• Originalpublikationen 2022 - 2023

    König S*, Marco HG*, Gäde G (2023) Oxidation products of tryptophen and proline in adipokinetic hormones - artefacts or posttranslational modifications? Life 13: 2315

    Suero Molina E, Black D, Walke A, Azemi G, d’Alessandro F, König S, Stummer W (2023) Unraveling the blue shift in porphyrin fluorescence in glioma: The 620 nm peak and its potential significance in tumor biology. Frontiers in Neuroscience 17:1261679

    Marco HG, König S*, Gäde G* (2023) Predicted novel hypertrehalosaemic peptides of cockroaches are verified by mass spectrometry. Amino Acids, doi.org/10.1007/s00726-023-03337-7

    König S, Marco HG, Gäde G (2023) The proline effect and the tryptophan immonium ion assist in de novo sequencing of adipokinetic hormones. Sci Rep 13:10894

    Aziz S, König S, Umer M, Akhter TS, Iqbal S, Ibrar M, Ur-Rehman T, Ahmad T, Hanafiah A, Zahra R, Rasheed F. (2023) Risk factor profiles for gastric cancer prediction with respect to Helicobacter pylori: A study of a tertiary care hospital in Pakistan. Artif Intell Gastroenterol 4(1), 10-27

    König S, Vollenberg R, Tepasse P. (2023) The renin-angiotensin-system in COVID-19: Can Long COVID be predicted?. Preprints.org 2023, 2023051298, Life 2023, 13, 1462

    Berg I, Mall A, Steffens L, Fertl J, Steiner T, Huber C, Graß C, Say R, Huber H, Katsyv A, Müller V, Cortina NS, Erb T, König S, Eisenreich W. (2022) H2 partial pressure switches autotrophic pathways in an anaerobic bacterium. Research Square, DOI: 10.21203/rs.3.rs-1456100/v1

    Gola L, Bierhansl L, Csatári J ... König S … Kovac S (2023) NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores. Cell. Mol. Life Sci. 80, 127

    Walke A, Black D, Valdes PA, Stummer W, König S, Suero-Molina E (2023) Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements. Sci Rep 13: 3829

    König S. (2023) Spectral data quality in mass spectrometry-based proteomics. Molecules 28: 2541

    Feickert MK, Sanz-Soler R, Niland S, König S, Eble JA, Obermann WMJ (2023) Stimulation of platelet aggregation by affinity captured rhodocytin from the Malayan pit viper Calloselasma rhodostoma. Toxicon 225: 107058

    Nickelsen A, Lenz F, Niefind K, König S, Jose J (2023) Analyzing the interactome of human CK2β in prostate carcinoma cells reveals HSP70-1 and Rho guanin nucleotide exchange factor 12 as novel interaction partners. FASEB Bioadvances 2023;00:1-17, DOI: 10.1096/fba.2022-00098

    Aziz S, Rasheed F, Zahra R, König S. (2023) Mass spectrometry-based proteomics of minor species in the bulk: Questions to raise with respect to the untargeted analysis of viral proteins in human tissue. Life 13: 544

    Herting JR, Berg AM, Hadova K, Heinick A, König S, Kuhlmann M, Müller FU, Kirchhefer U. Myocardial overexpression of protein phosphatase 2A-B56α improves resistance against ischemia-reperfusion injury. J Mol Cell Cardiol Plus 2022, 100030

    Gola L, Bierhansl L, Hummel N, Korn L, Pawlowski M, Cerina M, Hundehege P, Budde T, König S, Meuth S, Wiendl H, Kovac S. (2023) MMF induces antioxidative and anaplerotic pathways and is neuroprotective in hyperexcitability in vitro. Free Radical Biology and Medicine 194: 337-346

    Marco HG*, König S*, Gäde G. (2022) Mass spectrometric proof of predicted peptides: Novel adipokinetic hormones in insects. Molecules 27, 6469

    Aziz S, Akher TS, Rasheed F, Zahra R, König S. (2022) Microbial proteins in stomach biopsies associated with gastritis, ulcer, and gastric cancer. Molecules 27: 5410

    König S, Obermann WMJ, Eble JA. (2022) The current state-of-the-art of the identification of unknown proteins using mass spectrometry exemplified on de novo sequencing of a venom protease from Bothrops moojeni. Molecules 27: 4976

    Aziz S, Rasheed F, Zahra R, König S. (2022) Gastric cancer pre-stage detection and early diagnosis of gastritis using serum protein signatures. Molecules 27:2857

    Tepasse P-R, Vollenberg R, Steinebrey N, König S. (2022) The dysregulation of the renin–angiotensin system in COVID-19 studied by serum proteomics: Angiotensinogen increases with disease severity. Molecules 27(8):2495

    Walscheid K, Wildschütz L, Ackermann D, Kasper M, Busch M, Thanos S, Bauer D, Stoll M, König S, Heiligenhaus A (2022) Assessment of angiogenesis-related parameters in juvenile idiopathic arthritis-associated uveitis. Molecular Biology Reports, 2022

    Tepasse P-R, Vollenberg R, Steinebrey N, König S (2022) High angiotensin-converting enzyme and low carboxypeptidase N serum activity correlate with disease severity in COVID-19 patients. J Personalized Med. 12: 406

    Aziz S, König S, Noor H, Nadeem M, Zahra R, Rasheed F (2022) Isolated dextrogastria with eventration of right hemidiaphragm and hiatal hernia in an adult male. BMC Gastroenterology 22:56

