Medical Faculty, University of Münster
Von-Esmarch-Straße 56, Building 2352, Room 130.114Phone: +49 251 83-59058
Fax: +49 251 83-59060Email: email@example.com
I am interested in understanding the physiological role of the Ca2+-mediated Actin Reset (CaAR) described by our group, particularly focusing on the wound healing process on single cell level. Further, I investigate the activation of CaAR regulator Inverted Formin 2 (Inf2) in Ca2+-dependent manner, including mutated forms of Inf2 occurring in pathological phenotypes.
In my work, I use methods of molecular biology (cloning, site-directed mutagenesis), biochemistry (pull-down, immunoblotting), and fluorescent microscopy in live or fixed cells.
Wales P*, Schuberth CE*, Aufschnaiter R*, Fels J, García-Aguilar I, Janning A, Dlugos CP, Schäfer-Herte M, Klingner C, Wälte M, Kuhlmann J, Menis E, Hockaday Kang L, Maier KC, Hou W, Russo A, Higgs HN, Pavenstädt H, Vogl T, Roth J, Qualmann B, Kessels MM, Martin DE, Mulder B, Wedlich-Söldner R (2016). Calcium-mediated actin reset (CaAR) mediates acute cell adaptions. Elife 2016 Dec 6;5. pii: e19850