© Raphael Fehrmann

Wissenschaftliche Publikationen des SFB 1009 Breaking Barriers

Die jeweiligen Teilprojektleiter sind hervorgehoben.

  • Allgemeine Publikation des SFB 1009

    Unter dem Titel "Pushing the barriers of knowledge" publizierten Mitglieder des Sonderforschungsbereichs 1009 "Breaking Barriers" in der International Innovation einen Bericht über aktuelle Forschungsansätze, in dem sie die Bedeutung der Erkenntnis über Erreger-Wirt-Wechselwirkungen auf zellulärer Ebene darstellten, um neue klinische Interventionen zu ermöglichen.

    Hier finden Sie die Publikation zur Ansicht 

    (Format: PDF, Adobe Reader). 

    Pushing the barriers of knowledge, International Innovation, Regional Research, Issue September 2013, pages 86-88

     

     

     

     

     

     

     

  • Reviews des SFB 1009

    2017

    • Rüter C, Schmidt MA (2017) Cell-Penetrating Bacterial Effector Proteins: Better Tools than Targets. Trends Biotechnol 35(2): 109-120. doi: 10.1016/j.tibtech.2016.08.002. Epub 2016 Sep 1)

    2016

    • Di Russo J, Hannocks MJ, Luik AL, Song J, Zhang X, Yousif L, Aspite G, Hallmann R, Sorokin L (2016) Vascular laminins in physiology and pathology. Matrix Biol pii: S0945-053X(16)30102-0. (doi: 10.1016/j.matbio.2016.06.008. [Epub ahead of print])
    • Goswami D, Vestweber D (2016) How leukocytes trigger opening and sealing of gaps in the endothelial barrier. F1000Research 5(F1000 Faculty Rev):2321 (doi: 10.12688/f1000research.9185.1)
    • Rehm N, Berger M, Dobrindt U (2016) Bacterial Genome Plasticity. In: Encyclopedia of Evolutionary Biology (R.M. Kliman, ed.) Elsevier Amsterdam, in press.
    • Schirmeier S, Matzat T, Klämbt C (2016) Axon ensheathment and metabolic supply by glial cells in Drosophila. Brain Res 1641(Pt A): 122-129. (doi: 10.1016/j.brainres.2015.09.003. Epub 2015 Sep 12.)

    2015

    • Dobrindt U, Tjaden S, Shah S, Hacker J (2015b) Mobile genetic elements and pathogenicity islands encoding bacterial toxins. In: The Comprehensive Sourcebook of Bacterial Protein Toxins (Alouf, J., Ladant, D., Popoff, M. eds.) Elsevier Amsterdam, 40-76.
    • Vestweber D (2015) How leukocytes cross the vascular endothelium. Nat Rev Immunol 15: 692-704.

    2014

    • Bogdani, M., Korpos, E., Simeonovic, C. J., Sorokin, L. and Wright, T. N. (2014). Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr. Diab. Rep. 14, 552-564.
    • Schoofs T, Berdel WE, Müller-Tidow C (2014) Origins of aberrant DNA methylation in acute myeloid leukemia. Leukemia 28: 1–14.

    2013

    • Wiendl H, Gross CC (2013) Modulation of IL-2Rα with daclizumab for treatment of multiple sclerosis. Nature Rev Neurol 9: 394-404.
  • Publikationen 2017

