit monoclonal antibodies directed at the T3SS effector protein YopM identify human pathogenic Yersinia Isolates.

Int. J. Med.Microbiol.304(3-4):444-51. doi: 10.1016/j.ijmm.2014.02.003.

Höfling S., Scharnert J., Cromme C., Bertrand J., Pap, T., Schmidt  M.A., and Rüter, C. (2014)
Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2.

Virulence 5(7):761-71.doi: 10.4161/viru.29062.

Lubos M-L., Norkowski S., Stolle, A.S., Langel, Ü., Schmidt, M.A., and Rüter, C. (2014)
Analysis of T3SS-independent Autonomous Internalization of the Bacterial Effector Protein SspH1 from Salmonella typhimurium.

Inflammation and Cell Signaling. 1(6):e423,doi: 10.14800/ics.423


2013-2010

Schweer J., Kulkarni D., Kochut A., Pezoldt J., Pisano F., Pils M.C., Genth H., Huehn J. and Dersch P. (2013).
The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases.
PLoS Pathog.9(11): e1003746. doi: 10.1371/journal.ppat.1003746.
Article recommended by F1000

SchaakeJ., Kronshage M., Uliczka F., Rohde M., Knuuti T.,Strauch E., Fruth A., Wos-Oxley M. andDerschP.(2013).
Human and animal isolates of Yersinia enterocolitica show significant serotype-specific coloni­zation and host-specific immune defense properties.
Infect. Immun. 81: 4013-4025. doi: 10.1128/IAI.00572-13. 

Steinmann R., & Dersch P. (2013)
Thermosensing to adjust bacterial virulence in a fluctuating environment.
Future Microbiology8:85-105.  doi: 10.2217/fmb.12.129. 

Kochut A., and Dersch P. (2013)
Bacterial invasion factors: tools for crossing biological barriers and drug delivery?
Eur J Pharm Biopharm. 84(2): 242-50.  doi: 10.1016/j.ejpb.2012.11.013. 

Scharnert J., Greune L., Zeuschner D., Lubos ML, Schmidt M.A., and Rüter, C. (2013)
Autonomous translocation and intracellular trafficking of the cell-penetrating and immune-suppressive effector protein YopM.

Cell Mol Life Sci. 70(24):4809-23.doi: 10.1007/s00018-013-1413-2.

Bielaszewska M.+, Rüter C.+, Kunsmann L., Greune L., Bauwens, A., Zhang, W., Kuczius, T., Kim, K.S., Mellmann, A., Schmidt, M.A., and Karch, H. (2013)
Enterohemorrhagic Escherichia coli Hemolysin Employs Outer Membrane Vesicles to Target Mitochondria and Cause Endothelial and Epithelial Apoptosis.

PLOS Pathogens9(12):e1003797.doi: 10.1371/journal.ppat.1003797.

Rüter C., and Hardwidge P.R. (2013)
'Drugs from Bugs': bacterial effector proteins as promising biological (immune-) therapeutics.

FEMS Microbiol Lett. 351(2):126-32,doi: 10.1111/1574-6968.12333.
including cover picture

Heroven A.K., Sest M., Pisano F., Scheb-Wetzel M., Steinmann R., Böhme K., Klein J., Münch R., Schomburg D., & Dersch P. (2012)
Crp induces switching of the CsrB and CsrC RNAs in Yersinia pseudotuberculosis and links nutritional status to virulence.
Front. Cell. Infect. Microbiol. 2: 158. doi: 10.3389/fcimb.2012.00158. 

QuadeN. +, MendoncaC. +, HerbstK., HerovenA.K., HeinzD.W. & DerschP. (2012)
Structural basis of thermosensing by the master virulence regulator RovA of Yersinia.
J. Biol. Chem. 287(43): 35796-35803. doi: 10.1074/jbc.M112.379156. 

Böhme K.+, Steinmann R.+, Kortmann J., Seekircher S., Heroven A.K., Berger E., Pisano F., Thiermann T., Wolf-Watz H., Narberhaus F., and Dersch P. (2012)
Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor con­trol Yersinia virulence.
PLoS Pathog.8(2): e1002518. doi: 10.1371/journal.ppat.1002518. 

