Special model: Drosophila melanogaster


Drosophila melanogaster as model in neuroscience and neuropathology

We strongly feel that Drosophila represents a fascinating and extremely versatile model for studying pathogenesis of neurological disease as well as for exploring interactions between brain, behavior and environment. This is the reason why we have established a Drosophila lab in our institute building. We are experimentally using the fly in various areas, including neurooncology, neurodegeneration, neurotoxicology and lifestyle neuropathology.
Drosophila melanogaster, as a model organism, offers several advantages, including easy handling, rapid generation time, low cost, and a wide armamentarium of genetic techniques. Many molecular pathways are conserved between invertebrates and humans. Furthermore, Drosophila can be used in neuropharmacological experiments because this organism is amenable to external/food application, inhalation, or injection of substances in a large number of wild type or mutant animals.

Figure 1: The Drosophila lab in the Institute of Neuropathology


Selected publications:

  1. Ruland C, Berlandi J, Eikmeier K, Weinert T, Lin FJ, Ambree O, Seggewiss J, Paulus W, Jeibmann A
    Decreased Cerebral Irp-1B Limits Impact of Social Isolation in Wildtype and Alzheimer's Disease Modelled in Drosophila melanogaster. Genes Brain Behav. 2017 Dec 18. doi: 10.1111/gbb.12451. [Epub ahead of print]
  2. Berlandi J, Lin FJ, Ambrée O, Rieger D, Paulus W, Jeibmann A
    Swing Boat: Inducing and Recording Locomotor Activity in a Drosophila melanogaster Model of Alzheimer's Disease. Front Behav Neurosci. 2017 Aug 30;11:159
  3. Niehoff AC, Schulz J, Soltwisch J, Meyer S, Kettling H, Sperling M, Jeibmann A, Dreisewerd K, Francesconi KA, Schwerdtle T, Karst U
    Imaging by Elemental and Molecular Mass Spectrometry Reveals the Uptake of an Arsenolipid in the Brain of Drosophila melanogaster. Anal Chem. 2016 May 17;88(10):5258-63
  4. Niehoff AC, Bauer OB, Kröger S, Fingerhut S, Schulz J, Meyer S, Sperling M, Jeibmann A, Schwerdtle T, Karst U
    Quantitative Bioimaging to Investigate the Uptake of Mercury Species in Drosophila melanogaster. Anal Chem. 2015 Oct 20;87(20):10392-6
  5. Meyer S, Schulz J, Jeibmann A, Taleshi MS, Ebert F, Francesconi KA, Schwerdtle T
    Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster. Metallomics. 2014 Nov;6(11):2010-4
  6. Jeibmann A, Halama K, Witte HT, Kim SN, Eikmeier K, Koos B, Klämbt C, Paulus W
    Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. J Neurooncol. 2015 Sep;124(3):373-83
  7. Kim SN, Jeibmann A, Halama K, Witte HT, Wälte M, Matzat T, Schillers H, Faber C, Senner V, Paulus W, Klämbt C
    ECM stiffness regulates glial migration in Drosophila and mammalian glioma models. Development. 2014 Aug;141(16):3233-42
  8. Jeibmann A, Eikmeier K, Linge A, Kool M, Koos B, Schulz J, Albrecht S, Bartelheim K, Frühwald MC, Pfister SM, Paulus W, Hasselblatt M
    Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster. Nat Commun. 2014 Jun 3;5:4005
  9. Witte HT, Jeibmann A, Klämbt C, Paulus W
    Modelling glioma growth and invasion in Drosophila melanogaster. Neoplasia 11(9): 882-8 (2009)
  10. Jeibmann A, Paulus W
    Drosophila melanogaster as model organism of brain diseases. Int J Mol Sci 10: 407 (2009)


Astrid Jeibmann (Email)