IZKF Regular Projects - Scientific Focus Vascular Diseases
- Kha1/002/20 - New therapeutic approaches for GFI1-36N expressing leukaemia
Principal investigator: Cyrus Khandanpour
Funding period: 01/20 - 12/22 - Kief1/019/20 - Assessing macrophage activation, migration and fate during a novel anti-atherosclerotic intervention
Principal investigator: Friedemann Kiefer
Funding period: 01/20 - 12/22 - Art1/019/18 - Identification of target genes for novel therapies for high-risk acute myeloid leukaemia (AML) patients via systematic CRISPR-based genetic screening
Principal investigator: Maria Francisca Arteaga Paz
Funding period: 01/18 - 12/20 - Mü1/011/17 - Inhibition of adenylylcyclase 5 by annexin A4 uand its role in cardiac remodeling
Principal investigator: Frank Ulrich Müller
Funding period: 1/2017 - 12/2019 - Bet1/013/17 - Effect of endothelial mechanics on leukocyte guidance and transmigration
Principal investigators: Timo Betz, Volker Gerke
Funding period: 1/2017 - 12/2019 - Rö1/009/15 - Combination of Chimeric Antigen Receptor (CAR) technology with retargeted tissue factor as cell mediated tumor therapy
Principal investigators: Claudia Rössig, Christoph Schliemann, Wolfgang E. Berdel
Funding period: 1/2015 - 12/2014 - See1/012/13 - Virus induced modulation of cardiac potassium channels as possible cause of viral myocarditis associated arrhythmias
Principal investigator: Guiscard Seebohm
Funding period:1/2013 - 12/2015 - Wa1/008/12 - Signal transduction defects in hypercholesterolemia-induced monocyte dysfunction
Principal investigator: Johannes Waltenberger
Funding period: 1/2012 - 10/2015 - Schu1/011/12 - Genomics of human myocardial repolarisation
Principal investigator: Eric Schulze-Bahr
Funding period: 1/2012 - 10/2015 - Mü1/014/11 - Relevance of cAMP-dependent transcription factors for heart failure associated arrhythmias
Principal investigators: Frank Ulrich Müller, Wilhelm Schmitz
Funding period: 1/2011 - 10/2014 - Ru1/022/08 - Genetics of arterial calcification
Principal investigator: Frank Rutsch
Funding period: 1/2008 - 10/2011 - Bra1/001/08 - Cellular and molecular characterization of granulocyte colony-stimulating factor(G-CSF)-mediated regeneration in infarcted heart and brain
Principal investigator: Eva Brand
Funding period: 1/2008 - 12/2010 - Pa1/011/08 - The role of the chemokine receptor CCR10 for the structure and function of arterial vessels
Principal investigator: Hermann-Joseph Pavenstädt
Funding period: 1/2008 - 12/2010 - Nik1/032/08 - Cellular and molecular characterization of granulocyte colony-stimulating factor(G-CSF)-mediated regeneration in infarcted heart and brain
Principal investigators: Sigrid Nikol, Wolf-Rüdiger Schäbitz
Funding period: 1/2008 - 12/2009 - Mü1/004/07 - Role of CREB/CREM/ATF1 transcription factors in the NO/cGMP-dependent regulation of vascular function
Principal investigators: Frank Ulrich Müller, Wilhelm Schmitz
Funding period: 1/2007-10/2010 - Keh1/037/07 - Candida Infection of the vascular compartments: Interaction between fungi, platelets and endothelial cells
Principal investigators: Beate Kehrel, Christof von Eiff, Andreas Uekötter
Funding period: 1/2007 -10/2010 - Kih1/010/07 - Activation of brain-type Na+ channels in the myocardium: a new therapeutic principle for positive inotropic non-toxic scorpion peptides in humans
Principal investigators: Uwe Kirchhefer, Larissa Fabritz
Funding period: 1/2007- 12/2009 - Schu1/031/07 - Molecular genetics of atrial septal defect
Principal investigator: Eric Schulze-Bahr
Funding period: 1/2007- 12/2009 - Schu1/001/04 - Molecular genetics of sinus node disease
Principal investigator: Eric Schulze-Bahr
Funding period: 06/2004 -12/2006 - Mü1/021/04 - Myocardial function and gene expression of ATF-4 deficient mice
Principal investigators: Frank Ulrich Müller, Wilhelm Schmitz
Funding period: 6/2004 -12/2006 - Ko1/031/04 - Molecular in-vivo imaging of apoptosis with SPECT- and PET-compatible small- molecular caspase inhibitors
Principal investigators: Klaus Kopka, Bodo Levkau, Michael Schäfers
Funding period: 6/2004 -12/2006 - Ku1/040/04 - Mechanisms and pathophysiological implications of desensitisation of the ANP receptor (GC-A)
Principal investigator: Michaela Kuhn
Funding period: 6/2004 -12/2006 - The1/068/04 - Anti-inflammatory properties of the thrombomodulin-lectin like domain with regard to tissue-remodelling after global and regional hypoxia – identifucation of ligands and signal tranduction
Principal investigators: Gregor Theilmeier, Hugo van Aken
Funding period: 6/2004 -12/2006 - Ki1/099/04 - Functional relevance of plakoglobin for cardiac function and arrythmias – a molecular model for arrythmogenic right ventricular cardiomyopathy
Principal investigators: Paulus Kirchhof, Thomas Wichter
Funding period: 6/2004 -12/2006 - Bo1/101/04 - Characterisation of a transgenic animal model overexpressing proteinphosphatase 5
Principal investigators: Peter Boknik, Ulrich Gergs, Joachim Neumann
Funding period: 6/2004 -12/2006
- Kha1/002/20 - New therapeutic approaches for GFI1-36N expressing leukaemia
IZKF Regular Projects - Scientific Focus Inflammation and Infection
- De2/006/20 - Analysis of a protective role of coagulation activities and fibrin matrix formation against Yersinia infections
Principal investigator: Petra Dersch
Funding period: 01/2020 - 12/2022 - Fö2/018/20 - The role of hexameric S100A12 complexes and type I interferon signals in promotingIL1/IL18-driven SJIA progression
Principal investigator: Dirk Föll
Funding period: 01/2020 - 12/2022 - Brau2/013/19 - Impaired function of the nuclear pore complex as a novel pathogenic mechanism in kidney diseases
Principal investigator: Daniela Braun
Funding period: 01/2019 - 06/2022 - Bru2/015/19 - Keeping the balance: Characterization of TRIM28 as a negative regulator of the pulmonary innate immune response during influenza A virus infection
Principal investigator: Linda Brunotte
Funding period: 01/2019 - 06/2022 - Bäu2/009/19 - Creation of a novel antibody-drug conjugate for the treatment of diffuse large B-cell lymphoma
Principal investigator: Sebastian Bäumer
Funding period: 01/2019 - 12/2021 - Ro2/023/19 - Molecular mechanisms of innate immune memory during activation of phagocytes
Principal investigator: Johannes Roth
Funding period: 01/2019 - 10/2021 - Za2/001/18 - Novel functions of pulmonary endothelial and epithelial CXCR2 in leukocyte trafficking to infected lungs and in lung injury
Principal investigator: Alexander Zarbock
Funding period: 01/2018 - 10/2021 - Ross2/010/18 - Renal tubular epithelial TLR4 signaling induces cell cycle arrest and attenuates acute kidney injury
Principal investigator: Jan Rossaint
Funding period: 01/2018 - 10/2021 - Wed2/022/18 - Coordination and control of cell organization through the multifunctional actin regulator INF2
Principal investigator: Roland Wedlich-Söldner
Funding period: 01/2018 - 10/2021 - Fa2/014/18 - InfectionImaging – Development of a pathogen-specific diagnostic imaging marker for infective endocarditis
Principal investigator: Cornelius Faber
Funding period: 01/2018 - 12/2020 - Schw2/020/18 - Mechanisms of mechanosignaling in pancreatic stellate cells and its role for pancreatic cancer
Principal investigator: Albrecht Schwab
Funding period: 01/2018 - 12/2020 - Hei2/027/18 - Mechanisms involved in extracellular (e)DNA-dependent staphylococcal biofilm formation?
