Dr. rer. nat. Christoph Brenker

Regenerative Biomedicine
Centre of Reproductive Medicine and Andrology
Albert-Schweitzer-Campus 1, Geb. D11
48149 Münster
Tel. +49 (0)251 83-58240
E-Mail  Dr. Christoph Brenker

 

 

 

  • Wissenschaftlicher Werdegang

    Seit 2015 PostDoc am Centrum für Reproduktionsmedizin und Andrologie (CeRA), Münster
    2013-2015 PostDoc am Deutschten Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn
    2011-2013 PostDoc am Center of Advanced European Studies And Research (caesar), Bonn
    2008-2011 Doktorand am Center of Advanced European Studies And Research (caesar), Bonn
    2002-2008 Physikstudium (Diplom) an der Universität Bonn
  • Publikationen

    Hamzeh H, Alvarez L, Strünker T, Kierzek M, Brenker C, Deal PE, Miller EW, Seifert R, Kaupp UB (2019) "Kinetic and photonic techniques to study chemotactic signaling in sea urchin sperm." Methods Cell Biol. 151:487-517
    Amedonu E, Brenker C, Barman S, Schreiber JA, Becker S, Peischard S, Strutz-Seebohm N, Strippel C, Dik A, Hartung HP, Budde T, Wiendl H, Strünker T, Wünsch B, Goebels N, Meuth SG, Seebohm G, Melzer N (2019) "An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis." Front Neurol. 2019 Mar 1;10:178.
    Lim S, Kierzek M, O'Connor AE, Brenker C, Merriner DJ, Okuda H, Volpert M, Gaikwad A, Bianco D, Potter D, Prabhakar R, Strünker T, O'Bryan MK (2019) "CRISP2 Is a Regulator of Multiple Aspects of Sperm Function and Male Fertility." Endocrinology. 2019 Apr 1;160(4):915-924
    Brenker C*, Rehfeld A*, Schiffer C, Kierzek M, Kaupp UB, Skakkebæk NE, Strünker T (2018) "Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals." Hum Reprod. 2018 Sep 5.
    Rennhack A, Schiffer C, Brenker C, Fridman D, Nitao ET, Cheng YM, Tamburrino L, Balbach M, Stölting G, Berger TK, Kierzek M, Alvarez L, Wachten D, Zeng XH, Baldi E, Publicover S, Kaupp UB, Strünker T (2018). "A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm." Br J Pharmacol. 2018 May 3. doi: 10.1111/bph.14355
    Brenker C*, Schiffer C*, Wagner IV, Tüttelmann F, Röpke A, Rennhack A, Kaupp UB and Strünker T (2018). "Action of steroids and plant triterpenoids on CatSper Ca(2+) channels in human sperm." Proc Natl Acad Sci U S A 115(3): E344-E346
    Berger TK, Fußhöller DM, Goodwin N, Bönigk W, Müller A, Dokani Khesroshahi N, Brenker C, Wachten D, Krause E, Kaupp UB & Strünker T. (2016) "Post-translational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating" J Physiol. doi: 10.1113/JP273189
    Jikeli JF, Alvarez L, Friedrich BM, Wilson LG, Pascal R, Colin R, Pichlo M, Rennhack A, Brenker C, Kaupp UB (2015) “Sperm navigation along helical paths in 3D chemoattractant landscapes” Nature Communications 6, 7985
    Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E (2014) „The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation” Nature Immunology 15, 727-737
    Schiffer C, Müller A, Egeberg DL, Alvarez L, Brenker C, Rehfeld A, Frederiksen H, Wäschle B, Kaupp UB, Balbach M, Wachten D, Skakkebaek NE, Almstrup K, Strünker T (2014) „Direct action of endocrine disrupting chemicals on human sperm.” EMBO Reports 15, 758-765
    Brenker C, Zhou Y, Müller A, Echeverry FA, Trötschel C, Poetsch A, Xia XM, Bönigk W, Lingle CJ, Kaupp UB & Strünker T (2014) „The Ca2+-activated K+ current of human sperm is mediated by Slo3“ eLife 2014;3:e01438
    Brenker C*, Goodwin N*, Weyand I, Kashikar ND, Naruse M, Krähling M, Müller A, Kaupp UB & Strünker T (2012) “The CatSper channel: a polymodal chemosensor in human sperm“ EMBO Journal 31, 1654 – 1665
    Strünker T*, Goodwin N*, Brenker C*, Kashikar ND, Weyand I, Seifert R & Kaupp UB (2011) "The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm" Nature 471, 382-386
     
    *equally contributed