Interact

Interaction of biological markers and psychological characteristics with indicators of social inequality in the onset of type 2 diabetes

With an estimated prevalence of about 7% of the German adult population (equivalent to about 4.6 million people), diabetes mellitus (type 2) is one of the “widespread diseases”. Various studies showed a relationship between social status and the onset of type 2 diabetes, as individuals with a low social status have an increased risk of developing diabetes compared to individuals with a high social status.

In the first funding period, the aim of the project was to analyze the relationship between biomarkers (such as HbA1c as a measure of glycemic control and CRP & IL-6 as inflammatory markers) and individual social factors as determinants of type 2 diabetes. These analyses help to better understand biological mechanisms that contribute to the link between social inequality and the onset of type 2 diabetes.

In the second funding period, the scope of the project was extended by the issue of mental health. The aim is to analyze the relationship between social factors and depression as well as to examine the potential mediating role of depression in the link between social status and type 2 diabetes. Further, specific characteristics of depression, namely distinct depression subtypes and symptom severity, will be taken into account.

The project is part of the German Center for Diabetes Research (DZD). The DZD is funded by the German Federal Ministry of Education and Research (BMBF) and some German federal states. The present project is based on prior projects within the former German Competence Network Diabetes mellitus (e.g. "DIAB-CORE").

Overview

Contact person: Corinna Rahe
Coordination: Corinna Rahe, Klaus Berger
Funding: German Center for Diabetes Research (DZD), funded by the German Federal Ministry of Education and Research (BMBF) and some German federal states
State: 1. funding period: 01/2015 – 12/2015;
2. funding period: 01/2016 – 12/2017
Homepage: Deutsches Zentrum für Diabetesforschung e.V.