Principal investigator: Christine Heilmann
Funding period: 01/2018 - 12/2020 - Lud2/008/17 - Influenza Virus-mediated reprogramming of immunologically defective tumor-associated macrophages
Principal investigator: Stephan Ludwig
Funding period: 01/2017 - 10/2020 - Drei2/018/17 - Deciphering bacterial communication under different environmental conditions at high spatio-temporal resolution by novel mass spectrometry imaging technologies
Principal investigators: Klaus Dreisewerd, Jens Soltwisch
Funding period: 01/2017 - 10/2020 - Fau2/014/17 - Bacterial vascular graft infections - impact of sterile inflammation and tissue injury on biofilm formation and bacterially elicited processes
Principal investigators: Andreas Faust, Silke Niemann
Funding period: 1/2017 - 06/2020 - Rüt2/002/16 -‘CREDIBLE’: A Cre-mediated double reporter system to study cargo transport by delivery systems in vitro and in vivo
Principal investigator: Christian Rüter
Funding period: 1/2016 - 10/2019 - Geo2/003/16 - Neurotrophic receptor kinase 3 (Ntrk3) in podocyte development and disease
Principal investigator: Britta George
Funding period: 1/2016 - 10/2019 - Lo2/004/16 - Role of 4-1BB/4-1BB ligand signalling for the progression of cutaneous inflammation and the development of itch
Principal investigator: Karin Loser
Funding period: 1/2016 - 10/2019 - Om2/015/16 - Molecular characterization of radial spoke composition and defects in Primary Ciliary Dyskinesia
Principal investigator: Heymut Omran
Funding period: 1/2016 - 10/2019 - Kah2/016/16 - The interaction of Staphylococcus aureus with „neutrophil extracellular traps “ (NETs) during the chronic persistent airway infection of cystic fibrosis patients
Principal investigator: Barbara Kahl
Funding period: 1/2016 - 10/2019 - Mat2/019/16 - Mechanobiological investigation of microtubules in tissue development and disease
Principal investigator: Maja Matis
Funding period: 1/2016 - 10/2019 - Dob2/022/16 - Analysis of structural requirements and mechanisms involved in genome plasticity of Escherichia coli
Principal investigator: Ulrich Dobrindt
Funding period: 1/2016 - 10/2019 - Me2/010/16 - EHEC-vesicles: their impact on host-pathogen interaction and gut flora
Principal investigators: Alexander Mellmann, Helge Karch
Funding period:1/2016 - 12/2018 - Ebl2/014/16 - Redox regulation of integrin-mediated cell-matrix contacts and its role in adhesion, cell morphology, and migration
Principal investigator: Johannes Eble
Funding period:1/2016 - 12/2018 - Raz2/021/16 - From cell migration to organ formation – Early interactions between somatic cells and migratory germ cells in early gonadogenesis
Principal investigator: Erez Raz
Funding period:1/2016 - 12/2018 - Ro2/003/15 - The role of calcium -binding proteins MRP8 and MRP14 during cellular dynamics in phagocytes
Principal investigator: Johannes Roth
Funding period:1/2015 - 10/2018 - EhC2/006/15 - Molecular mechanisms contributing to pathogenesis during influenza virus and Staphylococcus aureus co-infection
Principal investigator: Christina Ehrhardt
Funding period: 1/2015 - 10/2018 - So2/016/15 - The role of Matrix Metalloproteinase (MMP)-2 and MMP-9 in initiating peripheral immune responses: impact on dendritic cell (dc) migration and antigen presentation
Principal investigator: Lydia Sorokin
Funding period: 1/2015 - 10/2018 - Müth2/021/15 - Interaction of Shiga toxin with human intestinal and renal epithelial cells: therapy options for treatment of EHEC-mediated diseases
Principal investigator: Johannes Müthing
Funding period: 1/2015 - 10/2018 - Ros2/007/15 - Role of the three-dimensional chromatin structure in expression control of the tumor suppressor gene PU.1
Principal investigator: Frank Rosenbauer
Funding period: 1/2015 - 12/2017 - Re2/026/15 - Impact of late endosomal cholesterol homeostasis on tetraspanin-based signalling
Principal investigator: Ursula Rescher
Funding period: 1/2015 - 12/2017 - Har2/002/14 - Modified Wnt-signaling and its effects on degenerative and inflammatory joint alterations
Principal investigator: Christine Hartmann
Funding period: 1/2014 - 10/2017 - Vo2/004/14 - The role of alarmins MRP8 and MRP14 in the differentiation of ‚Myeloid-Derived Suppressor Cells ‘ (MDSCs) in allergies and autoimmune diseases
Principal investigator: Thomas Vogl
Funding period: 1/2014 - 10/2017 - Kl2/015/14 - Affinity-dependent modulation of T-cell responses- implications of DHODH and the de novo pyrimidine synthesis pathway
Principal investigator: Luisa Klotz
Funding period: 1/2014 - 10/2017 - Eb2/020/14 - The signalling role of JAM-A during angiogenesis and tumorigenesis
Principal investigator: Klaus Ebnet
Funding period: 1/2014 - 10/2017 - Hei2/027/14 - Characterization of the role of protein glycosylation in the Staphylococcus aureus pathogenesis
Principal investigator: Christine Heilmann
Funding period: 1/2014 - 10/2017 - Za2/001/14 - The role of SKAP-HOM in integrin activation, leukocyte recruitment, and inflammation
Principal investigator: Alexander Zarbock
Funding period: 1/2014 - 12/2016 - Ge2/009/14 - Plasma membrane wound repair in mechanically stressed cells
Principal investigator: Volker Gerke
Funding period: 1/2014 - 12/2016 - Lud2/017/13 - Unraveling the phosphoproteom of influenza virus infected cells
Principal investigator: Stephan Ludwig
Funding period:1/2013 - 10/2016 - Cia2/013/13 - Membrane transporters as mediators of cisplatin effects and side effects
Principal investigators: Giuliano Ciarimboli, Eberhard Schlatter, Antoinette am Zehnhoff-Dinnesen
Funding period:1/2013 - 09/2016 - Schl2/001/13 - Germline stem cells and their niches: Is male infertility associated with defects of migration and colonization of spermatogonia?
Principal investigator: Stefan Schlatt
Funding period: 1/2013 -12/2015 - SchMA2/014/13 - Application of bacterial immune regulatory cell -penetrating proteins in murine models of inflammatory bowel disease
Principal investigator: M. Alexander Schmidt
Funding period:1/2013 -12/2015 - Om2/009/12 - The role of cytoplasmic pre-assembly of axonemal components in primary ciliary dyskinesia
Principal investigator: Heymut Omran
Funding period:1/2012 - 10/2015 - Dob2/013/12 - Regulation of the biosynthesis of the enterobacterial genotoxin colibactin
Principal investigator: Ulrich Dobrindt
Funding period:1/2012 - 10/2015 - Pap2/015/12 - SUMO-1 as a modulator of inflammatory bone loss: Molecular mechanisms and therapeutic implications
Principal investigator: Thomas Pap
Funding period:1/2012 - 10/2015 - Me2/021/12 - Microevolution of enterohemorrhagic Escherichia coli (EHEC) O104:H4 and its impact on the pathogen-host interaction
Principal investigators: Alexander Mellmann, Helge Karch
Funding period:1/2012 - 10/2015 - Mei2/017/12 - Functions of CDKs in proliferation and inflammation
Principal investigator: Michael Meisterernst
Funding period:1/2012 - 12/2014 - Lo2/004/11 - Relevance of OX40-OX40 ligand signalling for allergic and anti-microbial cutaneous immune responses
Principal investigators: Karin Loser, Stefan Beissert
Funding period:1/2011-10/2014 - Mül2/020/11 - The relevance of Histone 4 acetyltransferases in myeloid differentiation
Principal investigator: Carsten Müller-Tidow
Funding period:1/2011 - 10/2014 - Lud2/010/11 - Activation and function of the p38 MAP kinase pathway in influenza virus infected cells
Principal investigator: Stephan Ludwig
Funding period:1/2011 - 12/2013 - Eh2/019/11 - New anti-inflammatory mechanisms of glucocorticoids in vivo
Principal investigators: Jan Ehrchen, Cord Sunderkötter
Funding period:1/2011 - 12/2013 - Be2/023/11 - Pathogenicity of Staphylococcus lugdunensis
Principal investigator: Karsten Becker
Funding period:1/2011 - 12/2013 - Ro2/004/10 - Characterisation of the molecular mechanisms of LPS- or stress-induced microbial tolerance in phagocytes
Principal investigator: Johannes Roth
Funding period:1/2010-10/2013 - Ge2/016/10 - Ca2+-dependent regulation of membrane/cytoskeleton interactions in migratory leukocytes and tumour cells
Principal investigator: Volker Gerke