    Nguyen HT, Herrmann F, König S, Goycoolea FM, Hensel A (202) Structural characterization of the carbohydrate and protein part of arabinogalactan protein from Basella alba stem and antiadhesive activity against Helicobacter pylori. Fitoterapia 157:105132

  • Originalpublikationen 2020 - 2021

    König S, Schütz U (2021) Schaffe ich den Marathon? – Bioprofilierung. GDCh Faszination Chemie, 06.10.2021

    König S, Engl C, Bayer M, Escolano-Lozano F, Rittner H, Rebhorn C, Birklein F. (2021) Substance P serum degradation in Complex Regional Pain Syndrome – another puzzle piece? J Pain, doi.org/10.1016/j.jpain.2021.10.005

    Black D, Kaneko S, Walke A, König S, Stummer W, Suero Molina E. (2021) Characterization of autofluorescence and quantitative protoporphyrin IX biomarkers for optical spectroscopy-guided glioma surgery. Sci Rep 11, 20009

    Ackermann D, König S. (2021) Comparative two-dimensional fluorescence gel electrophoresis. Protocol Exchange, Posted 15 Sep, 2021, DOI: 10.21203/rs.3.pex-1612/v1

    König S, Steinebrey N, Herrnberger M, Escolano-Lozano F, Schlereth T, Rebhorn C, Birklein F. (2021) Reduced serum protease activity in Complex Regional Pain Syndrome: The impact of angiotensin-converting enzyme and carboxypeptidases. Journal of Pharmaceutical and Biomedical Analysis 205:114307

    Liebmann M, Korn L, Janoschka C, Albrecht S, Herrmann AM, Schulte-Mecklenbeck A, Schwab N, Schneider-Hohendorf T, Eveslage M, Wildemann B, Luessi F, Schmidt S, Diebold M, Gross CC, Kovac S, Zipp F, Derfuss T, Kuhlmann T, König S, Meuth SG, Wiendl H, Klotz L. (2021) Dimethyl fumarate treatment restrains the antioxidative capacity of T cells to control autoimmunity. Brain, 144: 3126-3141

    Walke A, König S. (2021) Protorphyrin IX purification from blood and serum for mass analysis – considerations with respect to neurosurgery. RCM, DOI:10.1002/rcm.9138

    Altvater B, Kailayangiri S, Pérez-Lanuza LF, Urban K, Greune L, Flügge M, Meltzer J, Farwick N, König S, Hartmann W, Rössig C. (2021) HLA-G and HLA-E immune checkpoints are widely expressed in Ewing sarcoma but with limited functional impact on the effector functions of antigen-specific CAR T cells. Cancers 13(12), 2857

    Escolano-Lozano F, Gries E, Schlereth T, Dimova V, Baka P, Vlckova E, König S, Birklein F. (2021) Local and systemic expression pattern of MMP-2 and MMP-9 in complex regional pain syndrome. J Pain, doi.org/10.1016/j.jpain.2021.04.002

    Steffens L, Pettinato E, Steiner TM, Mall A, König S, Eisenreich W, Berg I (2021) High CO2 levels drive the TCA cycle backwards towards autotrophy. Nature 2021
    Behind the paper
    WWU Pressemitteilung

    König S (2021) Die Bedeutung des Massenspektrums in den Omics. GIT-Labor-Fachzeitschrift / Wiley Analytical Science

    Meißner J, Rezaei M, Siepe I, Ackermann D, König S , Eble JA, (2021) Redox proteomics reveals an interdependence of redox modification and location of adhesome proteins in NGF-treated PC12 cells. Free Radical Biol Medicine Jan 16. doi.org/10.1016/j.freeradbiomed.2021.01.019

    Liu L, Brown PC, Könneke M, Huber H, König S, Berg IA, (2021) Convergent evolution of a promiscuous 3-hydroxypropionyl-CoA dehydratase/crotonyl-CoA hydratase in Cren- and Thaumarchaeota. mSphere 6,1:e01079-20

    König S, Jockenhöfer C, Billich C, Beer M, Machann J, Schmidt-Trucksäss A*, Schütz U*, (2020) Long distance running: molecular indicators from urine profiling - can bioprofiling predict success in endurance athletes? Medical Hypotheses, 110474

    Gerwing M, Kocman V, Stölting M, Helfen A, Masthoff M, Roth J, Barczyk-Kahlert K, Greune L, Schmidt MA, Heindel W, Faber C, König S, Wildgruber M, Eisenblätter M, (2020) Tracking of tumor cell-derived extracellular vesicles in vivo reveals a specific distribution pattern with consecutive biological effects on target sites of metastasis. Mol Imaging Biol, doi: 10.1007/s11307-020-01521-9

    Bayer M, Savelsbergh A, Klinger C, Kaufmann M, König S, (2020) Derivatization of the amino acids glycine and valine causes peptide formation - Relevance for the analysis of prebiotic oligomerization. Rapid Commun Mass Spectrom

    König S, (2020) Spectral quality overrides software score – A brief tutorial on the analysis of peptide fragmentation data for mass spectrometry laymen. J Mass Spectrom

    Wallenstein A, Rehm N, Brinkmann M, Selle M, Bunk B, Spröer C, Wami H, Homburg S, König S, Overmann J, Müller R, Dobrindt U, (2020) ClbR is the key transcriptional activator of colibactin gene expression in Escherichia coli. mSphere

