Nanomedicine and pharmacology

Breaking the NPC barrier for non-viral gene therapy and
for nuclear delivery of therapeutic nanoparticles into non-dividing cells.

V. Shahin
, I. Liashkovich, G. Rosso

 

The presence of a tight NPC barrier poses a major hurdle for nuclear delivery of therapeutic nanoparticles, for instance for gene therapy or cancer treatment. We are interested in the design of different strategies and drugs targeted at breaking the NPC barrier in a controlled and reversible manner.

 

H. Andersen et al., 2016, Journal of Controlled Release

I. Liashkovich et al., 2012, Journal of Controlled Release