Pisano F., Kochut A., Uliczka F., Geyer R., Stolz T., Thiermann T., Rohde M. and Dersch P. (2012).
In vivo-induced InvA-like autotransporters Ifp and InvC of Yersinia pseudotuberculosis promote interactions with intestinal epithelial cells and contribute to virulence.
Infect. Immun.80: 1050-1064.

Heroven AK., Böhme K., and Dersch P. (2012)
The Csr/Rsm system of Yersinia and related pathogens: a post-transcriptional strategy for managing virulence
RNA Biology9(4): 379-91.  doi: 10.4161/rna.19333.

Dersch P. (2012)
Protein Folding, Transport and Degradation in Schomburg D. (Ed.): Biochemical Path­ways: An Atlas of Biochemistry and Molecular Biology, John Wiley & Sons, p. 244-258.

Uliczka F and Dersch P. (2012)
Unique virulence properties of Yersinia enterocolitica O:3.
Adv. Exp. Med. Biol. 954:281-7

Heroven AK, Böhme K., and Dersch P. (2012)
Regulation of virulence gene expression by regulatory RNA elements in Yersinia pseudo­tuberculosis
Adv. Exp. Med. Biol. 954:315-23

Cichon C, Veltman K, Hummel S, Sonnenborn U and Schmidt MA. (2012).
MiRNAs contribute to the probiotic effect of E. coli Nissle 1917 on host cells offering new perspectives for Inflammatory Bowel Disease treatment.
Gastroenterology, May;142(5):S392.

Veltman K, Hummel S, Cichon C, Sonnenborn U and Schmidt MA. (2012).
Identification of specific miRNAs targeting proteins of the apical junctional complex that simulate the probiotic effect of E. coli Nissle 1917 on T84 epithelial cells.
Int J Biochem Cell Biol. Feb;44(2):341-9.

Uliczka F., Pisano F., Schaake J., Stolz T., Rohde M., Fruth A., Strauch E., Skurnik M., Batzilla J., Rakin A., Heesemann J. and Dersch P. (2011)
Unique cell adhesion and invasion properties of Yersinia enterocolitica O:3, the most frequent cause of human yersiniosis.
PLoS Pathog.7(7): e1002117. doi: 10.1371/journal.ppat.1002117.

Uliczka F., Pisano P., Kochut A., Opitz W., Herbst K., Stolz T., and Dersch P. (2011)
Monitoring of gene expression in bacteria during infections using an adaptable set of bioluminescent, fluorescent and colorigenic fusion vectors.
PLoS One, 6(6): e20425. doi: 10.1371/journal.pone.0020425. 

Quade N., Dieckmann M., Haffke M., Heroven A.K., Dersch P. and Heinz D.W. (2011)
Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis.
Acta Crystallographica, Crystallogr D Biol Crystallogr. 67:81-90. doi: 10.1107/S0907444910049681. 

Göpel Y., LüttmannD., Heroven A.K., Reichenbach B., DerschP. and Görke B. (2011). Common and divergent features in transcription control of the homologous small RNAs GlmY and GlmZ in Enterobacteriaceae.
Nucleic Acids Res. 39: 1294-1309. doi: 10.1093/nar/gkq986.

Driouch H., Roth A., Dersch P., and Wittmann C. (2011)
Filamentous fungi in good shape: microparticles for tailor-made fungal morphology and en­hanced enzyme production.
Bioeng. Bugs2:2, 1-5, doi: 10.4161/bbug.2.2.13757.

Driouch H., Roth A., Dersch P. and C. Wittmann (2010)
Optimized bioprocess for production of fructofuranosidase by recombinant Aspergillus niger.
Appl. Microbiol. Biotechnol. 87:2011-24. doi: 10.1007/s00253-010-2661-9. 

Homann A., QamarR., Serim S., Dersch P. and SeibelJ. (2010)
Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid.
Beilstein J. Org. Chem.6: 24.doi: 10.3762/bjoc.6.24.

