Dr. med. Heike Minnerup (geb. Wersching), MSc (Epidemiology)

Wissenschaftliche Mitarbeiterin
  • Kontakt

    Kontakt

    Dr. med. Heike Minnerup (geb. Wersching), MSc (Epidemiology)
    Wissenschaftliche Mitarbeiterin

    Institut für Epidemiologie und Sozialmedizin der Universität
    Albert-Schweitzer-Campus 1,
    Gebäude D3
    Anfahrt: Domagkstraße 3
    D-48149 Münster

    Tel.: +49 251 83 56086
    h.minnerup@uni-muenster.de

  • Beruflicher und akademischer Werdegang

    Hochschulbildung

    1997 ‑ 2004 Studium der Humanmedizin, Ernst-Moritz-Arndt-Universität Greifswald
    2004 Dissertation, Institut für Medizinische Biochemie und Molekularbiologie, Ernst-Moritz-Arndt-Universität Greifswald
    2009 ‑ 2011 Master of Science (MSc) in Epidemiologie, Harvard School of Public Health, Harvard University, Boston

    Beruflicher Werdegang

    09/2004 ‑ 01/2005 ÄiP/ Assistenzärztin, Abteilung für Neurologie, Allgemeines Krankenhaus Harburg, Hamburg
    02/2005 ‑ 07/2009 Assistenzärztin / wissenschaftliche Mitarbeiterin, Klinik und Poliklinik für Neurologie, Universitätsklinikum Münster
    08/2009 ‑ 11/2011 Wissenschaftliche Mitarbeiterin, Koordinatorin der BMBF-geförderten Langzeitstudie ‚BiDirect‘, Institut für Epidemiologie und Sozialmedizin, Westfälische Wilhelms-Universität Münster
    12/2011 ‑ 11/2012 Assistenzärztin / wissenschaftliche Mitarbeiterin, Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Münster
    Seit 12/2012 Wissenschaftliche Mitarbeiterin, Leiterin der Arbeitsgruppe „Population Imaging“ am Institut für Epidemiologie und Sozialmedizin, Westfälische Wilhelms-Universität Münster
    Seit 08/2013 Fachärztin für Neurologie
  • Aktuelle Projekte

    Aktuelle Projekte

    2012 ‑ 2018 Bundesministerium für Bildung und Forschung (BMBF): Nachwuchs-gruppe in der Epidemiologie zum Thema ‘Gender differences in the aging brain – patterns, mechanisms and consequences’ (Projektleitung)
    2018 ‑ 2020 Bundesamt für Strahlenschutz (BfS): Evaluation der Brustkrebsmortalität im deutschen Mammographie-Screening-Programm, 1. Teil der Haupt-studie (Projektleitung)
    2016 ‑ 2021 Bundesministerium für Bildung und Forschung (BMBF): Langzeitstudie “BiDirect - Die bidirektionale Analyse der Beziehung zwischen subklinischer Arteriosklerose und der Depression“
  • Mitgliedschaften in wissenschaftlichen Gremien / aktuelle Stipendien

    Mitgliedschaften in wissenschaftlichen Gremien / aktuelle Stipendien

    Seit 2009 Deutsche Gesellschaft für Epidemiologie (DGEpi), seit 2016 (Ko-)Sprecherin der AG Neurologische und Psychische Erkrankungen
    2017 ‑ 2018 Stipendiatin des Förderprogramms „Erstklassig!“ für Nachwuchswissenschaftlerinnen der Universität Münster
  • Publikationen

    Publikationen

    • Feder S, Sundermann B, Wersching H, Teuber A, Kugel H, Teismann H, Heindel W, Berger K, Pfleiderer B.
      Sample heterogeneity in unipolar depression as assessed by functional connectivity analyses is dominated by general disease effects.
      J Affect Disord. 2017; 222:79-87. PMID: 28679115

    • Wersching H, Gardener H, Sacco RL.
      Sugar-Sweetened and Artificially Sweetened Beverages in Relation to Stroke and Dementia: Are Soft Drinks Hard on the Brain?
      Stroke. 2017; 48(5):1129-1131. PMID: 28428347

    • Diederich K, Bastl A, Wersching H, Teuber A, Strecker JK, Schmidt A, Minnerup J, Schäbitz WR.
      Effects of Different Exercise Strategies and Intensities on Memory Performance and Neurogenesis.
      Front Behav Neurosci. 2017; 11:47. PMID: 28360847