Funding period: 1/2010 -10/2013 - Re2/017/10 - Annexin A8 and the pathophysiology of tumours
Principal investigator: Ursula Rescher
Funding period:1/2010 -10/2013 - Müth2/028/10 - Interaction of glycosphingolipids from human cells with virulence factors of entero-hemorrhagic Escherichia coli (EHEC)
Principal investigator: Johannes Müthing
Funding period:1/2010 -10/2013 - Löf2/030/10 - Mechanisms of intracellular persistence of Staphylococcus aureus via formation of highly dynamic phenotypes
Principal investigators: Bettina Löffler, Georg Peters
Funding period:1/2010 -10/2013 - Za2/001/10 - The role of phopholipase C gamma (PLCγ) isoforms in selectin-mediated leukocyte activation
Principal investigator: Alexander Zarbock
Funding period: 1/2010-12/2012 - Wix2/005/10 - The LIM-domain protein FHL2 as a novel regulator of innate cellular anti-viral response
Principal investigators: Viktor Wixler, Christina Ehrhardt
Funding period: 1/2010-12/2012 - Goe2/023/10 - Role of platelet adhesion receptors for the acute and chronic inflammation of the skin
Principal investigator: Tobias Görge
Funding period: 1/2010-12/2012 - Vo2/014/09 - Novel strategies in sepsis therapy – characterization of pro-inflammatory mechanisms of human MRP8 and MRP14
Principal investigator: Thomas Vogl
Funding period:1/2009 - 10/2012 - Hei2/022/09 - Molecular characterization of the SasC -mediated mechanism of cell aggregation and biofilm formation in Staphylococcus aureus
Principal investigator: Christine Heilmann
Funding period:1/2009 - 10/2012 - Kah2/024/09 - In vivo evolution of Staphylococcus aureus during chronic airway infection of cystic fibrosis patients
Principal investigator: Barbara Kahl
Funding period:1/2009 - 10/2012 - Schä2/020/09 - Molecular imaging of activated matrix metalloproteinases in encephalomyelitis
Principal investigators: Michael Schäfers, Klaus Kopka, Lydia Sorokin
Funding period:1/2009 - 12/2011 - Eb2/028/09 - Regulation of membrane polarity in endothelial cells by the VE-cadherin - Par protein complex
Principal investigator: Klaus Ebnet
Funding period:1/2009 - 12/2011 - Me2/023/08 - Mobility and dynamic of pathogenicity determinants of enterohaemorrhagic Escherichia coli (EHEC) during infection
Principal investigators: Alexander Mellmann, Helge Karch
Funding period: 1/2008 - 10/2011 - SchMA2/027/08 - Probiotic Bacteria and the Gastrointestinal Barrier: target Structures and Molecular Repair Mechanisms
Principal investigator: M. Alexander Schmidt
Funding period: 1/2008 - 10/2011 - Schw2/030/08 - Calcium channels as mechanosensors in migrating cells
Principal investigator: Albrecht Schwab
Funding period: 1/2008 - 10/2011 - Mül2/018/07 - Combinatorial gene regulation as a prerequisite for cellular dynamics in hematopoietic differentiation
Principal investigator: Carsten Müller-Tidow
Funding period:1/2007 -10/2010 - Sun2/017/07 - Influence of initial epidermal cytokine expression on the adaptive immune response in experimental Leishmaniasis
Principal investigators: Cord Sunderkötter, Jan Ehrchen
Funding period:1/2007 -10/2010 - Pap2/003/07 - Regulation of apoptosis in rheumatoid arthritis syvnovial fibroblasts by the tissue inhibitor of metalloproteinases (TIMP-3)
Principal investigator: Thomas Pap
Funding period: 1/2007 - 12/2009 - Lo2/017/07 - Relevance of cutaneous RANK-RANKL signalling in immunity
Principal investigator: Karin Loser
Funding period: 1/2007 - 12/2009 - Wi2/023/07 - Potential of spermatogonial stem cells for cellular renewal in testis and bone marrow
Principal investigators: Joachim Wistuba, Steffen Koschmieder, Jörg Gromoll
Funding period: 1/2007 - 12/2009 - Re2/039/07 - Annexin 2 and raft domains and their associated proteins in cellular motility
Principal investigator: Ursula Rescher
Funding period: 1/2007 - 12/2009 - Fö2/005/06 - Molecular characterisation of RAGE-mediated endothelial activation
Principal investigators: Dirk Föll, Dorothee Viemann
Funding period: 1/2006 - 10/2009 - Ro2/012/06 - Anti-inflammatory mechanisms of macrophages
Principal investigator: Johannes Roth
Funding period:1/2006 - 10/2009 - Ge2/017/06 - Regulation of the acute secretion of inflammatory and thrombogenic factors from vascular endothelial cells
Principal investigator: Volker Gerke
Funding period:1/2006 - 10/2009 - Lud2/032/06 - Molecular basis of the oncolytic activity of RNA viruses
Principal investigator: Stephan Ludwig
Funding period:1/2006 - 10/2009 - Si2/039/06 - Mechanisms of induction of apoptosis by Staphylococcus aureus in leukocytes and endothelial cells
Principal investigators: Bhanu Sinha, Bettina Löffler
Funding period:1/2006 - 10/2009 - Kuc2/018/06 - The deletion of CCR6 inhibits Peyer’s patches and isolated lymphoid follicles – implications of the organized GALT for the intestinal immune system
Principal investigators: Torsten Kucharzik, Andreas Lügering
Funding period:1/2006 - 12/2008 - Schae2/026/06 - Macrophage-colony stimulating factor isoforms: relevance and regulation in Lupus nephritis
Principal investigators: Liliana Schaefer, Roland M. Schaefer, Peter Bruckner
Funding period:1/2006 - 12/2008 - Stei2/017/06 Molecular and functional investigations on the role of endopeptidases for the regulation of neuropeptide receptor signalling
Principal investigators: Martin Steinhoff, Thomas Luger
Funding period:1/2006 - 12/2008 - Ser2/038/06 - JAK-STAT signal transduction in leukemic transformation – role of SOCS1 as a conditional oncogene
Principal investigators: Hubert Serve, Christian Brandts
Funding period:1/2006 - 12/2008 - Vest2/006/04 - Role of CD99 in transendothelial migration and extravasation of leukocytes
Principal investigator: Dietmar Vestweber
Funding period: 6/2004 - 12/2006 - Na2/009/04 - Analyis of the S100 protein associated proteome in inflammation
Principal investigator: Wolfgang Nacken
Funding period: 6/2004 - 12/2006 - Kess2/023/04 - Hematopoetic stem cells as targets for antivascular treatment strategies in cancer
Principal investigators: Torsten Kessler, Rolf Mesters
Funding period: 6/2004 - 12/2006 - Hei2/042/04 - Molecular characterisation of adhesive interactions between Staphylococcus aureus and candida
Principal investigators: Christine Heilmann, Chrsitof von Eiff, Karsten Becker
Funding period: 6/2004 - 12/2006 - Ka2/061/04 - Pathomechanisms of the interaction between enterohaemorrhagic Escherichia coli and intestinal epithelial cells
Principal investigators: Helge Karch, Alexander W. Friedrich
Funding period: 6/2004 - 12/2006 - Lo2/065/04 - Investigations on the role of interleukin (IL)-15 for linking adaptive and innate cutaneous immunity
Principal investigator: Karin Loser
Funding period: 6/2004 - 12/2006 - Mül2/096/04 - The role of the Cyclin A1 interacting protein (FOCA1 – Friend of Cyclin A1) for cell cycle progression and proliferation of haematopoietic cells
Principal investigator: Carsten Müller-Tidow
Funding period: 6/2004 - 12/2006 - Pa2/108/04 - The role of C/EBP-homologous protein (CHOP) in oxygen-radical mediated damage of podocytes
Principal investigator: Hermann-Joseph Pavenstädt
Funding period: 6/2004 - 12/2006 - Ra2/109/04 - New therapeutic strategies for implant associated infections in surgery of the musculoskeletal system
Principal investigator: Michael Raschke
Funding period: 6/2004 - 12/2006 - Fö2/026/04 - Functional characterisation of calium-binding protein S100A12 specifically expressed in granulocytes
Principal investigators: Dirk Föll, Johannes Roth
Funding period: 6/2004 - 12/2005 - Re2/033/04 - Functional characterisation of calium-binding protein S100A12 specifically expressed in granulocytes
Principal investigators: Ursula Rescher, Volker Gerke
Funding period: 6/2004 - 12/2005 - Si2/048/04 - Analysis of structure and function of Staphylococcus aureus-FnBPin invasion of human host cells
Principal investigators: Bhanu Sinha, Christine Heilmann, Georg Peters
Funding period: 6/2004 - 12/2005 - Schae2/004/04 - Pathogenic role of proteolycans in the development of glomerulosclerosis and obstructive neuropathy
