Dr. Sandra Laurentino

Institut für Regenerations- und Reproduktionsbiologie
Centrum für Reproduktionsmedizin und Andrologie
Albert-Schweitzer-Campus 1, Geb. D11
48149 Münster
Tel. +49 (0)251 83-57365
E-Mail Dr. Sandra Laurentino
 

 

  • Research interests

    Epigenetic control and reprogramming; epigenetic heterogeneity; germ cell lineage regulation; hormone receptors and transcription factors; male infertility; mitochondrial epigenetics; next-generation sequencing technologies; regulation of gene expression; single-cell analysis; spermatogenesis; sperm DNA; testicular histology.

  • Wissenschaftlicher Werdegang

    Since 2012 Post-doctoral researcher at the Center of Reproductive Medicine and Andrology (CeRA), Münster, Germany
    2007-2011 PhD student at the Health Sciences Research Center (CICS), University of Beira Interior, Covilhã, Portugal Thesis: ‘Sexual Steroid Regulation of Spermatogenesis: New Actors Enter the Stage’
    2001-2006 Studies of Biochemistry (Licenciatura degree, pre-Bologna) at the University of Beira Interior Interior, Covilhã, Portugal Thesis: ‘Study of the Expression of Androgen Receptor, Estrogen Receptors α and β and α-Inhibin and Localization of Androgen Receptor in Testicular Tissue of Infertile Men’
  • Publikationen

    Borgmann J, Tuttelmann F, Dworniczak B, Ropke A, Song H, Kliesch S, Wilkinson MF, Laurentino S, Gromoll J. The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men. Hum Mol Genet 2016:25;4898–4910
    Langenstroth-Rower D, Gromoll J, Wistuba J, Trondle I, Laurentino S, Schlatt S, Neuhaus N. De novo methylation in male germ cells of the common marmoset monkey occurs during postnatal development and is maintained in vitro. Epigenetics 2017:12;527-539
    Laurentino S, Borgmann J, Gromoll J. On the origin of sperm epigenetic heterogeneity. Reproduction 2016:151;R71-8
    Laurentino S, Beygo J, Nordhoff V, Kliesch S, Wistuba J, Borgmann J, Buiting K, Horsthemke B, Gromoll J. Epigenetic germline mosaicism in infertile men. Hum Mol Genet 2015:5; 1295-1304.
    Laurentino SS, Pinto PI, Tomas J, Cavaco JE, Sousa M, Barros A, Power DM, Canario AV, Socorro S. Identification of androgen receptor variants in testis from humans and other vertebrates. Andrologia 2013:3; 187-194.
    Laurentino S, Pinto P, Correia S, Cavaco JE, Canário AVM, Socorro S. Structural variants of sex steroid hormone receptors in the testis: from molecular biology to physiological roles. OA Biotechnology 2012:1:4.
    Laurentino SS, Correia S, Cavaco JE, Oliveira PF, de Sousa M, Barros A, Socorro S. Regucalcin, a calcium-binding protein with a role in male reproduction? Mol Hum Reprod 2012:4; 161-170.
    Oliveira PF, Alves MG, Rato L, Laurentino S, Silva J, Sa R, Barros A, Sousa M, Carvalho RA, Cavaco JE et al. Effect of insulin deprivation on metabolism and metabolism-associated gene transcript levels of in vitro cultured human Sertoli cells. Biochim Biophys Acta 2012:2; 84-89.
    Laurentino SS, Correia S, Cavaco JE, Oliveira PF, Rato L, Sousa M, Barros A, Socorro S. Regucalcin is broadly expressed in male reproductive tissues and is a new androgen-target gene in mammalian testis Reproduction 2011:3; 447-456.
    Cavaco JE, Laurentino SS, Barros A, Sousa M, Socorro S. Estrogen receptors alpha and beta in human testis: both isoforms are expressed Syst Biol Reprod Med 2009:4; 137-144 (shared first-authorship with JE Cavaco).
    Book chapters:
    Cavaco JE, Laurentino S, Correia S, Pinto P and Socorro S. Chapter 2: Naturally Occurring Androgen Receptor Splice Variants: Impact on Androgen Signaling Pathways. In Androgen Receptors: Structural Biology, Genetics and Molecular Defects ed. Socorro S, pp. 27-52, Nova Science Publishers, New York, USA (ISBN:978-1-62948-693-2).