    • Albrecht S, Fleck AK, Kirchberg I, Hucke S, Liebmann M, Klotz L, Kuhlmann T. (2017) Activation of FXR pathway does not alter glial cell function. J Neuroinflammation 14(1):66. (doi: 10.1186/s12974-017-0833-6)
    • Bauwens A., Kunsmann L., Karch H., Mellmann A., Bielaszewska M. (2017) Antibiotic-mediated modulations of outer membrane vesicles in enterohemorrhagic Escherichia coli O104:H4 and O157:H7. Antimicrob Agents Chemother. 61(9):e00937-17. (doi: 10.1128/AAC.00937-17)
    • Bauwens A., Kunsmann L., Marejkova M., Zhang, W., Karch H., Bielaszewska M., et al. (2017) Intrahost milieu modulates production of outer membrane vesicles, vesicle-associated Shiga toxin 2a, and cytotoxicity in Escherichia coli O157:H7 and O104:H4. Environ Microbiol Rep. (doi:10.1111/1758-2229.12562.)
    • Benjamin Grabowski, M. Alexander Schmidt & Christian Rüter (2017) Immunomodulatory Yersinia outer proteins (Yops)–useful tools for bacteria and humans alike, Virulence. (doi: 10.1080/21505594.2017.1303588)
    • Bielaszewska M.*; Ruter, C.*; Bauwens, A.*; Greune, L.; Jarosch, K. A.; Steil, D.; Zhang, W.; He, X.; Lloubes, R.; Fruth, A.; Kim, K. S.; Schmidt, M. A.; Dobrindt, U.; Mellmann, A.; Karch, H. (2017) Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury. PLoS pathogens. 13(2):e1006159. (doi: 10.1371/journal.ppat.1006159)
    • Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, Van Marck V, Heitplatz B, Kliche S, Reinhold A, Lowell C, Zarbock A. (2017) Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. J Exp Med. 214(3):851-874. (doi: 10.1084/jem.20160647) [Epub 2017 Feb 9]
    • Di Russo J, Luik AL, Yousif L, Budny S, Oberleithner H, Hofschröer V, Klingauf J, van Bavel E, Bakker EN, Hellstrand P, Bhattachariya A, Albinsson S, Pincet F, Hallmann R, Sorokin L (2017) Endothelial basement membrane laminin 511 is essential for shear stress response. EMBO J 36(2): 183-201. (doi: 10.15252/embj.201694756) [Epub 2016 Dec 9]
    • Eble JA, McDougall M, Orriss GL, Niland S, Johanningmeier B, Pohlentz G, Meier M, Karrasch S, Estevao-Costa MI, Martins Lima A, Stetefeld J (2017) Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively. PLoS Biol 15: e2001492.
    • Galstyan A, Putze J, Dobrindt U. (2017) Striking an access to the bacteria via (reversible) control of lipophilicity.Chemistry. doi: 10.1002/chem.201704562.
    • Galstyan A, Schiller R, Dobrindt U. (2017) Boronic Acid Functionalized Photosensitizers: A Strategy to Target the Surface of Bacteria and Implement Active Agents in Polymer Coatings. Angew Chem Int Ed Engl. 56(35):10362-10366. (doi: 10.1002/anie.201703398)
    • Goswami D, März S, Li YT, Artz A, Schäfer K, Seelige R, Pacheco-Blanco M, Jing D, Bixel MG, Araki M, Araki K, Yamamura K, Vestweber D. (2017) Endothelial CD99 supports arrest of mouse neutrophils in venules ad binds to neutrophil PILRs. Blood 129(13): 1811-1822. (doi:10.1182/blood-2016-08-733394)
    • Haasbach E, Müller C, Ehrhardt C, Schreiber A, Pleschka S, Ludwig S, Planz O. (2017). The MEK-inhibitor CI-1040 displays a broad anti-influenza virus activity in vitro and provides a prolonged treatment window compared to standard of care in vivo. Antiviral Research 142 (2017) 178e184. doi: 10.1016/j.antiviral.2017.03.024
    • Heitmueller M, Billion A, Dobrindt U, Vilcinskas A, Mukherjee K. (2017) Epigenetic Mechanisms Regulate Innate Immunity against Uropathogenic and Commensal-Like Escherichia coli in the Surrogate Insect Model Galleria mellonella. Infect Immun. 85(10). pii: e00336-17. (doi: 10.1128/IAI.00336-17)
    • Jakobs P, Schulz P, Schurmann S, Niland S, Exner S, Rebollido-Rios R, Manikowski D, Hoffmann D, Seidler DG, Grobe K (2017) Calcium coordination controls sonic hedgehog structure and Scube2-cubulin domain regulated release. J Cell Sci., in press.
    • Klemm C, Bruchhagen C, van Kruchten A, Niemann S, Loffler B, Peters G, Ludwig S and Ehrhardt C. (2017) Mitogen-activated protein kinases (MAPKs) regulate IL-6 over-production during concomitant influenza virus and Staphylococcus aureus infection. Sci Rep. 7:42473. (doi:  10.1038/srep42473)
    • Lebughe M, Phaku P, Niemann S, Mumba D, Peters G, Muyembe-Tamfum JJ, Mellmann A, Strauss L and Schaumburg F. (2017) The Impact of the Staphylococcus aureus Virulome on Infection in a Developing Country: A Cohort Study. Front Microbiol. 8:1662. (doi: 10.3389/fmicb.2017.01662)
    • Leite Dantas R, Brachvogel B, Schied T, Bergmeier V, Skryabin B, Vogl T, Ludwig S, Wixler V. (2017). The LIM-Only Protein Four and a Half LIM Domain Protein 2 Attenuates Development of Psoriatic Arthritis by Blocking Adam17 Mediated Tumor Necrosis Factor Release. American Journal of Pathology. 187;11:2388. doi: 10.1016/j.ajpath.2017.07.015
    • Masemann D, Boergeling Y, Ludwig S. 2017. Employing RNA viruses to fight cancer: novel insights into oncolytic virotherapy. Biol. Chem. (2017); 398(8): 891-909 doi: 10.1515/hsz-2017-0103
    • Mykicki, N., Klenner, L., Baumann, C., Auriemma, M., Sternemann, C., Soeberdt, M., Elliott, G. R., Abels, C., Luger, T. A. and Loser, K. (2017) The tripeptide KdPT ameliorates ongoing psoriasis-like skin inflammation in murine and human skin. Exp Dermatol, 26: 328–334. (doi:10.1111/exd.13145)
    • Nacken W, Wixler V, Ehrhardt C, Ludwig S. ( 2017). Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked. Cell Microbiol. 2017 Jul 19(7). Doi: 10.1111/cmi.12721 [Epub ahead of print]
    • Sara Caviglia, David Flores-Benitez, Johanna Lattner, Stefan Luschnig &
      Marko Brankatschk (2017) Rabs on the fly: Functions of Rab GTPases during development, Small
      GTPases. (doi: 10.1080/21541248.2017.1279725)
    • Song J, Zhang X, Buscher K, Wang Y, Wang H, Di Russo J, Li L, Lütke-Enking S, Zarbock A, Stadtmann A, Striewski P, Wirth B, Kuzmanov I, Wiendl H, Schulte D, Vestweber D, Sorokin L (2017) Endothelial basement membrane Laminin 511 contributes to endothelial junctional tightness and thereby inhibits leukocyte transmigration. Cell Rep 18(5): 1256-1269. (doi: 10.1016/j.celrep.2016.12.092)
    • Stolle A-S, Norkowski S, Körner B, Schmitz J, Lüken L, Frankenberg M, Rüter C and Schmidt MA (2017) T3SS-Independent Uptake of the Short-Trip Toxin-Related Recombinant NleC Effector of Enteropathogenic Escherichia coli Leads to NF-κB p65 Cleavage. Front. Cell. Infect. Microbiol. 7:119. (doi: 10.3389/fcimb.2017.00119)
    • Thölking G, Schuette-Nuetgen K, Vogl T, Dobrindt U, Kahl BC, Brand M, Pavenstädt H, Suwelack B, Koch R, Reuter S. (2017) Male kidney allograft recipients at risk for urinary tract infection? PLoS One 12(11):e0188262. doi: 10.1371/journal.pone.0188262.
    • Tvisha Misra, Martin Baccino-Calace, Felix Meyenhofer, David Rodriguez-Crespo, Hatice Akarsu, Ricardo Armenta-Calderón, Thomas A. Gorr, Christian Frei, Rafael Cantera, Boris Egger, Stefan Luschnig (2017) A genetically encoded biosensor for visualising hypoxia responses in vivo. Biology Open 6: 296-304. (doi: 10.1242/bio.018226)
    • Wiegand S, Zakrzewski SS, Eichner M, Schulz E, Günzel D, Pieper R, Rosenthal R, Barmeyer C, Bleich A, Dobrindt U, Schulzke JD, Bücker R. (2017) Zinc treatment is efficient against Escherichia coli α-haemolysin-induced intestinal leakage in mice. Sci Rep. 7:45649. (doi: 10.1038/srep45649)
  • Publikationen 2016