    • Opel N, Redlich R, Kaehler C, Grotegerd D, Dohm K, Heindel W, Kugel H, Thalamuthu A, Koutsouleris N, Arolt V, Teuber A, Wersching H, Baune BT, Berger K, Dannlowski U.
      Prefrontal gray matter volume mediates genetic risks for obesity.
      Mol. Psychiatry. 2017; 22(5):703-710. PMID: 28348383

    • Hermesdorf M, Berger K, Szentkirályi A, Schwindt W, Dannlowski U, Wersching H.
      Reduced fractional anisotropy in patients with major depressive disorder and associations with vascular stiffness.
      Neuroimage Clin. 2017; 14:151-155. PMID: 28180073

    • Fisse AL, Kemmling A, Teuber A, Wersching H, Young P, Dittrich R, Ritter M, Dziewas R, Minnerup J.
      The Association of Lesion Location and Sleep Related Breathing Disorder in Patients with Acute Ischemic Stroke.
      PLoS ONE. 2017; 12(1):e0171243. PMID: 28135315

    • Kleffner I, Dörr J, Ringelstein M, Gross CC, Böckenfeld Y, Schwindt W, Sundermann B, Lohmann H, Wersching H, Promesberger J, von Königsmarck N, Alex A, Guthoff R, Frijns CJ, Kappelle LJ, Jarius S, Wildemann B, Aktas O, Paul F, Wiendl H, Duning T, .
      Diagnostic criteria for Susac syndrome.
      J. Neurol. Neurosurg. Psychiatr.. 2016; 87(12):1287-1295. PMID: 28103199

    • Sundermann B, Feder S, Wersching H, Teuber A, Schwindt W, Kugel H, Heindel W, Arolt V, Berger K, Pfleiderer B.
      Diagnostic classification of unipolar depression based on resting-state functional connectivity MRI: effects of generalization to a diverse sample.
      J Neural Transm (Vienna). 2017; 124(5):589-605. PMID: 28040847

    • Minnerup J, Broocks G, Kalkoffen J, Langner S, Knauth M, Psychogios MN, Wersching H, Teuber A, Heindel W, Eckert B, Wiendl H, Schramm P, Fiehler J, Kemmling A.
      Computed tomography-based quantification of lesion water uptake identifies patients within 4.5 hours of stroke onset: A multicenter observational study.
      Ann. Neurol.. 2016; 80(6):924-934. PMID: 28001316

    • Khil L, Rahe C, Wellmann J, Baune BT, Wersching H, Berger K.
      Association between major depressive disorder and odor identification impairment.
      J Affect Disord. 2016; 203:332-8. PMID: 27318533

    • Minnerup J, Wersching H, Teuber A, Wellmann J, Eyding J, Weber R, Reimann G, Weber W, Krause LU, Kurth T, Berger K, .
      Outcome After Thrombectomy and Intravenous Thrombolysis in Patients With Acute Ischemic Stroke: A Prospective Observational Study.
      Stroke. 2016; 47(6):1584-92. PMID: 27217508

    • Teuber A, Sundermann B, Kugel H, Schwindt W, Heindel W, Minnerup J, Dannlowski U, Berger K, Wersching H.
      MR imaging of the brain in large cohort studies: feasibility report of the population- and patient-based BiDirect study.
      Eur Radiol. 2017; 27(1):231-238. PMID: 27059857

    • Hermesdorf M, Berger K, Baune BT, Wellmann J, Ruscheweyh R, Wersching H.
      Pain Sensitivity in Patients With Major Depression: Differential Effect of Pain Sensitivity Measures, Somatic Cofactors, and Disease Characteristics.
      J Pain. 2016; 17(5):606-16. PMID: 26867484

    • Hermesdorf M, Sundermann B, Feder S, Schwindt W, Minnerup J, Arolt V, Berger K, Pfleiderer B, Wersching H.
      Major depressive disorder: Findings of reduced homotopic connectivity and investigation of underlying structural mechanisms.
      Hum Brain Mapp. 2016; 37(3):1209-17. PMID: 26704348