Roth A.H. and Dersch P. (2010)
A novel expression system for intracellular production and purification of recombinant affinity-tagged proteins in Aspergillus niger.
Appl. Microbiol. Biotechnol. 86: 659-670. doi: 10.1007/s00253-009-2252-9. 

Fleißner A. and Dersch P. (2010)
Expression and Export: Recombinant protein production systems for Aspergillus.
Appl. Microbiol. Biotechnol. 87:1255-1270.  doi: 10.1007/s00253-010-2672-6. 

Heroven A.K. and Dersch P. (2010)
Global virulence gene regulation networks in enteropathogenic Yersiniae. in Mohan RM (Ed.):
Research Advances in Mol. Microbiology.
Kerala, Indien: Global Research Network, p.1-17.

Rüter C., Buss C., Scharnert S., Heusipp G. and Schmidt, M.A. (2010).
A newly identified bacterial cell-penetrating peptide that reduces the transcription of pro-inflammatory cytokines.
J. Cell. Sci. 123(Pt 13): 2190-8. doi: 10.1242/jcs.063016.


2000-2009

UliczkaF.+, Kornprobst T.+, Eitel J., Schneider D. and Dersch P. (2009)
Cell invasion of Yersinia pseudotuberculosis by invasin and YadA requires protein kinase C, phospholipase C-g1 and Akt kinase.
Cell. Microbiol. 11:1782–1801. doi: 10.1111/j.1462-5822.2009.01371.x. 

Vlahou G., Schmidt O., Wagner B., Uenlue H., Dersch P., Rivero F. and Weissenmayer BA. (2009)
Yersinia outer protein YopE affects the actin cytoskeleton in Dictyostelium discoideum through targeting of multiple Rho family GTPases.
BMC Microbiology14:138 doi: 10.1186/1471-2180-9-138.

Herbst K.+, Bujara M.+, Heroven A.K., Opitz W., Weichert M., Zimmermann A. and Dersch P. (2009).
Intrinsic thermal sensing controls proteolysis of Yersinia virulence regulator RovA.
PLoS Pathog.5(5):e1000435. doi: 10.1371/journal.ppat.1000435. 

Buss C., Müller D., Rüter C., Heusipp G. and Schmidt M.A. (2009)
Identification and characterization of Ibe, a novel type III secreted protein of A/E pathogens that targets human IQGAP1.
Cell. Microbiol. 11(4):661-77. doi: 10.1111/j.1462-5822.2009.01284.x.

Heroven A.K., Böhme K., Rohde M. and Dersch P. (2008).
A Csr-type regulatory system, including small non-coding RNAs, regulates the global virulence regulator RovA of Yersinia pseudotuberculosis through RovM.
Mol. Microbiol. 68: 1179-1195. doi: 10.1111/j.1365-2958.2008.06218.x.

Zuccaro A., Götze S., Kneip S., Dersch P. and Seibel J. (2008)
Tailor-made fructooligosaccharides by combination of substrate and genetic engineering
Chembiochem. 9:143-149.

Dersch P. and Jahn D. (2008)
Mikrobielle Genetik
Book Chapter 6 in Mikrobiologie
K. Munk, Edt. Thieme

Melzer G., Dalpiaz A., Grote A., Kucklick M., Göcke Y., Jonas R., Dersch P., Franco-Lara E., Nörtemann B., Hempel D.C. (2007)
Metabolic flux analysis using stoichometric models for Aspergillus niger: comparison under glucoamylase-producing and non-producing conditions.
J. Biotechnol. 132: 405-417.

Heroven AK., Böhme K., Tran-Winkler H. and Dersch P. (2007).
Regulatory elements implicated in the environmental control of invasin expression in entero­pathogenic Yersinia, Book Chapter in: The Genus Yersinia. Edt: Springer
Adv. Exp. Med. Biol. 603:156-166.

Heise T. & Dersch P. (2007)
Interaktion mit Wirtszellen: individuell
Biospektrum 3: 258-259.