    • Ambite I, Lutay N, Stork C, Dobrindt U, Wollt B, Svanborg C (2016) Bacterial suppression of RNA polymerase II-dependent host gene expression. Pathogens 5: 49. (doi:10.3390/pathogens5030049) 
    • Artz A, Butz S, Vestweber D (2016) GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-bRII heterodimer. Blood 128(4): 529-541. (doi:10.1182/blood-2016-01-696617) 
    • Buscher K, Wang H, Zhang X, Striewski P, Wirth B, Saggu G, Lütke-Enking S, Mayadas TN, Ley K, Sorokin L, Song J (2016) Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules. Nat Commun 7: 10828. (doi: 10.1038/ncomms10828.)
    • Cordes F, Brückner M, Lenz P, Veltman K, Glauben R, Siegmund B, Hengst K, Schmidt MA, Cichon Ch, Bettenworth D (2016) MicroRNA-320a strengthens intestinal barrier function and follows the course of experimental colitis. Inflamm Bowel Dis 22(10): 2341-2355. (doi 10.1097/MIB.0000000000000917) 
    • Dobrindt U, Wullt B, Svanborg C (2016) Asymtomatic Bacteriuria as a Model to Study the Coevolution of Hosts and Bacteria. Pathogens 5:21.
    • Dudek SE, Nitzsche K, Ludwig S, Ehrhardt C (2016) Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability. Sci Rep 6: 27275. (doi: 10.1038/srep27275) 
    • Ghatak S, Niland S, Schulz JN, Wang F, Eble JA, Leitges M, Mauch C, Krieg T, Zigrino P, Eckes B (2016) Role of Integrins alpha1beta1 and alpha2beta1 in Wound and Tumor Angiogenesis in Mice. Am J Pathol 186(11): 3011-3027. (doi: 10.1016/j.ajpath.2016.06.021. Epub 2016 Sep 14) 
    • Gross CC, Schulte-Mecklenbeck A, Hanning U, Posevitz-Fejfár A, Korukewitz C, Schwab N, Meutz SG, Wiendl H, Klotz L (2016) Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets. Multiple Sclerosis Journal 1-6. (doi:10.1177/1352458516662726) 
    • Kathum OA, Schräder T, Anhlan D, Nordhoff C, Liedmann S, Pande A, Mellmann A, Ehrhardt C, Wixler V, Ludwig S (2016) Phosphorylation of influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity. Cell Microbiol 18(6): 784–791. (doi:10.1111/cmi.12559) 
    • Klasen T, Faber C (2016) Assessment of the myelin water fraction in rodent spinal cord using T2-prepared ultrashort echo time MRI. Magn Reson Mater Phy 29: 875. (doi:10.1007/s10334-016-0579-7) 
    • Kuzmanov I, Herrmann AM, Galla HJ, Meuth SG, Wiendl H, Klotz L (2016) An in vitro model of the blood-brain barrier using impedance spectroscopy: A focus on T cell-endothelial cell interaction. J Vis Exp Dec 8;(118). (doi: 10.3791/54592.) 
    • Muenzner P, Kengmo Tchoupa A, Klauser B, Brunner T, Putze J, Dobrindt U, Hauck CR (2016) Uropathogenic E. coli exploit CEA to promote colonization of the urogenital tract mucosa. PLoS Pathog 12(5): e1005608. 
    • Pelillo C, Mollica H, Eble JA, Grosche J, Herzog L, Codan B, Sava G, Bergamo A (2016) Inhibition of adhesion, migration and of alpha5beta1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. J Inorg Biochem 160: 225-235. (doi: 10.1016/j.jinorgbio.2016.02.025. Epub 2016 Feb 27.) 
    • Sanchez EF, Richardson M, Gremski LH, Veiga SS, Yarleque A, Niland S, Lima AM, Estevao-Costa MI, Eble JA (2016) Data for a direct fibrinolytic metalloproteinase, barnettlysin-I from Bothrops barnetti (barnett(,)s pitviper) snake venom with anti-thrombotic effect. Data Brief 7: 1609-1613. 
    • Sanchez EF, Richardson M, Gremski LH, Veiga SS, Yarleque A, Niland S, Lima AM, Estevao-Costa MI, Eble JA (2016) A novel fibrinolytic metalloproteinase, barnettlysin-I from Bothrops barnetti (barnett s pitviper) snake venom with anti-platelet properties. Biochim Biophys Acta 1860: 542-556. 
    • Strobel M, Pförtner H, Tuchscherr L, Völker U, Schmidt F, Kramko N, Schnitter HJ, Fraunholz MJ, Löffler B, Peters G, Niemann S (2016) Post-invasion events after infection with Staphylococcus aureus are strongly dependent on both the host cell type and the infecting. Clinical Microbiol Infect 22: 799-809. (doi: 10.1016/j.cmi.2016.06.020.) 

