Prof. Dr. rer. nat. Timo Strünker

Regenerative Biomedicine
Centre of Reproductive Medicine and Andrology
Albert-Schweitzer-Campus 1, Geb. D11
48149 Münster
Tel. +49 (0)251 83-58238
E-Mail  Prof. Dr. Timo Strünker
  • Wissenschaftlicher Werdegang

    since 2015 Professor at the Center of Reproductive Medicine and Andrology (CeRA), Münster
    2008 - 2015 Group Leader Research Center Caesar (Bonn), an Associate of the Max Planck Society
    2006 - 2008 Lab Head with Grünenthal GmbH, Germany
    2005 - 2006 Post-Doctoral Fellow at the Research Center Jülich, Germany
    2002 - 2005 PhD at the Research Center Juelich, Germany (PhD in Biochemistry, University of Cologne)
    1997 - 2002 Studies of Biology (Diplom-Biologe) at the University of Cologne
  • Publikationen

    Bollmann E, Schreiber JA, Ritter N, Peischard S, Ho HT, Wünsch B, Strünker T, Meuth S, Budde T, Strutz-Seebohm N, Seebohm G. (2020) "4,4'-Diisothiocyanato-2,2'-Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region." Cell Physiol Biochem. 2020 Apr 8; 54(2):321332. doi: 10.33594/000000222
    Schiffer C, Rieger S, Brenker C, Young S, Hamzeh H, Wachten D, Tüttelmann F, Röpke A, Kaupp UB, Wang T, Wagner A, Krallmann C, Kliesch S, Fallnich C, Strünker T. (2020) "Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling." EMBO J. (2020) Jan 39:e102363. doi: 10.15252/embj.2019102363.
    Trötschel C, Hamzeh H, Alvarez L, Pascal R, Lavryk F, Bönigk W, Körschen HG, Müller A, Poetsch A, Rennhack A, Gui L, Nicastro D, Strünker T, Seifert R, Kaupp UB (2019) "Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation." EMBO J. (2019) Dec 27:e102723. doi: 10.15252/embj.2019102723.
    Raju DN, Hansen JN, Rassmann S, Stüven B, Jikeli JF, Strünker T, Körschen HG, Möglich A, Wachten D. (2019) "Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains." Cells. 27;8(7). doi: 10.3390/cells8070648.
    Lim S, Kierzek M, O'Connor AE, Brenker C, Merriner DJ, Okuda H, Volpert M, Gaikwad A, Bianco D, Potter D, Prabhakar R, Strünker T, O'Bryan MK. (2019) “CRISP2 Is a Regulator of Multiple Aspects of Sperm Function and Male Fertility.” Endocrinology. 160(4):915-924. doi: 10.1210/en.2018-01076.
    Amedonu E, Brenker C, Barman S, Schreiber JA, Becker S, Peischard S, Strutz-Seebohm N, Strippel C, Dik A, Hartung HP, Budde T, Wiendl H, Strünker T, Wünsch B, Goebels N, Meuth SG, Seebohm G, Melzer N. (2019) “An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis.” Front Neurol. 10:178. doi: 10.3389/fneur.2019.00178.
    Hamzeh H, Alvarez L, Strünker T, Kierzek M, Brenker C, Deal PE, Miller EW, Seifert R, Kaupp UB. (2019) “Kinetic and photonic techniques to study chemotactic signaling in sea urchin sperm.” Methods Cell Biol. 151:487-517. doi: 10.1016/bs.mcb.2018.12.001.
    Brenker C, Rehfeld A, Schiffer C, Kierzek M, Kaupp UB, Skakkebæk NE, Strünker T (2018) "Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals." Hum Reprod. 2018 Sep 5. doi: 10.1093/humrep/dey275.
    Windler F, Bönigk W, Körschen HG, Grahn E, Strünker T, Seifert R, Kaupp UB (2018). "The solute carrier SLC9C1 is a Na+/H+-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding." Nat Commun. 2018 Jul 18;9(1):2809. doi: 10.1038/s41467-018-05253-x
    Rennhack A, Schiffer C, Brenker C, Fridman D, Nitao ET, Cheng YM, Tamburrino L, Balbach M, Stölting G, Berger TK, Kierzek M, Alvarez L, Wachten D, Zeng XH, Baldi E, Publicover S, Kaupp UB, Strünker T (2018). "A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm." Br J Pharmacol. 2018 May 3. doi: 10.1111/bph.14355
    Brenker C, Schiffer C, Wagner IV, Tüttelmann F, Röpke A, Rennhack A, Kaupp UB and Strünker T (2018). "Action of steroids and plant triterpenoids on CatSper Ca(2+) channels in human sperm." Proc Natl Acad Sci U S A 115(3): E344-E346
    Matschke V, Piccini I, Schubert J, Wrobel E, Lang F, Matschke J, Amedonu E, Meuth SG, Strünker T, Strutz-Seebohm N, Greber B, Scherkenbeck J & Seebohm G. (2017) "The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels" Cell Physiol Biochem. 40(6), 1549-1558
    Berger TK, Fußhöller DM, Goodwin N, Bönigk W, Müller A, Dokani Khesroshahi N, Brenker C, Wachten D, Krause E, Kaupp UB & Strünker T. (2016) "Post-translational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating" J Physiol. doi: 10.1113/JP273189
