Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, Linard Matos AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D. TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. 2021; Mol. Cell [ahead of print]

Apken LH, Oeckinghaus A. The RAL signaling network: Cancer and beyond. 2020; Int. Rev. Cell Mol. Biol. [in press]

Beel S, Kolloch L, Apken LH, Jürgens L, Bolle A, Sudhof N, Ghosh S, Wardelmann E, Meisterernst M, Steinestel K, Oeckinghaus A. κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis. 2020; Nat. Commun. 11:3409

Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan CH, Singh RK, Apken LH, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP 4th, Askan G, Grbovic-Huezo O, Ogrodowski P, Bermeo J, Saglimbeni J, Cruz CD, Ho YJ, Lawrence SA, Melchor JP, Goda GA, Bai K, Pastore A, Hogg SJ, Raghavan S, Bailey P, Chang DK, Biankin A, Shroyer KR, Wolpin BM, Aguirre AJ, Ventura A, Taylor B, Der CJ, Dominguez D, Kümmel D,Oeckinghaus A, Lowe SW, Bradley RK, Abdel-Wahab O, Leach SD. Altered RNA splicing by mutant p53 activates oncogenic RAS signaling in pancreatic cancer. 2020; Cancer Cell 38:198-211

Hansmann P, Brückner A, Kiontke S, Berkenfeld B, Seebohm G, Brouillard P, Vikkula M, Jansen FE, Nellist M, Oeckinghaus A, Kümmel D. Structure of the TSC2 GAP domain: Mechanistic insight into catalysis and pathogenic mutations. 2020; Structure 28:933-942

Zech R, Kiontke S, Mueller U, Oeckinghaus A, Kümmel D. Structure of the tuberous sclerosis complex 2 (TSC2) N terminus provides insight into complex assembly and tuberous sclerosis pathogenesis. 2016; J. Biol. Chem. 291:20008-20

Meininger I, Griesbach RA, Hu D, Gehring T, Seeholzer T, Bertossi A, Kranich J, Oeckinghaus A, Eitelhuber AC, Greczmiel U, Gewies A, Schmidt-Supprian M, Ruland J, Brocker T, Heissmeyer V, Heyd F, Krappmann D. Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells. 2016; Nat. Commun. 7:11292

Oeckinghaus A, Postler TS, Rao P, Schmitt H, Schmitt V, Grinberg-Bleyer Y, Kühn LI, Gruber CW, Lienhard GE, Ghosh S. κB-Ras proteins regulate both NF-κB-dependent inflammation and Ral-dependent proliferation. 2014; Cell Rep. 8:1793-807

Oeckinghaus A, Hayden MS, Ghosh S. Crosstalk in NF-κB signaling pathways. 2011; Nat. Immunol. 12:695-708 Review.

Rao P, Hayden MS, Long M, Scott ML, West AP, Zhang D, Oeckinghaus A, Lynch C, Hoffmann A, Baltimore D, Ghosh S. IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. 2010; Nature 466:1115-9

Oeckinghaus A, Ghosh S. The NF-kappaB family of transcription factors and its regulation. 2009;  Cold Spring Harb. Perspect. Biol. 1:a000034 Review.

Düwel M, Welteke V, Oeckinghaus A, Baens M, Kloo B, Ferch U, Darnay BG, Ruland J, Marynen P, Krappmann D. A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. 2009; J. Immunol. 182:7718-28

Kümmel D, Oeckinghaus A, Wang C, Krappmann D, Heinemann U. Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells. 2008; FEBS Lett. 582:3729-33

Oeckinghaus A, Wegener E, Welteke V, Ferch U, Arslan SC, Ruland J, Scheidereit C, Krappmann D. Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. 2007; EMBO J. 26:4634-45.

Wegener E, Oeckinghaus A, Papadopoulou N, Lavitas L, Schmidt-Supprian M, Ferch U, Mak TW, Ruland J, Heissmeyer V, Krappmann D. Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. 2006; Mol. Cell 23:13-23

Kraft P, Oeckinghaus A, Kümmel D, Gauss GH, Gilmore J, Wiedenheft B, Young M, Lawrence CM. Crystal structure of F-93 from Sulfolobus spindle-shaped virus 1, a winged-helix DNA binding protein. 2004; J. Virol. 78:11544-50

Kraft P, Kümmel D, Oeckinghaus A, Gauss GH, Wiedenheft B, Young M, Lawrence CM. Structure of D-63 from sulfolobus spindle-shaped virus 1: surface properties of the dimeric four-helix bundle suggest an adaptor protein function. 2004;J. Virol. 78:7438-42