    • Minnerup J, Wersching H, Unrath M, Berger K.
      Explaining the Decrease of In-Hospital Mortality from Ischemic Stroke.
      PLoS ONE. 2015; 10(7):e0131473. PMID: 26154704

    • Rahe C, Baune BT, Unrath M, Arolt V, Wellmann J, Wersching H, Berger K.
      Associations between depression subtypes, depression severity and diet quality: cross-sectional findings from the BiDirect Study.
      BMC Psychiatry. 2015; 15:38. PMID: 25886444

    • Teuber A, Tenberge JG, Kugel H, Deppe M, Berger K, Wersching H.
      Volume transition analysis: A new approach to resolve reclassification of brain tissue in repeated MRI scans.
      J. Neurosci. Methods. 2015. PMID: 25701591

    • Minnerup J, Trinczek B, Storck M, Hohenberger M, Wilpsbäumer S, Abdul-Rahim AH, Liesirova KT, Broeg-Morvay A, Meisterernst J, Lees KR, Mattle HP, Wersching H, Dziewas R, Schäbitz WR, Schilling M.
      Feasibility Platform for Stroke Studies: An Online Tool to Improve Eligibility Criteria for Clinical Trials.
      Stroke. 2014. PMID: 25395412

    • Teismann H, Wersching H, Nagel M, Arolt V, Heindel W, Baune BT, Wellmann J, Hense HW, Berger K.
      Establishing the bidirectional relationship between depression and subclinical arteriosclerosis - rationale, design, and characteristics of the BiDirect Study.
      BMC Psychiatry. 2014; 14(1):174. PMID: 24924233

    • Minnerup J, Wersching H, Schilling M, Schäbitz WR.
      Analysis of early phase and subsequent phase III stroke studies of neuroprotectants: outcomes and predictors for success.
      Exp Transl Stroke Med. 2014; 6(1):2. PMID: 24502346

    • Minnerup J, Wersching H, Unrath M, Berger K.
      Effects of emergency medical service transport on acute stroke care.
      Eur. J. Neurol.. 2014. PMID: 24471796

    • Speer P, Wersching H, Bruchmann S, Bracht D, Stehling C, Thielsch M, Knecht S, Lohmann H.
      Age- and gender-adjusted normative data for the German version of Rey's Auditory Verbal Learning Test from healthy subjects aged between 50 and 70 years.
      J Clin Exp Neuropsychol. 2013. PMID: 24341534

    • Forkert ND, Fiehler J, Suniaga S, Wersching H, Knecht S, Kemmling A.
      A Statistical Cerebroarterial Atlas Derived from 700 MRA Datasets.
      Methods Inf Med. 2013; 52(6):467-74. PMID: 24190179

    • Duning K, Wennmann DO, Bokemeyer A, Reissner C, Wersching H, Thomas C, Buschert J, Guske K, Franzke V, Flöel A, Lohmann H, Knecht S, Brand SM, Pöter M, Rescher U, Missler M, Seelheim P, Pröpper C, Boeckers TM, Makuch L, Huganir R, Weide T, Brand E, Pavenstädt H, Kremerskothen J.
      Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance.
      Transl Psychiatry. 2013; 3:e272. PMID: 23778582

    • Forkert ND, Suniaga S, Fiehler J, Wersching H, Knecht S, Kemmling A.
      Generation of a probabilistic arterial cerebrovascular atlas derived from 700 time-of-flight MRA datasets.
      Stud Health Technol Inform. 2012; 180:148-52. PMID: 22874170

    • Baune BT, Stuart M, Gilmour A, Wersching H, Heindel W, Arolt V, Berger K.
      The relationship between subtypes of depression and cardiovascular disease: a systematic review of biological models.
      Transl Psychiatry. 2012; 2:e92. PMID: 22832857

    • Ruscheweyh R, Deppe M, Lohmann H, Wersching H, Korsukewitz C, Duning T, Bluhm S, Stehling C, Keller SS, Knecht S.
      Executive performance is related to regional gray matter volume in healthy older individuals.
      Hum Brain Mapp. 2013; 34(12):3333-46. PMID: 22815223

    • Baune BT, Stuart M, Gilmour A, Wersching H, Arolt V, Berger K.
      Moderators of the relationship between depression and cardiovascular disorders: a systematic review.
      Gen Hosp Psychiatry. 0; 34(5):478-92. PMID: 22771109