    Schreiber U, Engl C, Bayer M, König S, (2020) Neuropeptide reporter assay for serum, capillary blood and blood cards. MethodsX 7:100985

  • Originalpublikationen 2018 - 2019

    Bayer M, Tsiskarishvili N, Stegemann A, Böhm M*, König S*, (2019) Fast oxidation of α-melanocyte stimulating hormone and derived peptides under laboratory conditions causes irreproducible results. Pigment Cell & Melanoma Research, DOI: 10.1111/pcmr.12852

    Schreiber U, Bayer M, König S (2019) Validation data for the use of bradykinin and substance P protease activity assay with capillary blood and blood cards. Data in Brief 104873

    Schreiber U, Engl C, Bayer M, König S (2019) Labeled substance P as a neuropeptide reporter for enzyme activity. Journal of Pharmaceutical and Biomedical Analysis 112953

    Busch M, Wefelmeyer KL, Walscheid K, Rothaus K, Bauer D, Deeg CA, Degroote R, Hauck SM, Ackermann D, König S, Thanos S, Kasper M, Heiligenhaus A (2019) Identification of ocular autoantigens associated with juvenile idiopathic arthritis-associated uveitis. Frontiers in Immunology, doi: 10.3389/fimmu.2019.01793

    Dietrich J, Roth M, König S, Geerling G, Mertsch S, Schrader S. (2019) Analysis of lacrimal gland derived mesenchymal stem cell secretome and its impact on epithelial cell survival. Stem Cell Res 38: 101477

    König S*, Bayer M*, Marco H, Gäde G (2019) The hypertrehalosaemic neuropeptides of cicadas consist of only L-amino acids: are they cis-trans isomers? Amino Acids, doi: 10.1007/s0076-019-02742-1

    Wildschütz L, Ackermann D, Witten A, Kasper M, Busch B, Glander S, Melkonyan H, Walscheid K, Tappeiner C, Thanos S, Baryzenka A, Koch J, Heinz C, Laffer B, Bauer D, Stoll M, König S, Heiligenhaus A (2019) Transcriptomic and proteomic analysis of iris and aqueous humor in juvenile idiopathic arthritis- associated uveitis. J Autoimmunity, 2018 10.1016/j.jaut.2019.03.004

    Bayer M, Angenendt L, Schliemann C, Hartmann W, König S (2019) Are formalin-fixed and paraffin-embedded tissues fit for proteomic analysis? Vale Alfred Yergey, J Mass Spectr 1-5, doi: 10.1002/jms.4347

    König S*, Bayer M*, Dimova V, Herrnberger M, Escolano-Lozano F, Bednarik J, Vlckova E, Rittner H, Schlereth T, Birklein F (2018) The serum protease network - one key to understand Complex Regional Pain Syndrome pathophysiology. PAIN, doi: 10.1097/j.pain.0000000000001503

    Schmidt A*, Strecker J-K*, Liebmann M, Massoth C, Beuker C, Hansen U, König S, Albrecht S, Bock S, Breuer J, Sommer C, Schwab N, Wiendl H, Klotz L, Minnerup J (2018) Dietary salt promotes ischemic brain injury and is associated with parenchymal migrasome formation. PLoS ONE 13(12): e0209871

    Zacharski DM, Esch S, König S, Mormann M, Brandt S, Ulrich-Merzenich G, Hensel A (2018) ß-1,3/1,4-Glucan Lichenan from Cetraria islandica (L.) ACH. induces cellular differentiation of human keratinocytes. Fitoterapia, 129:226-236, doi.org/10.1016/j.fitote.2018.07.010

    Esch S, König S, Bopp B, Jose J, Brandt S, Hensel A (2018) Cryptotanshinone from Salvia miltiorrhiza roots changes differentiation of keratinocytes by activation of peptidyl-prolyl-cis-trans-isomerase FKBP1A, leading to reduced cytokeratin CK1/10 expression. Planta Medica

    Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Fassl S, Zenker S, Dreiling A, Chakraborty D, Fröhling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schafers MA, Ludwig S, Stoll M, Leanderson T, Schultze J, König S, Pap T, Roth J (2018) Local restriction of sterile inflammation by auto-inhibitory regulation of S100A8/S100A9-alarmin activity. J Clinical Investigations, doi.org/10.1172/JCI89867

    Ruland T, Wolbert J, Gottschalk MG, König S, Schulte-Mecklenbeck A, Minnerup J, Meuth SG, Gross CC, Wiendl H, Meyer Zu Hörste G (2018) Cerebrospinal fluid concentrations of neuronal proteins are reduced in primary angiitis of the central nervous system. Frontiers in Neurology, doi: 10.3389/fneur.2018.00407

    König S, Hadrian K, Schlatt S, Wistuba J, Thanos S, Böhm MRR (2018) Topographic protein profiling of the age-related proteome in the retinal pigment epithelium of Callithrix jacchus with respect to macular degeneration. Journal of Proteomics

  • Originalpublikationen 2016 - 2017

    König, S., Marco, H., Gäde, G. (2017) The hypertrehalosaemic neuropeptides of cicadas are structural isomers – Evidence by ion mobility mass spectrometry. Anal. Bioanal. Chem., DOI: 10.1007/s00216-017-0583-4

    König, S., Altendorfer, I., Saenger, T., Bleck, E., Vordenbäumen, S., Schneider, M., Jose, J. (2017) Ser71 of αS1-casein is phosphorylated in breast milk – Evidence from targeted mass analysis. Mol. Nutr. Food Res., DOI: 10.1002/mnfr.201700496

