Methodisches Oberseminar - Mendelian Randomization: "Mendelian randomization: How can genetics guide the design of clinical trials", by Dr. Stephen Burgess
Guest speaker: Dr. Stephen Burgess, MRC Biostatistics Unit, University of Cambridge, Cambridge (United Kingdom)
Topic: Mendelian randomization: How can genetics guide the design of clinical trials
Abstract: When considering whether an exposure is a causal risk factor for an outcome, evidence from randomized trials is reliable but typically slow or impractical to gather, whereas evidence from conventional observational studies is often unreliable, as it is subject to bias from confounding and reverse causation. Mendelian randomization is an example of a quasi-experimental approach: it is analogous to a randomized trial, but relies on nature doing the randomization for us.
Mendelian randomization can be implemented rapidly for a range of exposures to provide insights about causal relationships that can prioritize or deprioritize exposures for further investigation. In this talk, I will present and discuss methods and examples that enable detailed Mendelian randomization analyses to inform the design of trials so that collection of randomized evidence can be as informative as possible: enabling trial interventions to target the right mechanism in the right population group at the right time.
Time and date: Monday, February 27, 2023, 2:00 pm
Online: This lecture will be transmitted via zoom only. https://wwu.zoom.us/j/65213385215
If you have any questions, please contact Hanna Wesselmann.
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