     

     

     

  • Publikationen 2015

    • Baldo C, Lopes DS, Faquim-Mauro EL, Jacysyn JF, Niland S, Eble JA, Clissa PB, Moura-da-Silva AM (2015) Jararhagin disruption of endothelial cell anchorage is enhanced in collagen enriched matrices. Toxicon, in press [doi 10.1016/j.toxicon.2015.10.016].
    • Becker A, Große Hokamp N, Zenker S, Flores-Borja F, Barzcyk K, Varga G, Roth J, Geyer C, Heindel W, Bremer C, Vogl T*, Eisenblaetter M* (2015) In vivo visualisation of the alarmin S100A9 in tumor lesions allows for estimation of the individual malignant potential by evaluation of tumor host-cell interaction. J. Nuc. Med. 56:450-456. *Shared first or senior authorship
    • Block H, Stadtmann A, Riad D, Rossaint J, Sohlbach C, Germena G, Wu D, Simon SI, Ley K, Zarbock A. (2015) Gnb isoforms orchestrate a signaling pathway comprising Rac1 and Plcβ2/3 leading to LFA-1 activation and neutrophil arrest in vivo. Blood 2015 Oct 14. pii: blood-2015-06-651034
    • Börgeling Y, Rozhdestvensky TS, Schmolke M, Resa-Infante P, Robeck T, Randau G, Wolff T, Gabriel G, Brosius J, Ludwig S (2015) Evidence for a novel mechanism of influenza virus-induced type I interferon expression by a defective RNA-encoded protein. PLoS Pathog 11: e1004924.
    • Dankbar B, Fennen M, Brunert D, Hayer S, Frank S, Wehmeyer C, Beckmann D, Paruzel P, Bertrand J, Redlich K, Koers-Wunrau C, Stratis A, Korb-Pap A, Pap T (2015) Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice. Nat Med. 21(9):1085-90.
    • Drechsler M, de Jong R, Rossaint J, Viola JR, Leoni G, Wang JM, Grommes J, Hinkel R, Kupatt C, Weber C, Döring Y, Zarbock A, Soehnlein O. (2015) Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment. Circ Res. 2015 Feb 27;116(5):827-35. AZ und OS contributed equally and share senior-authorship
    • Fassl SK, Austermann J, Papantonopoulou O, Riemenschneider M, Xue J, Bertheloot D, Freise N, Spiekermann C, Witten A, Viemann D, Kirschnek S, Stoll M, Latz E, Schultze JL, Roth J, Vogl T (2015) Transcriptome assessment reveals a dominant role for TLR4 in the activation of human phagocytes by the alarmin MRP8. J Immunol 194: 575-583. (doi/10.4049/jimmunol.1401085.)
    • Frye M, Dierkes M, Küppers V, Vockel M, Tomm J, Zeuschner D, Roissant J, Zarbock A, Koh GY, Peters K, Nottebaum AF, Vestweber D (2015) Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin. J Exp Med 212: 2267-2287.
    • Germena G, Volmering S, Sohlbach C, Zarbock A. Mutation in the CD45 inhibitory wedge modulates integrin activation and leukocyte recruitment during inflammation. J Immunol. 2015,15;194:728.
    • Hallmann R, Zhang X, Di Russo J, Li L, Song J, Hannocks M-J, Sorokin L (2015) The regulation of immune cell trafficking by the extracellular matrix. Curr Opin Cell Biol 36: 54-61.
    • Herold M, Posevitz V, Chudyka D, Hucke S, Groß C, Kurth F, Leder C, Loser K, Kurts C, Knolle P, Klotz L, Wiendl H (2015) Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway. J Immunol. 195(8):3584-95. (doi: 10.4049/jimmunol.1402746. Epub 2015 Sep 16).
    • Hillgruber C, Pöppelmann B, Weishaupt C, Steingräber AK, Wessel F, Berdel WE, Gessner JE, Ho-Tin-Noé B, Vestweber D*, Goerge T*(2015) Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia. J Exp Med 212: 1255-1266. (*equal contribution)
    • Holzinger D, Fassl SK, de Jager W, Lohse P, Rohrig UF, Gattorno M, Omenetti A, Chiesa S, Schena F, Austermann J, Vogl T, Kuhns DB, Holland SM, Rodriguez-Gallego C, Lopez-Almaraz R, Arostegui JI, Colino E, Roldan R, Fessatou S, Isidor B, Poignant S, Ito K, Epple HJ, Bernstein JA, Jeng M, Frankovich J, Lionetti G, Church JA, Ong PY, LaPlant M, Abinun M, Skinner R, Bigley V, Sachs UJ, Hinze C, Hoppenreijs E, Ehrchen J, Foell D, Chae JJ, Ombrello A, Aksentijevich I, Sunderkoetter C, Roth J (2015) Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases. J Allergy Clin Immunol 136: 1337-1345.
    • Höfling S, Grabowski B, Norkowski S, Schmidt MA, Rüter C. (2015) Current activities of the Yersinia effector protein YopM. Int J Med Microbiol., Apr 1., pii: S1438-4221(15)00028-4. doi: 10.1016/j.ijmm.2015.03.009. [Epub ahead of print] PMID:25865799