    König, S., Reproducibility in gel-based protein and proteome analysis: external and internal standardization with CoFGE. (2017) J. Integrated Omics 7:42-43

    Bayer, M., König, S. (2017) A vote for robustness: Monitoring serum enzyme activity by thin-layer chromatography of dabsylated bradykinin products. Journal of Pharmaceutical and Biomedical Analysis, DOI: 10.1016/j.jpba.2017.06.007

    Schildt, A., Schlereth, T., Birklein, F., König, S. (2017) Analyzing marker substances for CRPS. Mercator J. Biomol. Anal. 1:1-23

    Bayer, M., König, S. (2016) Pyrylium-based dye- and charge-tagging in proteomics. Electrophoresis, DOI: 10.1002/elps.201600318

    Bayer, M., König, S. (2016) Abundant cysteine side reactions in traditional buffers interfere with the analysis of posttranslational modifications and protein quantification – How to compromise. Rapid Commun. Mass Spectrom. 30: 1823-1828

  • Originalpublikationen 2014 - 2015

    Terwege, T., Hanekamp, W., König, S., Lehr, M. (2015) ω-Imidazolyl- and ω-tetrazolylalkylcarbamates as inhibitors of fatty acid amide hydrolase (FAAH): biological activity and in vitro metabolic stability. ChemMedChem, DOI: 10.1002/cmdc.201500445

    Brand, C., Fröhlich, M., Ring, J., Schliemann, C., Kessler, T., Mantke, V., König, S., Lücke, M., Mesters, R., Berdel, W., Schwöppe, C. (2015) Tumor Growth Inhibition via Occlusion of Tumor Vasculature Induced by N-terminally PEGylated Retargeted Tissue Factor tTF-NGR. Mol. Pharmaceutics, 12 (10): 3749–3758

    Böhm, M., Sturm, R., König, S., Bauer, J., Metze, D., Sunderkötter, C., Luger, T. A., Weishaupt, C. (2015) Lack of protection from development of multiple melanomas by an injected melanocortin analogue in a combined high risk MC1R/CDKN2A genotype patient. Journal of the European Academy of Dermatology and Venerology,

    Hensel, A., Zacharski, D., Brandt, S., Esch, S., König, S., Mormann, M., Ulrich-Merzenich, G. (2015) Xyloglucan from Tropaeolum majus seeds induces cellular differentiation of human keratinocytes by inhibition of EGFR phosphorylation and decreased activity of transcription factor CREB. Biomacromolecules, DOI: 10.1021/acs.biomac.5b00553

    Hanneken, M., Slais, K., König, S. (2015) pI-Control in Comparative Fluorescence Gel Electrophoresis (CoFGE) using amphoteric azo dyes. EuPA Open Proteomics 2015, 10.1016/j.euprot.2015.03.003; Data in Brief, DOI 10.1016/j.dib.2015.03.007

    Hanneken, M., Ackermann, D., König, S. (2014) Comparative two dimensional fluorescent electrophoresis (CoFGE). EuPA Open Proteomics 5, 44, doi:10.1016/j.euprot.2014.09.015

    Altendorfer, I.*, König, S.*, Braukmann, A., Saenger, T., Bleck, E., Vordenbäumen, S., Kubiak, A., Schneider, M., Jose, J. (2015) Quantification of αS1-casein in breast milk using a targeted mass spectrometry-based approach. J. Pharmac. Biomed. Anal. 103: 52-58

    Dreiling, A., Hanneken, M., König, S. (2014) Early cleavage of ethylene glycol bis(succinimidylsuccinate) (EGS)-linker moieties during enzymatic digestion of cross-linked proteins. Rapid Commun. Mass Spectrom. 28: 2385-2388

    Hanneken, M., Ackermann, D., König, S. (2014) Koordinatenbestimmung von Proteinpunkten in 2D-PAGE-Gelen. Biospektrum 20, 5.14

    Pakkianathan, B. C., Singh, N. K., König, S.*, Krishnan, M.* (2014) Anti-apoptotic activity of the 30 kDa family of lipoproteins from fat body tissue of silkworm, Bombyx mori. Insect Sci. Doi: 10.1111/1744-7917.12119

  • Originalpublikationen 2012 - 2013

    Hanneken, M., König, S., Horizontal comparative fluorescence two-dimensional gel electrophoresis for improved spot coordinate detection., Electrophoresis 2013,

    Kirchhefer, U., Heinick, A., König, S., Kristensen, T., Müller, F. U., Seidl, M., Boknik, P. (2013) Protein phosphatase 2A is regulated by PKC alpha-dependent phosphorylation of its targeting subunit B56alpha at Ser41. JBC

    Singh, N. K.*, Pakkianathan, B. C.*, Kumar, M., Prasad, T., Kannan, M., König, S.*, Krishnan, M.* (2013) Vitellogenin from the silkworm, Bombyx mori: An effective anti-bacterial agent. PlosOne

    Sehlbach, M., König, S., Mormann, M., Sendker, J., Swamy, M., Hensel, A. (2013) The arabinogalactan protein cluster isolated from Jatropha curcas L seed embryo contains fasciclin, xylogen and LysM proteins. Carbohydrate Polymers, DOI dx.doi.org/10.1016/j.carbpol.2013.06.003