    • Wersching H, Berger K.
      [New cohorts. The BiDirect study].
      Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012; 55(6):822-3. PMID: 22736162

    • Grabe HJ, Schulz A, Schmidt CO, Appel K, Driessen M, Wingenfeld K, Barnow S, Spitzer C, John U, Berger K, Wersching H, Freyberger HJ.
      [A brief instrument for the assessment of childhood abuse and neglect: the childhood trauma screener (CTS)].
      Psychiatr Prax. 2012; 39(3):109-15. PMID: 22422160

    • Kemmling A, Wersching H, Berger K, Knecht S, Groden C, Nölte I.
      Decomposing the Hounsfield unit: probabilistic segmentation of brain tissue in computed tomography.
      Clin Neuroradiol. 2012; 22(1):79-91. PMID: 22270832

    • Minnerup J, Ritter MA, Wersching H, Kemmling A, Okegwo A, Schmidt A, Schilling M, Ringelstein EB, Schäbitz WR, Young P, Dziewas R.
      Continuous positive airway pressure ventilation for acute ischemic stroke: a randomized feasibility study.
      Stroke. 2012; 43(4):1137-9. PMID: 22198979

    • Diederich K, Quennet V, Bauer H, Müller HD, Wersching H, Schäbitz WR, Minnerup J, Sommer C.
      Successful regeneration after experimental stroke by granulocyte-colony stimulating factor is not further enhanced by constraint-induced movement therapy either in concurrent or in sequential combination therapy.
      Stroke. 2012; 43(1):185-92. PMID: 22020031

    • Wersching H.
      Identifying the genetic contribution to ischemic stroke: in small steps to success.
      Stroke. 2011; 42(10):2716-7. PMID: 21940977

    • Wersching H.
      An apple a day keeps stroke away? Consumption of white fruits and vegetables is associated with lower risk of stroke.
      Stroke. 2011; 42(11):3001-2. PMID: 21921274

    • Minnerup J, Wersching H, Ringelstein EB, Heindel W, Niederstadt T, Schilling M, Schäbitz WR, Kemmling A.
      Prediction of malignant middle cerebral artery infarction using computed tomography-based intracranial volume reserve measurements.
      Stroke. 2011; 42(12):3403-9. PMID: 21903965

    • Czira ME, Wersching H, Baune BT, Berger K.
      Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population.
      Age (Dordr). 2012; 34(6):1529-41. PMID: 21898033

    • Minnerup J, Wersching H, Ringelstein EB, Schilling M, Schäbitz WR, Wellmann J, Berger K.
      Impact of the extended thrombolysis time window on the proportion of recombinant tissue-type plasminogen activator-treated stroke patients and on door-to-needle time.
      Stroke. 2011; 42(10):2838-43. PMID: 21852612

    • Laing KR, Mitchell D, Wersching H, Czira ME, Berger K, Baune BT.
      Brain-derived neurotrophic factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?
      Age (Dordr). 2012; 34(4):1011-22. PMID: 21695421

    • Minnerup J, Wersching H, Schäbitz WR.
      Erythropoietin for stroke treatment: dead or alive?
      Crit Care. 2011; 15(2):129. PMID: 21418552

    • Wersching H, Guske K, Hasenkamp S, Hagedorn C, Schiwek S, Jansen S, Witte V, Wellmann J, Lohmann H, Duning K, Kremerskothen J, Knecht S, Brand E, Floel A.
      Impact of common KIBRA allele on human cognitive functions.
      Neuropsychopharmacology. 2011; 36(6):1296-304. PMID: 21346737

    • Kleffner I, Wersching H, Schwindt W, Kuhlmann T, Keyvani K, Deppe M, Husstedt I.
      Triad of visual, auditory and corticospinal tract lesions: a new syndrome in a patient with HIV infection.
      AIDS. 2011; 25(5):659-63. PMID: 21252633

    • Pham TD, Salvetti F, Wang B, Diani M, Heindel W, Knecht S, Wersching H, Baune BT, Berger K.
      The hidden-Markov brain: comparison and inference of white matter hyperintensities on magnetic resonance imaging (MRI).
      J Neural Eng. 2011; 8(1):016004. PMID: 21248384

