Regenerative Biomedicine
Centre of Reproductive Medicine and Andrology
Albert-Schweitzer-Campus 1, Geb. D11
48149 Münster
Tel. +49 (0)251 83-58240
E-Mail  Dr. Christoph Brenker
ResearchGate

• Wissenschaftlicher Werdegang

  Seit 2015	Wissenschaftlicher Mitarbeiter am Centrum für Reproduktionsmedizin und Andrologie (CeRA), Münster
  2013-2015	PostDoc am Deutschten Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn
  2011-2013	PostDoc am Center of Advanced European Studies And Research (caesar), Bonn
  2008-2011	Doktorand am Center of Advanced European Studies And Research (caesar), Bonn
  2002-2008	Physikstudium (Diplom) an der Universität Bonn

• Publikationen

  Ritter N, Disse P, Aymanns I, Mücher L, Schreiber JA, Brenker C, Strünker T, Schepmann D, Budde T, Strutz-Seebohm N, Ametamey SM, Wünsch B, Seebohm G. (2023) "Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives." Mol Neurobiol. 2023 Aug 5. doi: 10.1007/s12035-023-03526-1

  Young, S.*, Schiffer, C.*, Wagner, A., Patz, J., Potapenko, A., Herrmann, L., Nordhoff, V., Pock, T., Krallmann, C., Stallmeyer, B., Röpke, A., Kierzek, M., Biagioni, C., Wang, T., Haalck, L., Deuster, D., Hansen, J. N., Wachten, D., Risse, B., Behre, H. M., Schlatt, S., Kliesch, S., Tüttelmann, F.*, Brenker, C.*, Strünker, T.* (2024) "Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation" Journal of Clinical Investigation 134(1):e173564 doi.org/10.1172/JCI173564.

  Schneider, S., Kovacevic, A., Mayer, M, Dicke, A. K., Arévalo, L., Koser, S. A., Hansen, J. N., Young, S., Brenker, C., Kliesch, S., Wachten, D., Kirfel, G., Strünker, T., Tüttelmann, F., Schorle, H., (2023) "Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human" eLife; 12:RP86100 doi.org/10.7554/eLife.86100.3

  Aprea I,O Wilken A, Krallmann C, Nöthe-Menchen T, Olbrich H, Loges NT, Dougherty GW, Bracht D, Brenker C, Kliesch S, Strünker T, Tüttelmann F, Raidt J, mran H. (2023) "Pathogenic gene variants in CCDC39, CCDC40, RSPH1, RSPH9, HYDIN, and SPEF2 cause defects of sperm flagella composition and male infertility" Front Genet. 2023 Feb 17;14:1117821. doi.org/10.3389/fgene.2023.1117821. eCollection 2023. PMID: 36873931

  Schierling T, Tosi B, Eisenhardt C, Reining S, Daniliuc CG, Brenker C, Strünker T, Wünsch B. (2022) "Synthesis and Functional Characterization of Novel RU1968-Derived CatSper Inhibitors with Reduced Stereochemical Complexity" ACS Pharmacol Transl Sci. 2022 Dec 2;6(1):115-127. doi.org/10.1021/acsptsci.2c00188. eCollection 2023 Jan 13. PMID: 36654752

  Jeschke JK, Biagioni C, Schierling T, Wagner IV, Börgel F, Schepmann D, Schüring A, Kulle AE, Holterhus PM, von Wolff M, Wünsch B, Nordhoff V, Strünker T, Brenker C. (2021) "The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm." Front Cell Dev Biol. 2021 Jul 26;9:699554. doi.org/10.3389/fcell.2021.699554.

  Kierzek M, Deal PE, Miller EW, Mukherjee S, Wachten D, Baumann A, Kaupp UB, Strünker T, Brenker C. (2021) "Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes." Elife 2021 Dec 3;10:e63129. doi.org/10.7554/eLife.63129.

  Rahban, R., Rehfeld, A., Schiffer, C., Brenker, C., Egberg Palme, D., Wang, T., Lorenz, J., Almstrup, K., Skakkebaek, N., Strünker, T., Nef, S. (2021) "The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm" Human Reproduction, doi.org/10.1093/humrep/deab190

  Balbach, M., Hamzeh, H., Jikeli, J. F., Brenker, C., Schiffer, C., Hansen, J. N., Neugebauer, P., Trötschel, C., Jovine, L., Han, L., Florman, H. M., Kaupp, U. B., & Strünker, T. (2020) "Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm." Frontiers in Cell and Developmental Biology, 8, 1–15. doi.org/10.3389/fcell.2020.572735

  Wang, T., Young, S., Krenz, H., Tüttelmann, F., Röpke, A., Krallmann, C., Kliesch, S., Zeng, X., Brenker, C., & Strünker, T. (2020) "The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA." Journal of Biological Chemistry. doi.org/10.1074/jbc.RA120.013218

  Mincheva M, Wistuba J, Brenker C, Schlatt S (2020) "Challenging human somatic testicular cell reassembly by protein kinase inhibition -setting up a functional in vitro test system." Sci Rep. 2020 Jun 2;10(1):8935. doi: 10.1038/s41598-020-65924-y