    Kaupp UB & Strünker T. (2016) "Signaling in Sperm: More Different than Similar" Trends Cell Biol. 27(2), 101-109.
    Mukherjee S, Jansen V, Jikeli JF, Hamzeh H, Alvarez L, Dombrowski M, Balbach M, Strünker T, Seifert R, Kaupp UB, Wachten D. (2016) "A novel biosensor to study cAMP dynamics in cilia and flagella" eLife 5, e14052
    Strünker T., Alvarez, L. & Kaupp, U.B. (2015) "At the physical limit - chemosensation in sperm" Curr. Opin. Neurobiol. 34, 110-116
    Strünker T., & Kaupp, U.B. (2015) "Larry Cohen-50 ways to DYE your science" Neurophotonics 2, 021004-021004
    Jansen, V., Alvarez, L., Balbach, M., Strünker T., Hegemann, P., Kaupp, U.B. & Wachten, D. (2015) "Controlling fertilization and cAMP signaling in sperm by optogenetics" eLife 4, e05161
    Seifert, R., Flick, M., Bönigk, W., Alvarez, L., Trötschel, C., Poetsch, A., Müller, A., Goodwin, N., Pelzer, P., Kashikar, N.D., Kremmer, E., Jikeli, J., Timmermann, B., Kuhl, H., Fridman, D., Windler, F., Kaupp, U.B. & Strünker T. (2015) "The CatSper channel controls chemosensation in sea urchin sperm" EMBO J. 34, 379-392
    Pichlo, M., Bungert-Plümke, S., Weyand, I., Seifert, R., Bönigk, W., Strünker, T., Kashikar, N.D., Goodwin, N., Müller, A., Pelzer, P., Van, Q., Enderlein, J., Klemm, C., Krause, E., Trotschel, C., Poetsch, A., Kremmer, E. & Kaupp, U.B. (2014) "High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor" J. Cell. Biol. 206, 541-557
    Schiffer, C., Müller, A., Egeberg, D.L., Alvarez, L., Brenker, C., Rehfeld, A., Frederiksen, H., Wäschle, B., Kaupp, U.B., Balbach, M., Wachten, D., Skakkebaek, N.E., Almstrup, K. & Strünker T. (2014) "Direct action of endocrine disrupting chemicals on human sperm" EMBO Rep., DOI:10.15252/embr.201438869
    Brenker, C., Zhou, Y., Muller, A., Echeverry, F.A., Trotschel, C., Poetsch, A., Xia, X.M., Bönigk, W., Lingle, C.J., Kaupp, U.B. & Strünker, T. (2014) "The Ca2+-activated K+ current of human sperm is mediated by Slo3" eLife 3, DOI: 10.7554/eLife.01438
    Krähling, M., Alvarez, L., Debowski, K., Van, Q., Gunkel, M., Irsen, S., Al-Amoudi, A., Strünker, T., Kremmer, E., Krause, E., Voigt, I., Wörtge, S., Waisman, A., Weyand, I., Seifert, R., Kaupp, U.B. & Wachten, D. (2013) "CRIS- a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending" PLoS Genetics, DOI: 10.1371/journal.pgen.1003960
    Brenker, C., Goodwin, N., Weyand, I., Kashikar, N. D., Naruse, M., Krahling, M., Muller, A., Kaupp, U. B. & Strünker, T. (2012) "The CatSper channel: a polymodal chemosensor in human sperm" EMBO J.31, 1654-1665
    Strünker, T. (2012) "A unique K+-selective ion channel activated by a single cGMP molecule controls chemotaxis of sea urchin sperm" In: Morisawa, M. (ed.): Sperm Cell Research in the 21st Century: Historical Discoveries to New Horizons (Tokyo: Adthree Publishing Co.m Ltd), 142-145
    Strünker, T., Goodwin, N., Brenker, C., Kashikar, N.D., Weyand, I., Seifert, R. & Kaupp, U.B. (2011) "The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm" Nature 471, 382-386
    Bönigk, W., Loogen, A., Seifert, R., Kashikar, N., Klemm, C., Krause, E., Hagen, V., Kremmer, E., Strünker, T., & Kaupp, U.B. (2009) "An atypical CNG channel activated by a single cGMP molecule controls sperm chemotaxis" Science Signal. 2, ra68
    Schröder-Lang, S., Schwärzel, M., Seifert, R., Strünker, T., Kateriya, S., Looser, J., Watanabe, M., Kaupp, U.B., Hegemann, P. & Nagel, G. (2007) "Fast manipulation of cellular cAMP level by light in vivo" Nature Methods 4, 39-42
    Strünker, T., Weyand, I., Bönigk, W., Van, Q., Loogen, A., Brown, J.E., Kashikar, N., Hagen, V., Krause, E. & Kaupp, U.B. (2006) "A K+-selective cGMP-gated ion channel controls chemosensation of sperm" Nature Cell Biology 8, 1149-1154
    Balfanz, S.*, Strünker, T.*, Frings, S. & Baumann, A. (2005) "A family of octopamine receptors that specially induce cyclic AMP production or Ca2+ release in Drosophila melanogaster" J. Neurochem. 93, 440-451
    Grohmann, L., Blenau, W., Erber, J., Strünker, T., & Baumann, A. (2003) "Molecular and functional characterization of an octopamine receptor from honeybee (Apis mellifera) brain" J. Neurochem. 86, 725-735
     
    *equally contributed