Heroven A.K. and Dersch P. (2006).
RovM, a novel LysR-type regulator of the virulence activator gene rovA, controls cell inva­sion, virulence and motility of Yersinia pseudotuberculosis.
Mol. Microbiol. 62: 1469-1483.

Heise T. and Dersch P. (2006).
Identification of a domain in Yersinia virulence factor YadA that is crucial for extracellular matrix-specific cell adhesion and uptake.
Proc. Natl. Acad. Sci. USA 103: 3375-3380.

Michgehl S., Heusipp G., Greune L., Rüter C. and Schmidt, M.A. (2006)
Esp-independent functional integration of the translocated receptor (Tir) of enteropathogenic Escherichia coli (EPEC) into host cell membranes.
Cell. Microbiol. 8(4):625-33. doi: 10.1111/j.1462-5822.2005.00655.x

Schlieker C., Zentgraf H., Dersch P., and A. Mogk (2005)
ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria.
Biol Chem. 386:1115-1127.

Tran H.J., Heroven A.K., Winkler L., Spreter T., Beatrix B. and Dersch P. (2005).
Analysis of RovA, a transcriptional regulator of Yersinia pseudotuberculosis virulence that acts through antirepression and direct transcriptional activation.
J. Biol. Chem. 280: 42423-42432.

Damasko C, Konietzny A., Kaspar, H., Appel B., Dersch P. and Strauch E. (2005)
Studies of the efficacy of enterocoliticin, a phage-tail like bacteriocin, as antimicrobial agent against Yersinia enterocolitica serotype O3 in a cell culture sytem and in mice.
J. Vet. Med. 52:171-179.

Eitel J., Heise T., Thiesen U. and Dersch P. (2005).
Cell invasion and IL-8 production pathways initiated by YadA of Yersinia pseudotuberculosis require common signalling molecules (FAK, c-Src, Ras) and distinct cell factors.
Cell. Microbiol. 7: 63-77.

Heroven A.K., Nagel G., Tran H.J., Parr S. and Dersch P. (2004).
RovA is autoregulated and antagonizes H-NS-mediated silencing of invasin and rovA expression in Yersinia pseudotuberculosis.
Mol. Microbiol. 53: 871-888.

Eitel J. & Dersch P. (2004)
Enteropathogene Yersinien: Wege ins Innere der Zelle
Bioforum 5: 50-51.

Strauch E, Kaspar, H. Schaudinn C., Damasko C., Konietzny A., Dersch P., Skurnik M, Appel B. (2003)
Analysis of enterocoliticin, a phage-tail like bacteriocin.
Book Chapter 48 in: The Genus Yersinia. Edt: M. Skurnik, Kluwer Academics
Adv. Exp. Med. Biol. 529:249-251.

Nagel G., Heroven AK., Eitel J. and Dersch P. (2003)
Function and regulation of the transcriptional activator RovA of Yersinia pseudotuberculosis.
Book Chapter 54 in: The Genus Yersinia. Edt: M. Skurnik, Kluwer Academics
Adv. Exp. Med. Biol. 529:285-287.

Dersch P.  and Hengge-Aronis (2003)
Survival of environmental and host-associated stress.
Book chapter in: Dormancy and low growth states in microbial disease,
Edt: A.R. Coates, Cambridge University Press, p: 37-75.

Dersch P. (2003)
Molecular and cellular mechanisms of bacterial entry into host cells. Book chapter in Host response mechanisms in infectious diseases, Edt: H. Herwald, Karger, Basel
Contrib. Microbiol. 10:183-209.
 
Eitel J. and Dersch P. (2002)
The YadA protein of Yersinia pseudotuberculosis mediates high-efficiency uptake into human cells under environmental conditions in which invasin is repressed.
Infect. Immun. 70 (9): 4880-4891.

Heroven AK. and Dersch P.  (2002)
Two different open reading frames named slyA in the E. coli sequence databases.
Trends in Microbiology 10 (6): 267-268.

Dersch P. (2002)
Bacterial survival: getting inside cells (Zelluläre Invasion: Eine Bakterielle Überlebensstrategie)
Bundesgesundheitsblatt 45: 577-582.

