Exploring the T-cell receptor repertoire in Neuromyelitis optica

Neuromyelitis optica (NMO) is a rare inflammatory autoimmune disease of the central nervous system, mainly affecting the optic nerves and spinal cord. In collaboration with the Clinic for Neurology with Institute for Translational Neurology (Univ.-Prof. Dr. Luisa Klotz), we aim to use recent advances in the technology of T-cell receptor sequencing to unravel T-cell related differences in NMO patients. We are mainly interested in general differences, like repertoire diversity, but also aim to identify disease specific clones / clusters, potentially differing between NMO subtypes.

Contact: imi@uni-muenster.de