    Quiskamp, N., Poeter, M., Raabe, C. A., Hohenester, U. M., König, S., Gerke, V., Rescher, U. (2013) The tumor suppressor annexin A10 is a novel component of nuclear paraspeckles. Cellular and Molecular Life Sciences, DOI 10.1007/s00018-013-1375-4

    Dreiling, A., König, S. (2013) Side reactions in protein cross-linking experiments using azide linkers. Rapid Commun. Mass Spectrom., 27:1887-1890

    Böhm, M. R. R., Mertsch, S., König, S., Spieker, T., Thanos, S. (2013) Macula-less rat and macula-bearing monkey retinas exhibit common lifelong proteomic changes. Neurobiology of Aging 2013, DOI dx.doi.org/10.1016/j.neurobiolaging.2013.04.020

    Schwöppe, C., Zerbst, C., Fröhlich, M., Schliemann, C., Kessler, T., Liersch, R., Overkamp, L., Holtmeier, R., Stypmann, J., Dreiling, A., König, S., Höltke, C., Lücke, M., Müller-Tidow, C., Mesters, R., Berdel, W. (2013) Anticancer therapy by tumor vessel infarction with polyethylene glycol (PEG) conjugated retargeted tissue factor. J. Medicinal Chemistry, 56: 2337-2347

    Tekook, M., Fabritz, L., Kirchhof, P., König, S., Müller, F. U., Schmitz, W., Tal, T., Zlotkin, E., Kirchhefer, U. (2012) Gene construction, expression and functional testing of an inotropic polypeptide from the venom of the black scorpion Hottentotta judaicusToxicon, online Oct. 18

    Hohenester, U.M., Ludwig, K., König, S. (2012) Chemical phosphorylation of histidine residues in proteins using potassium phosphoramidate - A tool for the analysis of acid-labile phosphorylation. Curr. Drug Deliv., Sep 17. [Epub ahead of print]

    Hermann, A., König, S., Lechtenberg, M., Sehlbach, M., Vakrushev, S., Peter-Katalinic, J., Hensel, A., Polysaccharides and glycoproteins from Boswellia serrata Roxb. and B. carteri Birdw. and identification of a proteolytic plant basic secretory protein. Glycobiology 2012

    König, S. »Progress in Bioanalysis of Protein Histidine Phosphorylation« Journal of Analytical and Bioanalytical Techniques (2012) 3:2

    Thanos, S., Gatzioufas, Z., Schallenberg, M., König, S., Meyer-Rüsenberg, H.-W., Busse, H., Clinical transplantation of individualized recipient-serum-adapted cornea (RSAC) reduces the risk of graft rejection after keratoplasty. Cell Transplant 2012

    Hahn, A., Kaufmann, J. K., Wies, E., Naschberger, E., Panteleev-Ivlev, J., Schmidt, K., Holzer, A., Schmidt, M., Chen, J., König, S., Ensser, A., Myoung, J., Brockmeyer, N. H., Stürzl, M., Fleckenstein, B., Neipel, F., The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi’s sarcoma-associated herpesvirus. Nat Med 2012

    Thierbach, S., Büldt-Karentzopoulos, K., Dreiling, A., Hennecke,U., König, S., Fetzner, S., Hydrolase-like properties of a cofactor-independent dioxygenase. ChemBioChem 2012, DOI: 10.1002/cbic.201200152

    Ackermann, D., Wang, W., Streipert, B., Geib, B., Grün, L., König, S., Comparative fluorescence two-dimensional gel electrophoresis using a gel strip sandwich assembly for the simultaneous on-gel generation of a reference protein spot grid., Electrophoresis 2012

    Pakkianathan, B. C., Singh, N. K., Krishnan, M., König, S., A proteomic view on the developmental transfer of homologous 30 kDa lipoproteins from peripheral fat body to perivisceral fat body via hemolymph in silkworm, Bombyx mori. BMC Biochemistry 2012, 13:5, doi:10.1186/1471-2091-13-5

    König, S., Thomas Letzel: Protein and peptide analysis by LC-MS, RSC Publishing 2011. Analytical and Bioanalytical Chemistry (2012) Book review, DOI 10.1007/s00216-011-5693-9

  • Originalpublikationen 2010 - 2011

    Kummer, M. P., Hermes, M., Hammerschmidt, T., Kumar, S., Terwel, D., Walter, J., Pape, H. C. König, S., Roeber, S., Kretschmar, H., Heneka, M. T., Nitration of Tyr10 critically enhances amyloid beta aggregation and plaque formation. Neuron (2011) 71: 833-844

    Ferenz, K., Rose, K., König, S.* Krieglstein, J.*, ATP-NGF-complex, but not NGF, is the neuroprotective ligand. Neurochemistry Intern. (2011)

    Ludwig, K., Habbach, S., Klumpp, S., Krieglstein, J., König, S., MALDI-TOF high mass calibration up to 200 kDa using human recombinant 16 kDa protein histidine phosphatase aggregates. Plos ONE (2011)

    Ackermann, D., Wang, W., Grün, L., König, S., Improved gel electrophoresis. Patent application EP11167383.6, May 25, 2011; Application to University of Münster, Feb. 25, 2009

    Gast, R., König, S., Rose, K., Ferenz, K., Krieglstein, J., Binding of ATP to vascular endothelial growth factor isoform VEGF-A165 is essential for inducing proliferation of human umbilical vein endothelial cells. BMC Biochemistry (2011) 12:28

