Optogentic control of epileptic seizures in a network mapped by simultaneous calcium recordings and fMRI.

Control of epileptic seizures may be achieved by targeting nodes and choke points of epileptic networks. The impact of optogenetic interference at seizure hubs is characterized and optimized in brain slices. Electrical stimulation of the internal capsule (IC) induces rhythmic activity in thalamic slices recorded extracellularly in the ventrobasal thalamic complex (VB) under control conditions and during application of bicuculline. The influence of optogentic interference is investigated