    • Klenner L, Hafezi W, Clausen BE, Lorentzen EU, Luger TA, Beissert S, Kühn JE, Loser K (2015) Cutaneous RANK-RANKL signaling upregulates CD8-mediated antiviral immunity during Herpes simplex virus infection by preventing virus-induced Langerhans Cell apoptosis. J Invest Dermatol 135: 2676-2687.
    • Kunsmann L, Rüter C, Bauwens A, Greune L, Glüder M, Kemper B, Fruth A, Wai SN, He X, Lloubes R, Schmidt MA, Dobrindt U, Mellmann A, Karch H, Bielaszewska M (2015) Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain. Sci Rep 5: 13252.
    • Liu Z, Xu Y, Zhang X, Song J, Sorokin L, Bähler M (2015) The motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery. J Neuroimmunol 282: 25-32.
    • Matzat T, Sieglitz F, Kottmeier R, Babatz F, Engelen D, Klämbt C (2015) Axonal wrapping in the Drosophila PNS is controlled by glia-derived neuregulin homolog Vein. Development 142: 1336-1345.
    • Momic T, Katzhendler J, Shai E, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Varon D, Lazarovici P (2015) Vipegitide: A folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity. Drug Des Devel Ther 9: 291-304.
    • Pruenster M, Kurz ARM, Chung KJ, Cao-Ehlker X, Bieber S, Nussbaum CF, Bierschenk S, Eggersmann TK, Rohwedder I, Heinig K, Immler R, Moser M, Koedel U, Gran S, McEver RP, Vestweber D, Verschoor A, Leandersson T, Chavakis T, Roth J, Vogl T,* Sperandio M* (2015) Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion. Nat Commun. 6:6915.
    • Silva IT, Carvalho A, Lang KL, Dudek SE, Masemann D, Durán FJ, Duran FJ, Caro MSB, Rapp UR, Wixler V, Schenkel EP, Simões CMO, Ludwig S (2015) In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B. PLoS ONE 10(2): e0117794. (doi:10.1371/journal.pone.0117794) 
    • Stadtmann A, Block H, Volmering S, Abram C, Sohlbach C, Boras M, Lowell CA, Zarbock A. (2015) Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment. J Immunol. 2015 Aug 1;195(3):1152-61.
    • Song J, Wu C, Agrawal S, Korpos E, Wang Y, Faber C, Schäfers M, Körner H, Opdenakker G, Hallmann R, Sorokin L (2015) Focal MMP-2 and MMP-9 activity at the blood-brain barrier (BBB) promotes chemokine-induced leukocyte migration. Cell Reports 10 (7): 1040-1054. [doi: 10.1016/j.celrep.2015.01.037] Epub 2015 Feb 19.
    • Van Crombruggen K, Vogl T, Pérez-Novo C, Holtappels G, Bachert C (2015) Differential release and deposition of S100A8/A9 proteins in inflamed upper airway tissue. Eur Respir J, in press [Oct 22. pii: ERJ-00159-2015. doi:10.1183/13993003.00159-2015].
    • Volmering S, Block H, Boras M, Lowell C, Zarbock A, The neutrophil Btk signalosome regulates multiple Mac-1 integrin activation events involved in neutrophil recruitment and functions during sterile inflammation. Immunity. Accepted for publication 2015.
    • Volkenhoff A, Weiler A, Letzel M, Stehling M, Klämbt C, Schirmeier S (2015) Glial glycolysis is essential for neuronal survival in Drosophila. Cell Metab 22: 437-447.
    • Wache C, Klein M, Ostergaard C, Angele B, Häcker H, Pfister HW, Pruenster M, Sperandio M, Leanderson T,Roth J, Vogl T, Koedel U (2015) Myeloid-related protein 14 promote inflammation and injury in meningitis. J Infect Dis (in press).  (pii: jiv028. Epub ahead of print)
    • Warnking K, Klemm C, Löffler B, Niemann S, van Krüchten A, Peters G, Ludwig S, Ehrhardt C (2015) Super-infection with Staphylococcus aureus inhibits influenza virus-induced type I IFN signaling through impaired STAT1-STAT2 dimerization. Cell Microbiol 17 (3): 303-317. [doi: 10.1111/cmi.12375. Epub 2014 Nov 19]
    • Wehmeyer C, Frank S, Beckmann D, Böttcher M, Cromme C, König U, Fennen M, Held A, Paruzel P, Hartmann C, Stratis A, Korb-Pap A, Kamradt T, Kramer I, van den Berg W, Kneissel M, Pap T, Dankbar B (2015) Sclerostin inhibition promotes inflammatory joint destruction through enhanced activation of TNFR-mediated 151lanning151g. Sci Transl Med. (accepted)
  • Publikationen 2014

