MARS

Münster Ageing and Retina Study

The age-dependent macular degeneration (AMD) is a degenerative disease of the retina that starts only late in life and leads in ist final stages to losses of central vision acuity and occasionally even blindness. The aim of the prospective MARS is to identify factors that influence the occurrence and, in particular, the progression of AMD.

To date, the MARS cohort has examined three times: MARS-I: 2001-2003, MARS-II: 2004 – 2007, and MARS-III: 2007-2009. A reexamination of a subcohort (MARS+) was carried out in 2010/11.

The examination program included: Digital fundus photography to characterise morphological alterations of the Retina; questionnaires on visual function (VFQ-25); genetic dispositions (SNP from stored DNA); 2-wavelength autofluorescence measurement of macular pigment optical density of the retina; anthropometry, medical history, medication use, life style factors (smoking etc). Optical coherence tomography (OCT) measurements in MARS+.

Overview

Contact person: Hans-Werner Hense, Birte Claes
Coordination: Hans-Werner Hense, Daniel Pauleikhoff (Augenklinik, St. Franziskus-Hospital, Münster)
Funding: DFG-Schwerpunktprogramm; Pro-Retina Foundation; Jackstädt Foundation; DFG-Sachmittelförderung
State: Start 2001 - continuing