Principal investigators: Roland M. Schaefer, Liliana Schaefer, Frank G. Echtermeyer
Funding period: 6/2004 - 12/2005 - Ser2/041/04 - Functional relevance of Flt-3 target genes in haematopoesis
Principal investigators: Hubert Serve, Christian Barndts
Funding period: 6/2004 - 12/2005 - Stei2/103/04 - Molecular mechanisms of cutaneous neurogenic inflammation
Principal investigators: Martin Steinhoff, Thomas Luger
Funding period: 6/2004 - 12/2005 - Schl2/008/04 - Pathophysiology and cellular mechanisms of tubular transport differences after kidney transplantation
Principal investigators: Eberhard Schlatter, Gerd Gabriels
Funding period: 6/2004 - 12/2004 - Kul2/016/04 - Molecular mechanisms of UV-induced apoptosis
Principal investigators: Dagmar Kulms, Thomas Schwarz
Funding period: 6/2004 - 12/2004
- De2/006/20 - Analysis of a protective role of coagulation activities and fibrin matrix formation against Yersinia infections
IZKF Regular Projects - Scientific Focus Nervous System Diseases
- La3/013/20 - Neuronal network analysis of BDNF mediated prevention of long-lasting stress effects
Principal investigator: Maren Denise Lange
Funding period: 01/2020 - 12/2022 - Ha3/017/20 - Role of ASCL1 in the biology of atypical teratoid/rhabdoid tumors (ATRT)
Principal investigator: Martin Hasselblatt
Funding period: 01/2020 - 12/2022 - Gro3/001/19 - An integrated approach for studying dynamic body-brain interactions: The case of respiration
Principal investigator: Joachim Groß
Funding period: 01/2019 - 06/2022 - Kl3/010/19 - Antigen-specific CD8 T-cell responses in Neuromyelitis Optica and Susac syndrome
Principal investigators: Luisa Klotz, Catharina Groß
Funding period: 01/2019 - 06/2022 - Mi3/004/19 - Defects of synaptic function caused by ASD and PHLS-associated missense mutations in the neurexin-1 gene
Principal investigator: Markus Missler
Funding period: 01/2019 - 10/2021 - Kli3/025/20 - Microstructured and functionalized chips for rapid neuronal differentiation and presynapse formation of human neural precursor cells
Principal investigator: Jürgen Klingauf
Funding period: 01/2020 - 10/2022 (terminated 12/2020) - Meu3/015/18 - Silent K2P-channels in the immune system: the role of TWIK2-channels in multiple sclerosis
Principal investigators: Sven Meuth, Petra Hundehege
Funding period: 01/2018 - 09/2020 - Dan3/012/17 - Machine learning and pattern recognition in psychiatry - translational approaches in diagnostics and prediction
Principal investigator: Udo Dannlowski
Funding period: 01/2017 - 10/2020 - Jün3/003/17 - Opioid-dependent modulation of fear-relevant connections between the paraventricular thalamic nucleus, the prefrontal cortex and amygdala
- Principal investigator: Kay Jüngling
Funding period:1/2017 - 12/2019 - Bud3/001/16 - Cell type-specific regulation and therapeutic potential of 2-pore-domain K+ channels in the thalamus
Principal investigator: Thomas Budde
Funding period:1/2016 - 12/2018 - Alf3/018/16 - The role of the Chemokine receptor CCR4 and its ligand CCL22 in the APP/PS1 mouse model
Principal investigator: Judith Alferink
Funding period:1/2016 - 12/2018 - KuT3/012/15 - In- and extrinsic signalling pathways modulating oligodendroglial migration
Principal investigator: Tanja Kuhlmann
Funding period:1/2015 - 10/2018 - Ha3/019/15 - Role of epigenetic alterations in the biology of atypical teratoid/rhabdoid tumors (AT/RT))
Principal investigator: Martin Hasselblatt
Funding period:1/2015 - 10/2018 - Ju3/024/15 - Transcranial direct current stimulation of the medial prefrontal cortex for therapy of unipolar major depression
Principal investigators: Markus Junghöfer, Carsten Wolters, Volker Arolt
Funding period:1/2015 - 10/2018 - Kli3/027/15 - Putative role of endosome-like compartments for synaptic vesicle recycling and presynaptic short-term plasticity
Principal investigator: Jürgen Klingauf
Funding period:1/2015 - 10/2018 - PaHC3/001/15 - Pathways and mechanisms of NPY and Y2 receptors for controlling conditioned fear
Principal investigator: Hans-Christian Pape
Funding period:1/2015 - 12/2017 - Zha3/005/14 - The functional relevance of neuron-type-specific Nrg1-III-ErbB4-signaling on defined synapses in prefrontal cortex of mouse
Principal investigator: Weiqi Zhang
Funding period:1/2014 - 10/2017 - Ru3/006/13 - Functional studies on the role of LM BD1 and ABCD4 in lysosomal cobalamin transport
Principal investigator: Frank Rutsch
Funding period:1/2013 - 10/2016 - Fa3/016/13 - Imaging networks of the brain by combining multimodal functional imaging with opto-genetic control
Principal investigator: Cornelius Faber
Funding period:1/2013 - 10/2016 - Meu3/10/12 - The role of NADPH-oxidases in Multiple Sclerosis and its animal model
Principal investigator: Sven Meuth
Funding period:1/2012 - 10/2015 - Et3/019/12 - The role of the microglia in pathogenesis of age-related macular degeneration
Principal investigator: Nicole Eter
Funding period:1/2012 - 12/2014 - SchwJ3/001/11 - Regulation of adult neurogenesis by neuroinflammation
Principal investigator: Jens Schwamborn
Funding period: 1/2011 - 12/2013 - KuT3/006/11 - Modulation of Wnt-ß−catenin pathway to promote remyelination
Principal investigator: Tanja Kuhlmann
Funding period:1/2011 - 10/2014 - Wie3/011/11 - The role of the co-inhibitory B7-H1/PD1 pathway in immune-regulation related to neuroinflammation: mechanisms and therapeutic modulation by high affinity mutant B7-H1 Ig proteins
Principal investigator: Heinz Wiendl
Funding period:1/2011 - 12/2013 - Ha3/016/11 - Molecular pathogenesis of atypical teratoide/rhabdoid tumors (ATRT)
Principal investigator: Martin Hasselblatt
Funding period:1/2011 - 10/2014 - PaHC3/003/10 - The Neuropeptide S (NPS) system: properties of NPS neurons and mechanisms of receptor activation
Principal investigators: Hans-Christian Pape, Kay Jüngling
Funding period:1/2010 -12/2012 - Bud3/0101/10 - New players in the thalamus: physiological and pathophysiological relevance of KCNQ channels
Principal investigator: Thomas Budde
Funding period:1/2010 -10/2013 - Do3/021/10 - Dysfunctional corticolimbic interaction and its modulation by repetitive transcranial magnetic stimulation (rTMS) in anxiety - emotional word learning as trait marker for anxiety disorders
Principal investigators: Christian Dobel, Peter Zwanzger
Funding period:1/2010 -12/2012 - Tha3/002/09 - New neuroregenerative strategies at the injured optic nerve in vivo: the use of embryonic neural progenitor cells
Principal investigator: Solon Thanos
Funding period:1/2009 - 12/2011 - Stei3/034/09 - Relevance of cytokine receptors in the sensory nervous system: cellular communication of the neuronal cytokine receptor interleukin -31 RA and ion channels during inflammation and pain
Principal investigator: Martin Steinhoff
Funding period:1/2009 - 12/2011 - Floe3/004/08 - Ecogenetic context: Effect of genetic predisposition and environmental factors on memory function in the elderly
Principal investigator: Agnes Flöel
Funding period:1/2008 - 12/2010 - Mi3/025/08 - Impaired synaptic function in autism spectrum disorders: role of neurexophilins in regulating neurotransmission
Principal investigator: Markus Missler
Funding period:1/2008 - 10/2011 - Pan3/008/07 - Integration of magnetoencephalographic (MEG) and functional magnetic resonance imaging (fMRI) studies in somato-sensory perception and executive control as de-pending on the serotonergic and dopaminergic system
Principal investigators: Christo Pante, Katharina Domschke
Funding period: 1/2007 - 10/2010 - Bud3/005/07 - Control of Gq-Proten dependent signal processing in the thalamocortical system with respect to new strategies for the therapy of absence epilepsy
Principal investigators: Thomas Budde, Thomas Seidenbecher
Funding period: 1/2007- 12/2009 - Hen3/003/06 - The role of locus coeruleus degeneration for neuroinflammatory and neurodegnerative mechanisms in Alzheimer’s disease
Principal investigators: Michael Heneka, Hans-Christian Pape
Funding period:1/2006 - 12/2008 - You3/016/06 - Molecular aspects of neuronal degeneration in the peripheral nervous system: impact of demyelination on gene regulation in neurons