Strauch E., Kaspar H., Schaudinn C., Dersch P., Madela K., Gewinner, C., Hertwig, S., Wecke J., and Appel B. (2001)
Characterization of enterocoliticin, a phage tail-like bacteriocin, and its effect on pathogenic Yersinia enterocolitica strains.
Appl. Environ. Microbiol. 67(12): 5634-5642.

Nagel G., Lahrz A. and Dersch P. (2001)
Environmental control of invasin expression in Yersinia pseudotuberculosis is mediated by regulation of RovA, a transcriptional activator of the SlyA/Hor family.
Mol. Microbiol. 41(6): 1249-1269.

Deibel C., Dersch P. and Ebel F. (2000)
Intimin from Shiga toxin-producing Escherichia coli and its isolated C-terminal domain exhibit different binding properties for Tir and a eukaryotic surface receptor.
Int. J. Med. Microbiol. 290 (8): 683-691.

Dersch, P. and Isberg, R.R. (2000).
An immunoglobulin superfamily-like domain unique to the Yersinia pseudotuberculosis invasin protein is required for stimulation of bacterial uptake via integrin receptors.
Infect. Immun. 68: 2930-2938.

Isberg, R. R., Hamburger, Z. and Dersch, P. (2000)     
Signaling and invasin-promoted uptake via integrin receptors.
Microbes & Infection7: 793-801.


1989-1999

Dersch, P. and Isberg, R.R. (1999).
A region of the Yersinia pseudotuberculosis invasin protein enhances integrin-mediated up­take into mammalian cells and promotes self-association.
EMBO J. 18: 1199-1213.

Krukonis E.S., Dersch P., Eble J.A., & Isberg R.R. (1998)
Differential effects of integrin alpha chain mutations on invasin and natural ligand interaction.
J. Biol. Chem. 273: 31837-31843.

Eble J.A., Wucherpfennig K.W., Gauthier L., Dersch P., Krukonis E., Isberg R.R., & Hemler M.E. (1998)
Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner.
Biochemistry  37: 10945-10955.

Dersch, P. & Isberg, R. R. (1997)
Mechanism of binding and internalization of Yersinia pseudotuberculosis into epithelial cells.
Annales de l´Institut Pasteur, Actualités 8,2:119-129.

Dersch, P., Kneip, S. and Bremer, E. (1994)
The nucleoid-associated DNA-binding protein H-NS is required for the efficient adaptation of Escherichia coli K-12 to a cold environment.

Mol. Gen. Genet.
245: 255-259.         

Dersch, P., Fsihi H. and Bremer, E. (1994)
Low-copy-number T7-vectors for selective gene expression and efficient protein over­production in Escherichia coli.
FEMS Microbiol. Lett. 123: 19-26.

Lucht, J.M., Dersch, P., Kempf, B. and Bremer, E. (1994).
Interactions of the nucleoid-associated DNA-binding protein H-NS with the regulatory region of the osmotically controlled proU operon of Escherichia coli.
J. Biol. Chem. 269: 6578-6586.

Bremer, E., Dersch, P.,Lucht, J.M.(1994)
Einfluß des Nukleoid-assoziierten DNA-Bindeproteins H-NS auf die bakterielle Genexpression. pp: 7-21. In: Modulation der Virulenz von Krankheitserregern, Editors: J. Hacker, J. Heesemann Upjohn GmbH, Medical Sciences Liaison

Dersch, P., Schmidt, K. and Bremer, E. (1993).
Synthesis of the Escherichia coli K-12 nucleoid-associated DNA-binding protein H-NS is subjected to growth-phase control and autoregulation.
Mol. Microbiol. 8: 875-889.

May, G., Dersch, P., Haardt, M., Middendorf, A. and Bremer, E. (1990)
The osmZ (bglY) gene encodes the DNA-binding protein H-NS (H1a), a component of the Escherichia coli K-12 nucleoid.
Mol. Gen. Genet. 224: 81-90.