    Kriegeskorte, A.*, König, S.*, Sander, G., Pirkl, A., Mahabir, E., Proctor, R. A., von Eiff, C., Peters, G., Becker, K., Small colony variants of Staphylococcus aureus reveal distinct protein profiles. (2011) Proteomics,

    Wang, W., Ackermann, D., Mehlich, A.-M., König, S., Impact of quenching failure of Cy dyes in DIGE. Plos One (2011)

    König, S., Dimitri Pappas: Practical cell analysis, Wiley 2010, Analytical and Bioanalytical Chemistry (2010) 398, 1:13-14

    Arriaga, E. A., König, S., Analytical tools for cell research. Analytical and Bioanalytical Chemistry (2010) 397,8: 3161-3162

    Hohenester, U. M., Ludwig, K., Krieglstein, J., König, S., Proteomic methodologies access acid-labile histidine phosphorylation. Biomacromol. Mass Spectrom. 2010, 2,2: 71-76

    Wang, W., Ackermann, D., Mehlich, A.-M., König, S., False labelling due to quenching failure of N-hydroxysuccinimide-ester coupled dyes., Proteomics 2010, 10, 1-5

    Hohenester, U. M., Ludwig, K., Krieglstein, J., König, S., Stepchild phosphohistidine – Acid-labile phosphorylation becomes accessible by functional proteomics, Anal. Bioanal. Chem. 2009

    Hasche, A., Ferenz, K.B., Rose, K., König, S., Humpf, H.-U., Klumpp, S., Krieglstein, J., Binding of ATP to nerve growth factor: Characterization and relevance for bioactivity, Neurochemistry Intern. (2010) 56: 276-284, Paper in Forefront

    Pirkl, A., Dreisewerd, K., Yew, J., König, S., Field-based ion generation from microscale emitters on natural and artificial objects for atmospheric pressure mass spectrometry. Analytical and Bioanalytical Chemistry (2010) 397,8: 3311-3316

  • Originalpublikationen 2008 - 2009

    Lewin, G., Matus, M., Basu, A., Frebel, K., Rohsbach, S.P., Safronenko, A., Seidl, M.D., Stümpel, F., Buchwalow, I., König, S., Engelhardt, S., Lohse, M. J., Schmitz, W., Müller, F.U., Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction. Circulation 2009, 119:79-88

    Thanos, S., König, S., Gatzioufas, Z., Schallenberg, M., Meyer-Rüsenberg, H.-W., Stupp, T., Busse, H. Differentielle Wirkung von serumfaktoren auf die kultivierten Spenderhornhäute: Ein proteomischer Vergleich zwischen fötalem Kälberserum und humanem Serum. Posterpreis der Deutschen Ophthalmologischen Gesellschaft 2008

    Rose, K., Schröer, U., Volk, G. F., Schlatt, S., König, S., Feigenspan, A, Thanos, S., Axonal regeneration in the organotypically cultured monkey retina: Biological aspects, dependence on substrates and age-related proteomic profiling.Restor. Neurol. Neurosci. 2008, 26, 4-5: 249-266

    König, S., Pirkl A., Dreisewerd, K. FLIE ion source, European Patent Application EP08157207, WO 2009/152945

    Raberg, M., Reinecke, F., Reichelt, R., Malkus, U., König, S., Pötter, M., Fricke, W.F., Pohlmann, A., Voigt, B., Hecker, M., Friedrich, B., Bowien, B., Steinbüchel, A.  Ralstonia eutropha H16 changes flagellation according to nutrient supply and state of poly(3-hydroxybutyrate) accumulation, Appl. Environ. Microbiol. 008,74(14):4477-4490

    König, S., Mehlich, A.-M., Ackermann, D., Hamid, M. E., Saeed, N. S., Mukhtar, M., ElHassan, M.  Homologous housekeeping proteins in Nocardia - The NoDaMS proteomic database. Frontiers in Bioscience (2008) 13: 842-855, Special issue Biomolecular structure, function and location: The universal role of mass spectrometry

    König, S., Hasche, A., Pallast, S., Krieglstein, J., Klumpp, S., Detection of ATP-binding to growth factors, JASMS (2008) 19/1: 91-95

    König, S. Target coatings and desorption surfaces in biomolecular MALDI-MS. Proteomics (2008) 8:706-14

    Scobiola, S., Klocke, R., Kuhlmann, M., Tian, W., Hasib, L., Milting, H., König, S., Eisenacher, M., El-Banayosy, A., Tenderich, G., Michel, G., Breithardt, G., Nikol, S.  Up-regulation of nestin in the infarcted myocardium potentially indicates differentiation of resident cardiac stem cells into various lineages including cardiomyocytes. FASEB Journal

    Fonagy, A., Marco, H., König, S., Gäde, G., Biological activity and identification of neuropeptides in the neurosecretory complexes of the cabbage pest insect, Mamestra brassicae (Noctuidae; Lepidoptera). Acta Biologica Hungarica (2008) 59,4:384-402

  • Originalpublikationen 2006 - 2007

    König, S., Kollas, O., Dreisewerd, K.  Generation of highly-charged peptide and protein ions by atmospheric pressure matrix-assisted infrared laser desorption ionization ion trap mass spectrometry. Anal. Chem. (2007) 79, 14: 5484 -5488

    Lasseck, J., Schröer, U., König, S., Thanos, S. Regeneration of retinal ganglion cell axons in organ culture is increased in rats with hereditary buphthalmos. Exp. Eye Res. (2007) 85: 90-104