    • Austermann J, Friesenhagen J, Fassl SK, Ortkras T, Burgmann J, Barczyk-Kahlert K, Faist E, Zedler S, Pirr S, Rohde C, Müller-Tidow C, von Köckritz-Blickwede M, von Kaisenberg CS, Flohé SB, Ulas T, Schultze JL, Roth J, Vogl T, Viemann D (2014) Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions.Cell Rep 9(6): 2112-2123. (doi: 10.1016/j.celrep.2014.11.020. Epub 2014 Dec 11)
    • Bäumer N, Krause A, Köhler G, Lettermann S, Evers G, Hascher A, Bäumer S, Berdel WE, Müller-Tidow C, Tickenbrock L (2014) Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions. PLoS One 9 (4): e94993. [doi: 10.1371/journal.pone.0094993. eCollection 2014]
    • Bielaszewska M, Schiller R, Lammer L, Bauwens A, Fruth A, Middendorf B, Schmidt MA, Tarr PI, Dobrindt U, Karch H, Mellmann A (2014) Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6. EMBO Mol Med 6: 347-357. (IF 10,3)
    • Bittner S, Ruck T, Göbel K, Henschel C, Afzali AM, Göb E, Müntefering T, Kleinschnitz C, Wiendl H, Meuth SG (2014) Effects of Glatiramer Acetate in a Spontaneous Model of Autoimmune Neuroinflammation. Am J Pathol 184(7): 2056-2065. (doi: 10.1016/j.ajpath.2014.03.009)
    • Bolas G, de Rezende FF, Lorente C, Sanz L, Eble JA, Calvete JJ (2014) Inhibitory effects of recombinant RTS-jerdostatin on integrin α1β1 function during adhesion, migration and proliferation of rat aortic smooth muscle cells and angiogenesis. Toxicon 79: 45-54.
    • Börgeling Y, Schmolke M, Viemann D, Nordhoff C, Roth J, Ludwig S (2014) Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection. J Biol Chem 289(1): 13-27.
    • Breuer J*, Schwab N*, Schneider-Hohendorf T, Marziniak M, Mohan H, Bhatia U, Gross CC,Clausen BE, Weishaupt C, Luger TA, Meuth SG, Loser K*, Wiendl H* (2014) Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity. Ann Neurol 75: 739-758. *equal contribution.
    • Dierkes R, Warnking K, Liedmann S, Seyer R, Ludwig S, Ehrhardt C (2014) The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity. PloS one 9: e88520.
    • Herter JM, Rossaint J, Spieker T, Zarbock A (2014) Adhesion molecules involved in neutrophil recruitment during sepsis-induced acute kidney injury. J Innate Immun 6(5): 597-606. [doi: 10.1159/000358238. Epub 2014 Feb 25.]
    • Hoerr V, Faber C (2014) Magnetic resonance imaging characterization of microbial infections. J Pharm Biomed Anal 93: 136-146.
    • Holzinger D, Nippe N, Vogl T, Marketon K, Mysore V, Weinhage T, Dalbeth N, Pool B, Merriman T, Baeten D, Ives A, Busso N, Foell D, Bas S, Gabay C, Roth J (2014) Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout. Arthritis Rheumatol 66: 1327-1339.
    • Köther K, Nordhoff C, Masemann D, Varga G, Bream JH, Gaestel M, Wixler V, Ludwig S (2014) MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection. FASEB J 28: 4235-4246.
    • Köves B, Salvador E, Grönberg-Hernandez J, Zdziarski J, Wullt B, Svanborg C, Dobrindt U (2014) Rare emergence of symptoms during long-term asymptomatic E. coli 83972 carriage, without altered virulence factor repertoire. J Urol 191: 519-528. doi:10.1016/j.juro.2013.07.060.
    • Liedmann S, Hrincius ER, Anhlan D, McCullers JA, Ludwig S, Ehrhardt C (2014) New virulence determinants contribute to the enhanced immune response and reduced virulence of an influenza A virus A/PR8/34 variant. J Infect Dis 209: 532-541.
    • Liedmann S, Hrincius ER, Guy C, Anhlan D, Dierkes R, Carter R, Wu G, Staeheli P, Green DR, Wolff T, McCullers JA, Ludwig S, Ehrhardt C (2014) Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions. Nature Comm 5: 5645.
    • Limmer S, Weiler A, Volkenhoff A, Babatz F, Klämbt C (2014) The Drosophila blood-brain barrier: development and function of a glial endothelium. Front Neurosci 8: 365. [Stefanie Schirmeier, neé Limmer]
    • Lubos M-L, Norkowski S, Stolle A-S, Langel Ü, Schmidt MA, Rüter C (2014) Analysis of T3SS-independent autonomous internalization of the bacterial effector protein SspH1 from Salmonella typhimurium. Inflammation & Cell Signaling 1: e423. [doi: 10.14800/ics.423]
    • Momic T, Katzehendler J, Benny O, Lahiani A, Cohen G, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Lazarovici P (2014) Vimocin and vidapin, cyclic KTS peptides, are dual antagonists of α1β1/α2β1 integrins with antiangiogenic activity. J Pharmacol Exp Ther 350: 506-519.
    • Musumeci L, Kuijpers MJ, Gilio K, Hego A, Théâtre E, Maurissen L, Vandereyken M, Diogo CV, Lecut C, Guilmain W, Bobkova EV, Rascon J, Eble JA, Dahl R, Drion P, Mostofi Y, Yuan H, Sergienko E, Chung TD, Thiry M, Senis Y, Moutschen M, Mustelin T, Lancellotti P, Heemskerk JW, Tautz L, Oury C, Rahmouni S (2014) DUSP3 phosphatase deficiency or inhibition limit platelet activation and arterial thrombosis. Circulation (in press). [CIRCULATIONAHA.114.010186. Epub ahead of print]
    • Nacken W, Anhlan D, Hrincius ER, Mostafa A, Wolff T, Sadewasser A, Pleschka S, Ehrhardt C, Ludwig S (2014) Activation of c-jun N-terminal kinase upon Influenza A Virus (IAV) infection is independent of pathogen related receptors, but dependent on amino acid sequence variations of the IAV NS1. J Virol, 88: 8843-8852.
    • Poeter M, Brandherm I, Rossaint J, Rosso G, Shahin V, Skryabin BV, Zarbock A, Gerke V, Rescher U (2014) Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63. Nat Commun 5: 3738. [doi: 10.1038/ncomms4738.]
    • Rüter C, Ruiz Silva M, Grabowski B, Lubos M-L, Scharnert J, Poceva M, von Tils D, Flieger A, Heesemann J, Bliska JB, Schmidt MA (2014) Rabbit monoclonal antibodies directed at the T3SS effector protein YopM identify human pathogenic Yersinia isolates. Int J Med Microbiol 304: 444–451.
    • Schmidt R, Nippe N, Strobel K, Masthoff M, Reifschneider O, Castelli DD, Höltke C, Aime S, Karst U, Sunderkötter C, Bremer C, Faber C (2014) Highly Shifted Proton MRI - Cell tracking by direct detction of paramagnetic compounds. Radiology 272(3): 785-795. (doi: 10.1148/radiol.14132056. Epub 2014 May 18) 
    • Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H (2014) VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med 211 (9): 1833-1846. (doi: 10.1084/jem.20140540)
    • Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nácher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi MD, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A (2014) Neutrophils scan for activated platelets to initiate inflammation. Science 346(6214): 1234-1238.
    • Vogl T, Eisenblätter M, Völler T, Zenker S, Hermann S, van Lent P, Faust A, Geyer C, Petersen B, Roebrock K, Schäfers M, Bremer C, Roth J (2014) Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity. Nat Commun 5: 4593. [doi: 10.1038/ncomms5593]
    • Warnking K, Klemm C, Löffler B, Niemann S, van Krüchten A, Peters G, Ludwig S, Ehrhardt C (2014). Super-infection with Staphylococcus aureus inhibits influenza virus-induced type I IFN signalling through impaired STAT1-STAT2 dimerization. Cell Microbiol (in press). [ doi: 10.1111/cmi.12375. Epub ahead of print].
  • Publikationen 2013