Principal investigator: Peter Young
Funding period:1/2006 - 12/2008 - Kie3/071/04 - Characterisation of functional differences between resident microglial cells and hematogenous macrophages in the pathophysiology of focal cerebral ischemia in vivo
Principal investigator: Reinhard Kiefer
Funding period:6/2004 - 12/2005 - Tha3/005/04 - Molecular mechanisms of neuronal regeneration: The role of growth-associated proteins (GAP) and integrins in newly developed animal mutants and primates
Principal investigator: Solon Thanos
Funding period: 6/2004 - 12/2006 - Bro3/054/04 - Small RNAs in neuropsychiatric diseases
Principal investigators: Jürgen Brosius, Boris Skryabin
Funding period: 6/2004 - 12/2006 - Küh3/064/04 - Analysis of the reciprocal assembly/disassembly pathways during neuroepithelial spread of Herpes simplex-Virus Typ 1 (HSV-1)
Principal investigator: Joachim Kühn
Funding period: 6/2004 - 12/2006 - Kne3/074/04 - Boosting of learning with dopamine
Principal investigators: Stefan Knecht, Catarina Breitenstein
Funding period: 6/2004 - 12/2006 - Ker3/086/04 - The proteolipid complex S100A9-GM2AP-GM2 causes glial cytotoxicity in Multilpe Sclerosis
Principal investigator: Claus Kerkhoff
Funding period: 6/2004 - 12/2006
- La3/013/20 - Neuronal network analysis of BDNF mediated prevention of long-lasting stress effects
SEED projects
- SEED 015/20 - Direct reprogramming of kidney mesenchymal cells into podocytes as a therapeutic strategy for chronic kidney disease
Group leader: Markus Carl Döser
Dispatching clinic: Department of Medicine D - Nephrology and Rheumatology
Host institute: Max-Planck-Institute for Molecular Biomedicine
Project duration: 01/2020-12/2022 - SEED 014/20 - The impact of monocyte / macrophage SHP-2 tyrosine phosphatase on diabetes-induced atherosclerosis progression
Group leader: Marc Dorenkamp
Dispatching clinic: Department of Cardiovascular Medicine
Host institute: European Institute for Molecular Imaging
Project duration: 01/2020-12/2022 - SEED 013/20 - BRD4 as novel epigenetic vulnerability of early T-cell precursor acute lymphoblastic leukemia (ETP-ALL)
Group leader: Sebastian Balbach
Dispatching clinic: Department of Pediatric Hematology and Oncology
Host institute: Department of Pediatric Hematology and Oncology - Stem cell transplatation
Project duration: 01/2020-12/2022 - SEED 12/18 - The influence of platelet migration, thrombopoiesis and platelet subpopulations on the course of inflammation
Group leader: Andreas Margraf
Dispatching clinic: Department of Anaesthesiology, Intensive Care and Pain Therapy
Host institute: AG Vascular Inflammation and Platelets
Project duration: 09/2018-08/2021 - SEED 11/19 - Individualised prediction of the clinical course of affective disorders by the use of integrated clinical and experimental data
Group leader: Nils Opel
Dispatching clinic: Department of Mental Health (formerly Department of Psychiatry and Psychotherapy)
Host institute: Institute of Medical Informatics
Project duration: 01/2019-12/2021 - SEED 10/19 - The impact of the calcium-regulated K2P channel TRESK on T-cell functions in experimental stroke
Group leader: Leoni Rolfes
Dispatching clinic: Division of General Neurology
Host institute: Institute for Translational Neurology
Project duration: 01/2019 - 03/2021 (the project was terminated prematurely since the group leader moved to the University Hospital, Düsseldorf) - SEED 09/17 - Interleukin 24 in renal ischemia-reperfusion injury: Analysis of the pathophysiological role and evaluation of potential therapeutic options
Group leader: Katharina Schütte-Nütgen
Dispatching clinic: Department of Medicine D - Nephrology and Rheumatology
Host institute: Institute of Medical Biochemistry (ZMBE)
Funding period: 01/2017 - 12/2019 - SEED 07/17 - Leukocyte migration and endothelial integrity in cerebral ischaemia – pathophysiology, interaction, and relevance for outcome and secondary haemorrhage after intravenous thrombolysis
Group leader: Antje Schmidt-Pogoda
Dispatching clinic: Division of General Neurology
Host institute: Max Planck Institute for Molecular Biomedicine
Funding period: 01/2017 - 12/2019 - SEED 06/15 - Analysis of the regulation of the actin cytoskelton in podocytes
Group leader: Christopher Dlugos
Dispatching clinic: Department of Medicine D - Nephrology and Rheumatology
Host institute: Institute of Cell Dynamics and Imaging
Funding period: 01/2015 - 12/2017 - SEED 05/15 - The role of GABAergic transmission and chloride homeostasis in pain development and processing
Group leader: Tobias Schmidt
Dispatching clinic: Department of Anaesthesiology, Intensive Care and Pain Therapy
Host institute: Institute of Physiology I
Funding period: 01/2015 - 12/2017 - SEED 04/12 - The role of L-selectin topography in integrin activation and lymphocyte homing
Group leader: Konrad-Robert Buscher
Dispatching clinic: Department of Anaesthesiology, Intensive Care and Pain Therapy
Host institute: Institute of Physiological Chemistry and Pathobiochemistry
Funding period: 04/2012 - 03/2014 - SEED 03/12 - The role of K2P-channels (TASK1-3, TRESK) for intracellular signalling pathways in T-Lymphocytes
Group leader: Stefan Bittner
Dispatching clinic: Division of General Neurology
Host institute: Institute of Physiology - Neuropathophysiology
Funding period: 01/2012 - 12/2014 - SEED 02/12 - Functional analysis of the WWC-protein family in epithelial cell polarity
Group leader: Dirk Oliver Wennmann
Dispatching clinic: Department of Medicine D - Nephrology and Rheumatology
Host institute: Institute of Medical Biochemistry (ZMBE)
Funding period: 01/2012 - 12/2014 - SEED 01/12 - The role of growth-differentiation factor (GDF)-15 in platelet activation, thrombus formation and platelet-mediated inflammation
Group leader: Jan Rossaint
Dispatching clinic: Department of Anaesthesiology, Intensive Care and Pain Therapy
Host institute: Max Planck Institute für Molecular Biomedicine
Funding period: 01/2012 - 12/2014
- SEED 015/20 - Direct reprogramming of kidney mesenchymal cells into podocytes as a therapeutic strategy for chronic kidney disease
Clinical Translation Start Trials - ClinicStarT
- CST/001/19 - Biomarker-guided implementation of glutamine to reduce the occurrence of AKI after cardiac surgery (Acronym: Glutamine to reduce cardiac surgery-associated AKI (Glacé-Trial))
Principal investigator: Alexander Zarbock
Funding period: 09/2019 - 08/2021 - CST/002/19 - Phase II trial to assess the efficacy of low dose involved site radiation therapy (ISRT) with 20 Gy in localized indolent gastric or duodenal lymphoma
Principal investigators: Gabriele Reinartz, Burkhard Greve, Hans Theodor Eich
Funding period: 09/2019 - 02/2022
- CST/001/19 - Biomarker-guided implementation of glutamine to reduce the occurrence of AKI after cardiac surgery (Acronym: Glutamine to reduce cardiac surgery-associated AKI (Glacé-Trial))
Clinical Translation Research Projects - CTRP
- CTRP/007/13 - Neurophysiological and molecular biological investigations into sensory processing of chronic pruritus with cutaneous and non-cutaneous causes in the cowhage model (PruriCow)
Principal investigators: Sonja Ständer, Esther M. Pogatzki-Zahn
Funding period: 08/2013 - 12/2016 - CTRP/008/13 - Emotional processing in limbic encephalitis
Principal investigator: Thomas Straube
Funding period: 06/2013 - 12/2016 - CRA/004/12 - Prevention of disease flares by risk-adapted stratification of therapy withdrawal in juvenile idiopathic arthritis (JIA)
Principal investigators: Dirk Föll, Dirk Holzinger, Joachum Gerß
Funding period: 07/2011 - 09/2015 - CRA/005/11 - Optimization and clinical transfer of a new strategy for treatment of tonal tinnitus
Principal investigators: Christo Pantev, Claudia Rudack
Funding period: 07/2011 - 06/2014 - CRA/003/09 - Klinefelter Syndrome: Do the parental origin and epigenetic profile of the supernumerary X chromosome determine phenotype, morbidity, inflammatory status and cardiovascular risk?
