The role of GABAergic transmission and chloride homeostasis in pain development and processing

Tobias Schmidt, Nikoo Ghaffarian Shoaee

Chronic pain, which originates from a peripheral nerve injury, causes an inadequate sensitization on subthreshold stimuli at both the peripheral and the central level. It has been proposed that a disturbed chloride homeostasis contributes to the development of chronic pain. Changes in chloride homeostasis have been addressed in detail at the spinal level, but the supraspinal level, and in particular the thalamus, which plays a key role in central pain processing, has been largely ignored. The aim of this study is to investigate the region-specific regulation of chloride homeostasis in sub-nuclei of the thalamus and its contribution to the development of chronic pain.

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