    • Bielaszewska M, Rüter C, Kunsmann L, Greune L, Bauwens A, Zhang W, Kuczius T, Kim KS, Mellmann A, Schmidt MA, Karch H (2013) Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis. PLoS Pathog 9: e1003797. doi: 10.1371/journal.ppat.1003797.
    • Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Göbel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H, Meuth SG (2013) Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nature Med 19 (9):  1161-1169. (doi:10.1038/nm.3303)
    • Foell D, Wittkowski H, Kessel C, Lüken A, Weinhage T, Varga G, Vogl T, Wirth T, Viemann D, Björk P, van Zoelen MAD, Gohar F, Srikrishna G, Kraft M, Roth J (2013) Pro-inflammatory S100A12 can activate human monocytes via Toll-like Receptor 4. Am J Respir Crit Care Med 187: 1324-1334. [IF: 11.04]
    • Ghavampour S, Lange C, Bottino C, Gerke V (2013) Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration. PLOS One 8 (9): e73981.
    • Gopal R, Monin L, Torres D, Slight S, Mehra S, McKenna K, Fallert-Junecko BA, Reinhart TA, Kolls J, Báez-Saldaña R, Cruz-Lagunas A, Rodríguez-Reyna TS, Kumar NP, Tessier P, Roth J, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Cumming B, Kasprowicz VO, Steyn AJ, Babu S, Kaushal D, Zúñiga J, Vogl T, Rangel-Moreno J, Khader SA (2013) S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis. Am J Respir Crit Care Med 188: 1137-1146. [IF: 11.04]
    • Herter JM, Rossaint J, Block H, Welch H, Zarbock A (2013) Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling. Blood 121(12): 2301-2310.
    • Hoerr V, Tuchscherr L, Hüve J, Nippe N, Loser K, Glyvuk N, Tsytsyura Y, Holtkamp M, Sunderkötter C, Karst U, Klingauf J, Peters G, Löffler B, Faber C (2013) Bacteria tracking by in vivo magnetic resonance imaging. BMC Biol 11: 63. [doi: 10.1186/1741-7007-11-63]
    • Kuipers MT*, Vogl T*, Aslami H, Jongsma G, van den Berg E, Vlaar APJ, Roelofs JJTH, Juffermans NP, Schultz MJ, van der Poll T, Roth J, Wieland CW (2013) High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling. PLoS One 8: e68694. [IF: 3.73] * Both authors made equal contributions.
    • Löffler B, Niemann S, Ehrhardt C, Horn D, Lanckohr C, Lina G, Ludwig S, Peters G (2013) Pathogenesis of Staphylococcus aureus necrotizing pneumonia: the role of PVL and an influenza coinfection. Expert Rev Anti Infect Ther 11: 1041-1051.
    • Michaelis UR, Chavakis E, Kruse C, Jungblut B, Kaluza D, Wandzioch K, Manavski Y, Heide H, Santoni MJ, Potente M, Eble JA, Borg JP, Brandes RP (2013) The polarity protein Scrib is essential for directed endothelial cell migration. Circ Res 112: 924-934.
    • Musiol A, Gran S, Ehrhardt C, Ludwig S, Grewal T, Gerke V, Rescher U (2013) Annexin A6-balanced late endosomal cholesterol controls Influenza A replication and propagation. MBio 4(6): e00608-13. (doi: 10.1128/mBio.00608-13)
    • Nikolic I, Stankovic ND, Bicker F, Meister J, Braun H, Awwad K, Baumgart J, Simon K, Thal SC, Patra C, Harter PN, Plate KH, Engel FB, Dimmeler S, Eble JA, Mittelbronn M, Schafer MK, Jungblut B, Chavakis E, Fleming I, Schmidt MH (2013) EGFL7 ligates αvβ3 integrin to enhance vessel formation. Blood 121: 3041-3050.
    • Niland S, Ditkowski B, Parrandier D, Roth L, Augustin H, Eble JA (2013) Rhodocetin-αβ-induced neuropilin-1-cMet association triggers restructuring of matrix contacts in endothelial cells. Arterioscler Thromb Vasc Biol 33: 544-554.
    • Petersen B, Wolf M, Austermann J, van Lent PLEM, Foell D, Ahlmann M, Kupas V, Loser K, Sorg C, Roth J, Vogl T(2013) The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. EMBO J 32: 100-111. [IF: 9.82]
    • Revelles O, Millard P, Nougayrède J-P, Dobrindt U, Oswald E, Létisse F, Portais J-C (2013) The Carbon storage regulator (Csr) system exerts a nutrient-specific control over central metabolism in Escherichia coli strain Nissle 1917. PLoS One 8: e66386.
    • Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PL, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V. (2013) Doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice results in psoriasislike arthritis. Arthritis Rheum. 65(9):2290-300
    • Rüter C, Hardwidge PR (2013) 'Drugs from Bugs': bacterial effector proteins as promising biological (immune-) therapeutics. FEMS Microbiol Lett 351: 126-132. (cover)
    • Seelige R, Natsch C, März S, Jing D, Frye M, Butz S, Vestweber D (2013) Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo. J Immunol 190: 892-896.
    • Song J, Wu C, Zhang X, Sorokin L (2013) In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1β-induced peritonitis. J Immunol 190: 401-410.
    • Sváb D, Horváth B, Maróti G, Dobrindt U, Tóth I (2013) Sequence variability of P2-like prophage genomes carrying the cytolethal distending toxin V operon in Escherichia coli O157. Appl Environ Microbiol 79: 4958-4964.
    • Zhang X, Wu C, Jian Song, Götte M, Sorokin L (2013) Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis. J Immunol 191: 4551-4561.