    Arias-Loza, P.-A., Hu, K., Dienesch, C., König, S., Mehlich, A.M., Jazbutyte, V., Fritzemeier, K.-H.,  Hegele-Hartung, C., Neyses,  L., Theo Pelzer, T. Both estrogen receptor subtypes, ER alpha and ER beta, attenuate cardiovascular remodeling in aldosteron-salt treated rats. Hypertension (2007) 50:432-438

    Scholzen, T. E., König, S., Luger, T. Terminating the stress: Peripheral peptidolysis of proopiomelanocortin-derived regulatory hormones by the dermal microvascular endothelial cell extracellular peptidases neprilysin and angiotensin-converting enzyme. Endocrinology (2007) 148, 6: 2793-2805

    Tessmer, N., König, S., Malkus, U., Reichelt, R., Pötter, M., Steinbüchel, A.  Heat-shock protein HspA mimics the function of phasins sensu strictu in recombinant strains of Escherichia coli accumulating polythioesters or polyhydroxyalkanoates. Microbiology (2007) 153,2:366-374

    Hoffmann, S., Jonas, E., König, S., Preusser-Kunze, A., Willbold, W. Nef protein of human immunodeficiency virus type 1 binds its own myristoylated N-terminus. Biol. Chem. (2007) 388: 181-183

    Zeller, M. Levkau, B., and König, S. Protein kinase B autophosphorylation affects activity, Biomacromol. Mass Spectrom. 1, 3 (2007) 179-186

    Zeller, M., T. Vogl, J. Roth, and S. König, Phosphorylation site analysis of MRP14 purified from granulocytes. Biomacromolecular Mass Spectrometry 1, 2 (2007) 127-133

    Fales, H. M. and S. König Reflections on mass spectrometry and other issues. Biomacromolecular Mass Spectrometry 1, 2 (2007) 99-125

    König, S. The crux of proteome analysis. Comment, Biomacromolecular Mass Spectrometry 1, 2 (2007) 135-141

    Grote, J., König, S., Ackermann, D., Sopalla, C., Benedik, M., Los, M., Kerkhoff, C. Identification of  poly(ADP-ribose) polymerase-1 and Ku70/Ku80 as transcriptional regulator of S100A9 gene expression.  BMC Molecular Biology 2006, 7:48 - HIGHLY ACCESSED -

    König, S., Mehlich, A.-M., Büllesbach, J., Michiels, N. Allohormones in Lumbricus terrestris? Mass spectrometry of the setal gland product indicates possible role of ubiquitin. Invertebrate Reproduction & Dev. 49, 1-2 (2006) 103-111, SwissProt submission P84589

    von Otte, S., Paletta, J., Becker, S., König, S., Fobker, M., Greb, R., Kiesel, L., Assmann, G., Diedrich, K., and J.-R. Nofer, Follicular fluid high density lipoprotein (HDL) -associated sphingosine 1-phosphate is a novel mediator of ovarian angiogenesis. J. Biol. Chem. 281, 9 (2006) 5398-5405

    Eisenacher, M., deBraaf, J., König, S. Mass analysis peptide sequence prediction (MAPSP) Bioinformatics 22, 8 (2006) 1002-1003

  • Originalpublikationen 2004 - 2005

    König, S., Albers, C, Gäde, G. Mass spectral signature for insect adipokinetic hormones. RCM 19 (2005) 3021-3024

    König, S. Prediction of insect adipokinetic hormone sequences assists in de novo structure elucidation. RCM 19 (2005) 2103-2104

    Grote, J., N. Dankbar, E. Gedig, and S. König, A surface plasmon resonance / mass spectrometry interface. Anal. Chem. 77, 4 (2005), 1157-1162

    Zeller, M., M. Pötter, A. Steinbüchel, F. Reinecke, W. I. Burkitt, P. Derrick, and S. König. Mass spectrometry identifies homologues of phasin PhaP1 protein of Ralstonia eutropha on polyhydroxybutyrate granules. Biomacromolecular Mass Spectrometry 1, 1 (2005) 75-84

    Sun, G., Y. Ma, X. Gao, S. König, H. M. Fales, and P. Kador Method for isolating tight-binding inhibitors of rat lens aldose reductase Exp. Eye Res. 79, 6 (2004) 919-926

    Suder, P., A. Bierczynska, S. König, and J. Silberring Acid-labile surfactant assists in-solution digestion of proteins resistant to enzymatic attack. Rapid Commun. Mass Spectrom. 18 (2004) 822-824

    König, S., F. Wagner, E. Kauschke, and I. Eue Sequence analysis of earthworm hemolysins. Spectroscopy – An Intern. J, Special Issue 18, 2 (2004) 347-353

  • Originalpublikationen 2002 - 2003

    Koltzscher, M., C. Neumann, S. König, and V. Gerke. Ca2+-dependent Binding and Activation of Dormant Ezrin by Dimeric S100P. Mol. Biol. of the Cell 14 (2003) 2372-2384

    Zeller, M., F. Essmann, R..U. Jänicke, K.Schulze-Osthoff, and S. König, A rapid non-radioactive peptide phosphorylation assay. J. Exp. Therapeutics and Oncology 3 (2003) 1-3

    König, S., O. Schmidt, K. Rose, S. Thanos, M. Besselmann, and M. Zeller Sodium dodecyl sulfate versus Acid-labile Surfactant Gel Electrophoresis: Comparative Proteomic Studies on Rat Retina and Mouse Brain. Electrophoresis 24 (2003) 751-756.