    • Kemmling A, Duning T, Lemcke L, Niederstadt T, Minnerup J, Wersching H, Marziniak M.
      Case report of MR perfusion imaging in sinking skin flap syndrome: growing evidence for hemodynamic impairment.
      BMC Neurol. 2010; 10:80. PMID: 20831824

    • Minnerup J, Kleffner I, Wersching H, Zimmermann J, Schäbitz WR, Niederstadt T, Dziewas R.
      Late Onset Postpartum Eclampsia: It is Really Never Too Late-A Case of Eclampsia 8 Weeks after Delivery.
      Stroke Res Treat. 2010; 2010. PMID: 20798839

    • Sakellaridou E, Wersching H, Reinholz J, Lohmann H, Knecht S.
      Comprehension of complex instructions deteriorates with age and vascular morbidity.
      Age (Dordr). 2011; 33(1):101-6. PMID: 20589439

    • Minnerup J, Wersching H, Diederich K, Schilling M, Ringelstein EB, Wellmann J, Schäbitz WR.
      Methodological quality of preclinical stroke studies is not required for publication in high-impact journals.
      J. Cereb. Blood Flow Metab.. 2010; 30(9):1619-24. PMID: 20517323

    • Minnerup J, Wersching H, Schäbitz WR.
      EPO for stroke therapy - Is there a future for further clinical development?
      Exp Transl Stroke Med. 2010; 2(1):10. PMID: 20459870

    • Wersching H, Duning T, Lohmann H, Mohammadi S, Stehling C, Fobker M, Conty M, Minnerup J, Ringelstein EB, Berger K, Deppe M, Knecht S.
      Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function.
      Neurology. 2010; 74(13):1022-9. PMID: 20350977

    • Pham TD, Elfiqi HZ, Knecht S, Wersching H, Baune BT, Berger K.
      Structural simplexity of the brain.
      J. Neurosci. Methods. 2010; 188(1):113-26. PMID: 20132839

    • Minnerup J, Wersching H, Brokinkel B, Dziewas R, Heuschmann PU, Nabavi DG, Ringelstein EB, Schäbitz WR, Ritter MA.
      The impact of lesion location and lesion size on poststroke infection frequency.
      J. Neurol. Neurosurg. Psychiatr.. 2010; 81(2):198-202. PMID: 19726403

    • Knecht S, Wersching H, Lohmann H, Berger K, Ringelstein EB.
      How much does hypertension affect cognition?: explained variance in cross-sectional analysis of non-demented community-dwelling individuals in the SEARCH study.
      J. Neurol. Sci.. 2009; 283(1):149-52. PMID: 19304296

    • Minnerup J, Schilling M, Wersching H, Olschläger C, Schäbitz WR, Niederstadt T, Dziewas R.
      Development of a mycotic aneurysm within 4 days.
      Neurology. 2008; 71(21):1745. PMID: 19015494

    • Rösser N, Heuschmann P, Wersching H, Breitenstein C, Knecht S, Flöel A.
      Levodopa improves procedural motor learning in chronic stroke patients.
      Arch Phys Med Rehabil. 2008; 89(9):1633-41. PMID: 18760148

    • Knecht S, Oelschläger C, Duning T, Lohmann H, Albers J, Stehling C, Heindel W, Breithardt G, Berger K, Ringelstein EB, Kirchhof P, Wersching H.
      Atrial fibrillation in stroke-free patients is associated with memory impairment and hippocampal atrophy.
      Eur. Heart J.. 2008; 29(17):2125-32. PMID: 18667399

    • Stehling C, Wersching H, Kloska SP, Kirchhof P, Ring J, Nassenstein I, Allkemper T, Knecht S, Bachmann R, Heindel W.
      Detection of asymptomatic cerebral microbleeds: a comparative study at 1.5 and 3.0 T.
      Acad Radiol. 2008; 15(7):895-900. PMID: 18572126

    • Flöel A, Witte AV, Lohmann H, Wersching H, Ringelstein EB, Berger K, Knecht S.
      Lifestyle and memory in the elderly.
      Neuroepidemiology. 2008; 31(1):39-47. PMID: 18535399

    • Knecht S, Wersching H, Lohmann H, Bruchmann M, Duning T, Dziewas R, Berger K, Ringelstein EB.
      High-normal blood pressure is associated with poor cognitive performance.
      Hypertension. 2008; 51(3):663-8. PMID: 18250360