Group LeaderGerd Meyer zu Hörste, MD is an Attending Neurologist at the University Clinic Münster and head of an independent research group at the Westfälische Wilhelms-University Münster. The overarching theme of his research is to understand the relationship between the nervous system and the immune system in health and disease combining training in experimental neurobiology, clinical neurology, and T lymphocyte biology.
Group leader - CVDr. Meyer zu Hörste received his M.D. from Georg-August-University Göttingen, Germany in 2005. In his MD thesis work and during a post-doctoral period in the lab of Dr. Klaus-Armin Nave at the Max-Planck-Institute of Experimental Medicine in Göttingen he focused his work on genetically defined disorders of the nervous system and contributed a key proof-of-principle study describing the first experimental therapy of an inherited neuropathy. In 2006 Dr. Meyer zu Hörste moved to receive his residency training at the Department of Neurology of the Heinrich-Heine-University Düsseldorf. He developed his research interest towards immune reactions in the nervous system and contributed several studies regarding the antigen presenting function of myelin forming glia cells. This formed the basis for identifying a compound that redistributes antigen presenting molecules and ameliorates an animal model of inflammatory neuropathies. In addition, he generated a novel animal model of chronic inflammatory neuropathies and tested prognostic factors in this model. After receiving his Board Certification in Neurology in 2012 he joined the lab of Dr. Vijay Kuchroo lab at Brigham and Women’s Hospital and Harvard Medical School in Boston, MA as a Postdoctoral Research Fellow and extended his basic immunology expertise. During this postdoctoral period Dr. Meyer zu Hörste identified the transcriptional mechanisms essential for the ability of pro-inflammatory T helper cells to induce autoimmunity. In addition, he identified and characterized a novel function of a cell surface receptor in controlling the balance between competing pro- and anti-inflammatory T helper cell subsets. While working as an Associated Scientist at the lab of Dr. Aviv Regev at the Broad Institute of MIT and Harvard in Cambridge, MA he used RNA-sequencing and bioinformatic protein-protein network modeling to identify the mechanistic basis of these observations. In 2015 Dr. Meyer zu Hörste was awarded a competitive state-financed ‘Return-Fellowship’ and established an independent lab at the University Clinic Münster and the Westfälische Wilhelms-University Münster, Germany. He received his Habilitation and venia legendi in Neurology in 2015. His research lab additionally receives project-related funding from the Hertie foundation and from the medical faculty Münster. Melding previous experience from diverse backgrounds the lab is now working at the intersection of neurology, neurobiology, and immunology to address how the immune system interacts with the nervous system and how this translates to neuroimmunological diseases.
Post-DocsDr. Xiaolin Li received his PhD from China Agricultural University in 2009. He joined the MzH lab in 2018 and has extensive experience in Next Generation sequencing and single-cell sequencing technologies. He has previously worked at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena in the group of Dr. Christoph Kaether with focus on transmembrane-based ER-retention sorting signals. Then he worked in one of China’s Top3 NGS companies with focus on Next Generation Sequencing techniques including Hi-C and single-cell sequencing. He has 11 patents and 10 publications. His scientific interests are new techniques for single-cell sequencing and their applications.
Dr. Heming received his MD from the University of Münster. He finished his doctoral thesis about the role of PPAR-γin macrophages in 2017 in the Institute of Immunology Münster (Prof. Johannes Roth). He began his residency training in Neurology at the University Clinic Münster in 2017. He has been part of the MzH lab since 2018. His special interest lies in the bioinformatical analysis of clinical and single cell transcriptional datasets using machine learning algorithms to better understand neuroimmunological diseases.
Dr Ruland received his MD from the University of Münster in 2012. He joined the MzH lab in 2016 and has long-standing expertise in proteomics technologies. He has previously worked at the Department of Psychiatry in Münster in the group of Prof. Zwanzger with focus on affective disorders and anxiety. As part of the European Union funded Psych-Aid project he then spent a year at PsynovaNeurotech Limited, a spin off company established by Prof. Sabine Bahn at Cambridge University. There he worked on proteomic biomarkers for diagnosis and response prediction in psychiatric disorders.His scientific interests are mass spectrometry based methods for the identification of biomarkers as well as statistical methods for complex dataset analysis.
Maike Hartlehnert received her M.Sc. in Molecular Medicine from the Friedrich-Alexander-University Erlangen-Nuremberg in 2015. She joined the MzH lab in 2016. Her project focuses on T Follicular Helper (TFH) Cells and the formation and function of ectopic lymphoid follicles (eLF) in EAE/MS.
David Schafflick received his M.Sc. in Biotechnology from Carolo-Wilhelmina University in Braunschweig in 2016. He joined the lab in May 2016. His interests are antigen-presentation, the interaction between antigen-presenting cells and T cells interaction, T-cell functionality, autoimmune diseases and inflammatory neuropathies. His main project focuses on antigen-presentation in EAE/MS. In addition, he studies the phenotype and functionality of lymphocyte subsets in the nervous system of different transgenic mouse lines and humans and is the operator of the group's fluorescence activated cell sorting tasks.Jolien Wolbert received her M.Sc. in Bio-Pharmaceutical Sciences from Leiden University, The Netherlands in 2016. She is interested in T cell immunology and the role of T cells in autoimmune diseases. In 2017, she joined the MzH lab and studies non-pathogenic Th17 cells and their contribution to intestinal inflammation and to inflammation of the central nervous system in specific genetically engineered mouse lines.
Anna-Lena supports the experimental work of the lab by performing routine experimental tasks. She is an undergraduate student in Biosciences.
Alumni2016 - 2018 Tobias Lautwein, PhD