    König, S., J. Grote, and E. Gedig, High-Capacity Dextran Hydrogels for Protein Mass Spectrometry Intern. Biotechn. Lab. 20, 1 (2002) 10

    Eue, I., S. König, J. Pior, and C. Sorg, S100A8, S100A9 and the S100A8/A9 heterodimer complex specifically bind to human endothelial cells. Identification, characterization and structural analysis of a S100A9 - binding protein from HMEC-1 cells. Intern. Immun. 14, 3 (2002) 287-297

    König, S., and J. Grote, Hydrophobic targets for MALDI mass spectrometry. BioTechniques 32, 4 (2002) 912-915

    Zeller, M., E. K. Brown, E.Bouvier, and S. König, Use of an Acid-labile Surfactant as SDS Substitute for Gel Electrophoresis and Proteomic Analysis. J. Biomol. Techn. 13 (2002) 1-4

    König, S., F. Wagner, E. Kauschke, J. Peter-Katalinic, E. L. Cooper, and I. Eue, Mass Spectrometric Analysis of CL39, CL41, and H1, H2, H3 Confirm Identity With Fetidin and Lysenin Produced by Earthworm Leucocytes. Dev. Comp. Immun. 27 (2002) 513- 520

    Huss, M., G. Ingenhorst, S. König, M. Gaßel, S. Dröse, A. Zeeck, K. Altendorf, and H. Wieczorek, Concanamycin A, the Specific Inhibitor of V-ATPases, Binds to the V0 Subunit c. JBC 277, 43 (2002) 40544-40548

    Yiallouros, I., R. Kappelhoff, O. Schilling, F. Wegmann, M. W. Helms, A. Auge, G. Brachtendorf, E. Große Berkhoff, B. Beermann, H.-J. Hinz, S. König, J. Peter-Katalinic, and W. Stöcker, Activation mechanism of pro-astacin. Role of pro-peptide, tryptic and autoproteolytic cleavage and importance of precise amino-terminal processing. J. Mol. Biol. 324 (2002) 237-246.

  • Originalpublikationen 2000 - 2001

    Kauschke, E., K. Komiyama, I. Moro, I. Eue, S. König, and E. Cooper, Evidence for Perforin-like Activity Associated with Earthworm Leukocytes. Zoology, 104 (2001) 13-24

    König, S., M. Zeller, J. Peter-Katalinic, J. Roth, C. Sorg, and T. Vogl, Use of Non-Specific Cleavage Products for Protein Sequence Analysis as Shown on Calcyclin Isolated from Human Granulocytes. J. Am. Soc. Mass Spectrom. 12, 11 (2001) 1180-1185

    König, B., D. C. Mitchell, S. König, B. J. Litman, S. Grzesiek and A. Bax, Measurement of dipolar couplings in a transducin peptide fragment weakly bound to oriented photo-activated rhodopsin. J. Biomol. NMR, 16 (2000) 121-125

    Driscoll, W., S. König, Henry M. Fales, L. Pannell, Betty A. Eipper, and Gregory P. Mueller ,Mechanism-Based Inactivation of Peptidylglycine-α-Hydroxylating Monooxygenase by the Suicide Substrate Analog 4-Phenyl-3-Butenoic Acid. Biochemistry, 39 (2000) 8007-8016

    Zamfir, A., S. König, J. Althoff, and J. Peter-Katalinic, Capillary Electrophoresis and Off-line CE-ESI-QTOF Tandem-Mass Spectrometry of Carbohydrates. J. Chromatography A, 895 (2000) 291-299

  • Originalpublikationen 1997 - 1999

    König, S., and H. M. Fales, Calibration of Mass Ranges up to m/z 10,000 in Electrospray Mass Spectrometers. J. Am. Soc. Mass Spectrom. 10 (1999) 273-276

    Barrett, W., J. P. DeGnore, S. König, H. M. Fales, Y.-F. Keng, Z.-Y. Zhang, M.-B. Yim, and P. B. Chock, Regulation of PTP1B via Glutathionylation of the Active Site Cysteine 215. Biochemistry 38 (1999) 6699-6705

    König, S., S. Weiler, and H. M. Fales, On-line Microdialysis for Mass Spectrometry. BioTechniques, 24 (1998) 712-716

    Nosworthy, N., A. Peterkofsky, S. König, Y.-J. Seok, R. H. Szczepanowski, and A. Ginsburg »Phosphorylation Destabilizes the Amino Terminal Domain of Enzyme I of the Escherichia coli Phosphoenolpyruvate:sugar Phosphotransferase System« Biochemistry 37 (1998) 6718-6726

    König, S., and H. M. Fales, Formation and Decomposition of Water Clusters as Observed in a Triple Quadrupole Mass Spectrometer. J. Am. Soc. Mass Spectrom., 9 (1998) 814-822

    König, S., K. D. Haegele, and H. M. Fales, Comment on the Cylindrical Capacitor Electrospray Interface. Anal. Chem., 70 (1998) 4453-4455

    DeGnore, J., S. König, W. Barrett, P. B. Chock, and H. M. Fales, Identification of the Oxidation States of the Active Site Cysteine in a Recombinant Protein-Tyrosine Phosphatase by Electrospray Mass Spectrometry Using On-line Desalting. Rapid Commun. Mass Spectrom. 12 (1998) 1457-1462

    König, S., and H. M. Fales, Gradient-Based Automated Protein Folding. BioTechniques 23, 6 (1997) 1010-1013