Principal investigators: Michael Zitzmann, Frank Tüttelmann
Funding period: 01/2010 - 12/2012 - CRA/001/09 - Genetics of cerebrovascular (CVD) disease in children
Principal investigators: Ulrike Nowak-Göttl, Klaus Berger
Funding period: 01/2010 - 12/2012
- CTRP/007/13 - Neurophysiological and molecular biological investigations into sensory processing of chronic pruritus with cutaneous and non-cutaneous causes in the cowhage model (PruriCow)
IZKF funded MedK theses (only available in German)
Name, Vorname Institut / Klinik IZKF-Projekt Kohorte / Laufzeit Thema der Dissertation Vorwerk, Jan Medizinische Klinik A Hämatologie, Hämostaseologie, Onkologie und Pneumologie Kha1/002/20 2020-1/01.21-01.22 Funktion von GFI1-36N in der DNA-Reparatur Bäßler, Josefine Physiologie II Li1/029/20 2021-1/08.21 - 07.22 Analyse der zellulären Pathomechanismen von Dilatativer Kardiomyopathie aufgrund von Titinmutationen Wetter, Kai Alexander Klinik für Kinder- und Jugendmedizin Om2/010/20 2021-1/08.21 - 07.22 Charakterisierung der molekularen Mechanismen zur Regulation der beta-Dyneinketten in Atemwegszilien Schwacha, Annika Carolin EIMI Kief1/019/20 2020-1/ 08.20-07.21 Untersuchung des Einflusses der Stimulation von Fcγ-Rezeptoren auf die Polarisierung von Makrophagen der Maus in vivo Budde, Ilka Physiologie II Schw2/020/18 2019-1 / 08.19-07.20 Functional role of mechanosensitive ion channels in pancreatic stellate cell durotaxis Goetsch, Ole Physiologie II Schw2/020/18 2018-1 / 08.18-07.19 Die pH-Abhängigkeit des mechanosensitiven Kanals PIEZO1 in Pankreassternzellen Schumacher, Robert Physiologie I Jün3/003/17 2017-2 / 02.18-01.19 Einfluss der stressrelevanten Neuropeptide NPY und CRH auf die synaptische Aktivität ausgewählter Zellpopulationen im BNST Wennemann, Lucas Kinder- und Jugendmedizin Om2/015/16 2017-1/ 08.17-07.18 Primäre Ziliäre Dyskinesie verursacht durch Defekte der Radialspeichen Prengel, Jonas Zellbiologie (ZMBE) Raz2/021/16 2016-1/ 08.16-07.17 From cell migration to organ formation – interactions between migratory progenitor cells and other cell types during early organ formation Dohn, Mira Biomagnetismus und Biosignalanalyse Ju3/024/15 2016-1/ 08.16-07.17 Beeinflussung des Belohnungssystems durch nicht-invsaive Hirnstimulation bei depressiven Patienten Fischer, Aaron W.R. Labor für Molekulare Psychiatrie Zha3/005/14 2016-1/ 08.16-07.17 Der Einfluss der Ng1-III-vermittelten Signaltransduktion auf die reziproke Inhibition im präfrontalen Cortex Jahns, Lucas Medizinische Mikrobiologie Kah2/016/16 2016-1/ 08.16-07.17 Die Interaktion von Staphylococcus aureus, der in den Atemwegen von Mukoviszidose-Patienten persistiert, mit Neutrophilen und neutrophilen extrazellulären traps (NETs) Mewis, Carolin Virologie (ZMBE) EhC2/006/15 2016-1/ 08.16-07.17 Funktionelle Analyse des Raf/MEK/ERK Signalwegs während einer Infektion mit Respiratorischen Synzytial Viren Bäumer, Sina Medizinische Mikrobiologie Hei2/027/14 2016-1/ 08.16-07.17 Charakterisierung der Bedeutung der Pls-Glykosylreste für die Biofilmbildung in klinischen Methicillin-resistenten Staphylococcus aureus (MRSA) Stämmen Kebben, Natascha Neuropathologie KuT3/012/15 2016-1/ 08.16-07.17 Die funktionelle Rolle von Polaritätsproteinen bei der oligodendroglialen Migration und Differenzierung Zidek, Franziska Hautklinik Lo2/004/16 2016-1/ 08.16-07.17 Relevanz von TNF/TNF-Rezeptor Signalen bei kutanen Entzündungen sowie der Interaktion von Immun- und Nervenzellen in der Haut Kästingschäfer, Vera Clarissa Medizinische Physik und Biophysik Kli3/027/15 2016-1/ 08.16-07.17 Mechanismen und Konsequenzen präsynaptischer Dysfunktion an hippokampalen Synapsen nach akutem metabolischem Stress Dach, Felix Medizinische Mikrobiologie Kah2/016/16 2015-2/ 02.16-01.17 Die Interaktion von Staphylococcus aureus, der in den Atemwegen von Mukoviszidose-Patienten persistiert, mit Neutrophilen und neutrophilen extrazellulären traps (NETs) Van Alst, Timo Mauritz Klinische Radiologie Fa3/016/13 2015-2/ 02.16-01.17 Optogenetik-fMRT zur Manipulation von Netzwerken im Gehirn: Etablierung von Zell- und HirnarealspezifischeOptogenetischer Kontrolle Grotefeld, Kirsten Labor für Molekulare Psychiatrie Zha3/005/14 2015-2/ 02.16-01.17 Der Einfluss der NRG1-III-vermittelten Signaltransduktion auf die reziproke Inhibition im präfrontalen Cortex Beckers, Lena Medizinische Klinik A Rö1/009/15 2015-2/ 02.16-01.17 Antivaskuläre Kombinationstherapien mit tTF-NGR und L19-TNF
IZKF Rotation Programme - (only available in German)
- Rot98 - 07/16 - 12/16
Julia Wallmeier - Molekulare Charakterisierung der Zusammensetzung und der Defekte der radialspeichen-Komplexe in der Primären Ciliären Dyskinesie - Rot97 11/15 - 10/16
Melina Czeh - Genome-wide identification of DNA enhancers responsible for relapse of acute myeloid leukaemia (AML) - Rot96 01/15 - 10/15
Maged Alnawaiseh - Darstellung und Erkennung von frühen diabetischen Veränderungen durch innovative ophthalmologische Abbildungsmodalitäten in vivo und die morphologische und funktionelle Korrelation mittels histologischer und elektroretinographischer Untersuchungen bei der Maus Retina - Rot95 06/15 - 05/16
Arne Bokemeyer - The role of the Wiscott-Aldrich Syndrome protein (WASp) for leukocyte recruitment, integrin activation and inflammation in ischemia-induced acute kidney injury - Rot94 10/14 - 09/15
Sebene Mayorandan - Functional studies on the role of LMBD1 and ABCD4 in lysosomal cobalamin transport - Rot93 05/14 - 04/15
Nadine Vogelsang - Etablierung und Charakterisierung eines humanen proximal-tubulären Zellmodells zur Untersuchung der Cisplatin-Toxizität und möglicher neuer protektiver Therapieansätze - Rot92 05/13 - 10/13
Benjamin Brokinkel - Häufigkeit und prognostischer Einfluss genetischer und epigenetischer Alterationen des hTERT Promotors in kindlichen atypischen teratoiden/rhabdoiden Tumoren - Rot91 05/13 - 12/13
Kornelius Kerl - Die Rolle von CDKs in Rhabdoidtumoren - Rot90 01/13 - 12/13
Eva Schmidt - Analyse des Einflusses von Lats1 auf die Histon H3 und Histon H4 Acetylierung in der myeloischen Differenzierung - Rot89 09/11 - 08/12
Jan Herter - The role of the different Btk-domains in selectin-mediated integrin activation - Rot88 04/12 - 03/13
Kornelius Kerl - Die Rolle von CDKs in Rhabdoidtumoren - Rot87 07/11 - 06/12
Carolin Anna-Amalie Kreis - Global overview of the efficacy of various antimicrobial compounds in models of chronic S. aureus osteomyelitis - Rot86 06/11 - 05/12
Volker Meyer - Analysing glucocorticoid-induced regulatory monocytes in vivo - Rot85 01/11 - 12/11
