Pathways and mechanisms of NPY and Y2 receptors for controlling conditioned fear

Neuropeptide systems, such as neuropeptide Y (NPY), are promising targets for the modulation of anxiety-related disorders. High expression of the Y2 subtype of NPY receptors is found in the bed nucleus of the stria terminalis (BNST), which is part of the extended amygdala playing a crucial role in transforming fear to anxiety and pathological states. Here, we use optogenetics, electrophysiological and behavioral studies in mice and Y2 genetic mouse lines to identify the impact of Y2 receptors in amygdala-BNST pathways. Results will help to understand the usefulness of NPY and Y2 receptors as therapeutic targets.