  Schiffer C, Rieger S, Brenker C, Young S, Hamzeh H, Wachten D, Tüttelmann F, Röpke A, Kaupp UB, Wang T, Wagner A, Krallmann C, Kliesch S, Fallnich C, Strünker T. (2020) "Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling." EMBO J. (2020) Jan 39:e102363. doi.org/10.15252/embj.2019102363

  Hamzeh H, Alvarez L, Strünker T, Kierzek M, Brenker C, Deal PE, Miller EW, Seifert R, Kaupp UB (2019) "Kinetic and photonic techniques to study chemotactic signaling in sea urchin sperm." Methods Cell Biol. 151:487-517 doi.org/10.1016/bs.mcb.2018.12.001

  Amedonu E, Brenker C, Barman S, Schreiber JA, Becker S, Peischard S, Strutz-Seebohm N, Strippel C, Dik A, Hartung HP, Budde T, Wiendl H, Strünker T, Wünsch B, Goebels N, Meuth SG, Seebohm G, Melzer N (2019) "An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis." Front Neurol. 2019 Mar 1;10:178. doi.org/10.3389/fneur.2019.00178

  Lim S, Kierzek M, O'Connor AE, Brenker C, Merriner DJ, Okuda H, Volpert M, Gaikwad A, Bianco D, Potter D, Prabhakar R, Strünker T, O'Bryan MK (2019) "CRISP2 Is a Regulator of Multiple Aspects of Sperm Function and Male Fertility." Endocrinology. 2019 Apr 1;160(4):915-924 doi.org/10.1210/en.2018-01076

  Brenker C, Rehfeld A, Schiffer C, Kierzek M, Kaupp UB, Skakkebæk NE, Strünker T (2018) "Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals." Hum Reprod. 2018 Sep 5. doi.org/10.1093/humrep/dey275.

  Rennhack A, Schiffer C, Brenker C, Fridman D, Nitao ET, Cheng YM, Tamburrino L, Balbach M, Stölting G, Berger TK, Kierzek M, Alvarez L, Wachten D, Zeng XH, Baldi E, Publicover S, Kaupp UB, Strünker T (2018). "A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm." Br J Pharmacol. 2018 May 3. doi.org/10.1111/bph.14355

  Brenker, C.* & Schiffer, C.*, Wagner I.V., Tüttelmann, F., Röpke, A., Rennhack, A., Kaupp, U.B., Strünker, T. (2018) "Action of steroids and plant triterpenoids on CatSper Ca2+ channels in human sperm." PNAS 115, E344-E346. doi.org/10.1073/pnas.1717929115 *Equal contribution.

  Berger TK, Fußhöller DM, Goodwin N, Bönigk W, Müller A, Dokani Khesroshahi N, Brenker C, Wachten D, Krause E, Kaupp UB & Strünker T. (2016) "Post-translational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating" J Physiol. doi.org/10.1113/JP273189

  Jikeli JF, Alvarez L, Friedrich BM, Wilson LG, Pascal R, Colin R, Pichlo M, Rennhack A, Brenker C, Kaupp UB (2015) “Sperm navigation along helical paths in 3D chemoattractant landscapes” Nature Communications 6, 7985 doi.org/10.1038/ncomms8985

  Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E (2014) „The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation” Nature Immunology 15, 727-737 doi.org/10.1038/ni.2913

  Schiffer, C., Müller, A., Egeberg, D.L., Alvarez, L., Brenker, C., Rehfeld, A., Frederiksen, H., Wäschle, B., Kaupp, U.B., Balbach, M., Wachten, D., Skakkebaek, N.E., Almstrup, K. & Strünker, T. (2014) "Direct action of endocrine disrupting chemicals on human sperm.” EMBO Reports 15, 758-765. doi.org/10.15252/embr.201438869

  Brenker C, Zhou Y, Müller A, Echeverry FA, Trötschel C, Poetsch A, Xia XM, Bönigk W, Lingle CJ, Kaupp UB & Strünker T (2014) „The Ca2+-activated K+ current of human sperm is mediated by Slo3“ eLife 2014;3:e01438 doi.org/10.7554/eLife.01438

  Brenker C*, Goodwin N*, Weyand I, Kashikar ND, Naruse M, Krähling M, Müller A, Kaupp UB & Strünker T (2012) “The CatSper channel: a polymodal chemosensor in human sperm“ EMBO Journal 31, 1654 – 1665 doi.org/10.1038/emboj.2012.30

  Strünker T*, Goodwin N*, Brenker C*, Kashikar ND, Weyand I, Seifert R & Kaupp UB (2011) "The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm" Nature 471, 382-386 doi.org/10.1038/nature09769

  *contributed equally

• Current Grants

  2020 - 2023	The (patho)physiology of ion channels in human sperm (DFG, CRU326, BR 6398/1-2)
  2021 – 2022	CASA 2.0 – A new approach towards early diagnosis of hitherto unexplained male infertility (Pilot Project, CRU326, DFG)
  2018 - 2019	How to activate the oocyte? Development of a PLCζ assay to predict failure of IVF and ICSI (Pilot Project 3, CRU326, DFG)
  2016 - 2019	The action of CRISP proteins in mouse and human sperm (BR 1 2 15 07, IMF, Universität Münster)
  2016 - 2017	Molecular mechanisms of mechanosensation (PP-2016-12, Cells in Motion Universität Münster)