Carsten Weishaupt - Bedeutung der thrombozytären Adhäsionsrezeptoren für die akute und chronische Entzündung der Haut - Rot84 01/11 - 12/11
Michael Böhm - Neuroprotektive und neurodegenerative Aspekte embryonaler Progenitorzellen und ausgewählter neurotropher Faktoren im vitreoretinalen Kompartment sowie im Nervus opticus - Rot83 07/10 - 08/10
Nils Thoennissen - Kombinatorische Genregulation als Grundlage der zellulären Dynamik in der hämatopoetischen Differenzierung - Rot82 10/09 - 09/10
Marcel du Moulin - Genomweite Homozygotie-Kartierung und Next Generation-Sequencing identifizierter SAMHD1-Mutationen bei einer neuen Variante des Aicardi-Goutières-Syndroms - Rot81 04/09 - 03/10
Lars Henning Schmidt - Potential of spermatogonial stem cells for cellular renewal in testis and bone marrow - Rot80 03/09 - 03/10
Alexander Mellmann - Mobilität und Dynamik der Pathogenitätsdeterminanten von enterohämorrhagischen Escherichia coli (EHEC) im Infektionsverlauf - Rot79 10/08 - 09/09
Yasemin Sirin - Der Chemokinrezeptor CCR10 interagiert direkt mit S100A10 über ein neues Bindungsmotiv - Rot78 10/08 - 09/09
Petra Tschanter - Die Bedeutung von Transkriptionsfaktoren und Zellzyklusregulatoren in der Leukämogenese - Rot77 01/08 - 12/08
Burkhard Gess - Molekulare Mechanismen der neuronalen Degeneration im peripheren Nervensystem: Einfluss der Demyelinisierung auf die neuronale Genregulation - Rot76 01/08 - 06/09
Bettina Löffler - Mechanismen der Apoptose-Induktion durch Staphylococcus aureus bei Leukozyten und Endothelzellen - Rot75 01/08 - 12/08
Tanya Imai - Integration magnetenzephalographischer (MEG) und funktionell magnetresonanztomographischer (fMRT) Untersuchungen somatosensibler Perzeption und exekutiver Kontrollfunktionen in Abhängigkeit vom serotonergen und dopaminergen System - Rot74 10/07 - 09/08
Astrid V. Rauch - Erforschung neurobiologischer und neuroanatomischer Grundlagen der Gedächtnisorganisation für bedrohungsrelevante Reize - Rot73 09/07 - 04/08
Nils Thoennissen - Kombinatorische Genregulation als Grundlage der zellulären Dynamik in der hämatopoetischen Differenzierung - Rot72 09/07 - 02/09
Athanasios Tsianakas - Einfluss der initialen Zytokinexpression in der Epidermis auf die spezifische Immunantwort in der experimentellen Leishmaniasis - Rot71 09/07 - 08/08
Jan Däbritz - Molekulare Charakterisierung der RAGE-vermittelten Endothelaktivierung - Rot70 01/07 - 06/08
Sylvia Pauser - Role of ECE-1 on somatostatin receptor regulation - Rot69 11/06 - 10/07
Rüdiger Liersch - Etablierung eines murinen Knochenmark-Transplantations-Modells in der Maus - Rot68 10/06 - 09/07
Udo Dannlowski - Modulierung von Gedächtnisfunktionen durch emotionale Reize und affektive Zustände bei Gesunden und depressiven Patienten - Rot67 07/06 - 12/06
Jörg Haberland - Mesenchymale Stammzellen zur Therapie des Morbus Wilson - Rot66 07/06 - 12/06
Andrea Swintek - Zelltrafficking in der Maus in hochauflösendem Kleintier-PET und Phänotypisierung kardiovaskulärer Mausmodelle mit Micro-PET und 2D Echo - Rot65 02/06 - 01/07
Jan Larmann - Die Rolle der Leukozyten-Rekrutierung für das TMLeD-abhängige ventrikuläre Remodeling im Modell der Nachlast-induzierten LV-Hypertrophie - Rot64 01/06 - 12/06
Jan Niemeier - Die Rolle von ‚C/EBP-homologous protein’ (CHOP) bei der Sauerstoffradikal-vermittelten Schädigung des Podozyten - Rot63 01/06 - 12/06
Richard Stange - Neue Strategien zur Therapie Implantat-assoziierter Infektionen in der Chirurgie des Stütz- und Bewegungsapparates - Rot62 11/05 - 10/06
Steffen Koschmieder - Expansion hämatopoietischer Stammzellen in INCA1-Knockout Mäusen und Expression von INCA1 in BCR-ABL positiven Mäusen - Rot61 10/05 - 09/06
Tobias Warnecke - Beeinflussung assoziativen Lernens und motorischer Fähigkeiten durch G-CSF und EPO - Rot60 09/05 - 08/06
Alexander W. Friedrich - Pathomechanismen der Wechselwirkung zwischen enterohämorrhagischen Escherichia coli und intestinalen Epithelzellen - Rot59 07/05 - 06/06
Eric Schulze-Bahr - Molekulare Genetik der Sinusknotenerkrankung - Rot58 01/05 - 12/05
Carsten Konrad - Morphometrische Analysen in der psychiatrischen Forschung - Rot57 01/05 - 12/05
Stefanie Hanna Kreußer - Identifikation potentieller pathogenetischer Faktoren bei der Entstehung von Glomerulosklerose und tubulointerstitieller Fibrose - Rot56 01/05 - 12/05
Hans Meinhard Schiller - (a) Untersuchungen zur Relevanz von hautspezifischer IL-15 Überexpression für die kutane UV-induzierte Karzinogenese, (b) Interaktion der cAMP mediierten Signaltransduktion auf Schlüsselfunktionen von dermalen Fibroblasten - Rot55 01/05 - 12/05
Helmut Wittkowski - Funktionelle Charakterisierung des Granulozyten-spezifischen, Calcium-bindenden Proteins S100A12 - Rot54 11/04 - 10/05
Torsten Kessler - Vermindertes Tumorwachstum durch gezielten Einsatz gerinnungsaktivierender Peptide - Rot53 10/04 - 09/05
Uta Brunnberg - Etablierung neuer Laborverfahren zur Untersuchung der Signaltransduktion von Flt3 und nachgeschalteten Signalproteinen an klinischen AML-Proben - Rot52 08/04 - 07/05
Mitrofanis Pavlidis - Molekulare Mechanismen der neuronalen Regeneration: Resistenz der retinalen Neuronen in der diabetischen und der hypertensiven Retinopathie (Mensch vs. Affe) - Rot51 07/04 - 06/05
Paulus Kirchhof - Entwicklung der standardisierten echokardio-graphischen Untersuchung des rechten Ventrikels und weiterer Methoden - Rot50 01.04 - 12.04
Martin Steinhoff - Proteinase-activated receptors: Transducers of proteinase-mediated signalling in inflammation and immune response - Rot49 02/04 - 12/04
Eileen Dayal - Analyse der Expression verschiedener Peptid-rezeptoren und Transporterproteine im Modell der akuten Rejektion nach Nierentransplantation (NTX) bei der Ratte - Rot48 09/03 -05/04
Martina Ahlmann - Expressionsanalyse von Makrophagensubpopulationen während der Transmigration und Diapedese - Rot47 10/03 - 09/04
Sven Hermann - High-density lipoprotein stimulates myocardial perfusion in vivo - Rot46 11/03 - 10/04
Klaus Hahnenkamp - Rolle von u-PAR und Thrombomodulin für das Myokardischämie / Reperfusionssyndrom und das Post-CPR-Syndrom - Rot45 08/03 - 07/04
Bhanu Sinha - Struktur-Funktions-Analyse von Staphylococcus aureus-FnBPs bei der Invasion humaner Wirtszellen - Rot44 08/03 - 07/04
Tobias Stupp - Einfluss lentogener Faktoren auf die regenerierende retinale Ganglienzelle (RGZ) - Rot43 06/03 - 05/04
Björn Steffen - Analyse der Zielgene von Flt3 - Rot42 03/03 - 08/03
Matthias Schilling - Untersuchung der differenziellen Funktion residenter Mikrogliazellen im Vergleich mit hämatogenen Makrophagen bei der experimentellen zerebralen Ischämie - Rot41 03/03 - 08/03