       

  • Publikationen 2012

    • Holzinger D, Gieldon L, Mysore V, Nippe N, Taxman D, Duncan JA, Broglie PM, Marketon K, Austermann J, Vogl T, Foell D, Niemann S, Peters G, Roth J, Löffler B (2012) Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome. J Leukoc Biol 92: 1069-1081. [IF: 4.56]
    • Kusuma N, Denoyer D, Eble JA, Redvers RP, Parker BS, Pelzer R, Anderson RL, Pouliot N (2012) Integrindependent response to laminin-511 regulates breast tumor cell invasion and metastasis. Int J Cancer 130: 555-566.
    • Nacken W, Ehrhardt C, Ludwig S (2012) Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A viruses. Biol Chem 393: 525-534.
    • Niemann S, Ehrhardt C, Medina E, Warnking K, Tuchscherr L, Heitmann V, Ludwig S, Peters GLöffler B. Combined action of influenza virus and Staphylococcus aureus panton-valentine leukocidin provokes severe lung epithelium damage. J Infect Dis 206(7): 1138-1148. [doi: 10.1093/infdis/jis468.]
    • Niland S, Eble JA (2012) Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation. J Oncol 2012: 125278.
    • Rossaint J, Berger C, Van Aken H, Scheld HH, Zahn PK, Rukosujew A, Zarbock A (2012) Cardiopulmonary bypass during cardiac surgery modulates systemic inflammation by affecting different steps of the leukocyte recruitment cascade. PLoS One 7(9): e45738.

       

  • Buchartikel

    • Dejana E, Vestweber D (2013) The Role of VE-cadherin in Vascular Morphogenesis and Permeability Control. In: The Molecular Biology of Cadherins. F. v. Roy, ed Elsevier, 116: 119-144.

    Grafik © Raphael Fehrmann