Dr. rer. nat. Christian Schiffer

Regenerative Biomedizin
Centrum für Reproduktionsmedizin und Andrologie
Albert-Schweitzer-Campus 1, Geb. D11
48149 Münster
Tel. +49 (0)251 83-54837
E-Mail: Dr. Christian Schiffer

  • Scientific career

    seit 2021 Projektgruppenleiter
    2017 Preis für Wissenschaftskommunikation der Klaus Tschira Stiftung
    2016-2021 Wissenschaftlicher Mitarbeiter am Centrum für Reproduktionsmedizin und Andrologie (CeRA) des Universitätsklinikums Münster
    2016 Wissenschaftlicher Mitarbeiter am Center of Advanced European Studies and Research (caesar) der Max Planck Gesellschaft, Bonn
    2016 Promotion im Fach Biochemie an der Universität zu Köln
    2013-2016 Dissertation am Center of Advanced European Studies and Research (caesar) der Max Planck Gesellschaft, Bonn
    2006-2012 Biochemie-Studium an der Heinrich-Heine-Universität Düsseldorf

  • Publikationen

    Young, S.*, Schiffer, C.*, Wagner, A., Patz, J., Potapenko, A., Herrmann, L., Nordhoff, V., Pock, T., Krallmann, C., Stallmeyer, B., Röpke, A., Kierzek, M., Biagioni, C., Wang, T., Haalck, L., Deuster, D., Hansen, J. N., Wachten, D., Risse, B., Behre, H. M., Schlatt, S., Kliesch, S., Tüttelmann, F.*, Brenker, C.*, Strünker, T.* (2024) "Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation" Journal of Clinical Investigation 134(1):e173564 doi.org/10.1172/JCI173564.
    Rahban, R., Rehfeld, A., Schiffer, C., Brenker, C., Egberg Palme, D., Wang, T., Lorenz, J., Almstrup, K., Skakkebaek, N., Strünker, T., Nef, S. (2021) "The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm" Human Reproduction, doi.org/10.1093/humrep/deab190
    Brenker, C., Schiffer, C., Strünker, T. (2021) "Method for assessing the fertilizing potential of sperm based on longitudinal axis rotation." European Patent Application: PCT/EP2020/072724. patentscope.wipo.int/search/en/detail.jsf
    Schiffer, C., Brenker, C., Strünker, T., Young, S. (2020) "CatSper-Activity-Test for determining male infertility." European Patent Application: PCT/EP2020/057904. patentscope.wipo.int/search/en/detail.jsf
    Miguel-Jiménez, S., Schiffer, C., Strünker, T., Pérez-Pé, R. (2020) "Evaluation of CatSper channel activation in different sperm species by kinetic ion-sensitive fluorimetry." Animal Reproduction Science 220, 106374. doi.org/10.1016/j.anireprosci.2020.106374
    Gromoll, J., Schiffer, C., Tüttelmann, F. (2019) "Der vergessene Mann." DFG Forschung 44 (3), 4-9. doi.org/10.1002/fors.201970302
    Balbach, M., Hamzeh, H., Jikeli, J. F., Brenker, C., Schiffer, C., Hansen, J. N., Neugebauer, P., Trötschel, C., Jovine, L., Han, L., Florman, H. M., Kaupp, U. B., & Strünker, T. (2020) "Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm." Frontiers in Cell and Developmental Biology, 8, 1–15. doi.org/10.3389/fcell.2020.572735
    Wang, T., Young, S., Krenz, H., Tüttelmann, F., Röpke, A., Krallmann, C., Kliesch, S., Zeng, X., Brenker, C., & Strünker, T. (2020) "The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA." Journal of Biological Chemistry. doi.org/10.1074/jbc.RA120.013218
    Schiffer C, Rieger S, Brenker C, Young S, Hamzeh H, Wachten D, Tüttelmann F, Röpke A, Kaupp UB, Wang T, Wagner A, Krallmann C, Kliesch S, Fallnich C, Strünker T. (2020) "Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling." EMBO J. (2020) Jan 39:e102363. doi.org/10.15252/embj.2019102363.
    Brenker C, Rehfeld A, Schiffer C, Kierzek M, Kaupp UB, Skakkebæk NE, Strünker T (2018) "Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals." Hum Reprod. 2018 Sep 5. doi.org/10.1093/humrep/dey275.
    Rennhack A, Schiffer C, Brenker C, Fridman D, Nitao ET, Cheng YM, Tamburrino L, Balbach M, Stölting G, Berger TK, Kierzek M, Alvarez L, Wachten D, Zeng XH, Baldi E, Publicover S, Kaupp UB, Strünker T (2018). "A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm." Br J Pharmacol. 2018 May 3. doi.org/10.1111/bph.14355
    Brenker, C.* & Schiffer, C.*, Wagner I.V., Tüttelmann, F., Röpke, A., Rennhack, A., Kaupp, U.B., Strünker, T. (2018) "Action of steroids and plant triterpenoids on CatSper Ca2+ channels in human sperm." PNAS 115, E344-E346. doi.org/10.1073/pnas.1717929115 *Equal contribution.
    Schiffer, C., Müller, A., Egeberg, D.L., Alvarez, L., Brenker, C., Rehfeld, A., Frederiksen, H., Wäschle, B., Kaupp, U.B., Balbach, M., Wachten, D., Skakkebaek, N.E., Almstrup, K. & Strünker, T. (2014) "Direct action of endocrine disrupting chemicals on human sperm.” EMBO Reports 15, 758-765. doi.org/10.15252/embr.201438869
    Thamm, M., Rolke, D., Jordan, N., Balfanz, S., Schiffer, C., Baumann, A., Blenau, W. (2013) "Function and distribution of 5-HT2 receptors in the honeybee (Apis mellifera)." PLoS One 12, e82407. doi.org/10.1371/journal.pone.0082407
    *contributed equally