Bianca Dräger - Genetik der Hemisphärenlateralisation für Sprache - Rot40 04/03 - 03/04
Uta Hillebrand - Östrogen-induziertes ‚Remodeling’ der Endothelzelle - Rot39 02/03 - 05/03
Julia Mayerle - Die Funktion von Protein-Tyrosin-Phosphatasen als Regulatoren der Zelladhäsion bei der Metastasierung und Invasion des Pankreaskarzinoms - Rot38 10/02 - 09/03
Peter Kies - Nicht-invasive Quantifizierung des myokardialen Blutflusses und der Flussreserve bei Vorhofflimmern - Rot37 08/02 - 07/03
Dorothee Viemann - Mechanismen der von-Willebrand-Faktor- und Plasminogenaktivator-Freisetzung aus aktivierten Endothelzellen - Rot36 08/02 - 07/03
Jonas Denecke - Funktion der Enterozyten bei der oralen Toleranzentwicklung - Rot35 06/02 - 05/03
Axel Menzebach - Regulation der Integrin-Aktivierung durch die Integrin-assoziierten Proteine CD47 und u-PAR - Rot34 02/02 - 01/03
Bülent Sargin - Identifikation und Charakterisierung prognostisch relevanter Gene in Blasten der akuten myeloischen Leukämie - Rot33 01/02 - 12/02
Jan Ehrchen - Analyse der Pathomechanismen der leukozytoklastischen Vaskulitis anhand humaner Biopsieproben und im Tiermodell - Rot32 10/01 -10/02
Raihanatou Diallo - (a) Bestrahlungsinduzierte Änderungen der Telomeraseaktivität eines humanen Ewing-Xenografttumors (b) Telomerase als prognostischer Marker des Mammakarzinoms: Gewebechipanalyse von hTERT und hTR - Rot31 08/01 - 03/03
Martin Steinhoff - Bedeutung des Protease-aktivierten Rezeptors-2 (PAR-2) für die Pathogenese der neurogenen Entzündung - Rot30 08/01 - 07/02
Dorothee Viemann - Funktionelle Charakterisierung des granulozyten-spezifischen, calcium-bindenden Proteins S100A12 - Rot29 06/01 -11/01
Stephan Seeliger - Pathomechanismen der Gefäßschädigung bei der leukozytoklastischen Vaskulitis - Rot28 06/01 - 05/02
Ralf Niehues - Charakterisierung der Rolle des Mannose-6-Phosphat-Rezeptors in der Adressierung lysosomaler Proteine bei der experimentellen Pankreatitis - Rot27 06/00 - 05/01
Stephan Seeliger - Beeinflussung der Infektresistenz durch Modulation des myelomonozytären Infiltrates am Beispiel der experimentellen Leishmaniasis - Rot26 01/01 - 12/01
Peter Simon - Funktion von Protein-Tyrosin-Phosphatasen in der Tumormetastasierung - Rot25 10/00 - 01/02
Karsten Becker - Untersuchungen zu Schädigungs- und Abwehrmechanismen bei chronischen Infektionen durch Staphylokokken - Rot24 07/00 - 06/01
Gregor Theilmeier - u-PAR bzw. Thrombomodulin und Leukozyten-Trafficking in ischämischem Gewebe - Rot23 04/00 - 03/01
Martin Hausberg - Bestimmung der Diadenosinpolyphosphat-Konzentration in Thrombozyten und deren Beziehung zu strukturellen und funktionellen Gefäßwandeigenschaften großer Arterien - Rot22 02/00 - 01/01
Thomas Wichter - Integration bildgebender und elektrokardiographischer Verfahren bei chronischer Myokardischämie und arrythmogenen Erkrankungen - Rot21 02/00 - 01/01
Kai-Uwe Jürgens - Chronisch ischämisches Myokard: Optimierung der MR-Untersuchungsprotokolle, MR-tomographische Bestimmung der globalen und regionalen Dysfunktion - Rot20 01/00 - 06/00
Johannes Roth - Calciumabhängige Aktivierungsmechanismen und antientzündliche Wirkungsprinzipien auf Monozyten - Rot19 01/00 - 12/00
Burkhard Wiethoff - Entwicklung und Evaluation eines hochselektiven Radiopharmakons zur nicht-invasiven Quantifizierung der kardialen ß1-Adrenozeptordichte - Rot18 01/00 - 12/00
Heike Bantel - Detektion erhöhter Caspase-Aktivierung und früher Apoptose in Lebererkrankungen - Rot17 10/99 - 09/00
Sonja Ständer - Bestimmung der Expression des proapoptotischen Faktors TRAIL in der Haut mittels immunhisto-chemischer Methoden - Rot16 05/99 - 05/00
Michael Ragunath - Die Modulation der TGF-ß Wirkung durch a-MSH - Rot15 05/99 - 04/00
Stefan Turi - Magnesium als „second messenger“ und seine Rolle in physiologischen und pathophysiologischen intrazellulären Prozessen in Acinuszellen des Pankreas - Rot14 01/99 -12/99
Gert Gabriёls - Effekte von Diadenosin-Polyphosphaten in der renalen Mikrozirkulation in vivo - Rot13 01/99 - 12/99
Uli-Rüdiger Jahn - Untersuchungen zur Thrombozytenfunktion und zum Aktivierungszustand von Thrombozyten - Rot12 01/99 - 12/99
Peter Matheja - Quantifizierung der präsynaptischen neuronalen Noradrenalin-aufnahme mittels trägerfreiem I-123-meta-Iodobenzylguanidin - Rot11 11/98 - 12/99
Johannes Roth - Bedeutung von Phosporylierungsreaktionen an MRP14 im Rahmen der Aktivierung von Monozyten - Rot10 10/98 - 12/99
Cord Sunderkötter - Die Beeinflussung der Infektresistenz durch Modulation des myelomonozytären Infiltrates am Beispiel der experimentellen Leishmaniose - Rot9 07/98 - 12/98
Markus Knickmeier - Forschungsaufenthalt am Hammersmith Hospital, MRC Cyclotron Unit, PET Cardiology (Arbeitstechniken zum Aufbau des Münsteraner PET-Zentrums) - Rot8 07/98 - 12/98
Thomas Mehrens - Einfluss von Purinorezeptoren-Antagonisten auf die Wirkung von Diadenosinpentaphosphat (Ap5A) in vitro - Rot7 04/98 - 09/98
Jörg Mergenthaler - Effekt von Propafenon auf den HERG Kaliumkanal und Mutagenese des HERG Wildtypgenoms im heterologen Expressionsmodell der Xenopus- Oozyte - Rot6 (abgebrochen)
- Rot5 01/98 - 06/98
Michael Schäfers - Chronisch ischämisches Myokard - Rot4 05/97 -10/97
Michael Ragunath - Extrazelluläre Matrixmoleküle der Haut: Natürliche Modulatoren von Wachstumsfaktoren - Rot3 04/97 -03/98
Heike Pöppelmann - Calciumabhängige Aktivierung und anti-entzündliche Mechanismen auf Monozyten - Rot2 04/97 - 03/98
Cord Sunderkötter - Die Beeinflussung der Infektresistenz durch Modulation des myelomonozytären Infiltrates am Beispiel der experimentellen Leishmaniose - Rot1 01/97 - 06/98
Thomas Kohl - Chronisch ischämisches Myokard
- Rot98 - 07/16 - 12/16
Method development | Z-Projects
- Z/004/17 - Photoacoustic imaging (PAI) to non-invasively characterize atherosclerotic plaques in vivo
Principal investigators: Michael Schafers, Sven Hermann
Funding period: 01/2017 - 12/2019 - Z/003/14 - Analysis of glycolipid receptors of microbial virulence factors in cell cultures and organs using imaging mass spectrometry
Principal investigators: Klaus Dreisewerd
Funding period: 01/2014 - 10/2016 - Z/002/06 - Development of genomic oligonucleotide arrays for funtional system biology
Principal investigator: Carsten Müller-Tidow
Funding period: 07/2006 - 12/2007 - Z/001/02 - Expression analysis of macrophage subpopulations during transmigration and diapedesis
Principal investigators: Johannes Roth, Clemens Sorg
Funding period: 06/2002 - 05 /2004
- Z/004/17 - Photoacoustic imaging (PAI) to non-invasively characterize atherosclerotic plaques in vivo